Stephen B. Doty
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View article: Adverse Outcome Pathways Applied to Space Radiation Research
Adverse Outcome Pathways Applied to Space Radiation Research Open
Long‐duration spaceflight exposes astronauts to various stressors that can alter human physiology, potentially causing immediate and long‐term health effects. These stressors can damage biomolecules, cells, tissues, and organs, leading to …
View article: AOP Report: Development of an adverse outcome pathway for deposition of energy leading to bone loss
AOP Report: Development of an adverse outcome pathway for deposition of energy leading to bone loss Open
Bone loss, commonly seen in osteoporosis, is a condition that entails a progressive decline of bone mineral density and microarchitecture, often seen in post‐menopausal women. Bone loss has also been widely reported in astronauts exposed t…
View article: Role of mitochondria in the myopathy of juvenile dermatomyositis and implications for skeletal muscle calcinosis
Role of mitochondria in the myopathy of juvenile dermatomyositis and implications for skeletal muscle calcinosis Open
Overall, our study demonstrates the mitochondrial involvement in the skeletal muscle pathology and calcinosis of JDM and mtROS as a central player in the calcification of human skeletal muscle cells. Therapeutic targeting of mtROS and/or u…
View article: Development of an adverse outcome pathway for deposition of energy leading to bone loss.
Development of an adverse outcome pathway for deposition of energy leading to bone loss. Open
Bone loss, commonly seen in osteoporosis, is a condition that entails a progressive decline of bone mineral density and microarchitecture, often seen in post-menopausal women. Bone loss has been widely reported in astronauts exposed to a p…
View article: Polymeric mesh and insulin‐like growth factor 1 delivery enhance cell homing and graft−cartilage integration
Polymeric mesh and insulin‐like growth factor 1 delivery enhance cell homing and graft−cartilage integration Open
Cartilage injury, such as full‐thickness lesions, predisposes patients to the premature development of osteoarthritis, a degenerative joint disease. While surgical management of cartilage lesions has improved, long‐term clinical efficacy h…
View article: Botox‐induced muscle paralysis alters intracortical porosity and osteocyte lacunar density in skeletally mature rats
Botox‐induced muscle paralysis alters intracortical porosity and osteocyte lacunar density in skeletally mature rats Open
Reduced mechanical loading can lead to disuse osteoporosis, resulting in bone fragility. Disuse models report macroscopic bone loss due to muscle inactivity and immobilization, yet only recently has there been quantification of the effects…
View article: Integrating soft and hard tissues via interface tissue engineering
Integrating soft and hard tissues via interface tissue engineering Open
The enthesis, or interface between bone and soft tissues such as ligament and tendon, is prone to injury and often does not heal, even post surgical intervention. Interface tissue engineering represents an integrative strategy for regenera…
View article: Adele Ludin Boskey, PhD
Adele Ludin Boskey, PhD Open
The orthopedic community has lost one of its most prestigious and beloved scientists. Adele Ludin Boskey, PhD, passed away on May 2, 2017 in New York City. A memorial service was held at the Hospital for Special Surgery (HSS) on May 17, 20…
View article: Compositional mapping of the mature anterior cruciate ligament‐to‐bone insertion
Compositional mapping of the mature anterior cruciate ligament‐to‐bone insertion Open
The anterior cruciate ligament (ACL)‐to‐bone interface constitutes a complex, multi‐tissue structure comprised of contiguous ligament, non‐mineralized fibrocartilage, mineralized fibrocartilage, and bone regions. This composite structure e…