Stephen Ahenkorah
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View article: A Cursory Gaze at Solitary Radiopharmaceutical Chelators Incorporating Macrocyclic and Acyclic Moieties
A Cursory Gaze at Solitary Radiopharmaceutical Chelators Incorporating Macrocyclic and Acyclic Moieties Open
Radiopharmaceutical development usually requires chelators to route radiometals to specific cancer targets. However, there is no universal chelator. To reduce off-target side effects, new chelators are needed as the radiometal toolset grow…
View article: Preclinical characterization of 3p-C-DEPA-NCS and 3p-C-DEPA-TFP-PEG4 as potential Actinium-225 bifunctional chelators using DOTA-NCS and macropa-NCS as benchmarks.
Preclinical characterization of 3p-C-DEPA-NCS and 3p-C-DEPA-TFP-PEG4 as potential Actinium-225 bifunctional chelators using DOTA-NCS and macropa-NCS as benchmarks. Open
Background Actinium-225 (225Ac) based targeted alpha therapies (TAT) have emerged as a promising strategy for the treatment of several cancer types due to its favourable decay properties, including high linear energy transfer an…
View article: Gallium Uncouples Iron Metabolism to Enhance Glioblastoma Radiosensitivity
Gallium Uncouples Iron Metabolism to Enhance Glioblastoma Radiosensitivity Open
Gallium-based therapy has been considered a potentially effective cancer therapy for decades and has recently re-emerged as a novel therapeutic strategy for the management of glioblastoma tumors. Gallium targets the iron-dependent phenotyp…
View article: Radiochemical and Biological Evaluation of 3p-C-NETA-ePSMA-16, a Promising PSMA-Targeting Agent for Radiotheranostics
Radiochemical and Biological Evaluation of 3p-C-NETA-ePSMA-16, a Promising PSMA-Targeting Agent for Radiotheranostics Open
Bifunctional chelators (BFCs) are a key element in the design of radiopharmaceuticals. By selecting a BFC that efficiently complexes diagnostic and therapeutic radionuclides, a theranostic pair possessing almost similar biodistribution and…
View article: 3p-C-NETA-TATE: A Potential Somatostatin Analogue for Diagnostic and Therapeutic SSTR2 Targeting Radiopharmaceuticals
3p-C-NETA-TATE: A Potential Somatostatin Analogue for Diagnostic and Therapeutic SSTR2 Targeting Radiopharmaceuticals Open
Introduction: Somatostatin-based radiopharmaceuticals (e.g., [68Ga] Ga-DOTATATE and [177Lu] Lu-DOTATATE) have been used successfully to diagnose, monitor, and treat patients with neuroendocrine tumors. [18F] AlF-NOTA-octreotide, a promisin…
View article: <sup>18</sup>F-Labeled Somatostatin Analogs as PET Tracers for the Somatostatin Receptor: Ready for Clinical Use
<sup>18</sup>F-Labeled Somatostatin Analogs as PET Tracers for the Somatostatin Receptor: Ready for Clinical Use Open
Molecular imaging of the somatostatin receptor plays a key role in the clinical management of neuroendocrine tumors. PET imaging with somatostatin analogs (SSAs) labeled with 68Ga or 64Cu is currently the gold standar…
View article: Direct comparison of [18F]AlF-NOTA-JR11 and [18F]AlF-NOTA-octreotide for PET imaging of neuroendocrine tumors: Antagonist versus agonist
Direct comparison of [18F]AlF-NOTA-JR11 and [18F]AlF-NOTA-octreotide for PET imaging of neuroendocrine tumors: Antagonist versus agonist Open
[18F]AlF-NOTA-JR11 was obtained in good RCY, albeit with a moderate RCP. The cell binding study showed significant higher binding of [18F]AlF-NOTA-JR11 compared to [18F]AlF-NOTA-octreotide, despite the high…
View article: Gamma counting protocols for the accurate quantification of 225Ac and 213Bi without the need for a secular equilibrium between parent and gamma-emitting daughter
Gamma counting protocols for the accurate quantification of 225Ac and 213Bi without the need for a secular equilibrium between parent and gamma-emitting daughter Open
Background Quantification of actinium-225 through gamma counter measurements, when there is no secular equilibrium between actinium-225 and its gamma emitting daughters bismuth-213 and/or francium-221, can provide valuable information rega…
View article: 3p-C-NETA: A versatile and effective chelator for development of Al<sup>18</sup>F-labeled and therapeutic radiopharmaceuticals
3p-C-NETA: A versatile and effective chelator for development of Al<sup>18</sup>F-labeled and therapeutic radiopharmaceuticals Open
Background: Radiolabeled somatostatin analogues (e.g. [68Ga]Ga-DOTATATE and [177Lu]Lu-DOTATATE) have been used to diagnose, monitor, and treat neuroendocrine tumour (NET) patients with great success. [
View article: Radiolabeling of Human Serum Albumin With Terbium-161 Using Mild Conditions and Evaluation of in vivo Stability
Radiolabeling of Human Serum Albumin With Terbium-161 Using Mild Conditions and Evaluation of in vivo Stability Open
Targeted radionuclide therapy (TRNT) is a promising approach for cancer therapy. Terbium has four medically interesting isotopes ( 149 Tb, 152 Tb, 155 Tb and 161 Tb) which span the entire radiopharmaceutical space (TRNT, PET and SPECT imag…
View article: Bismuth-213 for Targeted Radionuclide Therapy: From Atom to Bedside
Bismuth-213 for Targeted Radionuclide Therapy: From Atom to Bedside Open
In contrast to external high energy photon or proton therapy, targeted radionuclide therapy (TRNT) is a systemic cancer treatment allowing targeted irradiation of a primary tumor and all its metastases, resulting in less collateral damage …
View article: Bismuth-213 for Targeted Radionuclide Therapy: From Atom to Bedside
Bismuth-213 for Targeted Radionuclide Therapy: From Atom to Bedside Open
Besides external high-energy photon or proton beam therapy, targeted radionuclide therapy (TRNT) is an alternative approach to deliver radiation to cancer cells. TRNT is distributed within the body by the vascular system and allows targete…
View article: Antimalarial <i>N</i><sup>1</sup>,<i>N</i><sup>3</sup>-Dialkyldioxonaphthoimidazoliums: Synthesis, Biological Activity, and Structure–activity Relationships
Antimalarial <i>N</i><sup>1</sup>,<i>N</i><sup>3</sup>-Dialkyldioxonaphthoimidazoliums: Synthesis, Biological Activity, and Structure–activity Relationships Open
Here we report the nanomolar potencies of N 1,N 3-dialkyldioxonaphthoimidazoliums against asexual forms of sensitive and resistant Plasmodium falciparum. Activity was dependent on the presence of …
View article: Loratadine analogues as MAGL inhibitors
Loratadine analogues as MAGL inhibitors Open