Stephen Large
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View article: Organ donation for research purposes: a qualitative focus group study on the views of donor families, transplant recipients and heart failure patients in the UK
Organ donation for research purposes: a qualitative focus group study on the views of donor families, transplant recipients and heart failure patients in the UK Open
Background Declined donor organs and explanted recipient organs may hold considerable value for biomedical research, particularly in advancing knowledge of disease mechanisms and supporting drug development. However, public perceptions of …
View article: Increasing the acceptance of thoracoabdominal normothermic regional perfusion in donation after circulatory determination of death heart donation: A case for collaborative donor research
Increasing the acceptance of thoracoabdominal normothermic regional perfusion in donation after circulatory determination of death heart donation: A case for collaborative donor research Open
Donation after circulatory determination of death transplantation offers an effective and safe method of increasing the number of heart transplants performed. Donation after circulatory determination of death heart is ischemic at the time …
View article: Non-bacterial thrombotic endocarditis masquerading as infective endocarditis: a paraneoplastic process
Non-bacterial thrombotic endocarditis masquerading as infective endocarditis: a paraneoplastic process Open
A 76-year-old lady presented to her local hospital with chest pain, malaise, and fever, suspected to be due to infective endocarditis. Echocardiography showed a mass on the anterior mitral valve leaflet. Multimodal imaging showed several s…
View article: Heart Transplantation and Donation After Circulatory Death in Children. A Review of the Technological, Logistical and Ethical Framework
Heart Transplantation and Donation After Circulatory Death in Children. A Review of the Technological, Logistical and Ethical Framework Open
Heart transplant for adults following Donation after Circulatory Death (DCD) is well established in many parts of the world, including the United Kingdom (UK). Small child DCD hearts have now been recovered in the UK and internationally ut…
View article: A critical evaluation of donor heart offer acceptance in the United Kingdom
A critical evaluation of donor heart offer acceptance in the United Kingdom Open
Donor heart function and PMH are the most common reasons for declining heart offers, with non-clinical factors also contributing to offer declines. Greater acceptance rates can be achieved with greater logistical support for the UK heart t…
View article: Repairing the mitral valve without touching the mitral valve—a novel technique
Repairing the mitral valve without touching the mitral valve—a novel technique Open
A 44-year-old gentleman presented with severe ischemic cardiomyopathy and mitral regurgitation post-inferior myocardial infarction. Echocardiography and magnetic resonance imaging revealed a dilated left ventricle with a large left ventric…
View article: Inequalities for women diagnosed with distal arch and descending thoracic aortic aneurysms: results from the Effective Treatments for Thoracic Aortic Aneurysms (ETTAA) cohort study
Inequalities for women diagnosed with distal arch and descending thoracic aortic aneurysms: results from the Effective Treatments for Thoracic Aortic Aneurysms (ETTAA) cohort study Open
Background Women with thoracic aortic aneurysms within the arch or descending thoracic aorta have poorer survival than men. Sex differences in relative thoracic aortic aneurysm size may account for some of the discrepancy. The aim of this …
View article: Metabolic Considerations in Direct Procurement and Perfusion Protocols with DCD Heart Transplantation
Metabolic Considerations in Direct Procurement and Perfusion Protocols with DCD Heart Transplantation Open
Heart transplantation with donation after circulatory death (DCD) provides excellent patient outcomes and increases donor heart availability. However, unlike conventional grafts obtained through donation after brain death, DCD cardiac graf…
View article: Costs of endovascular and open repair of thoracic aortic aneurysms
Costs of endovascular and open repair of thoracic aortic aneurysms Open
Background Repair of thoracic aortic aneurysms with either endovascular repair (TEVAR) or open surgical repair (OSR) represents major surgery, is costly and associated with significant complications. The aim of this study was to establish …
View article: The British Transplantation Society guidelines on cardiothoracic organ transplantation from deceased donors after circulatory death
The British Transplantation Society guidelines on cardiothoracic organ transplantation from deceased donors after circulatory death Open
Maximising organ utilisation from donation after circulatory death (DCD) donors could help meet some of the shortfall in organ supply, but it represents a major challenge, particularly as organ donors and transplant recipients become older…
View article: Machine Perfusion of the Human Heart
Machine Perfusion of the Human Heart Open
This brief communication about machine perfusion of potential human donor hearts describes its historical development. Included in the review are both the isolated perfusion of donor hearts retrieved from heart beating and non-heart-beatin…
View article: Heart transplantation from an extended criteria donation after circulatory death donor
Heart transplantation from an extended criteria donation after circulatory death donor Open
Transplantation of donation after circulatory death (DCD) donor hearts is gaining acceptance. However, DCD heart selection has been understandably cautious. We report a case of reconditioning a DCD heart using thoraco-abdominal normothermi…
View article: Aneurysm growth, survival, and quality of life in untreated thoracic aortic aneurysms: the effective treatments for thoracic aortic aneurysms study
Aneurysm growth, survival, and quality of life in untreated thoracic aortic aneurysms: the effective treatments for thoracic aortic aneurysms study Open
Aims To observe, describe, and evaluate management and timing of intervention for patients with untreated thoracic aortic aneurysms. Methods and results Prospective study of UK National Health Service (NHS) patients aged ≥18 years, with ne…
View article: Psychological Adaptation to Transplanted Organ: A Hermeneutic Phenomenological Study
Psychological Adaptation to Transplanted Organ: A Hermeneutic Phenomenological Study Open
Background: While organ transplantation is a common surgical procedure worldwide, it is yet well-examined how the recipients of newly-transplanted organs adapt and accept a new organ from another body. Adaptation and acceptance of a vital …
View article: Emergency medical staffs’ knowledge and attitude about organ donation after circulatory determined death (DCD) and its related factors
Emergency medical staffs’ knowledge and attitude about organ donation after circulatory determined death (DCD) and its related factors Open
Background Adverse attitudes and insufficient knowledge about organ donation after Circulatory Determined Death (DCD) among emergency staff can have important consequences for the proper identification of potential DCD donors. This is aide…
View article: Systematic review of endovascular stent grafting versus open surgical repair for the elective treatment of arch/descending thoracic aortic aneurysms
Systematic review of endovascular stent grafting versus open surgical repair for the elective treatment of arch/descending thoracic aortic aneurysms Open
Objective To review comparisons of the effectiveness of endovascular stent grafting (ESG) against open surgical repair (OSR) for treatment of chronic arch or descending thoracic aortic aneurysms (TAA). Design Systematic review and meta-ana…
View article: Issue Information Page
Issue Information Page Open
to get the results it gets
View article: Impact of stroke on outcomes following cardiac surgery: Propensity matched analysis
Impact of stroke on outcomes following cardiac surgery: Propensity matched analysis Open
Background Stroke remains a devastating complication of cardiac surgery. The aim of this study was to characterise the incidence of stroke and analyse the impact of stroke on patient outcomes and survival. Methods A retrospective analysis …
View article: Maintaining the permanence principle for death during in situ normothermic regional perfusion for donation after circulatory death organ recovery: A United Kingdom and Canadian proposal
Maintaining the permanence principle for death during in situ normothermic regional perfusion for donation after circulatory death organ recovery: A United Kingdom and Canadian proposal Open
There is international variability in the determination of death. Death in donation after circulatory death (DCD) can be defined by the permanent cessation of brain circulation. Post-mortem interventions that restore brain perfusion should…
View article: Transplantation of Hearts Donated after Circulatory Death
Transplantation of Hearts Donated after Circulatory Death Open
Cardiac transplantation has become limited by a critical shortage of suitable organs from brain-dead donors. Reports describing the successful clinical transplantation of hearts donated after circulatory death (DCD) have recently emerged. …