Stephen E. Wright
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View article: Large row-constrained supersaturated designs for high-throughput screening
Large row-constrained supersaturated designs for high-throughput screening Open
High-throughput screening, in which large numbers of compounds are traditionally studied one-at-a-time in multiwell plates against specific targets, is widely used across many areas of the biological sciences, including drug discovery. To …
View article: Interferon gamma applied ex vivo restores function to neutrophils from critically ill patients
Interferon gamma applied ex vivo restores function to neutrophils from critically ill patients Open
Introduction Critically ill patients commonly develop acquired neutrophil dysfunction, which increases susceptibility to intensive care unit-acquired infection (ICU-AI). This study aimed to assess whether interferon gamma (IFN-γ) can resto…
View article: Reproductive success and offspring survival decline for female elephant seals past prime age
Reproductive success and offspring survival decline for female elephant seals past prime age Open
Maternal age can influence reproductive success and offspring fitness, but the timing, magnitude and direction of those impacts are not well understood. Evolutionary theory predicts that selection on fertility senescence is stronger than m…
View article: The Effect of Perioperative Cimetidine on the Outcomes of Stage 2 Melanoma
The Effect of Perioperative Cimetidine on the Outcomes of Stage 2 Melanoma Open
Objectives The use of immunotherapies in the treatment of melanoma has significantly improved the survival of patients with advanced disease. Historically, histamine has been implicated in the pathogenesis of several cancers. Cimetidine do…
View article: Large Row-Constrained Supersaturated Designs for High-throughput Screening
Large Row-Constrained Supersaturated Designs for High-throughput Screening Open
High-throughput screening, in which multiwell plates are used to test large numbers of compounds against specific targets, is widely used across many areas of the biological sciences and most prominently in drug discovery. We propose a sta…
View article: Comparison of Two High-Dose Versus Two Standard-Dose Influenza Vaccines in Adult Allogeneic Hematopoietic Cell Transplant Recipients
Comparison of Two High-Dose Versus Two Standard-Dose Influenza Vaccines in Adult Allogeneic Hematopoietic Cell Transplant Recipients Open
Background Adult hematopoietic cell transplant (HCT) recipients are at high risk for influenza-related morbidity and mortality and have suboptimal influenza vaccine immune responses compared to healthy adults, particularly within 2 years o…
View article: A group concept mapping and ethnographic study of intensive care rehabilitation culture
A group concept mapping and ethnographic study of intensive care rehabilitation culture Open
Background Early physical activity and physical rehabilitation are advocated in the critical care unit for patients recovering from critical illness. Despite this, there are still many factors associated with implementation of early physic…
View article: Efficacy and safety of proton pump inhibitors versus histamine-2 receptor blockers in the cardiac surgical population: insights from the PEPTIC trial
Efficacy and safety of proton pump inhibitors versus histamine-2 receptor blockers in the cardiac surgical population: insights from the PEPTIC trial Open
OBJECTIVES The comparative effectiveness and safety of proton pump inhibitors (PPIs) versus histamine-2 receptor blockers for stress ulcer prophylaxis in the cardiac surgical intensive care unit population is uncertain. Although the Proton…
View article: Atovaquone Suppresses Triple-Negative Breast Tumor Growth by Reducing Immune-Suppressive Cells
Atovaquone Suppresses Triple-Negative Breast Tumor Growth by Reducing Immune-Suppressive Cells Open
A major contributing factor in triple-negative breast cancer progression is its ability to evade immune surveillance. One mechanism for this immunosuppression is through ribosomal protein S19 (RPS19), which facilitates myeloid-derived supp…
View article: A framework and toolkit of interventions to enhance reflective learning among health-care professionals: the PEARL mixed-methods study
A framework and toolkit of interventions to enhance reflective learning among health-care professionals: the PEARL mixed-methods study Open
Background Although most health care is high quality, many patients and members of staff can recall episodes of a lack of empathy, respect or effective communication from health-care staff. In extreme form, this contributes to high-profile…
View article: More research is required to understand factors influencing antibiotic prescribing in complex conditions like suspected ventilator-associated pneumonia
More research is required to understand factors influencing antibiotic prescribing in complex conditions like suspected ventilator-associated pneumonia Open
We read with interest the commentary by Yoshimura et al. in relation to our recently published trial investigating whether a novel, rapid biomarker-based rule-out of ventilator-associated pneumonia (VAP) could improve antibiotic stewardshi…
View article: Effect of Stress Ulcer Prophylaxis With Proton Pump Inhibitors vs Histamine-2 Receptor Blockers on In-Hospital Mortality Among ICU Patients Receiving Invasive Mechanical Ventilation
Effect of Stress Ulcer Prophylaxis With Proton Pump Inhibitors vs Histamine-2 Receptor Blockers on In-Hospital Mortality Among ICU Patients Receiving Invasive Mechanical Ventilation Open
anzctr.org.au Identifier: ACTRN12616000481471.
View article: Gemcitabine-Related Acute Coronary Syndrome
Gemcitabine-Related Acute Coronary Syndrome Open
A strong association of gemcitabine to acute coronary syndrome (ACS) is not currently established in the literature. In this series, we highlight that both patients with gemcitabine-related ACS were more than 50 years old, had underlying c…
View article: Biomarker-guided antibiotic stewardship in suspected ventilator-associated pneumonia (VAPrapid2): a randomised controlled trial and process evaluation
Biomarker-guided antibiotic stewardship in suspected ventilator-associated pneumonia (VAPrapid2): a randomised controlled trial and process evaluation Open
UK Department of Health and the Wellcome Trust.
View article: Role of Phytochemicals in Cancer Prevention
Role of Phytochemicals in Cancer Prevention Open
The use of synthetic, natural, or biological agents to minimize the occurrence of cancer in healthy individuals is defined as cancer chemoprevention. Chemopreventive agents inhibit the development of cancer either by impeding DNA damage, w…
View article: Family satisfaction with critical care in the UK: a multicentre cohort study
Family satisfaction with critical care in the UK: a multicentre cohort study Open
Objective To assess family satisfaction with intensive care units (ICUs) in the UK using the Family Satisfaction in the Intensive Care Unit 24-item (FS-ICU-24) questionnaire, and to investigate how characteristics of patients and their fam…
View article: Patient experience and reflective learning (PEARL): a mixed methods protocol for staff insight development in acute and intensive care medicine in the UK
Patient experience and reflective learning (PEARL): a mixed methods protocol for staff insight development in acute and intensive care medicine in the UK Open
Introduction Patient and staff experiences are strongly influenced by attitudes and behaviours, and provide important insights into care quality. Patient and staff feedback could be used more effectively to enhance behaviours and improve c…
View article: IgG4-Related Sclerosing Disease Causing Spinal Cord Compression: The First Reported Case in Literature
IgG4-Related Sclerosing Disease Causing Spinal Cord Compression: The First Reported Case in Literature Open
Immunoglobulin G4-related disease (IgG4-RD) is known for forming soft tissue mass lesions that may have compressive effects. It is an extremely rare disease that most frequently affects the pancreas causing autoimmune pancreatitis. It can …
View article: A cluster randomised, crossover, registry-embedded clinical trial of proton pump inhibitors versus histamine-2 receptor blockers for ulcer prophylaxis therapy in the intensive care unit (PEPTIC study): study protocol
A cluster randomised, crossover, registry-embedded clinical trial of proton pump inhibitors versus histamine-2 receptor blockers for ulcer prophylaxis therapy in the intensive care unit (PEPTIC study): study protocol Open
Australian and New Zealand Clinical Trials Registry (ANZCTRN 12616000481471).
View article: Randomised controlled trial of GM-CSF in critically ill patients with impaired neutrophil phagocytosis
Randomised controlled trial of GM-CSF in critically ill patients with impaired neutrophil phagocytosis Open
Background Critically ill patients with impaired neutrophil phagocytosis have significantly increased risk of nosocomial infection. Granulocyte-macrophage colony-stimulating factor (GM-CSF) improves phagocytosis by neutrophils ex vivo. Thi…
View article: Excess Mucin Impairs Subglottic Epithelial Host Defense in Mechanically Ventilated Patients
Excess Mucin Impairs Subglottic Epithelial Host Defense in Mechanically Ventilated Patients Open
Mechanical ventilation in the ICU is characterized by substantial mucin secretion and neutrophilic inflammation. Mucin impairs neutrophil function and promotes bacterial growth. Mucolytic agents reverse mucin-mediated neutrophil dysfunctio…
View article: Intensive versus standard physical rehabilitation therapy in the critically ill (EPICC): a multicentre, parallel-group, randomised controlled trial
Intensive versus standard physical rehabilitation therapy in the critically ill (EPICC): a multicentre, parallel-group, randomised controlled trial Open
Background Early physical rehabilitation in the intensive care unit (ICU) has been shown to improve short-term clinical outcomes but long-term benefit has not been proven and the optimum intensity of rehabilitation is not known. Methods We…
View article: Immune consequences of penfluridol treatment associated with inhibition of glioblastoma tumor growth
Immune consequences of penfluridol treatment associated with inhibition of glioblastoma tumor growth Open
Glioblastoma is the most common and lethal brain tumor associated with only 12% median survival rate of patients. Despite the development of advanced surgical, radiation or use of combinations of anti-cancer drugs, treatment for glioblasto…
View article: Reducing the incidence of pressure ulcers in critical care units: a 4-year quality improvement
Reducing the incidence of pressure ulcers in critical care units: a 4-year quality improvement Open
A quality improvement programme including technical and non-technical interventions, data feedback to staff and clinical leadership was associated with a sustained reduction in the incidence of pressure ulceration in the critically ill. St…