Stephen Hamlet
YOU?
Author Swipe
View article: Neutrophils Respond Selectively to Physical Cues: Roughness Modulates Its Granule Release, and NETosis
Neutrophils Respond Selectively to Physical Cues: Roughness Modulates Its Granule Release, and NETosis Open
Our study examined how different titanium alloy Ti6Al4V (Ti64) and zirconia (ZrO2) surfaces, ranging from rough to very smooth, affect the expression of elastase (NE), matrix metalloproteinase (MMP)-8, MMP-9, and extracellular traps (NETs)…
View article: Neutrophils Respond Selectively to Physical Cues: Roughness Modulates Its Granule Release, and NETosis
Neutrophils Respond Selectively to Physical Cues: Roughness Modulates Its Granule Release, and NETosis Open
This study evaluated the impact of rough, smooth, and very smooth Titanium (Ti) and zirconia (Zr) surfaces on the neutrophil expression of elastase (NE), matrix metalloproteinase (MMP)-8, MMP-9 and extracellular traps (NETs). Ti and Zr dis…
View article: The effects of keratin-coated titanium on osteoblast function and bone regeneration
The effects of keratin-coated titanium on osteoblast function and bone regeneration Open
Wool derived keratin, due to its demonstrated ability to promote bone formation, has been suggested as a potential bioactive material for implant surfaces. The aim of this study was to assess the effects of keratin-coated titanium on osteo…
View article: Medication‐related osteonecrosis of the jaw: A disease of significant importance for older patients
Medication‐related osteonecrosis of the jaw: A disease of significant importance for older patients Open
Background Medication‐related osteonecrosis of the jaw (MRONJ) is clinically defined as a non‐healing jawbone ulcerative‐necrotic lesion appearing after dental therapy or minor trauma in patients treated previously with anti‐resorptive, an…
View article: The Effect of Titanium Surface Topography on Adherent Macrophage Integrin and Cytokine Expression
The Effect of Titanium Surface Topography on Adherent Macrophage Integrin and Cytokine Expression Open
Immunomodulatory biomaterials have the potential to stimulate an immune response able to promote constructive and functional tissue remodeling, as opposed to persistent inflammation and scar tissue formation. This study examined the effect…
View article: The mechanical properties of 3D printed denture base resin incorporating essential oil microcapsules
The mechanical properties of 3D printed denture base resin incorporating essential oil microcapsules Open
Incorporation of microencapsulated plant essential oils into 3D printed denture base resin was successfully achieved. While incorporation negatively influenced flexural strength and surface roughness, little effect on flexural modulus and …
View article: Titanium Implant Surface Effects on Adherent Macrophage Phenotype: A Systematic Review
Titanium Implant Surface Effects on Adherent Macrophage Phenotype: A Systematic Review Open
Immunomodulatory biomaterials have the potential to stimulate an immune response able to promote constructive and functional tissue remodeling responses as opposed to persistent inflammation and scar tissue formation. As such, the controll…
View article: Angiogenesis-osteogenesis coupling: a key element in bone physiology and regeneration
Angiogenesis-osteogenesis coupling: a key element in bone physiology and regeneration Open
Bone represents a well vascularized structure which is remodelled and renewed continuously. It consists of osteoblasts, osteoclasts and osteocytes which have a precise role in the context of endochondral and intramembranous ossification. W…
View article: Enamel matrix derivative promotes new bone formation in xenograft assisted maxillary anterior ridge preservation—A randomized controlled clinical trial
Enamel matrix derivative promotes new bone formation in xenograft assisted maxillary anterior ridge preservation—A randomized controlled clinical trial Open
Objectives To compare the effectiveness of deproteinized bovine bone mineral with 10% collagen alone (DBBMC) or with enamel matrix derivative (DBBMC‐EMD) in ridge preservation. Methods 42 maxillary anterior teeth were extracted and receive…
View article: The SARS-CoV2 - ACE2 link: a physiopathological analysis
The SARS-CoV2 - ACE2 link: a physiopathological analysis Open
The Covid-19 pandemic represents an unsolved problem which has caused numerous fatalities. At the present time, there is no vaccination available or curative therapy. However, recent reports suggest that SARS-CoV2 acts upon its functional …
View article: Influence of Chitosan or Keratin on Titanium Implant Surface - A Systematic Review
Influence of Chitosan or Keratin on Titanium Implant Surface - A Systematic Review Open
Purpose: This systematic review was carried out to investigate the effects of keratin and chitosan hydrogel preparations on dental implant osseointegration. Materials and Methods: The electronic search was conducted on five databases: Scop…
View article: Silver Nanoparticles at Biocompatible Dosage Synergistically Increases Bacterial Susceptibility to Antibiotics
Silver Nanoparticles at Biocompatible Dosage Synergistically Increases Bacterial Susceptibility to Antibiotics Open
Antibiotics used to treat bacterial infections can become ineffective over time or result in the emergence of antibiotic resistant pathogens. With the advent of nanotechnology, silver nanoparticles (AgNPs) have gained significant attention…
View article: In vivo bone regeneration assessment of offset and gradient melt electrowritten (MEW) PCL scaffolds
In vivo bone regeneration assessment of offset and gradient melt electrowritten (MEW) PCL scaffolds Open
Background Biomaterial-based bone tissue engineering represents a promising solution to overcome reduced residual bone volume. It has been previously demonstrated that gradient and offset architectures of three-dimensional melt electrowrit…
View article: Porous scaffolds for bone regeneration
Porous scaffolds for bone regeneration Open
Globally, bone fractures due to osteoporosis occur every 20 s in people aged over 50 years. The significant healthcare costs required to manage this problem are further exacerbated by the long healing times experienced with current treatme…
View article: Role of offset and gradient architectures of 3-D melt electrowritten scaffold on differentiation and mineralization of osteoblasts
Role of offset and gradient architectures of 3-D melt electrowritten scaffold on differentiation and mineralization of osteoblasts Open
Background Cell-scaffold based therapies have the potential to offer an efficient osseous regenerative treatment and PCL has been commonly used as a scaffold, however its effectiveness is limited by poor cellular retention properties. This…
View article: MOESM1 of Role of offset and gradient architectures of 3-D melt electrowritten scaffold on differentiation and mineralization of osteoblasts
MOESM1 of Role of offset and gradient architectures of 3-D melt electrowritten scaffold on differentiation and mineralization of osteoblasts Open
Additional file 1. Osteoblast Proliferation. Proliferation of osteoblasts in osteogenic (+) and basal medium (−) seeded on PCL scaffolds with different porosity for 1, 3, 14, and 30 days. * significant versus other scaffolds. Δ nonsignific…
View article: Fabrication of a thick three-dimensional scaffold with an open cellular-like structure using airbrushing and thermal cross-linking of molded short nanofibers
Fabrication of a thick three-dimensional scaffold with an open cellular-like structure using airbrushing and thermal cross-linking of molded short nanofibers Open
Nanoscale fibers mimicking the extracellular matrix of natural tissue can be produced by conventional electrospinning, but this approach results in two-dimensional thin dense fibrous mats which can hinder effective cell infiltration. The a…
View article: Regenerative surgical therapy for peri‐implantitis using deproteinized bovine bone mineral with 10% collagen, enamel matrix derivative and Doxycycline—A prospective 3‐year cohort study
Regenerative surgical therapy for peri‐implantitis using deproteinized bovine bone mineral with 10% collagen, enamel matrix derivative and Doxycycline—A prospective 3‐year cohort study Open
Objectives There is limited evidence regarding the long‐term efficacy of regenerative treatment for peri‐implantitis. The aim of this study was to evaluate a combination therapy of deproteinized bovine bone mineral with 10% collagen (DBBMC…
View article: 3‐Dimensional functionalized polycaprolactone‐hyaluronic acid hydrogel constructs for bone tissue engineering
3‐Dimensional functionalized polycaprolactone‐hyaluronic acid hydrogel constructs for bone tissue engineering Open
Aim Alveolar bone regeneration remains a significant clinical challenge in periodontology and dental implantology. This study assessed the mineralized tissue forming potential of 3‐D printed medical grade polycaprolactone ( mPCL ) construc…
View article: The effect of bisphosphonates on the endothelial differentiation of mesenchymal stem cells
The effect of bisphosphonates on the endothelial differentiation of mesenchymal stem cells Open
The contribution of the local stem cell niche to providing an adequate vascular framework during healing cannot be overemphasized. Bisphosphonates (BPs) are known to have a direct effect on the local vasculature, but their effect on progen…