Stephen J. Peterson
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View article: Bimagrumab: Novel Medical Therapy for Inclusion Body Myositis, Sarcopenia, and Medication-Induced Lean Body Mass Loss
Bimagrumab: Novel Medical Therapy for Inclusion Body Myositis, Sarcopenia, and Medication-Induced Lean Body Mass Loss Open
Bimagrumab is a monoclonal antibody that targets activin type II receptors, blocks myostatin and related proteins: it promotes muscle growth and prevents muscle loss, while causing weight loss. It has been effective in sporadic inclusion b…
View article: Sitosterolemia and Early Atherosclerosis: A Review of Genetic Mechanisms and Newer Diagnostic Methods
Sitosterolemia and Early Atherosclerosis: A Review of Genetic Mechanisms and Newer Diagnostic Methods Open
Sitosterolemia is an autosomal recessive disorder associated with premature atherosclerotic disease and the production of physical xanthomas in response to increased plant sterols in the body. Since its initial report in 1974, there has be…
View article: Clustered Regularly Interspaced Short Palindromic Repeats Genome Editing for Cardiovascular Disease: The Future Is Here
Clustered Regularly Interspaced Short Palindromic Repeats Genome Editing for Cardiovascular Disease: The Future Is Here Open
Clustered regularly interspaced short palindromic repeats (CRISPR)-based genome editing has expanded from experimental biology to early clinical application, raising the possibility of durable therapies for cardiovascular disease. Because …
View article: Hereditary Hemorrhagic Telangiectasia: A Review of Gene Targets and Emerging Therapies
Hereditary Hemorrhagic Telangiectasia: A Review of Gene Targets and Emerging Therapies Open
Hereditary hemorrhagic telangiectasis (HHT), formerly called Osler-Weber-Rendu syndrome, is a rare autosomal-dominant vascular disorder characterized by mucocutaneous and visceral telangiectasis involving multiple organ systems, such as sk…
View article: Cardiac Cachexia: A Comprehensive Review
Cardiac Cachexia: A Comprehensive Review Open
Cardiac cachexia remains a phenomenon seen more particularly in New York Heart Association Classification class III or IV heart failure patients. This is frequently missed and written off as “old age.” It has a mortality rate of 50% within…
View article: RETRACTED: Shen et al. Cold-Pressed Nigella Sativa Oil Standardized to 3% Thymoquinone Potentiates Omega-3 Protection against Obesity-Induced Oxidative Stress, Inflammation, and Markers of Insulin Resistance Accompanied with Conversion of White to Beige Fat in Mice. Antioxidants 2020, 9, 489
RETRACTED: Shen et al. Cold-Pressed Nigella Sativa Oil Standardized to 3% Thymoquinone Potentiates Omega-3 Protection against Obesity-Induced Oxidative Stress, Inflammation, and Markers of Insulin Resistance Accompanied with Conversion of White to Beige Fat in Mice. Antioxidants 2020, 9, 489 Open
The journal retracts the article “Cold-Pressed Nigella Sativa Oil Standardized to 3% Thymoquinone Potentiates Omega-3 Protection against Obesity-Induced Oxidative Stress, Inflammation, and Markers of Insulin Resistance Accompanied with Con…
View article: Cardiac Regeneration From Scar to Syncytium: Mitigating the Formation of Scar Tissue
Cardiac Regeneration From Scar to Syncytium: Mitigating the Formation of Scar Tissue Open
Myocardial infarction and heart failure remain among the leading global causes of morbidity and mortality, mainly due to the irreversible loss of cardiomyocytes and the human heart’s inherently limited regenerative capacity. Cardiac regene…
View article: Tricuspid regurgitation and chronic kidney disease in patients with cardiogenic shock: Review of the literature and real-world experience from a single center
Tricuspid regurgitation and chronic kidney disease in patients with cardiogenic shock: Review of the literature and real-world experience from a single center Open
View article: Antiplatelet and Anticoagulation Therapy for Peripheral Arterial Disease: Risks Versus Benefits
Antiplatelet and Anticoagulation Therapy for Peripheral Arterial Disease: Risks Versus Benefits Open
Peripheral arterial disease (PAD) affects millions of people worldwide. It is a progressive atherosclerotic condition that ranges from asymptomatic disease to severe manifestations such as chronic limb-threatening ischemia and acute limb i…
View article: Navigating Bleeding, Thrombosis, and Antithrombotic Management in Transcatheter Aortic Valve Replacement
Navigating Bleeding, Thrombosis, and Antithrombotic Management in Transcatheter Aortic Valve Replacement Open
Transcatheter aortic valve replacement (TAVR) has revolutionized the treatment of aortic stenosis, providing a less invasive alternative to surgical valve replacement. However, post-TAVR management remains complex, particularly concerning …
View article: Efficacy of Beta-Blockers in Acute Management and Prevention of Recurrence in Takotsubo Syndrome
Efficacy of Beta-Blockers in Acute Management and Prevention of Recurrence in Takotsubo Syndrome Open
Takotsubo cardiomyopathy is a nonischemic cardiomyopathy characterized by a transient ballooning of the apical cardiac wall secondary to stress. Since its discovery and diagnosis in Japan in 1990, Takotsubo cardiomyopathy has been known as…
View article: New Therapies for the Management of Chronic Kidney Disease
New Therapies for the Management of Chronic Kidney Disease Open
View article: Iloprost: Old and New Indications
Iloprost: Old and New Indications Open
Iloprost is a synthetic long-acting prostacyclin-analog drug used to treat various vascular diseases. The Federal Drug Administration approved the drug in 2004 for pulmonary arterial hypertension, and it has since been shown to be helpful …
View article: The Relationship of Duffy Gene Polymorphism with High-Sensitivity C-Reactive Protein, Mortality, and Cardiovascular Outcomes in Black Individuals
The Relationship of Duffy Gene Polymorphism with High-Sensitivity C-Reactive Protein, Mortality, and Cardiovascular Outcomes in Black Individuals Open
Background: Black adults have higher incidence of all-cause mortality and worse cardiovascular disease (CVD) outcomes when compared to other U.S. populations. The Duffy chemokine receptor is not expressed on erythrocytes in a large majorit…
View article: The Relationship of Duffy Gene Polymorphism with High-Sensitivity C-Reactive Protein, Mortality, and Cardiovascular Outcomes in Black Individuals
The Relationship of Duffy Gene Polymorphism with High-Sensitivity C-Reactive Protein, Mortality, and Cardiovascular Outcomes in Black Individuals Open
Background: Black adults have higher incidence of all-cause mortality and worse cardiovascular disease (CVD) outcomes when compared to other U.S. populations. The Duffy chemokine receptor is not expressed on erythrocytes in a large majorit…
View article: Nanotechnology: The Future for Diagnostic and Therapeutic Intervention in Cardiovascular Diseases is Here
Nanotechnology: The Future for Diagnostic and Therapeutic Intervention in Cardiovascular Diseases is Here Open
With advances in technology and medicine over the last 3 decades, cardiovascular medicine has evolved tremendously. Nanotechnology provides a promising future in personalized precision medicine. In this review, we delve into the current an…
View article: Titin: The Missing Link in Cardiac Physiology
Titin: The Missing Link in Cardiac Physiology Open
Titin, an extraordinary protein known for its colossal size and multifaceted roles, is a cornerstone in the structural and functional dynamics of striated muscle tissues, including the heart and skeletal muscles. Its sheer enormity, with a…
View article: Do Gender Differences Persist in ICD Implantation in Patients with Acute on Chronic Heart Failure?
Do Gender Differences Persist in ICD Implantation in Patients with Acute on Chronic Heart Failure? Open
View article: Pegozafermin Is a Potential Master Therapeutic Regulator in Metabolic Disorders: A Review
Pegozafermin Is a Potential Master Therapeutic Regulator in Metabolic Disorders: A Review Open
Pegozafermin (PGZ), a novel glycopegylated version of human fibroblast growth factor 21 (FGF21), has demonstrated potential for addressing metabolic comorbidities, including severe hypertriglyceridemia, insulin resistance, nonalcoholic fat…
View article: Neutrophil-to-lymphocyte ratio and prognosis in patients undergoing percutaneous coronary intervention for acute coronary syndrome
Neutrophil-to-lymphocyte ratio and prognosis in patients undergoing percutaneous coronary intervention for acute coronary syndrome Open
Our data confirm the independent prognostic significance of inflammation to mortality after ACS and may provide some insight into the putative benefits of inflammation modulation.
View article: The Relationship of Duffy Gene Polymorphism, High Sensitivity C-Reactive Protein, and Long-term Outcomes
The Relationship of Duffy Gene Polymorphism, High Sensitivity C-Reactive Protein, and Long-term Outcomes Open
Background Black adults have higher incidence of all-cause death and worse cardiovascular outcomes when compared to other populations. The Duffy chemokine receptor is not expressed in a large majority of Black adults and the clinical impli…
View article: The Critical Role of the Adipocytokine NOV in Obstructive Sleep Apnea Induced Cardiometabolic Dysfunction: A Review
The Critical Role of the Adipocytokine NOV in Obstructive Sleep Apnea Induced Cardiometabolic Dysfunction: A Review Open
Obstructive sleep apnea (OSA) is highly prevalent and associated with oxidative stress, chronic inflammation, and adverse cardiovascular consequences. The comorbid condition of obesity remains epidemic. Both obesity and OSA are highly como…
View article: Silencing the Adipocytokine NOV: A Novel Approach to Reversing Oxidative Stress-Induced Cardiometabolic Dysfunction
Silencing the Adipocytokine NOV: A Novel Approach to Reversing Oxidative Stress-Induced Cardiometabolic Dysfunction Open
Objective: NOV/CCN3 is an adipocytokine recently linked to obesity, insulin resistance, and cardiometabolic dysfunction. NOV is manufactured and secreted from adipose tissue, with blood levels highly correlated with BMI. NOV levels are inc…
View article: Clinical variables for predicting type-1 and type-2 non-ST segment elevation myocardial infarction in those presenting with ischemic symptoms
Clinical variables for predicting type-1 and type-2 non-ST segment elevation myocardial infarction in those presenting with ischemic symptoms Open
Introduction The accuracy of detecting myocardial infarction (MI) has greatly improved with the advent of more sensitive assays, and this has led to etiologic subtyping. Distinguishing between type 1 and type 2 non-ST-segment elevation myo…
View article: Adipocyte-Specific Expression of PGC1α Promotes Adipocyte Browning and Alleviates Obesity-Induced Metabolic Dysfunction in an HO-1-Dependent Fashion
Adipocyte-Specific Expression of PGC1α Promotes Adipocyte Browning and Alleviates Obesity-Induced Metabolic Dysfunction in an HO-1-Dependent Fashion Open
Recent studies suggest that PGC1-α plays a crucial role in mitochondrial and vascular function, yet the physiological significance of PGC1α and HO expression in adipose tissues in the context of obesity-linked vascular dysfunction remains …
View article: Cancer and cardiovascular-related perceived risk in a diverse cancer center catchment area
Cancer and cardiovascular-related perceived risk in a diverse cancer center catchment area Open
View article: Left ventricular hypertrophy subtype and long-term mortality in those with subclinical cardiovascular disease: The Multi-Ethnic Study of Atherosclerosis (MESA)
Left ventricular hypertrophy subtype and long-term mortality in those with subclinical cardiovascular disease: The Multi-Ethnic Study of Atherosclerosis (MESA) Open
The clinical and biochemical profile of differing LVH phenotypes and its effect on long term outcomes is ill-defined. The study investigated the differences in risk profiles and prognostic effect of concentric (CH) and eccentric hypertroph…
View article: How One NYC Hospital Handled the Covid-19 Pandemic- The Chief Residents’ Perspective
How One NYC Hospital Handled the Covid-19 Pandemic- The Chief Residents’ Perspective Open
In March of 2020, life as we knew it changed in a series of seemingly insurmountable challenges.The inpatient medicine ward of New York-Presbyterian Brooklyn Methodist Hospital (NYPBMH), a large Weill Cornell Medicine university hospital l…
View article: Heme-oxygenase and lipid mediators in obesity and associated cardiometabolic diseases: Therapeutic implications
Heme-oxygenase and lipid mediators in obesity and associated cardiometabolic diseases: Therapeutic implications Open
View article: The effect of cardiac geometry variation according to sex and race on outcomes in patients with acute coronary syndrome undergoing percutaneous coronary intervention
The effect of cardiac geometry variation according to sex and race on outcomes in patients with acute coronary syndrome undergoing percutaneous coronary intervention Open
Introduction The prevalence and long-term consequences of differences in baseline cardiac geometry (as a result of hypertension) in patients undergoing percutaneous coronary intervention (PCI) for acute coronary syndrome (ACS) are ill-defi…