Stephen Ejeh
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View article: In-silico screening, pharmacokinetic evaluation, DFT study, and molecular dynamic simulation as approaches for the identification of acetamide and acetic acid derivatives as potential antisickling agents targeting Hba protein
In-silico screening, pharmacokinetic evaluation, DFT study, and molecular dynamic simulation as approaches for the identification of acetamide and acetic acid derivatives as potential antisickling agents targeting Hba protein Open
One of the most prevalent genetic conditions is sickle cell disease (SCD), a multiorgan condition that impacts about 15 million people around the globe. The current standard of care for SCD mainly consists of hydroxyurea therapy or support…
View article: Computational techniques for analyzing and interpreting some quinoxaline-containing molecules as possible anti-schistosomal agents using docking, pharmacokinetics, drug-likeness, QSAR, and molecular dynamics evaluation
Computational techniques for analyzing and interpreting some quinoxaline-containing molecules as possible anti-schistosomal agents using docking, pharmacokinetics, drug-likeness, QSAR, and molecular dynamics evaluation Open
View article: Genetic function algorithm (GFA) based QSAR, molecular design, and ADMET screening to assess the antimalarial potential of Amodiaquine derivatives
Genetic function algorithm (GFA) based QSAR, molecular design, and ADMET screening to assess the antimalarial potential of Amodiaquine derivatives Open
The ongoing fight against endemic diseases is complicated by the increasing resistance of malaria parasites to widely used drugs. As a result, the search for more effective antimalarial treatments continues. This research focuses on develo…
View article: In silico screening, pharmacokinetic, DFT, and dynamics simulation study of ant-hepatitis C virus compounds as potential NS5B Polymerase inhibitors
In silico screening, pharmacokinetic, DFT, and dynamics simulation study of ant-hepatitis C virus compounds as potential NS5B Polymerase inhibitors Open
Cirrhosis, hepatocellular carcinoma, and other serious liver diseases are caused by the hepatitis C virus (HCV) infection. An oral NS5B inhibitor for the therapy of HCV called Sofosbuvir has received approval. However, its high cost and nu…
View article: In-silico screening and ADMET evaluation of therapeutic MAO-B inhibitors against Parkinson disease
In-silico screening and ADMET evaluation of therapeutic MAO-B inhibitors against Parkinson disease Open
MAOs are flavoenzymes that aid in the oxidative deamination of neurotransmitters such as dopamine, serotonin, and epinephrine. MAO inhibitors are antidepressants that act by inhibiting neurotransmitter breakdown in the brain and controllin…
View article: QSAR, molecular docking, and molecular designs of some anti-epilepsy compounds
QSAR, molecular docking, and molecular designs of some anti-epilepsy compounds Open
Epilepsy is a non-communicable central nervous system (CNS) disease that accounts for approximately 0.8–1.2 % of the global population at any time. The hyper-activities of gamma butyric acid aminotransferase (GABAAT) enzyme have been confi…
View article: In silico screening of potential Tumor necrosis factor alpha (TNF-α) inhibitors through molecular modeling, molecular docking, and pharmacokinetics evaluations
In silico screening of potential Tumor necrosis factor alpha (TNF-α) inhibitors through molecular modeling, molecular docking, and pharmacokinetics evaluations Open
The multifunctional cytokine TNF-α serves as a key biological mediator for several important immune processes, such as inflammation, infection, and antitumor responses. It is crucial for both acute and chronic neuroinflammation, as well as…
View article: Modelling the Permeation Properties of Self-Compacting Concrete Incorporating Sporocarcina Pasteuri
Modelling the Permeation Properties of Self-Compacting Concrete Incorporating Sporocarcina Pasteuri Open
The face of concreting has been revolutionized with the development of self-compacting concrete, the introduction of Microbial Induced Calcite Precipitation (MICP) in concrete as well as the use of secondary cementitious materials in concr…
View article: Pharmacoinformatics-based strategy in designing and profiling of some Pyrazole analogues as novel hepatitis C virus inhibitors with pharmacokinetic analysis
Pharmacoinformatics-based strategy in designing and profiling of some Pyrazole analogues as novel hepatitis C virus inhibitors with pharmacokinetic analysis Open
Hepatitis C virus (HCV) infection promotes death rates all over the world. Sofosbuvir is a standard drug for the cure of HCV but unfortunately, it receives a lot of attention for its pricing problems. As a result, it is crucial to consider…
View article: Chemical bioinformatics study of Nonadec-7-ene-4-carboxylic acid derivatives via molecular docking, and molecular dynamic simulations to identify novel lead inhibitors of hepatitis c virus NS3/4a protease
Chemical bioinformatics study of Nonadec-7-ene-4-carboxylic acid derivatives via molecular docking, and molecular dynamic simulations to identify novel lead inhibitors of hepatitis c virus NS3/4a protease Open
One of the most common viruses in the world today is the hepatitis C virus (HCV). It is a virus with a wide range of characteristics, and it reproduces and evolves quickly. The nonstructural proteins (NS3/4a), are responsible for swift mul…
View article: <i>In Silico</i> Screening, Pharmacokinetic, DFT, and Dynamics Simulation Study of Ant-Hepatitis C Virus Compounds as Potential NS5B Polymerase Inhibitors
<i>In Silico</i> Screening, Pharmacokinetic, DFT, and Dynamics Simulation Study of Ant-Hepatitis C Virus Compounds as Potential NS5B Polymerase Inhibitors Open
View article: EFFECT OF MIX RATIO AND CURING ON COMPRESSIVE STRENGTH OF SANDCRETE HOLLOW BLOCKS
EFFECT OF MIX RATIO AND CURING ON COMPRESSIVE STRENGTH OF SANDCRETE HOLLOW BLOCKS Open
The standards of the materials used in a building’s construction greatly influence its strength and durability. In Nigeria, hollow sandcrete block is the most common material used in buildings. This study evaluates the effect of the water-…
View article: Properties of Calcined Clay and Limestone Powder Blended Bio-Self Compacting Concrete
Properties of Calcined Clay and Limestone Powder Blended Bio-Self Compacting Concrete Open
Self-Compacting Concrete is a revolutionary concrete that has taken Europe, the America and Asia by storm following its development by Prof. Okamura’s research team in the late 20th century. Since then, it has been revolutionized into vari…
View article: Effects of Sesame Straw Ash as a Substitute for Cement on Strength Characteristics of Concrete
Effects of Sesame Straw Ash as a Substitute for Cement on Strength Characteristics of Concrete Open
Concrete is broadly used as a building material across the globe, and its use is raising the need of cement in the construction industries. High price of cement and environmental debasement are the driving problems forcing the researchers …
View article: In silico design and pharmacokinetics investigation of some novel hepatitis C virus NS5B inhibitors: pharmacoinformatics approach
In silico design and pharmacokinetics investigation of some novel hepatitis C virus NS5B inhibitors: pharmacoinformatics approach Open
Background Hepatitis C virus (HCV) is a contagious disease that damages the liver over time, eventually leading to cirrhosis and death. Chronic HCV infection is regarded as a serious health problem worldwide, impacting up to 3% of the popu…
View article: Modelling Of Sludge Drying Parameters in a Paved Drying Bed
Modelling Of Sludge Drying Parameters in a Paved Drying Bed Open
Contemporary studies on the use of paved drying bed (PDB) indicate a decline in knowledge and technology-gap on the performance of this infrastructure. In consequence therefore, environmental pollution arising from untreated sludge is on t…
View article: Computational insight to design new potential hepatitis C virus NS5B polymerase inhibitors with drug-likeness and pharmacokinetic ADMET parameters predictions
Computational insight to design new potential hepatitis C virus NS5B polymerase inhibitors with drug-likeness and pharmacokinetic ADMET parameters predictions Open
View article: In Silico Design, Drug-Likeness and ADMET Properties Estimation of Some Substituted Thienopyrimidines as HCV NS3/4A Protease Inhibitors
In Silico Design, Drug-Likeness and ADMET Properties Estimation of Some Substituted Thienopyrimidines as HCV NS3/4A Protease Inhibitors Open
In this study, we established a QSAR model for studying the antiviral activity of substituted thienopyrimidines derivatives as HCV NS3/4A protease inhibitors. We engaged in random analysis to split the datasets. Statistically, a robust mod…
View article: Computational techniques in designing a series of 1,3,4-trisubstituted pyrazoles as unique hepatitis C virus entry inhibitors
Computational techniques in designing a series of 1,3,4-trisubstituted pyrazoles as unique hepatitis C virus entry inhibitors Open
In this study, we developed a QSAR model for studying the antiviral activity of 1,3,4-trisubstituted pyrazoles derivatives on hepatitis C virus infected in human HuH-7 cell lines. We employed random analysis to split the data sets. Statist…
View article: Computer-aided identification of a series of novel ligands showing high potency as hepatitis C virus NS3/4A protease inhibitors
Computer-aided identification of a series of novel ligands showing high potency as hepatitis C virus NS3/4A protease inhibitors Open
Background Hepatitis C virus (HCV) is a global medical condition that causes several life-threatening chronic diseases in the liver. The conventional interferon-free treatment regimens are currently in use by a blend of direct-acting antiv…
View article: INVESTIGATION OF CONCRETE STRENGTH MADE WITH NANOPARTICLES AND METAKAOLIN IN ACID AND SULPHATE SOLUTION
INVESTIGATION OF CONCRETE STRENGTH MADE WITH NANOPARTICLES AND METAKAOLIN IN ACID AND SULPHATE SOLUTION Open
The investigation of concrete strength with nanoparticles and metakaolin in acid and sulphate solutions was the aim of this study. The nanoparticles were obtained from rice husk through sol-gel method and beneficiated metakaolin from kaoli…
View article: Durability Evaluation of Calcined Clay and Limestone Powder Blended Ternary Self-Compacting Concrete
Durability Evaluation of Calcined Clay and Limestone Powder Blended Ternary Self-Compacting Concrete Open
This research work investigates the durability-based properties of a ternary calcined clay and limestone powder blended Self Compacting Concrete by measuring the short- and long-term permeation properties using water absorption and sorptiv…
View article: Computational study of some cancer drugs as potent inhibitors of GSK3β
Computational study of some cancer drugs as potent inhibitors of GSK3β Open
A series of known Food and Drug Administration (FDA) approved anticancer drugs were collected from the literature and docked against Glycogen synthase kinase 3β (GSKβ) receptor which has been identified in present time as a target for ther…
View article: Effects of Compression Creep Deformation on the Microstructure of Terminalia Ivorensis (Black Afara) Timber
Effects of Compression Creep Deformation on the Microstructure of Terminalia Ivorensis (Black Afara) Timber Open
The effects of compression creep on Terminalia ivorensis timber was presented in this paper. One-year creep test was performed in the laboratory on Terminalia ivorensis timber samples. The creep data were fitted to linear, exponential and …
View article: Cold-formed Steel Cassette Wall System for Building Construction
Cold-formed Steel Cassette Wall System for Building Construction Open
View article: Determined uncertainty models of reference material properties and the en 338 strength class of Nigerian grown <i>Terminalia ivorensis</i> (black afara) timber
Determined uncertainty models of reference material properties and the en 338 strength class of Nigerian grown <i>Terminalia ivorensis</i> (black afara) timber Open
The purpose of this paper was the determination of the uncertainty models of reference material properties and [1] strength class of Nigerian Grown Terminalia ivorensis timber, so that it can be used in structures designed based on the Eur…
View article: Compression creep model for Nigeria grown <i>Terminalia ivorensis</i> (black afara) timber
Compression creep model for Nigeria grown <i>Terminalia ivorensis</i> (black afara) timber Open
Mathematical model of compression creep for Terminalia ivorensis (Black Afara) timber were developed and presented in this paper. One-year creep test was performed in this process on Terminalia ivorensis timber samples. The creep data were…
View article: The impact resistance effect of partially replacing coarse aggregate with ground-rubber aggregate in concrete
The impact resistance effect of partially replacing coarse aggregate with ground-rubber aggregate in concrete Open
The effect of ground-rubber used as aggregate on the impact resistance of concrete when partially replaced volume of mineral coarse aggregate (granite) was investigated. A total of six mix batches (using a mix ratio of 1:2:4 and a watercem…
View article: Phase and Micro-Chemical Characterization of Water Works Sludge Minerals and their Thermally-Decomposed Products
Phase and Micro-Chemical Characterization of Water Works Sludge Minerals and their Thermally-Decomposed Products Open
Environmental Regulations worldwide have created a critical need for a long term approach to sludge management for environmental sustainability. Several sludge disposal concepts adopt the reuse of sludge as a viable alternative to material…
View article: Load - Deflection Characteristics of Reinforced Concrete and Reinforced Latecrete Beams at Mid-Span
Load - Deflection Characteristics of Reinforced Concrete and Reinforced Latecrete Beams at Mid-Span Open
A laboratory Investigation of the Flexural Strength of Latecrete materials was carried out. The laterite used falls under AASHTO soil classification A-7-6 (10) with low plasticity clay (CL) according to the Unified soil classification syst…