Stephen Hancock
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View article: Metabolic Health, Overweight or Obesity, and Lung Function in Older Australian Adults
Metabolic Health, Overweight or Obesity, and Lung Function in Older Australian Adults Open
Background: Few studies have explored the links between adiposity, metabolic health, and lung function. This study examined the cross-sectional association between spirometric lung function and overweight/obesity, with and without metaboli…
View article: Using Genetics to Inform Interventions Related to Sodium and Potassium in Hypertension
Using Genetics to Inform Interventions Related to Sodium and Potassium in Hypertension Open
BACKGROUND: Hypertension is a key risk factor for major adverse cardiovascular events but remains difficult to treat in many individuals. Dietary interventions are an effective approach to lower blood pressure (BP) but are not equally effe…
View article: Metabolic Health, Overweight or Obesity, and Depressive Symptoms among Older Australian Adults
Metabolic Health, Overweight or Obesity, and Depressive Symptoms among Older Australian Adults Open
Background: The relationship between overweight or obesity and depressive symptoms in individuals with or without cardio-metabolic abnormalities is unclear. In a cross-sectional study we examined the odds of experiencing depressive symptom…
View article: Validity of three risk prediction models for dementia or cognitive impairment in Australia
Validity of three risk prediction models for dementia or cognitive impairment in Australia Open
Background no studies have compared the predictive validity of different dementia risk prediction models in Australia. Objectives (i) to investigate the predictive validity of the Australian National University-Alzheimer’s Disease Risk Ind…
View article: Overweight or Obesity increases the risk of cardiovascular disease among older Australian adults, even in the absence of cardiometabolic risk factors: A Bayesian survival analysis from the Hunter Community Study.
Overweight or Obesity increases the risk of cardiovascular disease among older Australian adults, even in the absence of cardiometabolic risk factors: A Bayesian survival analysis from the Hunter Community Study. Open
Objective To estimate the risk of cardiovascular disease (CVD) in older adults with overweight or obesity without metabolic risk factors using a Bayesian survival analysis. Design: Prospective cohort study with median follow-up of 9.7 year…
View article: Serum L‐arginine and endogenous methylarginine concentrations predict irritable bowel syndrome in adults: A nested case‐control study
Serum L‐arginine and endogenous methylarginine concentrations predict irritable bowel syndrome in adults: A nested case‐control study Open
Background & Aims Nitric oxide, a major inhibitory nonadrenergic, noncholinergic neurotransmitter that relaxes smooth muscle, may be implicated in the pathophysiology of visceral hypersensitivity in irritable bowel syndrome (IBS). Impaired…
View article: Genetic association and causal inference converge on hyperglycaemia as a modifiable factor to improve lung function
Genetic association and causal inference converge on hyperglycaemia as a modifiable factor to improve lung function Open
Measures of lung function are heritable, and thus, we sought to utilise genetics to propose drug-repurposing candidates that could improve respiratory outcomes. Lung function measures were found to be genetically correlated with seven drug…
View article: Author response: Genetic association and causal inference converge on hyperglycaemia as a modifiable factor to improve lung function
Author response: Genetic association and causal inference converge on hyperglycaemia as a modifiable factor to improve lung function Open
Article Figures and data Abstract eLife digest Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract Measures of lung function are…
View article: Genetically informed precision drug repurposing for lung function and implications for respiratory infection
Genetically informed precision drug repurposing for lung function and implications for respiratory infection Open
Impaired lung function is associated with significant morbidity and mortality. Restrictive and obstructive lung disorders are a large contributor to decreased lung function, as well as the acute impact of infection. Measures of pulmonary f…
View article: Additional file 1: of Phenome-wide association analysis of LDL-cholesterol lowering genetic variants in PCSK9
Additional file 1: of Phenome-wide association analysis of LDL-cholesterol lowering genetic variants in PCSK9 Open
Supplemental tables. (XLSX 62 kb)
View article: A Serological Diagnosis of Coeliac Disease Is Associated with Osteoporosis in Older Australian Adults
A Serological Diagnosis of Coeliac Disease Is Associated with Osteoporosis in Older Australian Adults Open
Previously thought to be mainly a disorder of childhood and early adult life, coeliac disease (CeD) is increasingly diagnosed in older adults. This may be important given the association between CeD and osteoporosis. The primary aim of thi…
View article: Phenome-wide association analysis of LDL-cholesterol lowering genetic variants in <i>PCSK9</i>
Phenome-wide association analysis of LDL-cholesterol lowering genetic variants in <i>PCSK9</i> Open
Background We characterised the phenotypic consequence of genetic variation at the PCSK9 locus and compared findings with recent trials of pharmacological inhibitors of PCSK9. Methods Published and individual participant level data (300,00…
View article: Establishing a Combined Neonatal and Paediatric Transport System From Scratch
Establishing a Combined Neonatal and Paediatric Transport System From Scratch Open
Centralisation of neonatal and paediatric intensive care over the last 30 years has led to a significant increase in the numbers of newborn babies and children requiring interfacility transport. Many early ad hoc transport teams have evolv…
View article: Preliminary Studies of the Prevalence and Possible Clinical Consequences of Potential Simple and Multifactorial Drug and Gene Interactions of Anti-depressants in Older Australians
Preliminary Studies of the Prevalence and Possible Clinical Consequences of Potential Simple and Multifactorial Drug and Gene Interactions of Anti-depressants in Older Australians Open
Event Abstract Back to Event Preliminary Studies of the Prevalence and Possible Clinical Consequences of Potential Simple and Multifactorial Drug and Gene Interactions of Anti-depressants in Older Australians Mohitosh Biswas1*, Thilani H D…
View article: Potential Clinically Significant Drug and Gene Interactions Involving Cytochrome P450 Family 2 Subfamily D Member 6 (CYP2D6) Relevant to Opioids Used for Chronic Pain in Community-dwelling Older Australians
Potential Clinically Significant Drug and Gene Interactions Involving Cytochrome P450 Family 2 Subfamily D Member 6 (CYP2D6) Relevant to Opioids Used for Chronic Pain in Community-dwelling Older Australians Open
Event Abstract Back to Event Potential Clinically Significant Drug and Gene Interactions Involving Cytochrome P450 Family 2 Subfamily D Member 6 (CYP2D6) Relevant to Opioids Used for Chronic Pain in Community-dwelling Older Australians Thi…
View article: Prevalence of clinically actionable genotypes and medication exposure of older adults in the community
Prevalence of clinically actionable genotypes and medication exposure of older adults in the community Open
This study analyzed clinically actionable pharmacogenotypes for clopidogrel, warfarin, statins, thiopurines, and tacrolimus using microarray data for 2121 participants (55-85 years) from the Australian Hunter Community Study (HCS). At leas…
View article: Prevalence of clinically actionable genotypes and medication exposure of older adults in the community
Prevalence of clinically actionable genotypes and medication exposure of older adults in the community Open
Nilofar Daneshi,1,2 Elizabeth Holliday,3,4 Stephen Hancock,3,4 Jennifer J Schneider,1,2 Rodney J Scott,1,2,5 John Attia,3,4 Elizabeth A Milward1,2 1Faculty of Health and Medicine, School of Biomedical Sciences and Pharmacy, 2Faculty of Hea…
View article: Bayesian methods in reporting and managing Australian clinical indicators
Bayesian methods in reporting and managing Australian clinical indicators Open
Sustained clinical improvement is unlikely without appropriate measuring and reporting techniques. Clinical indicators are tools to help assess whether a standard of care is being met. They are used to evaluate the potential to improve the…