Stephen Ahn
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View article: IMMU-45. Allogeneic B7-H3 γδ CAR-T Cells Effectively Eradicate Glioblastoma in Preclinical Models
IMMU-45. Allogeneic B7-H3 γδ CAR-T Cells Effectively Eradicate Glioblastoma in Preclinical Models Open
BACKGROUND γδ T cells (GDTs) represent a promising allogeneic immune cell platform due to their MHC-unrestricted cytotoxicity. In this study, we developed a novel B7-H3-specific CAR vector (CD3ζ-CD28-based) and evaluated the therapeutic ef…
View article: SURG-61. Deep Learning-Driven Automated Assessment of Extent of Resection for Survival Prediction in Newly Diagnosed IDH-Wildtype Glioblastoma
SURG-61. Deep Learning-Driven Automated Assessment of Extent of Resection for Survival Prediction in Newly Diagnosed IDH-Wildtype Glioblastoma Open
BACKGROUND Extent of resection (EOR) is a well-established prognostic factor in glioblastoma (GBM), yet its measurement in clinical settings is often subjective and time-consuming. We aimed to develop a deep learning-based model for automa…
View article: NCOG-31. Clinicopathological analysis of non-functioning pituitary adenomas (PAs) according to the 2022 WHO classification
NCOG-31. Clinicopathological analysis of non-functioning pituitary adenomas (PAs) according to the 2022 WHO classification Open
For asymptomatic non-functioning pituitary adenomas (NFPAs), conservative management such as observation is generally preferred. However, a subset of NFPAs demonstrates poor prognoses. This study aimed to identify clinicopathological chara…
View article: Boron Neutron Capture Therapy in Recurrent High-Grade Gliomas: Safety, Efficacy, and Pharmacokinetics From a Multicenter, Dose-Escalation Phase 1 Trial
Boron Neutron Capture Therapy in Recurrent High-Grade Gliomas: Safety, Efficacy, and Pharmacokinetics From a Multicenter, Dose-Escalation Phase 1 Trial Open
View article: Burnout among Korean Neurosurgeons Following a National Trainee Withdrawal during 2024–2025 Medical Crisis in Korea
Burnout among Korean Neurosurgeons Following a National Trainee Withdrawal during 2024–2025 Medical Crisis in Korea Open
Burnout among Korean neurosurgeons is widespread after the national medical crisis, with substantial deterioration in workload and lifestyle. Coordinated efforts at both hospital and national levels are essential to protect surgeon well-be…
View article: A deep learning–based model for postoperative resection assessment in glioblastoma: a comparative validation study
A deep learning–based model for postoperative resection assessment in glioblastoma: a comparative validation study Open
Background Post-operative imaging of glioblastoma presents unique challenges for tumor segmentation due to surgical cavities, hemorrhage, and treatment-related changes. Although multiple open-source artificial intelligence (AI) tools have …
View article: Tumor microenvironment-preserving gliosarcoma organoids as an in vitro preclinical platform: a comparative analysis with glioblastoma models
Tumor microenvironment-preserving gliosarcoma organoids as an in vitro preclinical platform: a comparative analysis with glioblastoma models Open
View article: Evaluating AI Chatbots in Neurological Function Test Interpretation for Brain Tumor Surgery
Evaluating AI Chatbots in Neurological Function Test Interpretation for Brain Tumor Surgery Open
Background Neuropsychological assessments are essential for evaluating functional status and guiding surgical planning in patients with brain tumors. However, their complexity may hinder interpretation for patients and junior clinicians. L…
View article: Anthropometrics, cancer risks, and survival outcomes in adult patients with glioma – a systematic review and meta-analysis
Anthropometrics, cancer risks, and survival outcomes in adult patients with glioma – a systematic review and meta-analysis Open
Purpose The association between anthropometric measures including BMI, height and cancer has been widely discussed. However, the role of these in the development and prognosis of glioma remains controversial. We aimed to study these relati…
View article: Risk Factors of Developing Leptomeningeal Seeding After Resection of Brain Metastasis in Patients With Breast Cancer: Defining the Indication for Preoperative SRS
Risk Factors of Developing Leptomeningeal Seeding After Resection of Brain Metastasis in Patients With Breast Cancer: Defining the Indication for Preoperative SRS Open
Patients with breast cancer brain metastases who were ≤45 years old, had TNBC, or underwent piecemeal resection were at high risk of developing LMS, regardless of the postoperative RT technique used. Patients with these risk factors are es…
View article: Anthropometrics, Cancer Risks, and Survival Outcomes in Adult Patients with Glioma – a Systematic Review and Meta-Analysis
Anthropometrics, Cancer Risks, and Survival Outcomes in Adult Patients with Glioma – a Systematic Review and Meta-Analysis Open
View article: Anthropometrics, Cancer Risks, and Survival Outcomes in Adult Patients with Glioma – A Systematic Review and Meta-analysis
Anthropometrics, Cancer Risks, and Survival Outcomes in Adult Patients with Glioma – A Systematic Review and Meta-analysis Open
Background The association between anthropometric measures, including height and BMI, and cancer has been widely discussed, but their role glioma development and survival remains unclear due to conflicting evidence. We synthesized existing…
View article: 422 A novel multifunctional engineered MSC cell line induces complete tumor regression, and establishes immune memory in an orthotopic GBM model
422 A novel multifunctional engineered MSC cell line induces complete tumor regression, and establishes immune memory in an orthotopic GBM model Open
View article: Inhibitory Fcγ receptor deletion enhances CD8 T cell stemness increasing anti-PD-1 therapy responsiveness against glioblastoma
Inhibitory Fcγ receptor deletion enhances CD8 T cell stemness increasing anti-PD-1 therapy responsiveness against glioblastoma Open
Background Certain cancers present challenges for treatment because they are resistant to immune checkpoint blockade (ICB), attributed to low tumor mutational burden and the absence of T cell-inflamed features. Among these, glioblastoma (G…
View article: Intratumoral IL-12 delivery via mesenchymal stem cells combined with PD-1 blockade leads to long-term antitumor immunity in a mouse glioblastoma model
Intratumoral IL-12 delivery via mesenchymal stem cells combined with PD-1 blockade leads to long-term antitumor immunity in a mouse glioblastoma model Open
Anti-PD-1 and MSC_IL-12 monotherapies show long-term therapeutic responses, and their combination further enhances antitumor efficacy against glioblastoma via inducing immune-favorable tumor microenvironment.
View article: Establishment of tumor microenvironment-preserving organoid model from patients with intracranial meningioma
Establishment of tumor microenvironment-preserving organoid model from patients with intracranial meningioma Open
View article: Comprehensive Molecular Genetic Analysis in Glioma Patients by Next Generation Sequencing
Comprehensive Molecular Genetic Analysis in Glioma Patients by Next Generation Sequencing Open
We analyzed precisely diagnosing the classification of gliomas, detailing the frequency and co-occurrence of genetic alterations and identifying genetic alterations with potential therapeutic targets by NGS-based molecular analysis. The hi…
View article: Anthropometrics, Cancer Risks, and Survival Outcomes in Adult Patients with Glioma – A Systematic Review and Meta-Analysis
Anthropometrics, Cancer Risks, and Survival Outcomes in Adult Patients with Glioma – A Systematic Review and Meta-Analysis Open
View article: Potential impact of high-density lipoprotein cholesterol in the postoperative outcomes of chronic subdural hematoma patients: multi-institutional study in Korea
Potential impact of high-density lipoprotein cholesterol in the postoperative outcomes of chronic subdural hematoma patients: multi-institutional study in Korea Open
View article: EXTH-84. INTRATUMORAL IL-12 DELIVERY VIA MESENCHYMAL STEM CELLS COMBINED WITH PD-1 BLOCKADE LEADS TO LONG-TERM ANTITUMOR IMMUNITY IN A MOUSE GLIOBLASTOMA MODEL
EXTH-84. INTRATUMORAL IL-12 DELIVERY VIA MESENCHYMAL STEM CELLS COMBINED WITH PD-1 BLOCKADE LEADS TO LONG-TERM ANTITUMOR IMMUNITY IN A MOUSE GLIOBLASTOMA MODEL Open
Although PD-1 blockade is effective for treating several types of cancer, the efficacy of this agent in glioblastoma is largely limited. To overcome non-responders and the immunosuppressive tumor microenvironment, combinational immunothera…
View article: MODL-04. ESTABLISHMENT OF TUMOR MICROENVIRONMENT-PRESERVING ORGANOID MODEL FROM PATIENTS WITH INTRACRANIAL MENINGIOMA
MODL-04. ESTABLISHMENT OF TUMOR MICROENVIRONMENT-PRESERVING ORGANOID MODEL FROM PATIENTS WITH INTRACRANIAL MENINGIOMA Open
Although meningioma is the most common primary brain tumor, treatments depend only on the surgery and radiotherapy, and recurrent meningiomas have no standard therapeutic options due to a lack of clinically relevant research models. Curren…
View article: Balancing Bleeding Risk and Thromboembolic Complications in Elderly Chronic Subdural Hematoma Patients Undergoing Burr Hole Trephination : A Multicenter Retrospective Cohort Study and Literature Review
Balancing Bleeding Risk and Thromboembolic Complications in Elderly Chronic Subdural Hematoma Patients Undergoing Burr Hole Trephination : A Multicenter Retrospective Cohort Study and Literature Review Open
Objective : Chronic subdural hematoma (CSDH) patients using antithrombotic agents (AT) at high risk for cardiovascular disease are increasing. The authors aimed to analyze the factors influencing outcome by targeting patients using AT and …
View article: Polymorphisms of Killer Ig-like Receptors and the Risk of Glioblastoma
Polymorphisms of Killer Ig-like Receptors and the Risk of Glioblastoma Open
Purpose: The immune responses of natural killer (NK) cells against cancer cells vary by patient. Killer Ig-like receptors (KIRs), which are some of the major receptors involved in regulating NK cell activity for killing cancer cells, have …
View article: The Korean Society for Neuro-Oncology (KSNO) Guideline for the Management of Brain Tumor Patients During the Crisis Period: A Consensus Survey About Specific Clinical Scenarios (Version 2023.1)
The Korean Society for Neuro-Oncology (KSNO) Guideline for the Management of Brain Tumor Patients During the Crisis Period: A Consensus Survey About Specific Clinical Scenarios (Version 2023.1) Open
It is imperative that proper medical care for brain tumor patients be sustained and provided, even during the crisis period. The findings of this consensus survey will be a useful reference in determining appropriate treatment options for …
View article: Is drug discontinuation necessary before burr hole trephination surgery in chronic subdural hematoma patients taking antithrombotic agents?: a multicenter retrospective cohort study
Is drug discontinuation necessary before burr hole trephination surgery in chronic subdural hematoma patients taking antithrombotic agents?: a multicenter retrospective cohort study Open
View article: The Korean Society for Neuro-Oncology (KSNO) Guideline for the Management of Brain Tumor Patients During the Crisis Period: A Consensus Recommendation Using the Delphi Method (Version 2023.1)
The Korean Society for Neuro-Oncology (KSNO) Guideline for the Management of Brain Tumor Patients During the Crisis Period: A Consensus Recommendation Using the Delphi Method (Version 2023.1) Open
It is crucial that adequate medical care for patients with brain tumors is maintained and provided, even during times of crisis. This guideline will serve as a valuable resource, assisting in the delivery of treatment to brain tumor patien…
View article: Compassionate use of recombinant human <scp>IL‐7‐hyFc</scp> as a salvage treatment for restoring lymphopenia in patients with recurrent glioblastoma
Compassionate use of recombinant human <span>IL‐7‐hyFc</span> as a salvage treatment for restoring lymphopenia in patients with recurrent glioblastoma Open
Purpose Addressing lymphopenia in cancer patients has been suggested as a novel immunotherapeutic strategy. As interleukin‐7 (IL‐7) is necessary for proliferation of lymphocytes and to increase total lymphocyte count (TLC), IL‐7 therapy ha…
View article: IMMU-15. HUMAN ALLOGENIC γδ T CELLS KILL PATIENT-DERIVED GLIOBLASTOMA CELLS IN A PVR- AND DNAM-1-DEPENDENT MANNER
IMMU-15. HUMAN ALLOGENIC γδ T CELLS KILL PATIENT-DERIVED GLIOBLASTOMA CELLS IN A PVR- AND DNAM-1-DEPENDENT MANNER Open
Background Adoptive transfer of γδ T cells is a novel immunotherapeutic approach to glioblastoma. Few recent studies have shown the efficacy of γδ T cells against glioblastoma, but no previous studies have identified the ligand–receptor in…
View article: Human allogenic γδ T cells kill patient-derived glioblastoma cells expressing high levels of DNAM-1 ligands
Human allogenic γδ T cells kill patient-derived glioblastoma cells expressing high levels of DNAM-1 ligands Open
Adoptive transfer of γδ T cells is a novel immunotherapeutic approach to glioblastoma. Few recent studies have shown the efficacy of γδ T cells against glioblastoma, but no previous studies have identified the ligand-receptor interactions …
View article: Sinonasal Outcomes of the Combined Transseptal/Transnasal Approach with Unilateral Nasoseptal Rescue Flap in Endoscopic Endonasal Transsphenoidal Surgery: A Propensity Score Matching Analysis
Sinonasal Outcomes of the Combined Transseptal/Transnasal Approach with Unilateral Nasoseptal Rescue Flap in Endoscopic Endonasal Transsphenoidal Surgery: A Propensity Score Matching Analysis Open
Objectives The authors applied surgical techniques acquired during the use of endoscopic combined transseptal/transnasal approach to reduce approach-related morbidity and improve sinonasal outcomes. Study Design This is a retrospective coh…