Stephen Chu‐Sung Hu
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View article: From mothers to offspring: Polystyrene nanoplastics create a hidden toxic legacy via mitochondrial dysfunction
From mothers to offspring: Polystyrene nanoplastics create a hidden toxic legacy via mitochondrial dysfunction Open
Plastic pollution has become a global concern, with nanoplastics (NPs) threatening aquatic ecosystems through their persistence, mobility, and biological effects. Although the ecological risks are increasingly recognized, the mechanisms of…
View article: NDUFS1 promotes malignant breast cancer behaviors through activation of mitochondrial metabolism and PROX1/c-Myc signaling
NDUFS1 promotes malignant breast cancer behaviors through activation of mitochondrial metabolism and PROX1/c-Myc signaling Open
Breast cancer is the most prevalent cancer among women. Previous studies demonstrated that adipose-derived stem cells (ADSCs) co-cultured with resistin promote malignant behaviors in breast cancer cells. This study explores the roles of AD…
View article: Bullous pemphigoid associated with acquired hemophilia A: A case report
Bullous pemphigoid associated with acquired hemophilia A: A case report Open
BACKGROUND Acquired hemophilia A (AHA) is a rare and potentially severe bleeding disorder caused by circulating autoantibodies against factor VIII (FVIII). In approximately 50% of the patients, the condition is associated with autoimmune d…
View article: Recent advances in treatment of prurigo nodularis
Recent advances in treatment of prurigo nodularis Open
Prurigo nodularis is a chronic skin condition which has significant negative impacts on the psychosocial function and quality of life of affected patients. It is a heterogeneous disease with complex underlying pathogenic mechanisms, and th…
View article: Rare manifestation of metastatic calcinosis cutis with milky calcific fluid in a patient with end-stage renal disease
Rare manifestation of metastatic calcinosis cutis with milky calcific fluid in a patient with end-stage renal disease Open
Dear Editor, Metastatic calcinosis cutis occurs when there is a precipitation of calcium in the skin, resulting from an underlying defect in calcium or phosphate metabolism.[1] It is associated with hypervitaminosis D, milk-alkali syndrome…
View article: Dermoscopy and imaging findings of disseminated cutaneous gout: A rare manifestation of a common disease
Dermoscopy and imaging findings of disseminated cutaneous gout: A rare manifestation of a common disease Open
Dear Editor, Gout is a common metabolic disease with the deposition of monosodium urate crystals in the synovial fluid and skin overlying the articular sites.[1] However, extensive skin involvement by gouty tophi is an extremely rare prese…
View article: The impact of the synergistic effect of SO2 and PM2.5/PM10 on obstructive lung disease in subtropical Taiwan
The impact of the synergistic effect of SO2 and PM2.5/PM10 on obstructive lung disease in subtropical Taiwan Open
Background Chronic Obstructive lung diseases (COPD) are complex conditions influenced by various environmental, lifestyle , and genetic factors. Ambient air pollution has been identified as a potential risk factor, causing 4.2 million deat…
View article: IL-1RA promotes oral squamous cell carcinoma malignancy through mitochondrial metabolism-mediated EGFR/JNK/SOX2 pathway
IL-1RA promotes oral squamous cell carcinoma malignancy through mitochondrial metabolism-mediated EGFR/JNK/SOX2 pathway Open
Background Interleukin-1 receptor antagonist (IL-1RA), a member of the IL-1 family, has diverse roles in cancer development. However, the role of IL-1RA in oral squamous cell carcinoma (OSCC), in particular the underlying mechanisms, remai…
View article: Mpox (Monkeypox) with atypical clinical presentation and distinctive dermoscopic findings
Mpox (Monkeypox) with atypical clinical presentation and distinctive dermoscopic findings Open
Dear Editor, Mpox (formerly known as monkeypox), a zoonotic disease caused by the monkeypox virus, has caused recent global outbreaks.[1,2] The initial clinical presentation of mpox may manifest with nonspecific symptoms, which may result …
View article: IL-1RA promotes oral squamous cell carcinoma malignancy through mitochondrial metabolism-mediated EGFR/JNK/SOX2 pathway
IL-1RA promotes oral squamous cell carcinoma malignancy through mitochondrial metabolism-mediated EGFR/JNK/SOX2 pathway Open
Background Interleukin-1 receptor antagonist (IL-1RA), a member of the IL-1 family, has diverse roles in cancer development. However, the role of IL-1RA in oral squamous cell carcinoma (OSCC), in particular the underlying mechanisms, remai…
View article: Data from Extracellular Visfatin-Promoted Malignant Behavior in Breast Cancer Is Mediated Through c-Abl and STAT3 Activation
Data from Extracellular Visfatin-Promoted Malignant Behavior in Breast Cancer Is Mediated Through c-Abl and STAT3 Activation Open
Purpose: Visfatin is an adipocytokine involved in cellular metabolism, inflammation, and cancer. This study investigated the roles of extracellular visfatin in breast cancer, and explored underlying mechanisms in clinical and experimental …
View article: Supplementary Figure 2 from Extracellular Visfatin-Promoted Malignant Behavior in Breast Cancer Is Mediated Through c-Abl and STAT3 Activation
Supplementary Figure 2 from Extracellular Visfatin-Promoted Malignant Behavior in Breast Cancer Is Mediated Through c-Abl and STAT3 Activation Open
Supplementary Figure 2. Association of disease-free survival with serum visfatin levels according to adjuvant treatment in breast cancer patients.
View article: Supplementary Figure 1 from Extracellular Visfatin-Promoted Malignant Behavior in Breast Cancer Is Mediated Through c-Abl and STAT3 Activation
Supplementary Figure 1 from Extracellular Visfatin-Promoted Malignant Behavior in Breast Cancer Is Mediated Through c-Abl and STAT3 Activation Open
Supplementary Figure 1. Association of overall survival with serum visfatin levels according to adjuvant treatment in breast cancer patients.
View article: Supplementary Figure 1 from Extracellular Visfatin-Promoted Malignant Behavior in Breast Cancer Is Mediated Through c-Abl and STAT3 Activation
Supplementary Figure 1 from Extracellular Visfatin-Promoted Malignant Behavior in Breast Cancer Is Mediated Through c-Abl and STAT3 Activation Open
Supplementary Figure 1. Association of overall survival with serum visfatin levels according to adjuvant treatment in breast cancer patients.
View article: supplemental figure legend from Extracellular Visfatin-Promoted Malignant Behavior in Breast Cancer Is Mediated Through c-Abl and STAT3 Activation
supplemental figure legend from Extracellular Visfatin-Promoted Malignant Behavior in Breast Cancer Is Mediated Through c-Abl and STAT3 Activation Open
supplemental figure legend
View article: Supplementary Figure 6 from Extracellular Visfatin-Promoted Malignant Behavior in Breast Cancer Is Mediated Through c-Abl and STAT3 Activation
Supplementary Figure 6 from Extracellular Visfatin-Promoted Malignant Behavior in Breast Cancer Is Mediated Through c-Abl and STAT3 Activation Open
Supplementary Figure 6. A, Comparison of serum visfatin levels according to molecular subtypes of breast cancer patients.
View article: Supplemental Tables from Extracellular Visfatin-Promoted Malignant Behavior in Breast Cancer Is Mediated Through c-Abl and STAT3 Activation
Supplemental Tables from Extracellular Visfatin-Promoted Malignant Behavior in Breast Cancer Is Mediated Through c-Abl and STAT3 Activation Open
Supplementary Table 1. Association between clinicopathological characteristics of breast cancer patients and disease-free survival Supplementary Table 2. Association of serum visfatin with disease recurrence after radiotherapy, chemotherap…
View article: Supplemental Tables from Extracellular Visfatin-Promoted Malignant Behavior in Breast Cancer Is Mediated Through c-Abl and STAT3 Activation
Supplemental Tables from Extracellular Visfatin-Promoted Malignant Behavior in Breast Cancer Is Mediated Through c-Abl and STAT3 Activation Open
Supplementary Table 1. Association between clinicopathological characteristics of breast cancer patients and disease-free survival Supplementary Table 2. Association of serum visfatin with disease recurrence after radiotherapy, chemotherap…
View article: Supplementary Figure 5 from Extracellular Visfatin-Promoted Malignant Behavior in Breast Cancer Is Mediated Through c-Abl and STAT3 Activation
Supplementary Figure 5 from Extracellular Visfatin-Promoted Malignant Behavior in Breast Cancer Is Mediated Through c-Abl and STAT3 Activation Open
Supplementary Figure 5. Body weight and blood test for orthotopic xenograft nude mice.
View article: Supplementary Figure 3 from Extracellular Visfatin-Promoted Malignant Behavior in Breast Cancer Is Mediated Through c-Abl and STAT3 Activation
Supplementary Figure 3 from Extracellular Visfatin-Promoted Malignant Behavior in Breast Cancer Is Mediated Through c-Abl and STAT3 Activation Open
Supplementary Figure 3. A-B, Effect of visfatin on cell viability and activation of c-Abl and STAT3 in SKBR-3 breast cancer cells.
View article: Supplementary Figure 6 from Extracellular Visfatin-Promoted Malignant Behavior in Breast Cancer Is Mediated Through c-Abl and STAT3 Activation
Supplementary Figure 6 from Extracellular Visfatin-Promoted Malignant Behavior in Breast Cancer Is Mediated Through c-Abl and STAT3 Activation Open
Supplementary Figure 6. A, Comparison of serum visfatin levels according to molecular subtypes of breast cancer patients.
View article: Supplementary Figure 4 from Extracellular Visfatin-Promoted Malignant Behavior in Breast Cancer Is Mediated Through c-Abl and STAT3 Activation
Supplementary Figure 4 from Extracellular Visfatin-Promoted Malignant Behavior in Breast Cancer Is Mediated Through c-Abl and STAT3 Activation Open
Supplementary Figure 4. A, Effect of visfatin on anoikis cell death.