Stephen D. Holmes
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View article: Encephalomyocarditis virus protein 2B* interacts with 14-3-3 proteins through a phosphorylated C-terminal binding motif
Encephalomyocarditis virus protein 2B* interacts with 14-3-3 proteins through a phosphorylated C-terminal binding motif Open
Encephalomyocarditis virus (EMCV) has been an important model RNA virus for decades. Although most of the EMCV proteins are obtained via proteolytic cleavage of a long polyprotein, 2B* is expressed from a short overlapping open reading fra…
View article: Encephalomyocarditis virus protein 2B* antagonises innate immune signalling by interacting with 14-3-3 protein family members
Encephalomyocarditis virus protein 2B* antagonises innate immune signalling by interacting with 14-3-3 protein family members Open
Encephalomyocarditis virus (EMCV) has for decades served as an important model RNA virus. Although most of the EMCV proteins are obtained via proteolytic cleavage of a long polyprotein, 2B* is expressed from a short overlapping open readin…
View article: Noise helps cochlear implant listeners to categorize vowels
Noise helps cochlear implant listeners to categorize vowels Open
Theoretical studies demonstrate that controlled addition of noise can enhance the amount of information transmitted by a cochlear implant (CI). The present study is a proof-of-principle for whether stochastic facilitation can improve the a…
View article: Lambda0 polarization in p p ---> p Lambda0 K+ (pi+ pi-) at 27.5-GeV
Lambda0 polarization in p p ---> p Lambda0 K+ (pi+ pi-) at 27.5-GeV Open
The polarization of 1973 {Lambda}{sup 0}'s from the specific reaction pp {yields} p{Lambda}{sup 0}K{sup +}({pi}{sup +}{pi}{sup -}){sup 5} created by 27.5 Gev incident protons on a liquid hydrogen target, as a function of {chi}{sub F}, P{su…
View article: Fermilab Tevatron and upgrade status
Fermilab Tevatron and upgrade status Open
Performance and performance limitations of the Tevatron proton-antiproton collider at Fermilab will be discussed along with plans for improving the performance by a factor of five by the end of the decade. The centerpiece of this effort is…
View article: Limits on the transverse phase space density in the Fermilab Booster
Limits on the transverse phase space density in the Fermilab Booster Open
Recent results on intensity and transverse density limitations in the Fermilab 8-GeV Booster are presented. The evidence suggests that the limits are set by incoherent space-charge effects at low energy. Data are interpreted in terms of th…
View article: Superconducting radiofrequency linac development at Fermilab
Superconducting radiofrequency linac development at Fermilab Open
As the Fermilab Tevatron Collider program draws to a close, a strategy has emerged of an experimental program built around the high intensity frontier. The centerpiece of this program is a superconducting H- linac that will support world l…
View article: PIP-II Status and Strategy
PIP-II Status and Strategy Open
Proton Improvement Plan-II (PIP-II) is the centerpiece of Fermilab's plan for upgrading the accelerator complex to establish the leading facility in the world for particle physics research based on intense proton beams. PIP-II has been dev…
View article: Outlook for the Future
Outlook for the Future Open
The charge separation between electrons and ions that exists within an electron plasma density wave can create large electric fields. In 1979 Tajima and Dawson first recognized that the longitudinal component of the field of a so-called “r…
View article: The PIP-II Conceptual Design Report
The PIP-II Conceptual Design Report Open
The Proton Improvement Plan-II (PIP-II) encompasses a set of upgrades and improvements to the Fermilab accelerator complex aimed at supporting a world-leading neutrino program over the next several decades. PIP-II is an integral part of th…
View article: Long Term Plans to Increase Fermilab's Proton Intensity to Meet the Needs of the Long Baseline Neutrino Program
Long Term Plans to Increase Fermilab's Proton Intensity to Meet the Needs of the Long Baseline Neutrino Program Open
The flagship of Fermilab's long term research program is the Deep Underground Neutrino Experiment (DUNE), located Sanford Underground Research Facility (SURF) in Lead, South Dakota, which will study neutrino oscillations with a baseline of…
View article: A Staged Muon Accelerator Facility For Neutrino and Collider Physics
A Staged Muon Accelerator Facility For Neutrino and Collider Physics Open
Muon-based facilities offer unique potential to provide capabilities at both the Intensity Frontier with Neutrino Factories and the Energy Frontier with Muon Colliders. They rely on a novel technology with challenging parameters, for which…
View article: Minimally invasive mitral valve surgery without aortic cross-clamping and with femoral cannulation is not associated with increased risk of stroke compared with traditional mitral valve surgery: a propensity score-matched analysis
Minimally invasive mitral valve surgery without aortic cross-clamping and with femoral cannulation is not associated with increased risk of stroke compared with traditional mitral valve surgery: a propensity score-matched analysis Open
A minimally invasive approach for mitral valve surgery on a fibrillating heart was not associated with a greater incidence of stroke/TIA than was median sternotomy. When performed by highly experienced surgeons, the minimally invasive appr…
View article: PIP-II Status and Strategy
PIP-II Status and Strategy Open
Proton Improvement Plan-II (PIP-II) is the centerpiece of Fermilab’s plan for upgrading the accelerator complex to establish the leading facility in the world for particle physics research based on intense proton beams. PIP-II has been dev…