Stephen W. Fenwick
YOU?
Author Swipe
View article: Subgroup analyses of the phase 3 FOCUS study of melphalan/hepatic delivery system in patients with unresectable metastatic uveal melanoma
Subgroup analyses of the phase 3 FOCUS study of melphalan/hepatic delivery system in patients with unresectable metastatic uveal melanoma Open
Results demonstrate a favorable benefit-risk profile for melphalan/HDS across clinically relevant subgroups. However, early treatment in patients with low tumor burden may offer best results.
View article: Uveal Melanoma UK national guidelines: 2023 update
Uveal Melanoma UK national guidelines: 2023 update Open
UK Guidelines for the management of uveal melanoma (UM) were first published in 2015 using an evidence-based systematic approach. The primary aim of this guideline was to optimise patient care by providing recommendations based on the best…
View article: Update to the role of staging laparoscopy in the assessment of resectability of perihilar cholangiocarcinoma: have improvements in cross-sectional and functional imaging rendered it redundant?
Update to the role of staging laparoscopy in the assessment of resectability of perihilar cholangiocarcinoma: have improvements in cross-sectional and functional imaging rendered it redundant? Open
Advances in cross-sectional imaging, including FDG PET-CT, have improved radiological staging. However, at 1-in-8, the diagnostic yield of staging laparoscopy remains high, justifying its continued role in evaluating resectability.
View article: HPB SO07 - Update to the role of staging laparoscopies in stratifying patients by operability in perihilar cholangiocarcinoma
HPB SO07 - Update to the role of staging laparoscopies in stratifying patients by operability in perihilar cholangiocarcinoma Open
Background Radical resection of perihilar cholangiocarcinoma (pCCA) is only an option for the minority presenting at an early stage. Sensitivity of radiological imaging to detect liver and peritoneal metastases is insufficient. Our publish…
View article: The importance of preclinical models in cholangiocarcinoma
The importance of preclinical models in cholangiocarcinoma Open
Cholangiocarcinoma (CCA) is an adenocarcinoma of the hepatobiliary system with a grim prognosis. Incidence is rising globally and surgery is currently the only curative treatment, but is only available for patients who are fit and diagnose…
View article: 832 Analysis of Surgical Outcomes and Survival Benefit of Simultaneous Resection of the Primary Colonic Tumour and Liver Metastasis – Experience of a UK Tertiary Centre Between 2013-2022
832 Analysis of Surgical Outcomes and Survival Benefit of Simultaneous Resection of the Primary Colonic Tumour and Liver Metastasis – Experience of a UK Tertiary Centre Between 2013-2022 Open
Introduction 22% of patients with colorectal cancer present with synchronous metastases. Traditionally, surgical management for these patients is performed separately although increasingly these are being done as simultaneous resections as…
View article: A systems approach reveals species differences in hepatic stress response capacity
A systems approach reveals species differences in hepatic stress response capacity Open
To minimize the occurrence of unexpected toxicities in early phase preclinical studies of new drugs, it is vital to understand fundamental similarities and differences between preclinical species and humans. Species differences in sensitiv…
View article: Oncological Outcomes after Laparoscopic and Open Liver Resection in patients with Colorectal Liver Metastases: A Single Centre Propensity Score Matched Study
Oncological Outcomes after Laparoscopic and Open Liver Resection in patients with Colorectal Liver Metastases: A Single Centre Propensity Score Matched Study Open
Introduction Minimally invasive approaches to oncological liver resection is common in many hepatobiliary centres. This study aims to compare the key oncological and survival outcomes of patients with colorectal liver metastases (CRLM) und…
View article: Genomic profiling of idiopathic peri-hilar cholangiocarcinoma reveals new targets and mutational pathways
Genomic profiling of idiopathic peri-hilar cholangiocarcinoma reveals new targets and mutational pathways Open
Peri-hilar cholangiocarcinoma (pCCA) is chemorefractory and limited genomic analyses have been undertaken in Western idiopathic disease. We undertook comprehensive genomic analyses of a U.K. idiopathic pCCA cohort to characterize its mutat…
View article: PINCER (A Platform Study for solId orgaN CancERs): an agile pan-network platform study to deliver high-quality translational research
PINCER (A Platform Study for solId orgaN CancERs): an agile pan-network platform study to deliver high-quality translational research Open
Journal Article PINCER (A Platform Study for solId orgaN CancERs): an agile pan-network platform study to deliver high-quality translational research Get access Robert P Jones, Robert P Jones Department of Molecular and Clinical Cancer Med…
View article: HPB P19 Our experience comparing multi-visceral and single organ excision of retroperitoneal sarcomas from a HPB centre
HPB P19 Our experience comparing multi-visceral and single organ excision of retroperitoneal sarcomas from a HPB centre Open
Background Sarcomas are a heterogenous set of soft tissue cancers with an estimated incidence of up to 5.0 cases per 100,00 worldwide. Retroperitoneal sarcomas (RPS) account for up to 20% of these. The aetiology behind the pathogenesis is …
View article: A systems approach reveals species differences in hepatic stress response capacity
A systems approach reveals species differences in hepatic stress response capacity Open
To minimise unexpected toxicities in early phase clinical studies of new drugs, it is vital to understand fundamental similarities and differences between preclinical test species and humans. We have used physiologically-based pharmacokine…
View article: O-L02 Evaluation of the Utility of Prognostic Models for Patients Diagnosed with Peri-hilar Cholangiocarcinoma
O-L02 Evaluation of the Utility of Prognostic Models for Patients Diagnosed with Peri-hilar Cholangiocarcinoma Open
Background Several potential prognostic models have been developed to stratify patients with peri-hilar cholangiocarcinoma (PHC) by Overall Survival (OS). The American Joint Committee on Cancer (AJCC) staging system is a post-resectional m…
View article: O-L09 Determining the Prognostic Utility of Immuno-histochemically detected Trans-membranous Human Equilibriative Nucleoside Transporter 1 (hENT1) in Patients Undergoing Hilar Cholangiocarcinoma Resection
O-L09 Determining the Prognostic Utility of Immuno-histochemically detected Trans-membranous Human Equilibriative Nucleoside Transporter 1 (hENT1) in Patients Undergoing Hilar Cholangiocarcinoma Resection Open
Background Human equilibriative nucleoside transporter protein 1 (hENT1) is a trans-membranous protein which facilitates nucleoside transport in to the cell. Immunohistochemically-detected hENT1 abundance is increased in cholangiocarcinoma…
View article: Surgical management of suspected gallbladder cancer: The role of intraoperative frozen section for diagnostic confirmation
Surgical management of suspected gallbladder cancer: The role of intraoperative frozen section for diagnostic confirmation Open
Background Preoperative diagnosis for suspected gallbladder cancers is challenging, with a risk of overtreating benign disease, for example, xanthogranulomatous cholecystitis, with radical cholecystectomies. We retrospectively evaluated th…
View article: DS05: Two‐thirds of patients may not require review after Mohs micrographic surgery
DS05: Two‐thirds of patients may not require review after Mohs micrographic surgery Open
has increased over the last 10 years, with more fellows completing UK-based fellowships.The average number of PAs allocated for MMS has also increased from 1Á84 to 2Á87.This study provides a valuable update to the 2011 national survey outc…
View article: DS06: Contending with COVID‐19 in a Mohs micrographic surgery service
DS06: Contending with COVID‐19 in a Mohs micrographic surgery service Open
has increased over the last 10 years, with more fellows completing UK-based fellowships.The average number of PAs allocated for MMS has also increased from 1Á84 to 2Á87.This study provides a valuable update to the 2011 national survey outc…
View article: The Impact of 68Gallium DOTA PET/CT in Managing Patients With Sporadic and Familial Pancreatic Neuroendocrine Tumours
The Impact of 68Gallium DOTA PET/CT in Managing Patients With Sporadic and Familial Pancreatic Neuroendocrine Tumours Open
Objective Pancreatic neuroendocrine tumours (panNETs) arise sporadically or as part of a genetic predisposition syndrome. CT/MRI, endoscopic ultrasonography and functional imaging using Octreoscan localise and stage disease. This study aim…
View article: Pharmacological Activation of Nrf2 Enhances Functional Liver Regeneration
Pharmacological Activation of Nrf2 Enhances Functional Liver Regeneration Open
Background and Aims The transcription factor nuclear factor erythroid 2‐related factor 2 (Nrf2) regulates an array of cytoprotective genes, yet studies in transgenic mice have led to conflicting reports on its role in liver regeneration. W…
View article: Treatment algorithm of metastatic rectal cancer
Treatment algorithm of metastatic rectal cancer Open
Around 50% of patients suffering from colorectal cancer will develop metastasis within their lifetime. Some liver and lung metastases are amenable to surgical resection, and these patients can enjoy an improved overall survival (OS), altho…