Stephen E. Cunningham
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View article: Modulation of Temporoammonic-CA1 Synapses by Neuropeptide Y is Through Y1 Receptors
Modulation of Temporoammonic-CA1 Synapses by Neuropeptide Y is Through Y1 Receptors Open
The reduction of neuropeptide Y (NPY), an abundant neuromodulator in the brain, has been implicated in multiple neuropsychiatric disorders, such as depression and post-traumatic stress disorder (PTSD). The CA1 region of hippocampus is an i…
View article: Hypothalamic Glucagon Receptors Regulate Feeding in Mice
Hypothalamic Glucagon Receptors Regulate Feeding in Mice Open
Glucagon is an essential regulator of glucose and lipid metabolism. We have reported that chronic glucagon receptor (GCGR) activation with the highly selective, long-acting GCGR-agonist, IUB288, promotes weight-loss by stimulating energy e…
View article: Glucagon-receptor signaling regulates weight loss via central KLB receptor complexes
Glucagon-receptor signaling regulates weight loss via central KLB receptor complexes Open
Glucagon regulates glucose and lipid metabolism and promotes weight loss. Thus, therapeutics stimulating glucagon receptor (GCGR) signaling are promising for obesity treatment; however, the underlying mechanism(s) have yet to be fully eluc…