Stephen J. Libby
YOU?
Author Swipe
View article: Evasion of serum antibodies and complement by Salmonella Typhi and Paratyphi A
Evasion of serum antibodies and complement by Salmonella Typhi and Paratyphi A Open
Nontyphoidal and enteric fever serovars of Salmonella enterica display distinctive interactions with serum antibodies and the complement system, which initiate the host immune response to invading microbes. This study examines the contribu…
View article: Evasion of serum antibodies and complement by <i>Salmonella</i> Typhi and Paratyphi A
Evasion of serum antibodies and complement by <i>Salmonella</i> Typhi and Paratyphi A Open
Nontyphoidal and enteric fever serovars of Salmonella enterica display distinctive interactions with serum antibodies and the complement system, which initiate the host immune response to invading microbes. This study examines the contribu…
View article: Development, confirmation, and application of a seeded Escherichia coli process control organism to validate Salmonella enterica serovar Typhi environmental surveillance methods
Development, confirmation, and application of a seeded Escherichia coli process control organism to validate Salmonella enterica serovar Typhi environmental surveillance methods Open
Salmonella enterica serovar Typhi ( S . Typhi) is the causative agent of Typhoid fever. Blood culture is the gold standard for clinical diagnosis, but this is often difficult to employ in resource limited settings. Environmental surveillan…
View article: Nuclear factor kappa B-dependent persistence of <i>Salmonella</i> Typhi and Paratyphi in human macrophages
Nuclear factor kappa B-dependent persistence of <i>Salmonella</i> Typhi and Paratyphi in human macrophages Open
Salmonella serovars Typhi and Paratyphi cause a prolonged illness known as enteric fever, whereas other serovars cause acute gastroenteritis. Mechanisms responsible for the divergent clinical manifestations of nontyphoidal and enteric feve…
View article: The actin-regulatory protein Hem-1 is essential for alveolar macrophage development
The actin-regulatory protein Hem-1 is essential for alveolar macrophage development Open
Hematopoietic protein-1 (Hem-1) is a hematopoietic cell–specific actin-regulatory protein. Loss-of-function (LOF) variants in the NCKAP1L gene encoding Hem-1 have recently been found to result in primary immunodeficiency disease (PID) in h…
View article: Manganese import protects<i>Salmonella enterica</i>serovar Typhimurium against nitrosative stress
Manganese import protects<i>Salmonella enterica</i>serovar Typhimurium against nitrosative stress Open
Nitric oxide (NO˙) is a radical molecule produced by mammalian phagocytic cells as part of the innate immune response to bacterial pathogens. It exerts its antimicrobial activity in part by impairing the function of metalloproteins, partic…
View article: The Evolution of SlyA/RovA Transcription Factors from Repressors to Countersilencers in <i>Enterobacteriaceae</i>
The Evolution of SlyA/RovA Transcription Factors from Repressors to Countersilencers in <i>Enterobacteriaceae</i> Open
Bacteria primarily evolve via horizontal gene transfer, acquiring new traits such as virulence and antibiotic resistance in single transfer events. However, newly acquired genes must be integrated into existing regulatory networks to allow…
View article: Nitric Oxide Disrupts Zinc Homeostasis in Salmonella enterica Serovar Typhimurium
Nitric Oxide Disrupts Zinc Homeostasis in Salmonella enterica Serovar Typhimurium Open
Nitric oxide (NO·) produced by mammalian cells exerts antimicrobial actions that result primarily from the modification of protein thiols ( S -nitrosylation) and metal centers. A comprehensive approach was used to identify novel targets of…
View article: The Evolution of SlyA/RovA Transcription Factors From Repressors to Counter-Silencers in<i>Enterobacteriaceae</i>
The Evolution of SlyA/RovA Transcription Factors From Repressors to Counter-Silencers in<i>Enterobacteriaceae</i> Open
Gene duplication and subsequent evolutionary divergence have allowed conserved proteins to develop unique roles. The MarR family of transcription factors (TFs) has undergone extensive duplication and diversification in bacteria, where they…
View article: The curli regulator CsgD mediates stationary phase counter‐silencing of <i>csgBA</i> in <i>Salmonella</i> Typhimurium
The curli regulator CsgD mediates stationary phase counter‐silencing of <i>csgBA</i> in <i>Salmonella</i> Typhimurium Open
Summary Integration of horizontally acquired genes into transcriptional networks is essential for the regulated expression of virulence in bacterial pathogens. In Salmonella enterica , expression of such genes is repressed by the nucleoid‐…
View article: The Rcs-Regulated Colanic Acid Capsule Maintains Membrane Potential in <i>Salmonella enterica</i> serovar Typhimurium
The Rcs-Regulated Colanic Acid Capsule Maintains Membrane Potential in <i>Salmonella enterica</i> serovar Typhimurium Open
The Rcs phosphorelay and Psp (phage shock protein) systems are envelope stress responses that are highly conserved in gammaproteobacteria. The Rcs regulon was found to be strongly induced during metal deprivation of Salmonella enterica ser…
View article: Redox-Active Sensing by Bacterial DksA Transcription Factors Is Determined by Cysteine and Zinc Content
Redox-Active Sensing by Bacterial DksA Transcription Factors Is Determined by Cysteine and Zinc Content Open
The four-cysteine zinc finger motif of the bacterial RNA polymerase regulator DksA is essential for protein structure, canonical control of the stringent response to nutritional limitation, and thiol-based sensing of oxidative and nitrosat…
View article: Loss of Multicellular Behavior in Epidemic African Nontyphoidal Salmonella enterica Serovar Typhimurium ST313 Strain D23580
Loss of Multicellular Behavior in Epidemic African Nontyphoidal Salmonella enterica Serovar Typhimurium ST313 Strain D23580 Open
Nontyphoidal Salmonella enterica serovar Typhimurium is a frequent cause of bloodstream infections in children and HIV-infected adults in sub-Saharan Africa. Most isolates from African patients with bacteremia belong to a single sequence t…