Stephen B. Freedman
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View article: Correction: PRagMatic Pediatric Trial of Balanced vs nOrmaL Saline FlUid in Sepsis: study protocol for the PRoMPT BOLUS randomized interventional trial
Correction: PRagMatic Pediatric Trial of Balanced vs nOrmaL Saline FlUid in Sepsis: study protocol for the PRoMPT BOLUS randomized interventional trial Open
View article: Clinically Significant Neuroimaging Findings Among Pediatric Patients Presenting to the Emergency Department With Symptoms of Psychosis: A Multicenter Retrospective Study
Clinically Significant Neuroimaging Findings Among Pediatric Patients Presenting to the Emergency Department With Symptoms of Psychosis: A Multicenter Retrospective Study Open
Background The clinical utility of diagnostic neuroimaging for pediatric patients presenting to the emergency department (ED) for psychosis remains unclear. We sought to estimate the prevalence of and characteristics associated with clinic…
View article: Evaluation of a pediatric post-acute sequelae of SARS-CoV-2 index score
Evaluation of a pediatric post-acute sequelae of SARS-CoV-2 index score Open
Objective This study aims to assess the performance of the Researching COVID-19 to Enhance Recovery (RECOVER) initiative's proposed post-acute sequelae of COVID-19 (PASC) index in a cohort of children evaluated for SARS-CoV-2 infection, 6–…
View article: HEADS-ED as a Predictor of Hospitalization in Children Seeking Emergency Department Care With Mental Health Concerns
HEADS-ED as a Predictor of Hospitalization in Children Seeking Emergency Department Care With Mental Health Concerns Open
In our study population, high-risk HEADS-ED scores are moderately associated with hospitalization. Adolescents with higher HEADS-ED scores reported lower well-being.
View article: Optimal Recovery Following Pediatric Concussion
Optimal Recovery Following Pediatric Concussion Open
Importance Pediatric concussion affects millions and results in heterogeneous outcomes and recovery trajectories. Given favorable outcome for most children, it is useful to understand characteristics of positive outcome to promote full rec…
View article: Pediatric SARS-CoV-2 infection and development of anxiety and depression
Pediatric SARS-CoV-2 infection and development of anxiety and depression Open
Objective It remains unclear whether emerging mental health concerns in children infected with SARS-CoV-2 are a direct result of the infection or due to the indirect effects of the pandemic. Therefore, we sought to assess the frequency of …
View article: Child Well‐Being and Family Quality of Life During the COVID‐19 Pandemic
Child Well‐Being and Family Quality of Life During the COVID‐19 Pandemic Open
Background Little is known about changes in child well‐being and family quality of life (QoL) among children seeking emergency department care because of mental health concerns over the course of the pandemic. Methods Prospective cohort st…
View article: Outcomes Following a Mental Health Care Intervention for Children in the Emergency Department
Outcomes Following a Mental Health Care Intervention for Children in the Emergency Department Open
Importance The emergency department (ED) is an important safety net for children experiencing mental and behavioral health crises and can serve as a navigational hub for families seeking support for these concerns. Objectives To evaluate t…
View article: Author response: Persistent cross-species transmission systems dominate Shiga toxin-producing Escherichia coli O157:H7 epidemiology in a high incidence region: A genomic epidemiology study
Author response: Persistent cross-species transmission systems dominate Shiga toxin-producing Escherichia coli O157:H7 epidemiology in a high incidence region: A genomic epidemiology study Open
View article: Persistent cross-species transmission systems dominate Shiga toxin-producing Escherichia coli O157:H7 epidemiology in a high incidence region: a genomic epidemiology study
Persistent cross-species transmission systems dominate Shiga toxin-producing Escherichia coli O157:H7 epidemiology in a high incidence region: a genomic epidemiology study Open
Background Several areas of the world suffer notably high incidence of Shiga toxin-producing Escherichia coli, among them Alberta, Canada. We assessed the impact of persistent cross-species transmission systems on the epidemiology of E. co…
View article: Author response: Persistent cross-species transmission systems dominate Shiga toxin-producing Escherichia coli O157:H7 epidemiology in a high incidence region: a genomic epidemiology study
Author response: Persistent cross-species transmission systems dominate Shiga toxin-producing Escherichia coli O157:H7 epidemiology in a high incidence region: a genomic epidemiology study Open
View article: Symptom Recovery in Children Aged 5 to 12 Years With Sport-Related and Non–Sport-Related Concussion
Symptom Recovery in Children Aged 5 to 12 Years With Sport-Related and Non–Sport-Related Concussion Open
Importance There is limited research on clinical features and symptom recovery from sport-related concussion (SRC) and non-SRC in younger children. Objective To investigate the trajectory of symptom recovery in children aged 5 to 7 years a…
View article: Respiratory Viral Co-infection in SARS-CoV-2-Infected Children During the Early and Late Pandemic Periods
Respiratory Viral Co-infection in SARS-CoV-2-Infected Children During the Early and Late Pandemic Periods Open
Background: Knowledge regarding the impact of respiratory pathogen co-infection in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-infected children seeking emergency department care is limited, specifically as it relates to t…
View article: Social Behaviors Associated with SARS-CoV-2 Test Positivity Among Children Evaluated in Canadian Emergency Departments, 2020 to 2022: A Cross-Sectional Survey Study
Social Behaviors Associated with SARS-CoV-2 Test Positivity Among Children Evaluated in Canadian Emergency Departments, 2020 to 2022: A Cross-Sectional Survey Study Open
Attending social gatherings increased the risk of SARS-CoV-2 test positivity in 5-<12-year-old children, but in-person daycare/school was associated with a reduced odds of testing positive across all ages. Settings with high public health …
View article: Persistent cross-species transmission systems dominate Shiga toxin-producing Escherichia coli O157:H7 epidemiology in a high incidence region: a genomic epidemiology study
Persistent cross-species transmission systems dominate Shiga toxin-producing Escherichia coli O157:H7 epidemiology in a high incidence region: a genomic epidemiology study Open
Background Several areas of the world suffer notably high incidence of Shiga toxin-producing Escherichia coli, among them Alberta, Canada. We assessed the role of persistent cross-species transmission systems in Alberta’s E. coli O157:H7 e…
View article: Persistent cross-species transmission systems dominate Shiga toxin-producing Escherichia coli O157:H7 epidemiology in a high incidence region: A genomic epidemiology study
Persistent cross-species transmission systems dominate Shiga toxin-producing Escherichia coli O157:H7 epidemiology in a high incidence region: A genomic epidemiology study Open
Several areas of the world suffer a notably high incidence of Shiga toxin-producing Escherichia coli . To assess the impact of persistent cross-species transmission systems on the epidemiology of E. coli O157:H7 in Alberta, Canada, we sequ…
View article: Author response: Persistent cross-species transmission systems dominate Shiga toxin-producing Escherichia coli O157:H7 epidemiology in a high incidence region: a genomic epidemiology study
Author response: Persistent cross-species transmission systems dominate Shiga toxin-producing Escherichia coli O157:H7 epidemiology in a high incidence region: a genomic epidemiology study Open
View article: Mental Health Hospitalizations in Canadian Children, Adolescents, and Young Adults Over the COVID-19 Pandemic
Mental Health Hospitalizations in Canadian Children, Adolescents, and Young Adults Over the COVID-19 Pandemic Open
Importance The COVID-19 pandemic resulted in multiple socially restrictive public health measures and reported negative mental health impacts in youths. Few studies have evaluated incidence rates by sex, region, and social determinants acr…
View article: Pandemic Stringency Measures and Hospital Admissions for Eating Disorders
Pandemic Stringency Measures and Hospital Admissions for Eating Disorders Open
Importance Hospitalizations for eating disorders rose dramatically during the COVID-19 pandemic. Public health restrictions, or stringency, are believed to have played a role in exacerbating eating disorders. Few studies of eating disorder…
View article: Persistent cross-species transmission systems dominate Shiga toxin-producing <i>Escherichia coli</i> O157:H7 epidemiology in a high incidence region: a genomic epidemiology study
Persistent cross-species transmission systems dominate Shiga toxin-producing <i>Escherichia coli</i> O157:H7 epidemiology in a high incidence region: a genomic epidemiology study Open
Background Several areas of the world suffer notably high incidence of Shiga toxin-producing Escherichia coli , among them Alberta, Canada. We assessed the impact of persistent cross-species transmission systems on the epidemiology of E. c…
View article: Household Transmission Dynamics of Asymptomatic SARS-CoV-2–Infected Children: A Multinational, Controlled Case-Ascertained Prospective Study
Household Transmission Dynamics of Asymptomatic SARS-CoV-2–Infected Children: A Multinational, Controlled Case-Ascertained Prospective Study Open
Background Asymptomatic SARS-CoV-2 infection in children is highly prevalent but its acute and chronic implications have been minimally described. Methods In this controlled case-ascertained household transmission study, we recruited asymp…
View article: Features Associated With Radiographic Pneumonia in Children with SARS-CoV-2
Features Associated With Radiographic Pneumonia in Children with SARS-CoV-2 Open
14% of children with SARS-CoV-2 infections had radiographic pneumonia. Hypoxemia, cough, higher temperature, and older age were associated with pneumonias. In children tested, SARS-CoV-2 test results were not associated with radiographic p…
View article: Persistent Cross-Species Transmission Systems Dominate Shiga Toxin-Producing Escherichia Coli O157:H7 Epidemiology in a High Incidence Region: A Genomic Epidemiology Study
Persistent Cross-Species Transmission Systems Dominate Shiga Toxin-Producing Escherichia Coli O157:H7 Epidemiology in a High Incidence Region: A Genomic Epidemiology Study Open
View article: Post–COVID-19 Condition in Children 6 and 12 Months After Infection
Post–COVID-19 Condition in Children 6 and 12 Months After Infection Open
Importance There is a need to understand the long-term outcomes among children infected with SARS-CoV-2. Objective To quantify the prevalence of post–COVID-19 condition (PCC) among children tested for SARS-CoV-2 infection in pediatric emer…
View article: A survey of caregiver preferences regarding research participation in the paediatric emergency department
A survey of caregiver preferences regarding research participation in the paediatric emergency department Open
Objectives Emergency department (ED) visits can be stressful for families and can affect caregiver willingness to consent to participating in research. Our objective was to describe when and how caregivers wish to be informed about clinica…
View article: Impact of SARS-CoV-2 Infection on the Association Between Laboratory Tests and Severe Outcomes Among Hospitalized Children
Impact of SARS-CoV-2 Infection on the Association Between Laboratory Tests and Severe Outcomes Among Hospitalized Children Open
Background To assist clinicians with identifying children at risk of severe outcomes, we assessed the association between laboratory findings and severe outcomes among severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)–infected c…
View article: Emergency department visits and hospital admissions for suicidal ideation, self-poisoning and self-harm among adolescents in Canada during the COVID-19 pandemic
Emergency department visits and hospital admissions for suicidal ideation, self-poisoning and self-harm among adolescents in Canada during the COVID-19 pandemic Open
The quarterly change in the percentage of hospital admissions for suicidal ideation, self-poisoning and self-harm increased among adolescent females in Canada during the first 2 years of the COVID-19 pandemic. This underscores the need to …
View article: 52 An Evaluation of Satisfaction with Emergency Department Care in Children and Adolescents with Mental Health Concerns
52 An Evaluation of Satisfaction with Emergency Department Care in Children and Adolescents with Mental Health Concerns Open
Background Increasingly, the emergency department (ED) is a vital safety net for children and adolescents with mental health concerns seeking crisis care. Evaluating patient and parent/caregiver experience and satisfaction with care is ess…
View article: Severe outcomes following pediatric cannabis intoxication: a prospective cohort study of an international toxicology surveillance registry
Severe outcomes following pediatric cannabis intoxication: a prospective cohort study of an international toxicology surveillance registry Open
An increasing number of jurisdictions have legalized recreational cannabis for adult use. The subsequent availability and marketing of recreational cannabis has led to a parallel increase in rates and severity of pediatric cannabis intoxic…
View article: Molecular epidemiology of rotavirus among children in Western Canada: Dynamic changes in genotype prevalence in four consecutive seasons
Molecular epidemiology of rotavirus among children in Western Canada: Dynamic changes in genotype prevalence in four consecutive seasons Open
Rotavirus molecular surveillance remains important in the postvaccine era to monitor the changes in transmission patterns, identify vaccine‐induced antigenic changes and discover potentially pathogenic vaccine‐related strains. The Canadian…