J. Stephen Dumler
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View article: EPR spectroscopy reveals antioxidant manganese defenses in the Lyme disease pathogen <i>Borrelia burgdorferi</i>
EPR spectroscopy reveals antioxidant manganese defenses in the Lyme disease pathogen <i>Borrelia burgdorferi</i> Open
Oxidative stress defense in aerobic bacteria relies on Mn-superoxide dismutase (MnSOD) and antioxidant Mn-metabolite complexes (H-Mn) to quench superoxide radicals (O 2 •− ). We investigated these antioxidant systems in Borrelia burgdorfer…
View article: All-flavor Time-dependent Search for Transient Neutrino Sources
All-flavor Time-dependent Search for Transient Neutrino Sources Open
View article: What’s in a Name? How Useful is Current Rickettsial Taxonomy and Is Revision of Nomenclature Needed?
What’s in a Name? How Useful is Current Rickettsial Taxonomy and Is Revision of Nomenclature Needed? Open
View article: Rickettsioses as Underrecognized Cause of Hospitalization for Febrile Illness, Uganda
Rickettsioses as Underrecognized Cause of Hospitalization for Febrile Illness, Uganda Open
The complexity of rickettsial serodiagnostics during acute illness has limited clinical characterization in Africa. We used archived samples from sepsis (n = 259) and acute febrile illness (n = 70) cohorts in Uganda to identify spotted fev…
View article: <i>Borrelia burgdorferi</i> radiosensitivity and Mn antioxidant content: antigenic preservation and pathobiology
<i>Borrelia burgdorferi</i> radiosensitivity and Mn antioxidant content: antigenic preservation and pathobiology Open
The bacterium responsible for Lyme disease, Borrelia burgdorferi , accumulates high levels of manganese without iron and possesses a polyploid genome, characteristics suggesting potential extreme resistance to radiation. Contrary to expect…
View article: Culture and other direct detection methods to diagnose human granulocytic anaplasmosis
Culture and other direct detection methods to diagnose human granulocytic anaplasmosis Open
Objectives We sought to assess the performance of 3 laboratory tests on blood specimens for direct detection of Anaplasma phagocytophilum, the cause of human granulocytic anaplasmosis (HGA), in patients tested at a single medical instituti…
View article: Metagenomic next generation sequencing of plasma RNA for diagnosis of unexplained, acute febrile illness in Uganda
Metagenomic next generation sequencing of plasma RNA for diagnosis of unexplained, acute febrile illness in Uganda Open
Metagenomic next generation metagenomic sequencing (mNGS) has proven to be a useful tool in the diagnosis and identification of novel human pathogens and pathogens not identified on routine clinical microbiologic tests. In this study, we a…
View article: Evidence of <i>Orientia</i> spp. Endemicity among Severe Infectious Disease Cohorts, Uganda
Evidence of <i>Orientia</i> spp. Endemicity among Severe Infectious Disease Cohorts, Uganda Open
At 3 severe infection cohort sites in Uganda, Orientia seropositivity was common. We identified 4 seroconversion cases and 1 PCR-positive case. These results provide serologic and molecular support for Orientia spp. circulating in sub-Saha…
View article: Emerging Tick-borne Infections in the Upper Midwest and Northeast United States Among Patients With Suspected Anaplasmosis
Emerging Tick-borne Infections in the Upper Midwest and Northeast United States Among Patients With Suspected Anaplasmosis Open
Background Emerging tick-transmitted illnesses are increasingly recognized in the United States (US). To identify multiple potential tick-borne pathogens in patients from the Upper Midwest and Northeast US with suspected anaplasmosis, we u…
View article: Benidipine impairs innate immunity converting sublethal to lethal infections in a murine model of spotted fever rickettsiosis
Benidipine impairs innate immunity converting sublethal to lethal infections in a murine model of spotted fever rickettsiosis Open
Spotted fever group rickettsiae are tick-borne obligate intracellular bacteria that infect microvascular endothelial cells. Humans and mammalian infection results in endothelial cell barrier dysfunction and increased vascular permeability.…
View article: Host-response transcriptional biomarkers accurately discriminate bacterial and viral infections of global relevance
Host-response transcriptional biomarkers accurately discriminate bacterial and viral infections of global relevance Open
View article: Characterization of the bacterial microbiome of non-hematophagous bats and associated ectoparasites from Brazil
Characterization of the bacterial microbiome of non-hematophagous bats and associated ectoparasites from Brazil Open
Introduction Bats, along with their ectoparasites, harbor a wide diversity of symbiotic and potential pathogenic bacteria. Despite the enormous diversity of bats (181 species), few studies aimed to investigate the bacterial microbiome of B…
View article: Corrigendum to ‘Assessment of a quantitative 5′ nuclease real-time polymerase chain reaction using groEL gene for Ehrlichia and Anaplasma species in rodents in Brazil’ [Ticks and Tick-Borne Diseases 8 (2017) 646–656/4]
Corrigendum to ‘Assessment of a quantitative 5′ nuclease real-time polymerase chain reaction using groEL gene for Ehrlichia and Anaplasma species in rodents in Brazil’ [Ticks and Tick-Borne Diseases 8 (2017) 646–656/4] Open
View article: Innate immunity in rickettsial infections
Innate immunity in rickettsial infections Open
Rickett s ial agents are a diverse group of alpha-proteobacteria within the order Rickettsiales, which possesses two families with human pathogens, Rickettsiaceae and Anaplasmataceae. These obligate intracellular bacteria are most frequent…
View article: Spotted fever rickettsia-induced microvascular endothelial barrier dysfunction is delayed by the calcium channel blocker benidipine
Spotted fever rickettsia-induced microvascular endothelial barrier dysfunction is delayed by the calcium channel blocker benidipine Open
View article: Host-response Transcriptional Biomarkers Accurately Discriminate Bacterial and Viral Infections of Global Relevance
Host-response Transcriptional Biomarkers Accurately Discriminate Bacterial and Viral Infections of Global Relevance Open
Limited diagnostics challenge management of acute febrile illness and sepsis (AFI/sepsis) globally. We generated transcriptomes for a 294-participant (USA, Sri Lanka) discovery cohort with AFI/sepsis. We used lasso to derive gene expressio…
View article: Distinct blood inflammatory biomarker clusters stratify host phenotypes during the middle phase of COVID-19
Distinct blood inflammatory biomarker clusters stratify host phenotypes during the middle phase of COVID-19 Open
The associations between clinical phenotypes of coronavirus disease 2019 (COVID-19) and the host inflammatory response during the transition from peak illness to convalescence are not yet well understood. Blood plasma samples were collecte…
View article: Visualization of the Dynamics of Invasion and Intravasation of the Bacterium That Causes Lyme Disease in a Tissue Engineered Dermal Microvessel Model
Visualization of the Dynamics of Invasion and Intravasation of the Bacterium That Causes Lyme Disease in a Tissue Engineered Dermal Microvessel Model Open
Lyme disease is a tick‐borne disease prevalent in North America, Europe, and Asia. Despite the accumulated knowledge from epidemiological, in vitro, and in animal studies, the understanding of dissemination of vector‐borne pathogens, such …
View article: Immune evasion strategies of major tick-transmitted bacterial pathogens
Immune evasion strategies of major tick-transmitted bacterial pathogens Open
View article: Assessing the use of a micro-sampling device for measuring blood protein levels in healthy subjects and COVID-19 patients
Assessing the use of a micro-sampling device for measuring blood protein levels in healthy subjects and COVID-19 patients Open
Background Venous phlebotomy performed by trained personnel is critical for patient diagnosis and monitoring of chronic disease, but has limitations in resource-constrained settings, and represents an infection control challenge during out…
View article: Dynamics of <i>Borrelia Burgdorferi</i> Invasion and Intravasation in a Tissue Engineered Dermal Microvessel Model
Dynamics of <i>Borrelia Burgdorferi</i> Invasion and Intravasation in a Tissue Engineered Dermal Microvessel Model Open
Lyme disease is a tick-borne disease prevalent in North America, Europe, and Asia. Dissemination of vector-borne pathogens, such as Borrelia burgdorferi ( Bb ), results in infection of distant tissues and is the main contributor to poor ou…
View article: Detection of antibodies to Anaplasma phagocytophilum and Babesia microti using linear peptides
Detection of antibodies to Anaplasma phagocytophilum and Babesia microti using linear peptides Open
Anaplasma phagocytophilum and Babesia microti are emerging tick-borne pathogens in the United States. Although active infection is typically diagnosed by direct diagnostic tests, such as blood smear or polymerase chain reaction assay, sero…
View article: Anaplasma phagocytophilum Ankyrin A Protein (AnkA) Enters the Nucleus Using an Importin-β-, RanGTP-Dependent Mechanism
Anaplasma phagocytophilum Ankyrin A Protein (AnkA) Enters the Nucleus Using an Importin-β-, RanGTP-Dependent Mechanism Open
Anaplasma phagocytophilum , a tick-borne obligately intracellular bacterium of neutrophils, causes human granulocytic anaplasmosis. Ankyrin A (AnkA), an effector protein with multiple ankyrin repeats (AR) is injected via type IV-secretion …
View article: Topological data analysis identifies distinct biomarker phenotypes during the ‘inflammatory’ phase of COVID-19
Topological data analysis identifies distinct biomarker phenotypes during the ‘inflammatory’ phase of COVID-19 Open
OBJECTIVES The relationships between baseline clinical phenotypes and the cytokine milieu of the peak ‘inflammatory’ phase of coronavirus 2019 (COVID-19) are not yet well understood. We used Topological Data Analysis (TDA), a dimensionalit…
View article: Rickettsioses and Q Fever in Tanzania: Estimating the Burden of Pervasive and Neglected Causes of Severe Febrile Illness in Sub-Saharan Africa
Rickettsioses and Q Fever in Tanzania: Estimating the Burden of Pervasive and Neglected Causes of Severe Febrile Illness in Sub-Saharan Africa Open
"Rickettsioses and Q Fever in Tanzania: Estimating the Burden of Pervasive and Neglected Causes of Severe Febrile Illness in Sub-Saharan Africa" published on 02 Feb 2022 by The American Society of Tropical Medicine and Hygiene.
View article: 438. Phenotypic Differences Between Distinct Immune Biomarker Clusters During the ‘Hyperinflammatory’ Middle-Phase of COVID-19
438. Phenotypic Differences Between Distinct Immune Biomarker Clusters During the ‘Hyperinflammatory’ Middle-Phase of COVID-19 Open
Background Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections peak during an inflammatory ‘middle’ phase and lead to severe illness predominately among those with certain comorbid noncommunicable diseases (NCDs). We us…
View article: Predictive Value of an Age-Based Modification of the National Early Warning System in Hospitalized Patients With COVID-19
Predictive Value of an Age-Based Modification of the National Early Warning System in Hospitalized Patients With COVID-19 Open
Background Early recognition of high-risk patients with coronavirus disease 2019 (COVID-19) may improve outcomes. Although many predictive scoring systems exist, their complexity may limit utility in COVID-19. We assessed the prognostic pe…
View article: Anaplasma phagocytophilum Activates NF-κB Signaling via Redundant Pathways
Anaplasma phagocytophilum Activates NF-κB Signaling via Redundant Pathways Open
Anaplasma phagocytophilum subverts neutrophil function permitting intracellular survival, propagation and transmission. Sustained pro-inflammatory response, recruitment of new host cells for population expansion, and delayed apoptos…
View article: 508. Biomarker elevation during COVID-19: Differences between ambulatory and hospitalized individuals
508. Biomarker elevation during COVID-19: Differences between ambulatory and hospitalized individuals Open
Background While the majority of illness due to COVID-19 does not require hospitalization, little has been described about the host inflammatory response in the ambulatory setting. Differences in the levels of inflammatory signaling protei…
View article: Rickettsioses as Major Etiologies of Unrecognized Acute Febrile Illness, Sabah, East Malaysia
Rickettsioses as Major Etiologies of Unrecognized Acute Febrile Illness, Sabah, East Malaysia Open
Orientia tsutsugamushi, spotted fever group rickettsioses, and typhus group rickettsioses (TGR) are reemerging causes of acute febrile illness (AFI) in Southeast Asia. To further delineate extent, we enrolled patients >4 weeks of age with …