Stefan C. Kane
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View article: A Diagnosis of Maturity-onset Diabetes of the Young Type 5 Provides Clarity and Broadens Reproductive Options
A Diagnosis of Maturity-onset Diabetes of the Young Type 5 Provides Clarity and Broadens Reproductive Options Open
Maturity-onset diabetes of the young type 5 (MODY5) is a rare form of monogenic diabetes caused by variants and deletions of the HNF1B gene. It is associated with a range of features including cystic renal disease, urogenital anomalies, an…
View article: Population-based, government-funded exome sequencing for fetal abnormalities: a state-wide implementation model for equity and clinical consistency
Population-based, government-funded exome sequencing for fetal abnormalities: a state-wide implementation model for equity and clinical consistency Open
Background: Congenital anomalies are a leading cause of perinatal mortality, with many having a genetic basis. Exome sequencing (ES) has transformed the diagnostic approach in the prenatal and post-mortem work-up of fetal congenital anomal…
View article: Maternal metabolic health And Mother and Baby health Outcomes (MAMBO): Protocol of a prospective observational study (Preprint)
Maternal metabolic health And Mother and Baby health Outcomes (MAMBO): Protocol of a prospective observational study (Preprint) Open
BACKGROUND Metabolic disease is increasingly impacting women of reproductive age. In pregnancy, uncontrolled metabolic disease can result in offspring with major congenital anomalies, preterm birth, and abnormal fetal growth. Pregnancy al…
View article: Maternal Metabolic Health and Mother and Baby Health Outcomes (MAMBO): Protocol of a Prospective Observational Study
Maternal Metabolic Health and Mother and Baby Health Outcomes (MAMBO): Protocol of a Prospective Observational Study Open
Background Metabolic disease is increasingly impacting women of reproductive age. In pregnancy, uncontrolled metabolic disease can result in offspring with major congenital anomalies, preterm birth, and abnormal fetal growth. Pregnancy als…
View article: In-utero transfer, survival-focused care and survival to 28-days at 22-24 weeks’ gestation pre- and post- implementation of an extreme prematurity management guideline in Victoria, Australia
In-utero transfer, survival-focused care and survival to 28-days at 22-24 weeks’ gestation pre- and post- implementation of an extreme prematurity management guideline in Victoria, Australia Open
Background Care for infants born at 22–24 weeks’ gestation varies globally, with an increasing willingness to provide survival-focused (‘active’) care for infants born at 22 weeks’ gestation in recent years. This study aims to report chang…
View article: Pharmaceuticals in pregnancy: a multifaceted challenge in Australia
Pharmaceuticals in pregnancy: a multifaceted challenge in Australia Open
View article: The Challenges of Distinguishing Different Causes of TMA in a Pregnant Kidney Transplant Recipient
The Challenges of Distinguishing Different Causes of TMA in a Pregnant Kidney Transplant Recipient Open
Thrombotic microangiopathy (TMA) reflects a syndrome of endothelial injury characterised by microangiopathic haemolytic anaemia (nonimmune), thrombocytopenia, and often end-organ dysfunction. TMA disorders are well-recognised in kidney tra…
View article: Improving accuracy of outcome prediction for infants born extremely preterm using a digital tool: Translating ‘<scp>NIC‐PREDICT</scp>’ into clinical practice, the first steps
Improving accuracy of outcome prediction for infants born extremely preterm using a digital tool: Translating ‘<span>NIC‐PREDICT</span>’ into clinical practice, the first steps Open
Background Many clinicians overestimate mortality and disability rates in infants born extremely preterm. We developed a digital tool (‘NIC‐PREDICT’) that predicts infant mortality and survival with and without major disability in infants …
View article: Prenatal iodine supplementation and early childhood neurodevelopment: the PoppiE trial – study protocol for a multicentre randomised controlled trial
Prenatal iodine supplementation and early childhood neurodevelopment: the PoppiE trial – study protocol for a multicentre randomised controlled trial Open
Introduction Observational studies suggest both low and high iodine intakes in pregnancy are associated with poorer neurodevelopmental outcomes in children. This raises concern that current universal iodine supplement recommendations for p…
View article: Perinatal predictors of clinical instability at birth in late-preterm and term infants
Perinatal predictors of clinical instability at birth in late-preterm and term infants Open
View article: Australian fertility preservation guidelines for people with cancer 2022: review and recommendations
Australian fertility preservation guidelines for people with cancer 2022: review and recommendations Open
Best practice in oncofertility care requires structured referral pathways, with access to fertility preservation counselling and technology Fertility preservation is a rapidly advancing field, and new strategies are continuously being deve…
View article: Reviewing Accuracy of First Trimester Screening for Preeclampsia Using Maternal Factors and Biomarkers
Reviewing Accuracy of First Trimester Screening for Preeclampsia Using Maternal Factors and Biomarkers Open
Preeclampsia is a common and important complication of pregnancy, one with potentially significant morbidity and even mortality to both mother and baby. Identifying those at high risk of developing the condition is helpful as there is evid…
View article: Placental OLAH Levels Are Altered in Fetal Growth Restriction, Preeclampsia and Models of Placental Dysfunction
Placental OLAH Levels Are Altered in Fetal Growth Restriction, Preeclampsia and Models of Placental Dysfunction Open
Previously, we identified elevated transcripts for the gene Oleoyl-ACP Hydrolase (OLAH) in the maternal circulation of pregnancies complicated by preterm fetal growth restriction. As placental dysfunction is central to the pathogenesis of …
View article: Physiologically based cord clamping for infants ≥32+0 weeks gestation: A randomised clinical trial and reference percentiles for heart rate and oxygen saturation for infants ≥35+0 weeks gestation
Physiologically based cord clamping for infants ≥32+0 weeks gestation: A randomised clinical trial and reference percentiles for heart rate and oxygen saturation for infants ≥35+0 weeks gestation Open
Background Globally, the majority of newborns requiring resuscitation at birth are full term or late-preterm infants. These infants typically have their umbilical cord clamped early (ECC) before moving to a resuscitation platform, losing t…
View article: NR4A2 expression is not altered in placentas from cases of growth restriction or preeclampsia, but is reduced in hypoxic cytotrophoblast
NR4A2 expression is not altered in placentas from cases of growth restriction or preeclampsia, but is reduced in hypoxic cytotrophoblast Open
View article: Ursodeoxycholic Acid in Intrahepatic Cholestasis of Pregnancy: A Systematic Review and Individual Participant Data Meta-analysis
Ursodeoxycholic Acid in Intrahepatic Cholestasis of Pregnancy: A Systematic Review and Individual Participant Data Meta-analysis Open
(Abstracted from Lancet Gastroenterol Hepatol 2021;6:547–558) Ursodeoxycholic acid (UA) is a common treatment for intrahepatic cholestasis of pregnancy (ICP), and its use is supported by the Society for Maternal-Fetal Medicine. However, ev…
View article: Parental Preconception Exposures to Outdoor Neighbourhood Environments and Adverse Birth Outcomes: A Protocol for a Scoping Review and Evidence Map
Parental Preconception Exposures to Outdoor Neighbourhood Environments and Adverse Birth Outcomes: A Protocol for a Scoping Review and Evidence Map Open
Parental preconception exposures to built and natural outdoor environments could influence pregnancy and birth outcomes either directly, or via a range of health-related behaviours and conditions. However, there is no existing review summa…
View article: LOX-1 expression is reduced in placenta from pregnancies complicated by preeclampsia and in hypoxic cytotrophoblast
LOX-1 expression is reduced in placenta from pregnancies complicated by preeclampsia and in hypoxic cytotrophoblast Open
View article: Ursodeoxycholic acid in intrahepatic cholestasis of pregnancy: a systematic review and individual participant data meta-analysis
Ursodeoxycholic acid in intrahepatic cholestasis of pregnancy: a systematic review and individual participant data meta-analysis Open
View article: The addition of fetal scalp blood lactate measurement as an adjunct to cardiotocography to reduce caesarean sections during labour: The Flamingo randomised controlled trial
The addition of fetal scalp blood lactate measurement as an adjunct to cardiotocography to reduce caesarean sections during labour: The Flamingo randomised controlled trial Open
Background Fetal scalp blood sampling for lactate measurement (FBSLM) is sometimes used to assist in identification of the need for expedited birth in the presence of an abnormal cardiotocograph (CTG). However, there is no randomised contr…
View article: DAAM2 is elevated in the circulation and placenta in pregnancies complicated by fetal growth restriction and is regulated by hypoxia
DAAM2 is elevated in the circulation and placenta in pregnancies complicated by fetal growth restriction and is regulated by hypoxia Open
View article: Lung ultrasound during newborn resuscitation predicts the need for surfactant therapy in very- and extremely preterm infants
Lung ultrasound during newborn resuscitation predicts the need for surfactant therapy in very- and extremely preterm infants Open
LUS in the delivery room and accurately predicts surfactant therapy in infants <320/7 weeks.
View article: Screening for Hypertension and Proteinuria in Pregnancy
Screening for Hypertension and Proteinuria in Pregnancy Open
View article: Lung ultrasound immediately after birth predicts the need for surfactant therapy in very- and extremely preterm infants, the DOLFIN Jr Study
Lung ultrasound immediately after birth predicts the need for surfactant therapy in very- and extremely preterm infants, the DOLFIN Jr Study Open
BackgroundEarly identification of infants requiring surfactant therapy improves outcomes. We evaluated the accuracy of delivery room lung ultrasound (LUS) to predict surfactant therapy in very- and extremely preterm infants.MethodsInfants …
View article: Circulating mRNAs are differentially expressed in pregnancies with severe placental insufficiency and at high risk of stillbirth
Circulating mRNAs are differentially expressed in pregnancies with severe placental insufficiency and at high risk of stillbirth Open
View article: Cervical length surveillance for predicting spontaneous preterm birth in women with uterine anomalies: A cohort study
Cervical length surveillance for predicting spontaneous preterm birth in women with uterine anomalies: A cohort study Open
Introduction Uterine anomalies occur in an estimated 5% of women and have been shown to confer a higher risk of spontaneous preterm birth (SPTB). A sonographically short cervix (<25 mm) is a risk indicator for SPTB, although its predictive…
View article: Prediction of preterm pre‐eclampsia at midpregnancy using a multivariable screening algorithm
Prediction of preterm pre‐eclampsia at midpregnancy using a multivariable screening algorithm Open
Background Competing risk models used for midpregnancy prediction of preterm pre‐eclampsia have shown detection rates (DR) of 85%, at fixed false‐positive rate (FPR) of 10%. The full algorithm used between 19 +0 and 24 +6 weeks includes ma…
View article: The Utility of the Congenital Pulmonary Airway Malformation-Volume Ratio in the Assessment of Fetal Echogenic Lung Lesions: A Systematic Review
The Utility of the Congenital Pulmonary Airway Malformation-Volume Ratio in the Assessment of Fetal Echogenic Lung Lesions: A Systematic Review Open
Although relatively uncommon, the incidence of fetal echogenic lung lesions – a heterogeneous group of anomalies that includes congenital pulmonary airway malformations (CPAM) and bronchopulmonary sequestrations (BPS) – has increased recen…
View article: Midpregnancy testing for soluble fms-like tyrosine kinase 1 (sFlt-1) and placental growth factor (PlGF): An inter-assay comparison of three automated immunoassay platforms
Midpregnancy testing for soluble fms-like tyrosine kinase 1 (sFlt-1) and placental growth factor (PlGF): An inter-assay comparison of three automated immunoassay platforms Open
View article: Midpregnancy prediction of pre-eclampsia using serum biomarkers sFlt-1 and PlGF
Midpregnancy prediction of pre-eclampsia using serum biomarkers sFlt-1 and PlGF Open