Explanipedia

Case Report: Collision tumors of the sellar region: pituitary adenoma and chordoma coexist in the sellar region Open

Shuo Gao, Pule Liu, Stephen C. Yang, Kai Liu, Zhiqiang Zhao , et al. · 2025

Collision tumors are relatively rare and refer to the coexistence of distinct tumors in the same anatomical region, where they invade each other. Sellar collision tumors are especially uncommon. Recent studies suggest that most cases invol…

75 Years of the Ravitch Procedure: A Historical Report and Review of Outcomes Open

Dianela Perdomo, Albert Leng, Deven Patel, Stephen C. Yang, Jinny S Ha · 2025

Fecal Microbiome Composition Correlates with Pathologic Complete Response in Patients with Operable Esophageal Cancer Treated with Combined Chemoradiotherapy and Immunotherapy Open

Fyza Y. Shaikh, Seoho Lee, James R. White, Yujie Zhao, Jordi Ferri , et al. · 2024

Background: Preclinical and clinical data indicate that chemoradiotherapy (CRT) in combination with checkpoint inhibitors may prime an anti-tumor immunological response in esophageal cancer. However, responses to neoadjuvant therapy can va…

Feasibility and safety of endoscopic ultrasound-guided diffusing alpha emitter radiation therapy for advanced pancreatic cancer: Preliminary data Open

Corey Miller, Magali Lecavalier‐Barsoum, Kim Ma, Míriam Santos Dutra, Youri Kaitoukov , et al. · 2024

Background and study aims Pancreatic cancer is a devastating disease with limited locoregional treatment options. Diffusing alpha-emitter radiation therapy (Alpha DaRT), a novel cancer treatment using alpha-particle interstitial radiothera…

Recurrence of Non–Small Cell Lung Cancer With Visceral Pleural Invasion Open

Nasser K. Altorki, Xiaofei Wang, Bryce Damman, David R. Jones, Dennis A. Wigle , et al. · 2024

Importance The randomized clinical trial Cancer and Leukemia Group B (CALGB) 140503 showed that for patients with clinically staged T1N0 non–small cell lung cancer (NSCLC; ≤2 cm), sublobar resections were associated with similar oncologica…

Neoadjuvant nivolumab or nivolumab plus LAG-3 inhibitor relatlimab in resectable esophageal/gastroesophageal junction cancer: a phase Ib trial and ctDNA analyses Open

Ronan J. Kelly, Blair V. Landon, Ali H. Zaidi, Dipika Singh, Jenna VanLiere Canzoniero , et al. · 2024

Mesothelioma: Pleural, Version 1.2024 Open

James Stevenson, David S. Ettinger, Douglas E. Wood, Dara L. Aisner, Wallace Akerley , et al. · 2024

Mesothelioma is a rare cancer that originates from the mesothelial surfaces of the pleura and other sites, and is estimated to occur in approximately 3,500 people in the United States annually. Pleural mesothelioma is the most common type …

Multi-institutional beta testing of a novel cervical esophagogastric anastomosis simulator Open

Jules Lin, Deborah M. Rooney, Stephen C. Yang, Mara B. Antonoff, Michael T. Jaklitsch , et al. · 2024

Computational pathology: A survey review and the way forward Open

Mahdi S. Hosseini, Babak Ehteshami Bejnordi, Vincent Quoc‐Huy Trinh, Lyndon Chan, Danial Hasan , et al. · 2024

Clinical features and outcomes of advanced HER2+ esophageal/GEJ cancer with brain metastasis Open

Kaili Liang, Josephine Feliciano, K.A. Marrone, Joseph C. Murray, Christine L. Hann , et al. · 2023

A dedicated robotic bedside physician assistant significantly enhances trainee console operating time in general thoracic surgery Open

Benjamin T. Jones, Jinny S. Ha, Chuck Lawrence, Lillian L. Tsai, Stephen C. Yang · 2023

Thoracic surgical trainees have increased opportunity for robotic skill development within a fellowship or resident program curriculum when a designated robotic physician assistant is present in the operating room. These findings are signi…

Lung tumor–infiltrating T<sub>reg</sub>have divergent transcriptional profiles and function linked to checkpoint blockade response Open

Arbor G. Dykema, Jiajia Zhang, Laurene S. Cheung, Sydney Connor, Boyang Zhang , et al. · 2023

Regulatory T cells (T reg ) are conventionally viewed as suppressors of endogenous and therapy-induced antitumor immunity; however, their role in modulating responses to immune checkpoint blockade (ICB) is unclear. In this study, we integr…

Mesothelioma: Peritoneal, Version 2.2023, NCCN Clinical Practice Guidelines in Oncology Open

David S. Ettinger, Douglas E. Wood, James Stevenson, Dara L. Aisner, Wallace Akerley , et al. · 2023

Mesothelioma is a rare cancer originating in mesothelial surfaces of the peritoneum, pleura, and other sites. These NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines) focus on peritoneal mesothelioma (PeM). The NCCN Guidelines…

Computational Pathology: A Survey Review and The Way Forward Open

Mahdi S. Hosseini, Babak Ehteshami Bejnordi, Vincent Quoc‐Huy Trinh, Danial Hasan, Xingwen Li , et al. · 2023

Computational Pathology CPath is an interdisciplinary science that augments developments of computational approaches to analyze and model medical histopathology images. The main objective for CPath is to develop infrastructure and workflow…

NCCN Guidelines® Insights: Non–Small Cell Lung Cancer, Version 2.2023 Open

David S. Ettinger, Douglas E. Wood, Dara L. Aisner, Wallace Akerley, Jessica R. Bauman , et al. · 2023

The NCCN Guidelines for Non–Small Cell Lung Cancer (NSCLC) provide recommendations for management of disease in patients with NSCLC. These NCCN Guidelines Insights focus on neoadjuvant and adjuvant (also known as perioperative) systemic th…

Lobar or Sublobar Resection for Peripheral Stage IA Non–Small-Cell Lung Cancer Open

Nasser K. Altorki, Xiaofei Wang, David Kozono, Colleen Watt, Rodney Landrenau , et al. · 2023

In patients with peripheral NSCLC with a tumor size of 2 cm or less and pathologically confirmed node-negative disease in the hilar and mediastinal lymph nodes, sublobar resection was not inferior to lobectomy with respect to disease-free …

Lung tumor-infiltrating T<sub>reg</sub>have divergent transcriptional profiles and function linked to checkpoint blockade response Open

Arbor G. Dykema, Jiajia Zhang, Boyang Zhang, Laurene S. Cheung, Zhen Zeng , et al. · 2022

Regulatory T cells (T reg ) are conventionally viewed to suppress endogenous and therapyinduced anti-tumor immunity; however, their role in modulating responses to immune checkpoint blockade (ICB) is unclear. In this study, we integrated s…

PSAT218 Technetium 99m-Methyl Diphosphonate (99mTc MDP) Radioguided Surgery in Patient With Tumor-Induced Osteomalacia (TIO) Open

Sara Anees Khan, Reema Goel, Stephen C. Yang, Suzanne M. Jan de Beur · 2022

Introduction TIO is a rare paraneoplastic syndrome of excess FGF23 secretion by mesenchymal tumors that results in myopathy, pain, weakness and osteomalacic fractures. Tumors are small and often difficult to locate, frequently delaying dia…

NCCN Guidelines® Insights: Lung Cancer Screening, Version 1.2022 Open

Douglas E. Wood, Ella A. Kazerooni, Denise R. Aberle, Abigail T. Berman, Lisa M. Brown , et al. · 2022

The NCCN Guidelines for Lung Cancer Screening recommend criteria for selecting individuals for screening and provide recommendations for evaluation and follow-up of lung nodules found during initial and subsequent screening. These NCCN Gui…

Objective Performance Indicators of Cardiothoracic Residents Are Associated with Vascular Injury During Robotic-Assisted Lobectomy on Porcine Models Open

John F. Lazar, Kristen C. Brown, Sadia Yousaf, Anthony Jarc, Ariana Metchik , et al. · 2022

Objective Surgical training relies on subjective feedback on resident technical performance by attending surgeons. A novel data recorder connected to a robotic-assisted surgical platform captures synchronized kinematic and video data durin…

Histokt: Cross Knowledge Transfer in Computational Pathology Open

Ryan Zhang, Jiadai Zhu, Stephen C. Yang, Mahdi S. Hosseini, Angelo Genovese , et al. · 2022

The lack of well-annotated datasets in computational pathology (CPath) obstructs the application of deep learning techniques for classifying medical images. Many CPath workflows involve transferring learned knowledge between various image …

HistoKT: Cross Knowledge Transfer in Computational Pathology Open

Ryan Zhang, Jiadai Zhu, Stephen C. Yang, Mahdi S. Hosseini, Angelo Genovese , et al. · 2022

The lack of well-annotated datasets in computational pathology (CPath) obstructs the application of deep learning techniques for classifying medical images. %Since pathologist time is expensive, dataset curation is intrinsically difficult.…

Trimodality therapy for esophageal cancer: The role of surgical and radiation treatment parameters in the development of anastomotic complications Open

Salem Alfaifi, Robert Chu, Xuan Hui, Stephen Broderick, Craig M. Hooker , et al. · 2021

Background Here, we investigated the relationship between clinical parameters, including the site of surgical anastomosis and radiation dose to the anastomotic region, and anastomotic complications in esophageal cancer patients treated wit…

P21.04 Comparing Outcomes for Patients Receiving Chemoradiation Followed by Surgery vs. Immune Checkpoint Inhibitors in Non Small Cell Lung Cancer Open

Turja Chakrabarti, Cole Friedes, Sarah Olson, Laura Prichett, Julie R. Brahmer , et al. · 2021

NCCN Guidelines Insights: Non–Small Cell Lung Cancer, Version 2.2021 Open

David S. Ettinger, Douglas E. Wood, Dara L. Aisner, Wallace Akerley, Jessica R. Bauman , et al. · 2021

The NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines) for Non–Small Cell Lung Cancer (NSCLC) address all aspects of management for NSCLC. These NCCN Guidelines Insights focus on recent updates to the NCCN Guidelines regarding…

Neoadjuvant nivolumab plus ipilimumab in resectable non-small cell lung cancer Open

Joshua E. Reuss, Valsamo Anagnostou, Tricia R. Cottrell, Kellie N. Smith, Franco Verde , et al. · 2020

Background We conducted the first trial of neoadjuvant PD-1 blockade in resectable non-small cell lung cancer (NSCLC), finding nivolumab monotherapy to be safe and feasible with an encouraging rate of pathologic response. Building on these…

Cardiothoracic surgery educational research and training innovation: A review of 2018-2019 Open

Megan Hunt, Katherine Giuliano, Eric Etchill, Stephen C. Yang · 2020

Epigenetic therapy inhibits metastases by disrupting premetastatic niches Open

Zhihao Lü, Jianling Zou, Shuang Li, Michael J. Topper, Yong Tao , et al. · 2020

Scholarships in cardiothoracic surgery—a guide for surgical trainees Open

Alejandro Suarez‐Pierre, Stephen C. Yang · 2020

NCCN Guidelines Insights: Non–Small Cell Lung Cancer, Version 1.2020 Open

David S. Ettinger, Douglas E. Wood, Charu Aggarwal, Dara L. Aisner, Wallace Akerley , et al. · 2019

The NCCN Guidelines for Non–Small Cell Lung Cancer (NSCLC) address all aspects of management for NSCLC. These NCCN Guidelines Insights focus on recent updates in immunotherapy. For the 2020 update, all of the systemic therapy regimens have…

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