Explanipedia

Multimodal biological profiles of symptom-based subgroups in recent-onset psychosis Open

Nikolaos Koutsouleris, Madalina-Octavia Buciuman, Clara Vetter, Ananda Bajrić, Clara Weyer , et al. · 2025

Symptom diversity in psychoses complicates the search for biological markers. Using Positive and Negative Symptom Scale data from 362 recent-onset patients in the multicenter PRONIA study, we identified four subgroups with dominant symptom…

The BMIgap tool to quantify transdiagnostic brain signatures of current and future weight Open

Adyasha Khuntia, David Popovic, Elif Sarisik, Madalina-Octavia Buciuman, Mads L. Pedersen , et al. · 2025

A Systematic Review of Neuroimaging Biomarkers to Predict Antipsychotic Treatment Response Open

Magdalene Rose de Rozario, J.E. Adams, Tahnee Bridson, Alexandra Stainton, Sidhant Chopra , et al. · 2025

Background:Up to a third of patients with schizophrenia do not experience sufficient improvement of symptoms and functioning on their first two trials of antipsychotic medications. This is concerning as ineffective antipsychotic treatment …

Functional Coupling and Longitudinal Outcome Prediction in First-Episode Psychosis Open

Isaac Z Pope, Sidhant Chopra, Alexander Holmes, Shona M. Francey, Brian O’Donoghue , et al. · 2025

642. A SYSTEMATIC REVIEW OF NEUROIMAGING BIOMARKERS TO PREDICT ANTIPSYCHOTIC TREATMENT RESPONSE Open

M de Rozario, Julia Adams, Elaine Painter, Tahnee Bridson, Sarah E. Herniman , et al. · 2025

Background Up to a third of patients with schizophrenia do not experience sufficient improvement of symptoms and functioning on their first two trials of antipsychotic medications. This is concerning as ineffective antipsychotic treatment …

709. RELATIONSHIP BETWEEN ELECTROENCEPHALOGRAPHY-BASED MISMATCH NEGATIVITY AND ANTIPSYCHOTIC TREATMENT RESPONSE IN YOUNG PEOPLE AT CLINICAL HIGH RISK FOR PSYCHOSIS Open

M de Rozario, E.C. Rowe, Michael Haaf, Julia Adams, Ilvana Dzafic , et al. · 2025

Background Antipsychotic medications are often used to treat individuals at clinical high risk for psychosis (CHR-P). However, up to 75% of these individuals will not develop psychotic disorders, nor benefit from such treatments. To optimi…

Identifying research priorities in early psychosis: A collaborative approach to shaping the future of early psychosis clinical trials in Australia. Open

Amity Watson, Stephen J. Wood, Isabel Zbukvic, Ellie Brown, Joanna Fitzsimons , et al. · 2025

Introduction: Psychotic disorders are major contributors to disability and mortality, disproportionately affecting young people. Despite advances in early psychosis care, there are still barriers to treatment, suboptimal outcomes, and limi…

From Snapshots to Stable Outcomes: Resting-State Functional Magnetic Resonance Imaging–Based Prognosis of Functioning in Patients With Psychosis Risk or Recent-Onset Depression Open

Madalina-Octavia Buciuman, Shalaila S. Haas, Linda A. Antonucci, Elif Sarisik, Adyasha Khuntia , et al. · 2025

We highlighted the prognostic value of fALFF for functional impairment in psychosis risk and early depression. Leveraging trajectorial information, we identified candidate imaging biomarkers to improve prognostication, thereby supporting p…

Predicting the First Onset of Suicidal Thoughts and Behaviors in Adolescents Using Multimodal Risk Factors: A 4-Year Longitudinal Study Open

Josh Nguyen, Dom Dwyer, Yara J. Toenders, Scott D Tagliaferri, Laura S. van Velzen , et al. · 2025

We worked to ensure sex and gender balance in the recruitment of human participants. We worked to ensure race, ethnic, and/or other types of diversity in the recruitment of human participants. We worked to ensure that the study questionnai…

Spatial Variation of Cooked Temperature in Pork Measured by Spontaneous Raman Spectroscopy Open

Korryn Narvaez, Eliza Ballantyne, Stephen J. Wood, Dustin W. Shipp · 2025

The food preparation industry relies on accurately measuring the endpoint temperature (EPT) of cooked pork to ensure the safety and quality of these products. Food thermometers are the current gold standard but become ineffectual as soon a…

The electroencephalography protocol for the Accelerating Medicines Partnership® Schizophrenia Program: Reliability and stability of measures Open

Daniel H. Mathalon, Spero Nicholas, Brian J. Roach, Tashrif Billah, Suzie Lavoie , et al. · 2025

Differential effects of illness and antipsychotics on cortical thinning in first episode psychosis Open

Sidhant Chopra, Alexander Holmes, Ashlea Segal, Xi-Han Zhang, Shona M. Francey , et al. · 2025

Introduction: Cortical grey matter loss is a common finding in Magnetic Resonance Imaging (MRI) studies of people with psychosis and has been shown to progress with ongoing illness. A major unresolved question concerns whether these change…

0923 Associations Between Sleep and Affect in Midlife Women: The Importance of Methodological Rigor Open

Stephen J. Wood, Rebecca C. Thurston, Yue-Fang Chang, Pauline M. Maki · 2025

Introduction In midlife women, sleep difficulties are associated with prolonged mood states like depression. Sleep difficulties may also associate with positive and negative emotions (“affect”) that can change rapidly over minutes and hour…

Disrupted Hierarchical Functional Brain Organization in Affective and Psychotic Disorders: Insights from Functional Brain Gradients Open

Joseph Kambeitz, H. Häcker, Linnea Hoheisel, Madalina Buciuman, Annkathrin Böke , et al. · 2025

Formulating Cognitive Functioning to Guide Personalised Treatment for People Diagnosed With Mental Disorders Open

Kelly Allott, Shayden Bryce, Katie M. Douglas, Alexandra Stainton, Stephen J. Wood , et al. · 2025

Introduction Objective and subjective cognitive impairment are highly prevalent in mental disorders and transdiagnostic phenomena. Cognitive impairment is associated with poorer functional outcomes and therefore requires treatment, but lit…

The MR neuroimaging protocol for the Accelerating Medicines Partnership® Schizophrenia Program Open

Michael P. Harms, Kang Ik K. Cho, Alan Anticevic, Nicolas R. Bolo, Sylvain Bouix , et al. · 2025

Neuroimaging with MRI has been a frequent component of studies of individuals at clinical high risk (CHR) for developing psychosis, with goals of understanding potential brain regions and systems impacted in the CHR state and identifying p…

Refining Schizophrenia Risk Assessment: Machine Learning Delineates a Brain Signature of Cognitive Basic Symptoms Open

Nikolaos Koutsouleris, Madalina Buciuman, L. Neuner, Clara Weyer, Clara Vetter , et al. · 2025

Biological risk signatures could aid the early detection of schizophrenia, but their precision likely depends on the clinical risk definitions they are derived from. Using machine learning, we analyzed structural MRI data from 1,425 patien…

Integrating Virtual Reality, Neurofeedback, and Cognitive Behavioral Therapy for Auditory Verbal Hallucinations (Hybrid): Protocol of a Pilot, Unblinded, Single-Arm Interventional Study Open

Jessica Spark, Elise Rowe, Mario Álvarez‐Jiménez, Imogen Bell, Linda K. Byrne , et al. · 2025

Background Current treatments for schizophrenia and other psychotic disorders have limited efficacy, with high rates of nonresponse to “gold standard” treatments. New approaches are therefore urgently required. Objective The aims of this p…

Dynamic Updating of Psychosis Prediction Models in Individuals at Ultra-High Risk of Psychosis Open

Simon Hartmann, Dominic Dwyer, Isabelle Scott, Cassandra Wannan, Josh Nguyen , et al. · 2025

Dynamic updating of psychosis prediction models may help to mitigate decreases in performance over time. Therefore, existing psychosis prediction models need to be monitored for temporal biases to mitigate potentially harmful decisions.

Cognitive assessment in the Accelerating Medicines Partnership® Schizophrenia Program: harmonization priorities and strategies in a diverse international sample Open

Kelly Allott, Walid Yassin, Luis Alameda, Tashrif Billah, Owen Borders , et al. · 2025

Cognitive impairment occurs at higher rates in individuals at clinical high risk (CHR) for psychosis relative to healthy peers, and it contributes unique variance to multivariate prediction models of transition to psychosis. Such impairmen…

Activation differentiates illness trajectories among youth seeking mental health care Open

Emiliana Tonini, Jacob J. Crouse, Mirim Shin, Jan Scott, Joanne S. Carpenter , et al. · 2025

These findings suggest that activation is a marker of poorer clinical and functional outcomes in youth presenting for mental health care.

Atypical hippocampal excitatory neurons express and govern object memory Open

A. Kinman, Daniel J. Merryweather, Sarah R. Erwin, Rebecca E. Campbell, Kaitlin E. Sullivan , et al. · 2025

Exploring the Implementation of Cognitive Screening in First‐Episode Psychosis Settings: The <span>CogScreen</span> Implementation Study Open

Isabel Zbukvic, Evangeline Fisher, Alexandra Stainton, Shayden Bryce, Dzenana Kartal , et al. · 2025

Aim Accurate and appropriate cognitive screening can significantly enhance early psychosis care, yet no screening tools have been validated for the early psychosis population and little is known about current screening practices, experienc…

Salivary cortisol measures across the clinical stages of psychosis: An individual participant data (IPD) meta-analysis Open

Susanne Häußler, Uzma Zahid, Fern Day, Simone Ciufolini, Natalia Petros , et al. · 2025

Clinical high-risk and first-episode psychosis participants differed from healthy controls in the peak-to-evening diurnal cortisol slope. This measure has not been examined in these populations before, and its potential predictive and prog…

Characterising symptomatic substates in individuals on the psychosis continuum: a hidden Markov modelling approach Open

Isabelle Scott, Emmeke Aarts, Cassandra Wannan, Caroline X. Gao, Scott R. Clark , et al. · 2025

Background To improve early intervention and personalise treatment for individuals early on the psychosis continuum, a greater understanding of symptom dynamics is required. We address this by identifying and evaluating the movement betwee…

Active treatment of affective disturbances may improve functional outcomes in patients in the early state of psychosis: Results of the PRONIA study Open

Raimo K. R. Salokangas, Julian Wenzel, Tiina From, Tuula Ilonen, Reetta-Liina Armio , et al. · 2025

Background and objectives The functional outcome of patients with psychotic disturbances is associated with several overlapping premorbid, societal, neuropsychological, and clinical factors. Extracting the factors associated with functiona…

New diagnosis in psychiatry: beyond heuristics Open

Patrick D. McGorry, Ian B. Hickie, Roman Kotov, Lianne Schmaal, Stephen J. Wood , et al. · 2025

Background Diagnosis in psychiatry faces familiar challenges. Validity and utility remain elusive, and confusion regarding the fluid and arbitrary border between mental health and illness is increasing. The mainstream strategy has been con…

The Prevalence of Attention Deficit Hyperactivity Disorder in Psychotic Disorders: Systematic Review and Meta-analysis Open

Nicholas Cheng, Shayden Bryce, Michael Takagi, Allie Pert, Audrey Rattray , et al. · 2024

Background Although attention deficit hyperactivity disorder (ADHD) is known to be common in psychotic disorders, reported prevalence rates vary widely, with limited understanding of how different factors (eg, assessment methods, geographi…

Exploring the Predictive Value of Structural Covariance Networks for the Diagnosis of Schizophrenia Open

Clara Vetter, A.E. Bender, Dominic Dwyer, Maxime Montembeault, Anne Ruef , et al. · 2024

Schizophrenia is a psychiatric disorder hypothesized to result from disturbed brain connectivity. Structural covariance networks (SCN) describe the shared variation in morphological properties emerging from coordinated neurodevelopmental p…

BMIgap: a new tool to quantify transdiagnostic brain signatures of current and future weight Open

Nikolaos Koutsouleris, Adyasha Khuntia, David Popovic, Elif Sarisik, Madalina-Octavia Buciuman , et al. · 2024

Understanding the neurobiological underpinnings of weight gain could reduce excess mortality and improve long-term trajectories of psychiatric disorders. We used support-vector machines and whole-brain voxel-wise grey matter volume to gene…

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