Stephen C. Harvey
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View article: The Organic Crystallizing Agent 2-Methyl-2,4-pentanediol Reduces DNA Curvature by Means of Structural Changes in A-tracts
The Organic Crystallizing Agent 2-Methyl-2,4-pentanediol Reduces DNA Curvature by Means of Structural Changes in A-tracts Open
Contemporary predictive models for sequence-dependent DNA structure provide a good estimation of overall DNA curvature in most cases. However, the two current models differ fundamentally in their view of the origin of DNA curvature. An ear…
View article: Projections of spring wheat growth in Alaska: Opportunity and adaptations in a changing climate
Projections of spring wheat growth in Alaska: Opportunity and adaptations in a changing climate Open
Recent accelerations of climate warmings can open agricultural opportunities in the region of Interior Alaska. In this paper, a simulation of spring wheat growth forced with projected climate scenarios was conducted by the Decision Support…
View article: Function of a viral genome packaging motor from bacteriophage T4 is insensitive to DNA sequence
Function of a viral genome packaging motor from bacteriophage T4 is insensitive to DNA sequence Open
Many viruses employ ATP-powered motors during assembly to translocate DNA into procapsid shells. Previous reports raise the question if motor function is modulated by substrate DNA sequence: (i) the phage T4 motor exhibits large translocat…
View article: Simulations and Electrostatic Analysis Suggest an Active Role for DNA Conformational Changes During Genome Packaging by Bacteriophages
Simulations and Electrostatic Analysis Suggest an Active Role for DNA Conformational Changes During Genome Packaging by Bacteriophages Open
Motors that move DNA, or that move along DNA, play essential roles in DNA replication, transcription, recombination, and chromosome segregation. The mechanisms by which these DNA translocases operate remain largely unknown. Some double-str…
View article: DNA Scrunching in the Packaging of Viral Genomes
DNA Scrunching in the Packaging of Viral Genomes Open
The motors that drive double-stranded DNA (dsDNA) genomes into viral capsids are among the strongest of all biological motors for which forces have been measured, but it is not known how they generate force. We previously proposed that the…
View article: Transitions of Double-Stranded DNA Between the A- and B-Forms
Transitions of Double-Stranded DNA Between the A- and B-Forms Open
The structure of double-stranded DNA (dsDNA) is sensitive to solvent conditions. In solution, B-DNA is the favored conformation under physiological conditions, while A-DNA is the form found under low water activity. The A-form is induced l…