Stephen J. Perle
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View article: Cell Therapy Ameliorates Cortical Circuit Dysfunction in an Alzheimer's Disease Model
Cell Therapy Ameliorates Cortical Circuit Dysfunction in an Alzheimer's Disease Model Open
Background The prevalence of Alzheimer's disease is rising. While disease modifying therapies have been made available to patients, these therapeutics pose serious health risks. Therefore, finding new treatment strategies is necessary. Alz…
View article: Transplantation of GABAergic Interneuron Progenitors Restores Cortical Circuit Function in an Alzheimer's Disease Mouse Model
Transplantation of GABAergic Interneuron Progenitors Restores Cortical Circuit Function in an Alzheimer's Disease Mouse Model Open
In addition to dementia, Alzheimer's patients suffer from sleep impairments and aberrations in sleep‐dependent brain rhythms. Deficits in inhibitory GABAergic interneuron function disrupt one of those rhythms, slow oscillation in particula…
View article: Transplantation of GABAergic Interneuron Progenitors Restores Cortical Circuit Function in an Alzheimer’s Disease Mouse Model
Transplantation of GABAergic Interneuron Progenitors Restores Cortical Circuit Function in an Alzheimer’s Disease Mouse Model Open
In addition to dementia, Alzheimer’s patients suffer from sleep impairments and aberrations in sleep-dependent brain rhythms. Deficits in inhibitory GABAergic interneuron function disrupt one of those rhythms, slow oscillation in particula…
View article: Impact of Perioperative Glucagon-Like Peptide-1 Receptor Agonists on Postoperative Outcomes Following Carpal Tunnel Release
Impact of Perioperative Glucagon-Like Peptide-1 Receptor Agonists on Postoperative Outcomes Following Carpal Tunnel Release Open
Prognostic III.
View article: Optogenetic targeting of cortical astrocytes selectively improves NREM sleep in an Alzheimer’s disease mouse model
Optogenetic targeting of cortical astrocytes selectively improves NREM sleep in an Alzheimer’s disease mouse model Open
Alzheimer's disease (AD) is a progressive neurodegenerative condition marked by memory impairments and distinct histopathological features such as amyloid-beta (Aβ) accumulations. Alzheimer's patients experience sleep disturbances at early…
View article: Ten-Year Experience of Skip Anterior Cervical Corpectomy and Fusion
Ten-Year Experience of Skip Anterior Cervical Corpectomy and Fusion Open
BACKGROUND: Anterior cervical corpectomy and fusion (ACCF) is often required to adequately decompress the spinal cord in patients with multilevel cervical spondylosis. Unfortunately, multilevel corpectomy constructs have high rates of earl…
View article: Additional file 1 of Sleep restoration by optogenetic targeting of GABAergic neurons reprograms microglia and ameliorates pathological phenotypes in an Alzheimer’s disease model
Additional file 1 of Sleep restoration by optogenetic targeting of GABAergic neurons reprograms microglia and ameliorates pathological phenotypes in an Alzheimer’s disease model Open
Supplementary Material 1: Table S1. Supplemental Statistical Analysis