Stephen Hyslop
YOU?
Author Swipe
View article: Properties and Pharmacology of Scorpion Toxins and Their Biotechnological Potential in Agriculture and Medicine
Properties and Pharmacology of Scorpion Toxins and Their Biotechnological Potential in Agriculture and Medicine Open
Scorpion venoms contain a wide range of toxins that interact with a variety of target molecules (ion channels, receptors and enzymes) associated with synaptic transmission, action potential propagation, cardiac function, hemostasis and oth…
View article: An Experimental Model of Acute Pulmonary Damage Induced by the Phospholipase A2-Rich Venom of the Snake Pseudechis papuanus
An Experimental Model of Acute Pulmonary Damage Induced by the Phospholipase A2-Rich Venom of the Snake Pseudechis papuanus Open
An experimental model of acute pulmonary damage was developed based on the intravenous injection of the phospholipase A2 (PLA2)-rich venom of Pseudechis papuanus (Papuan black snake) in mice. Venom caused pulmonary edema, with the accumula…
View article: Evaluation of Violacein Metabolic Stability and Metabolite Identification in Human, Mouse, and Rat Liver Microsomes
Evaluation of Violacein Metabolic Stability and Metabolite Identification in Human, Mouse, and Rat Liver Microsomes Open
Background: Malaria significantly impacts the health of populations living in poverty and vulnerable conditions. Resistance to current antimalarial drugs remains a major challenge and highlights the urgent need for novel, effective, and sa…
View article: Comparative Analysis of the Enzymatic, Coagulant, and Neuromuscular Activities of Two Variants of Crotalus durissus ruruima Venom and Antivenom Efficacy
Comparative Analysis of the Enzymatic, Coagulant, and Neuromuscular Activities of Two Variants of Crotalus durissus ruruima Venom and Antivenom Efficacy Open
Background: We compared the enzymatic, coagulant, and neuromuscular activities of two variants (yellow—CDRy and white—CDRw) of Crotalus durissus ruruima venom with a sample of C. d. terrificus (CDT) venom and examined their neutralization …
View article: Venom proteomics and Duvernoy's venom gland histology of Pseudoboa neuwiedii (Neuwied's false boa; Dipsadidae, Pseudoboini)
Venom proteomics and Duvernoy's venom gland histology of Pseudoboa neuwiedii (Neuwied's false boa; Dipsadidae, Pseudoboini) Open
The venom of Colombian specimens of the rear-fanged snake Pseudoboa neuwiedii contains proteolytic and phospholipase A2 (PLA2) activities, but is devoid of esterases. Mass spectrometric analysis of electrophoretic bands indicated that this…
View article: The Cloning and Characterization of a Three-Finger Toxin Homolog (NXH8) from the Coralsnake Micrurus corallinus That Interacts with Skeletal Muscle Nicotinic Acetylcholine Receptors
The Cloning and Characterization of a Three-Finger Toxin Homolog (NXH8) from the Coralsnake Micrurus corallinus That Interacts with Skeletal Muscle Nicotinic Acetylcholine Receptors Open
Coralsnakes (Micrurus spp.) are the only elapids found throughout the Americas. They are recognized for their highly neurotoxic venom, which is comprised of a wide variety of toxins, including the stable, low-mass toxins known as three-fin…
View article: Fipronil affects cockroach behavior and olfactory memory
Fipronil affects cockroach behavior and olfactory memory Open
Fipronil (Fpl), an insecticide belonging to the class of phenylpyrazoles, is associated with the widespread mortality of pollinator insects worldwide. Based on studies carried out on residual concentrations of Fpl commonly found in the env…
View article: Action of Varespladib (LY-315920), a Phospholipase A2 Inhibitor, on the Enzymatic, Coagulant and Haemorrhagic Activities of Lachesis muta rhombeata (South-American Bushmaster) Venom
Action of Varespladib (LY-315920), a Phospholipase A2 Inhibitor, on the Enzymatic, Coagulant and Haemorrhagic Activities of Lachesis muta rhombeata (South-American Bushmaster) Venom Open
Varespladib (VPL) was primarily developed to treat inflammatory disturbances associated with high levels of serum phospholipase A 2 (PLA 2 ). VPL has also demonstrated to be a potential antivenom support agent to prevent PLA 2 -dependent e…
View article: Temporal evolution of dermonecrosis in loxoscelism assessed by photodocumentation
Temporal evolution of dermonecrosis in loxoscelism assessed by photodocumentation Open
The sequential photographic documentation showed considerable variation in the process of wound healing, with complete epithelialization requiring up to 3 months after the bite.
View article: Temporal evolution of dermonecrosis in loxoscelism assessed by photodocumentation
Temporal evolution of dermonecrosis in loxoscelism assessed by photodocumentation Open
Background: Although loxoscelism (bites by brown spiders of the genus Loxosceles) frequently results in dermonecrosis, no previous clinical reports have provided detailed temporal photodocumentation of the evolution of dermonecrotic lesion…
View article: Evaluation of Protection by Caffeic Acid, Chlorogenic Acid, Quercetin and Tannic Acid against the In Vitro Neurotoxicity and In Vivo Lethality of Crotalus durissus terrificus (South American Rattlesnake) Venom
Evaluation of Protection by Caffeic Acid, Chlorogenic Acid, Quercetin and Tannic Acid against the In Vitro Neurotoxicity and In Vivo Lethality of Crotalus durissus terrificus (South American Rattlesnake) Venom Open
Systemic envenomation by Crotalus durissus terrificus (South American rattlesnake) can cause coagulopathy, rabdomyolysis, acute kidney injury, and peripheral neuromuscular blockade, the latter resulting in flaccid paralysis. Previous studi…
View article: Biological activities of phosphodiesterase from <em>Crotalus durissus terrificus</em> venom
Biological activities of phosphodiesterase from <em>Crotalus durissus terrificus</em> venom Open
Phosphodiesterases (PDEs) are an enzymes family that hydrolyze phosphodiester bonds sequentially from the 3´ terminus of polynucleotides to produce 5'-mononucleotides. Historically, snake venom PDEs have been widely used in sequencing and …
View article: Additional file 1 of A transcriptomic analysis of gene expression in the venom gland of the snake Bothrops alternatus (urutu)
Additional file 1 of A transcriptomic analysis of gene expression in the venom gland of the snake Bothrops alternatus (urutu) Open
Additional file 1:Table showing the positions and descriptions of SNPs identified in B. alternatus ESTs using the program QualitySNP[72]. (XLS 48 KB)
View article: Additional file 2 of A transcriptomic analysis of gene expression in the venom gland of the snake Bothrops alternatus (urutu)
Additional file 2 of A transcriptomic analysis of gene expression in the venom gland of the snake Bothrops alternatus (urutu) Open
Additional file 2:Table of transposable elements identified in B. alternatus ESTs. (XLS 122 KB)
View article: Additional file 3 of A transcriptomic analysis of gene expression in the venom gland of the snake Bothrops alternatus (urutu)
Additional file 3 of A transcriptomic analysis of gene expression in the venom gland of the snake Bothrops alternatus (urutu) Open
Additional file 3:Table of transposable elements fused with proteins in B. alternatus ESTs. (XLS 38 KB)
View article: Additional file 4 of A transcriptomic analysis of gene expression in the venom gland of the snake Bothrops alternatus (urutu)
Additional file 4 of A transcriptomic analysis of gene expression in the venom gland of the snake Bothrops alternatus (urutu) Open
Additional file 4:Table of inverted repeats (IR) identified in B. alternatus ESTs. (XLS 43 KB)
View article: Additional file of A transcriptomic analysis of gene expression in the venom gland of the snake Bothrops alternatus (urutu)
Additional file of A transcriptomic analysis of gene expression in the venom gland of the snake Bothrops alternatus (urutu) Open
Additional file of A transcriptomic analysis of gene expression in the venom gland of the snake Bothrops alternatus (urutu)
View article: Acute liver failure in a term neonate after repeated paracetamol administration
Acute liver failure in a term neonate after repeated paracetamol administration Open
Objective: Severe hepatotoxicity caused by paracetamol is rare in neonates. We report a case of paracetamol-induced acute liver failure in a term neonate.Case description: A 26-day-old boy was admitted with intestinal bleeding, shock signs…
View article: Additional file of A transcriptomic analysis of gene expression in the venom gland of the snake Bothrops alternatus (urutu)
Additional file of A transcriptomic analysis of gene expression in the venom gland of the snake Bothrops alternatus (urutu) Open
Additional file of A transcriptomic analysis of gene expression in the venom gland of the snake Bothrops alternatus (urutu)
View article: Additional file of A transcriptomic analysis of gene expression in the venom gland of the snake Bothrops alternatus (urutu)
Additional file of A transcriptomic analysis of gene expression in the venom gland of the snake Bothrops alternatus (urutu) Open
Additional file of A transcriptomic analysis of gene expression in the venom gland of the snake Bothrops alternatus (urutu)
View article: Additional file of A transcriptomic analysis of gene expression in the venom gland of the snake Bothrops alternatus (urutu)
Additional file of A transcriptomic analysis of gene expression in the venom gland of the snake Bothrops alternatus (urutu) Open
Additional file of A transcriptomic analysis of gene expression in the venom gland of the snake Bothrops alternatus (urutu)
View article: Are Silver Nanoparticles Useful for Treating Second-Degree Burns? An Experimental Study in Rats
Are Silver Nanoparticles Useful for Treating Second-Degree Burns? An Experimental Study in Rats Open
Purpose: In this work, the potential usefulness of silver nanoparticles (AgNPs) for treating burn wounds was examined. Methods: Second-degree burns were induced in male Wistar rats by touching the skin with a heated (70°C) metallic device …
View article: Chemical and Pharmacological Screening of Rhinella icterica (Spix 1824) Toad Parotoid Secretion in Avian Preparations
Chemical and Pharmacological Screening of Rhinella icterica (Spix 1824) Toad Parotoid Secretion in Avian Preparations Open
The biological activity of Rhinella icterica parotoid secretion (RIPS) and some of its chromatographic fractions (RI18, RI19, RI23, and RI24) was evaluated in the current study. Mass spectrometry of these fractions indicated the presence o…
View article: Entomotoxicity of jaburetox: revisiting the neurotoxic mechanisms in insects.
Entomotoxicity of jaburetox: revisiting the neurotoxic mechanisms in insects. Open
Ureases are metalloenzymes that hydrolyze urea to ammonia and carbamate. The main urease isoforms present in the seeds of Canavalia ensiformis (jack bean urease - JBU and canatoxin) exert a variety of biological activities. The insecticida…
View article: Biochemical characterization and cytotoxic effect of the skin secretion from the red-spotted Argentina frog Argenteohyla siemersi (Anura: Hylidae)
Biochemical characterization and cytotoxic effect of the skin secretion from the red-spotted Argentina frog Argenteohyla siemersi (Anura: Hylidae) Open
Results presented herein evidence the biochemical composition and biological effects of A. siemersi skin secretion and contribute to the knowledge on the defense mechanisms of casque-headed frogs.
View article: Inhibition of Kv2.1 Potassium Channels by MiDCA1, A Pre-Synaptically Active PLA2-Type Toxin from Micrurus dumerilii carinicauda Coral Snake Venom
Inhibition of Kv2.1 Potassium Channels by MiDCA1, A Pre-Synaptically Active PLA2-Type Toxin from Micrurus dumerilii carinicauda Coral Snake Venom Open
MiDCA1, a phospholipase A2 (PLA2) neurotoxin isolated from Micrurus dumerilii carinicauda coral snake venom, inhibited a major component of voltage-activated potassium (Kv) currents (41 ± 3% inhibition with 1 μM toxin) in mouse cultured do…
View article: Effects of Two Fractions of Swietenia macrophylla and Catechin on Muscle Damage Induced by Bothrops Venom and PLA2
Effects of Two Fractions of Swietenia macrophylla and Catechin on Muscle Damage Induced by Bothrops Venom and PLA2 Open
Plant natural products can attenuate the myonecrosis caused by Bothrops snake venom and their phospholipases A2 (PLA2). In this study, we evaluated the effects of two fractions (F4 and F6) from Swietenia macrophylla and purified catechin o…
View article: Management of severe pain after dermal contact with caterpillars (erucism): a prospective case series
Management of severe pain after dermal contact with caterpillars (erucism): a prospective case series Open
The association of local anesthesia with analgesics was apparently a good combination for the rapid management of severe pain in the ED.