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View article: “Ask” or “Inquire”: operationalizing speech formality in psychosis and its risk states using etymology
“Ask” or “Inquire”: operationalizing speech formality in psychosis and its risk states using etymology Open
Many individuals with psychotic symptoms have less complex language than healthy individuals. Word etymology is a lexical feature that has not yet been studied in clinical populations, but among healthy individuals, words of Old French ori…
View article: Cingulate dynamics track depression recovery with deep brain stimulation
Cingulate dynamics track depression recovery with deep brain stimulation Open
Deep brain stimulation (DBS) of the subcallosal cingulate (SCC) can provide long-term symptom relief for treatment-resistant depression (TRD) 1 . However, achieving stable recovery is unpredictable 2 , typically requiring trial-and-error s…
View article: A natural language processing approach reveals first-person pronoun usage and non-fluency as markers of therapeutic alliance in psychotherapy
A natural language processing approach reveals first-person pronoun usage and non-fluency as markers of therapeutic alliance in psychotherapy Open
It remains elusive what language markers derived from psychotherapy sessions are indicative of therapeutic alliance, limiting our capacity to assess and provide feedback on the trusting quality of the patient-clinician relationship. To add…
View article: Proceedings of the Ninth Annual Deep Brain Stimulation Think Tank: Advances in Cutting Edge Technologies, Artificial Intelligence, Neuromodulation, Neuroethics, Pain, Interventional Psychiatry, Epilepsy, and Traumatic Brain Injury
Proceedings of the Ninth Annual Deep Brain Stimulation Think Tank: Advances in Cutting Edge Technologies, Artificial Intelligence, Neuromodulation, Neuroethics, Pain, Interventional Psychiatry, Epilepsy, and Traumatic Brain Injury Open
DBS Think Tank IX was held on August 25–27, 2021 in Orlando FL with US based participants largely in person and overseas participants joining by video conferencing technology. The DBS Think Tank was founded in 2012 and provides an open pla…
View article: Acoustic and Facial Features From Clinical Interviews for Machine Learning–Based Psychiatric Diagnosis: Algorithm Development
Acoustic and Facial Features From Clinical Interviews for Machine Learning–Based Psychiatric Diagnosis: Algorithm Development Open
Background In contrast to all other areas of medicine, psychiatry is still nearly entirely reliant on subjective assessments such as patient self-report and clinical observation. The lack of objective information on which to base clinical …
View article: Feasibility Analysis of Phenotype Quantification from Unstructured Clinical Interactions
Feasibility Analysis of Phenotype Quantification from Unstructured Clinical Interactions Open
We conducted a feasibility analysis to determine the quality of data that could be collected ambiently during routine clinical conversations. We used inexpensive, consumer-grade hardware to record unstructured dialogue and open-source soft…
View article: Decision Models and Technology Can Help Psychiatry Develop Biomarkers
Decision Models and Technology Can Help Psychiatry Develop Biomarkers Open
Why is psychiatry unable to define clinically useful biomarkers? We explore this question from the vantage of data and decision science and consider biomarkers as a form of phenotypic data that resolves a well-defined clinical decision. We…
View article: A natural language processing approach to modelling treatment alliance in psychotherapy transcripts
A natural language processing approach to modelling treatment alliance in psychotherapy transcripts Open
Aims Patient-therapist alliance is a critical factor in psychotherapy treatment outcomes. This pilot will identify language concepts in psychotherapy transcripts correlating with the valence of treatment alliance using natural language pro…
View article: Parkinson’s disease medication state and severity assessment based on coordination during walking
Parkinson’s disease medication state and severity assessment based on coordination during walking Open
Walking is a complex motor function requiring coordination of all body parts. Parkinson’s disease (PD) motor signs such as rigidity, bradykinesia, and impaired balance affect movements including walking. Here, we propose a computational me…
View article: Acoustic and Facial Features From Clinical Interviews for Machine Learning–Based Psychiatric Diagnosis: Algorithm Development (Preprint)
Acoustic and Facial Features From Clinical Interviews for Machine Learning–Based Psychiatric Diagnosis: Algorithm Development (Preprint) Open
BACKGROUND In contrast to all other areas of medicine, psychiatry is still nearly entirely reliant on subjective assessments such as patient self-report and clinical observation. The lack of objective information on which to base clinical…
View article: Speech-based characterization of dopamine replacement therapy in people with Parkinson’s disease
Speech-based characterization of dopamine replacement therapy in people with Parkinson’s disease Open
People with Parkinson’s (PWP) disease are under constant tension with respect to their dopamine replacement therapy (DRT) regimen. Waiting too long between doses results in more prominent symptoms, loss of motor function, and greater risk …
View article: Using an unbiased symbolic movement representation to characterize Parkinson’s disease states
Using an unbiased symbolic movement representation to characterize Parkinson’s disease states Open
Unconstrained human movement can be broken down into a series of stereotyped motifs or ‘syllables’ in an unsupervised fashion. Sequences of these syllables can be represented by symbols and characterized by a statistical grammar which vari…
View article: Wearable Nail Deformation Sensing for Behavioral and Biomechanical Monitoring and Human-Computer Interaction
Wearable Nail Deformation Sensing for Behavioral and Biomechanical Monitoring and Human-Computer Interaction Open
The dynamics of the human fingertip enable haptic sensing and the ability to manipulate objects in the environment. Here we describe a wearable strain sensor, associated electronics, and software to detect and interpret the kinematics of d…