Stephen C. Strom
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View article: The PIK3CA/AKT pathway drives therapy resistance in rhabdomyosarcoma
The PIK3CA/AKT pathway drives therapy resistance in rhabdomyosarcoma Open
Olaparib and temozolomide (OT) combination therapy is in clinical trial evaluation for rhabdomyosarcoma (RMS). Unfortunately, OT resistance has been reported in other cancers. Using preclinical mouse xenograft experiments, we show that OT …
View article: Anti-migraine medications safety during pregnancy in the US
Anti-migraine medications safety during pregnancy in the US Open
Background Specific antimigraine medications (dihydroergotamine (DHE), triptans) have been associated with adverse pregnancy outcomes in individual studies but lack of consensus remains. Objectives Quantify the risk of prematurity, low bir…
View article: Effects of Pro-Inflammatory Cytokines on Hepatic Metabolism in Primary Human Hepatocytes
Effects of Pro-Inflammatory Cytokines on Hepatic Metabolism in Primary Human Hepatocytes Open
Three decades of hepatocyte transplantation have confirmed such a cell-based approach as an adjunct or alternative treatment to solid organ transplantation. Donor cell survival and engraftment were indirectly measured by hepatospecific sec…
View article: Early downregulation of hsa-miR-144-3p in serum from drug-naïve Parkinson’s disease patients
Early downregulation of hsa-miR-144-3p in serum from drug-naïve Parkinson’s disease patients Open
Advanced age represents one of the major risk factors for Parkinson’s Disease. Recent biomedical studies posit a role for microRNAs, also known to be remodelled during ageing. However, the relationship between microRNA remodelling and agei…
View article: Procurement and Evaluation of Hepatocytes for Transplantation From Neonatal Donors After Circulatory Death
Procurement and Evaluation of Hepatocytes for Transplantation From Neonatal Donors After Circulatory Death Open
Hepatocyte transplantation is a promising treatment for liver failure and inborn metabolic liver diseases, but progress has been hampered by a scarcity of available organs. Here, hepatocytes isolated from livers procured for a neonatal hep…
View article: Improving the Techniques for Human Hepatocyte Transplantation: Report from a Consensus Meeting in London
Improving the Techniques for Human Hepatocyte Transplantation: Report from a Consensus Meeting in London Open
On September 6 and 7, 2009 a meeting was held in London to identify and discuss what are perceived to be current roadblocks to effective hepatocyte transplantation as it is currently practiced in the clinics and, where possible, to offer s…
View article: Gene Editing Correction of a Urea Cycle Defect in Organoid Stem Cell Derived Hepatocyte-like Cells
Gene Editing Correction of a Urea Cycle Defect in Organoid Stem Cell Derived Hepatocyte-like Cells Open
Urea cycle disorders are enzymopathies resulting from inherited deficiencies in any genes of the cycle. In severe cases, currently available therapies are marginally effective, with liver transplantation being the only definitive treatment…
View article: Effects of a liver <i>APOEε4</i>‐genotype on synaptic integrity, gliosis and insulin signaling in the brain
Effects of a liver <i>APOEε4</i>‐genotype on synaptic integrity, gliosis and insulin signaling in the brain Open
Background APOEε4 is the strongest genetic risk factor for AD[1]. Although plasma apoE does not cross the blood‐brain‐barrier[2], altered plasma apoE levels have been linked to increased risk of AD[3] and to unfavorable CSF Aβ42 and tau le…
View article: Effects of Cryogenic Storage on Human Amnion Epithelial Cells
Effects of Cryogenic Storage on Human Amnion Epithelial Cells Open
Perinatal stem cells and epithelial cells isolated from full term amnion membrane, in particular, have attracted interest over the last decade, as a promising source of multipotent cells for cellular therapies. Human amnion epithelial cell…
View article: Aging and Caloric Restriction Modulate the DNA Methylation Profile of the Ribosomal RNA Locus in Human and Rat Liver
Aging and Caloric Restriction Modulate the DNA Methylation Profile of the Ribosomal RNA Locus in Human and Rat Liver Open
A growing amount of evidence suggests that the downregulation of protein synthesis is an adaptive response during physiological aging, which positively contributes to longevity and can be modulated by nutritional interventions like caloric…
View article: Insights From Liver‐Humanized Mice on Cholesterol Lipoprotein Metabolism and LXR‐Agonist Pharmacodynamics in Humans
Insights From Liver‐Humanized Mice on Cholesterol Lipoprotein Metabolism and LXR‐Agonist Pharmacodynamics in Humans Open
Background and Aims Genetically modified mice have been used extensively to study human disease. However, the data gained are not always translatable to humans because of major species differences. Liver‐humanized mice (LHM) are considered…
View article: Guide to the Assessment of Mature Liver Gene Expression in Stem Cell-Derived Hepatocytes
Guide to the Assessment of Mature Liver Gene Expression in Stem Cell-Derived Hepatocytes Open
Differentiation of stem cells to hepatocyte-like cells (HLCs) holds great promise for basic research, drug and toxicological investigations, and clinical applications. There are currently no protocols for the production of HLCs from stem c…
View article: Applying hydrodynamic pressure to efficiently generate induced pluripotent stem cells via reprogramming of centenarian skin fibroblasts
Applying hydrodynamic pressure to efficiently generate induced pluripotent stem cells via reprogramming of centenarian skin fibroblasts Open
Induced pluripotent stem cell (iPSC)-technology is an important platform in medicine and disease modeling. Physiological degeneration and disease onset are common occurrences in the aging population. iPSCs could offer regenerative medical …
View article: A liver‐humanized mouse model of carbamoyl phosphate synthetase 1‐deficiency
A liver‐humanized mouse model of carbamoyl phosphate synthetase 1‐deficiency Open
A liver‐humanized mouse model for CPS1‐deficiency was generated by the high‐level repopulation of the mouse liver with CPS1‐deficient human hepatocytes. When compared with mice that are highly repopulated with CPS1‐proficient human hepatoc…
View article: Targeting HSP90 with the small molecule inhibitor AUY922 (luminespib) as a treatment strategy against hepatocellular carcinoma
Targeting HSP90 with the small molecule inhibitor AUY922 (luminespib) as a treatment strategy against hepatocellular carcinoma Open
Hepatocellular carcinoma (HCC) is a highly malignant tumor that responds very poorly to existing therapies, most probably due to its extraordinary inter‐ and intra‐tumor molecular heterogeneity. The modest therapeutic response to molecular…
View article: Molecular Aging of Human Liver: An Epigenetic/Transcriptomic Signature
Molecular Aging of Human Liver: An Epigenetic/Transcriptomic Signature Open
The feasibility of liver transplantation from old healthy donors suggests that this organ is able to preserve its functionality during aging. To explore the biological basis of this phenomenon, we characterized the epigenetic profile of li…
View article: Oleocanthal exerts antitumor effects on human liver and colon cancer cells through ROS generation
Oleocanthal exerts antitumor effects on human liver and colon cancer cells through ROS generation Open
The beneficial health properties of the Mediter-ranean diet are well recognized. The principle source of fat in Mediterranean diet is extra-virgin olive oil (EVOO). Oleocanthal (OC) is a naturally occurring minor phenolic compound isolated…
View article: De Novo Donor-Specific HLA Antibody Formation in Two Patients With Crigler-Najjar Syndrome Type I Following Human Hepatocyte Transplantation With Partial Hepatectomy Preconditioning
De Novo Donor-Specific HLA Antibody Formation in Two Patients With Crigler-Najjar Syndrome Type I Following Human Hepatocyte Transplantation With Partial Hepatectomy Preconditioning Open
Clinical hepatocyte transplantation is hampered by low engraftment rates and gradual loss of function resulting in incomplete correction of the underlying disease. Preconditioning with partial hepatectomy improves engraftment in animal stu…
View article: Induced pluripotent stem cells model personalized variations in liver disease resulting from α1‐antitrypsin deficiency
Induced pluripotent stem cells model personalized variations in liver disease resulting from α1‐antitrypsin deficiency Open
In the classical form of α1‐antitrypsin deficiency (ATD), aberrant intracellular accumulation of misfolded mutant α1‐antitrypsin Z (ATZ) in hepatocytes causes hepatic damage by a gain‐of‐function, “proteotoxic” mechanism. Whereas some ATD …