Explanipedia

The Rate of Failure of Trabeculectomy and Tube Shunt Surgery in Eyes with Uveitic Glaucoma and Ocular Hypertension Open

Sylvia L. Groth, Craig Newcomb, Wei Yang, Abhishek R. Payal, Hosne Ara Begum , et al. · 2025

Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article.

Novel Lipophagy Inducers as Potential Therapeutics for Lipid Metabolism Disorders Open

Rachel Njeim, Bassel Awada, Haley M. Donow, Haley Gye, C. Stephen Foster , et al. · 2025

Dysregulation of lipid homeostasis is associated with a wide range of pathologies encompassing neurological, metabolic, cardiovascular, oncological, and renal disorders. We previously showed that lipid droplet (LD) accumulation in podocyte…

Integrating AI Cognition Networks with Real-Time Sensor Data Open

Valentín Ortiz‐Maldonado, Thomas Powell, Bruce Reed, C. Stephen Foster, Michael A. Simmons , et al. · 2025

Candy Cane Hypopyon Secondary to Intraocular Mantle Cell Lymphoma: A Case Report Open

Fatima Babiker, Avery Zhou, Ploysai Rujkorakarn, Andrew M. Philip, Tate Valerio , et al. · 2024

Introduction: Bilateral hemorrhagic hypopyon, also known as candy cane hypopyon, is an extremely rare presentation which we report as a unique case in association with intraocular mantle cell lymphoma (MCL). Case Presentation: A 63-year-ol…

Oral cyclophosphamide monotherapy in advanced resistant ocular cicatricial pemphigoid Open

Arash Maleki, Allison Richey, Hasan Bashir, Soheila Asgari, Tate Valerio , et al. · 2024

PURPOSE: The purpose of the study was to study the efficacy of oral cyclophosphamide monotherapy in advanced resistant ocular cicatricial pemphigoid (OCP). MATERIALS AND METHODS: This retrospective case series examines patients diagnosed w…

Updates on Systemic Immunomodulation in Peripheral Ulcerative Keratitis Open

Arash Maleki, Tate Valerio, Yasmin Massoudi, Maria Pia Ruggeri, C. Stephen Foster , et al. · 2024

Peripheral ulcerative keratitis (PUK) is an inflammatory process causing thinning of the cornea, epithelial defect, and inflammatory infiltrates and is caused by several etiologies. This sight-threatening condition can indicate the presenc…

Oral cyclophosphamide treatment for clinical periocular inflammation of unknown origin Open

Arash Maleki, Stephen D. Anesi, Peter Y. Chang, C. Stephen Foster · 2024

This study outlines a scenario involving unilateral periocular inflammation exhibited resistance to conventional immunomodulatory therapy (IMT) and biologic response modifying agents, which was successfully managed with oral cyclophosphami…

Incidence and Remission of Post‐Surgical Cystoid Macular Edema Following Cataract Surgery in Eyes With Intraocular Inflammation Open

Sapna Gangaputra, Craig Newcomb, Gui‐Shuang Ying, Sylvia L. Groth, Tonetta D Fitzgerald , et al. · 2024

Outcomes of IVIG monotherapy on non-paraneoplastic autoimmune retinopathy Open

Avery Zhou, Carla C. Fernandez-Santos, Andrew Dolinko, Andrew M. Philip, C. Stephen Foster · 2023

Use of immunosuppression and subsequent cancer incidence: cohort study Open

Jeanine M. Buchanich, Craig Newcomb, Terri Washington, C. Stephen Foster, Lucia Sobrin , et al. · 2023

Objective Evaluate the association between cancer incidence and immunosuppressive treatment in patients with ocular inflammatory disease (OID). Methods and analysis We performed a retrospective cohort study of patients from 10 US OID subsp…

Use of Immunosuppression and the Risk of Subsequent Overall or Cancer Mortality Open

John H. Kempen, Craig Newcomb, Terri Washington, C. Stephen Foster, Lucia Sobrin , et al. · 2023

Incidence of and Risk Factors for Cataract in Anterior Uveitis Open

George N. Papaliodis, Bernard Rosner, Kurt Dreger, Tonetta D. Fitzgerald, Pichaporn Artornsombudh , et al. · 2023

Threatened corneal graft rejection and ocular inflammation after SARS-CoV-2 infection and influenza vaccine Open

Andrew H. Dolinko, Arash Maleki, C. Stephen Foster · 2023

Introduction: To report the case of an individual who developed autoinflammation after contracting Coronavirus Disease 2019 (COVID-19) and receiving an influenza vaccination. Case Report: A 61-year-old woman presented to us after two episo…

A2Ar-dependent PD-1+ and TIGIT+ Treg cells have distinct homing requirements to suppress autoimmune uveitis in mice Open

Kayleigh Peters, Trisha McDonald, Fauziyya Muhammad, Marisa Walsh, Kayla Drenen , et al. · 2023

Response to “Similarities in clinical course and outcome between juvenile idiopathic arthritis (JIA)-associated and ANA-positive idiopathic anterior uveitis: data from a population-based nationwide study in Germany” Open

Avery Zhou, Fatima Babiker, Andrew M. Philip, Stephen D. Anesi, C. Stephen Foster · 2023

Limited Clinical Value of Anti-Retinal Antibody Titers and Numbers in Autoimmune Retinopathy Open

Ploysai Rujkorakarn, Michael J Margolis, Diana Morvey, Yujia Zhou, C. Stephen Foster · 2023

Changes in anti-retinal antibody titers or numbers were not associated with any vision outcome. Repeated anti-retinal antibody testing may be unnecessary after diagnosis of autoimmune retinopathy and detection of an anti-retinal antibody.

Rituximab Monotherapy versus Rituximab and Bortezomib Combination Therapy for Treatment of Non-paraneoplastic Autoimmune Retinopathy Open

Arash Maleki, Amanda Colombo, Sydney Look-Why, Peter Y. Chang, Stephen D. Anesi , et al. · 2022

Purpose: To study whether rituximab and bortezomib combination therapy is more effective than rituximab monotherapy in the treatment of nonparaneoplastic autoimmune retinopathy (npAIR). Methods: Retrospective case series involving six pati…

Adalimumab Monotherapy in the Treatment of Idiopathic Multifocal Choroiditis: A Case Report Open

Arash Maleki, Andrew M. Philip, C. Stephen Foster · 2022

In this study, we report a case of multifocal choroiditis that was successfully treated with adalimumab monotherapy. A 25-year-old male presented with a history of bilateral multifocal choroiditis which was resistant to a combination of az…

Lirentelimab for severe and chronic forms of allergic conjunctivitis Open

Stephen D. Anesi, Joseph Tauber, Quan Dong Nguyen, Peter Y. Chang, Gregg J. Berdy , et al. · 2022

Reply: Intravenous tocilizumab in the treatment of resistant optic perineuritis: a case report Open

Arash Maleki, Carla C. Fernandez, C. Stephen Foster · 2022

Appraisal of vitreous syphilis antibody as a novel biomarker for the diagnosis of syphilitic uveitis: a prospective case-control study Open

Sukhum Silpa‐archa, Tararat Hoopholerb, C. Stephen Foster · 2022

Corneal Endothelial Transplantation in Uveitis: Incidence and Risk Factors Open

Ana Roldan, Nazlee Zebardast, Maxwell Pistilli, Naira Khachatryan, Abhishek R. Payal , et al. · 2021

Intravenous tocilizumab in the treatment of resistant optic perineuritis Open

Arash Maleki, Koosha Ramezani, Amanda Colombo, C. Stephen Foster · 2021

COVID-19 Recombinant mRNA Vaccines and Serious Ocular Inflammatory Side Effects: Real or Coincidence? Open

Arash Maleki, Sydney Look-Why, Ambika Manhapra, C. Stephen Foster · 2021

Purpose: To report two cases; bilateral arteritic anterior ischemic optic neuropathy (AAION) and bilateral acute zonal occult outer retinopathy (AZOOR) after COVID-19 mRNA vaccination. Case Reports: The first patient was a 79-year-old fema…

Treatment of Noninfectious Retinal Vasculitis Using Subcutaneous Repository Corticotropin Injection Open

Stephen D. Anesi, Andrew Stephenson, Peter Y. Chang, Alyssa Montieth, Artur Filipowicz , et al. · 2021

Purpose: To show whether subcutaneous repository corticotropin injection (RCI, Acthar® Gel, a repository corticotropin injection, can be an effective potential therapeutic agent for noninfectious retinal vasculitis. Methods: Patients with …

Management of repository corticotropin injection therapy for non‐infectious uveitis: a Delphi study Open

Quan Dong Nguyen, Stephen D. Anesi, Saradha Chexal, David Chu, Pouya N. Dayani , et al. · 2021

Purpose Diagnosis and management of non‐infectious uveitis (NIU), a major cause of blindness worldwide, are challenging. Corticosteroids, the cornerstone of therapy, are not appropriate for long‐term use, and while non‐biologic and biologi…

Chlorambucil combination therapy in refractory serpiginous choroiditis: A cure? Open

Arash Maleki, Anapatricia Maldonado Cerda, Cristina M. Garcia, Mike Zein, Ambika Manhapra , et al. · 2021

The stability of WBC counts within toxic levels close to normal or lower limits of normal (3000-4500 cells/μl) during treatment with chlorambucil is an essential factor for the success of this therapy. A combination of dexamethasone intrav…

Poor prognostic factors in post-traumatic endophthalmitis following open globe injury Open

Sukhum Silpa‐archa, Akkaranisorn Dejkong, Kwanchanoke Kumsiang, Peranut Chotcomwongse, Janine M. Preble , et al. · 2020

AIM: To demonstrate prognostic factors for poor visual outcome in patients with post-traumatic endophthalmitis (PTE) following open globe injury. METHODS: A retrospective study was conducted on 66 patients (66 eyes) with PTE following open…

Efficacy and Safety of Infliximab in HLA-B27-associated Ocular Inflammation Refractory or Intolerant to Conventional Immunomodulatory Therapy Open

Asima Bajwa, Arash Maleki, Abhishek R. Payal, Adriana Fandiño, María Inés Menéndez Padrón , et al. · 2020

Purpose: To determine the efficacy and safety of infliximab therapy in patients with HLA B-27-associated ocular inflammation resistant or intolerant to conventional immunomodulatory therapy. Methods: This was a retrospective observational …

Randomized Phase 2 Trial of Reproxalap, a Novel Reactive Aldehyde Species Inhibitor, in Patients with Noninfectious Anterior Uveitis: Model for Corticosteroid Replacement Open

Kenneth J. Mandell, David L. Clark, David Chu, C. Stephen Foster, John D. Sheppard , et al. · 2020

Purpose: Topical corticosteroids used to treat ocular inflammation are associated with a high risk of clinically significant toxicities. Therefore, corticosteroid-sparing medications to treat ocular inflammation are needed. N…

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