Stephen M. Thirdborough
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View article: Supplementary Figures 1-5 from Cyclophosphamide Enhances Cancer Antibody Immunotherapy in the Resistant Bone Marrow Niche by Modulating Macrophage FcγR Expression
Supplementary Figures 1-5 from Cyclophosphamide Enhances Cancer Antibody Immunotherapy in the Resistant Bone Marrow Niche by Modulating Macrophage FcγR Expression Open
Supplemental Figure 1 (related to Figure 1A). BM-resident B-lymphoma cells are refractory to alemtuzumab treatment. Supplemental Figure 2 (related to Figure 1D). Human BM macrophages express higher levels of FcγRIIB compared to those in LN…
View article: Supplementary Figures 1-5 from Cyclophosphamide Enhances Cancer Antibody Immunotherapy in the Resistant Bone Marrow Niche by Modulating Macrophage FcγR Expression
Supplementary Figures 1-5 from Cyclophosphamide Enhances Cancer Antibody Immunotherapy in the Resistant Bone Marrow Niche by Modulating Macrophage FcγR Expression Open
Supplemental Figure 1 (related to Figure 1A). BM-resident B-lymphoma cells are refractory to alemtuzumab treatment. Supplemental Figure 2 (related to Figure 1D). Human BM macrophages express higher levels of FcγRIIB compared to those in LN…
View article: Data from Cyclophosphamide Enhances Cancer Antibody Immunotherapy in the Resistant Bone Marrow Niche by Modulating Macrophage FcγR Expression
Data from Cyclophosphamide Enhances Cancer Antibody Immunotherapy in the Resistant Bone Marrow Niche by Modulating Macrophage FcγR Expression Open
Therapy-resistant microenvironments represent a major barrier toward effective elimination of disseminated cancer. Many hematologic and solid tumors are resistant to therapeutic antibodies in the bone marrow (BM), but not in the periphery …
View article: Data from Cyclophosphamide Enhances Cancer Antibody Immunotherapy in the Resistant Bone Marrow Niche by Modulating Macrophage FcγR Expression
Data from Cyclophosphamide Enhances Cancer Antibody Immunotherapy in the Resistant Bone Marrow Niche by Modulating Macrophage FcγR Expression Open
Therapy-resistant microenvironments represent a major barrier toward effective elimination of disseminated cancer. Many hematologic and solid tumors are resistant to therapeutic antibodies in the bone marrow (BM), but not in the periphery …
View article: Data from PD-1 Blockade and CD27 Stimulation Activate Distinct Transcriptional Programs That Synergize for CD8<sup>+</sup> T-Cell–Driven Antitumor Immunity
Data from PD-1 Blockade and CD27 Stimulation Activate Distinct Transcriptional Programs That Synergize for CD8<sup>+</sup> T-Cell–Driven Antitumor Immunity Open
Purpose: PD-1 checkpoint blockade has revolutionized the field of cancer immunotherapy, yet the frequency of responding patients is limited by inadequate T-cell priming secondary to a paucity of activatory dendritic cells (DC). DC s…
View article: Data from Upregulated Glucose Metabolism Correlates Inversely with CD8<sup>+</sup> T-cell Infiltration and Survival in Squamous Cell Carcinoma
Data from Upregulated Glucose Metabolism Correlates Inversely with CD8<sup>+</sup> T-cell Infiltration and Survival in Squamous Cell Carcinoma Open
Antibodies that block T-cell–regulatory checkpoints have recently emerged as a transformative approach to cancer treatment. However, the clinical efficacy of checkpoint blockade depends upon inherent tumor immunogenicity, with variation in…
View article: Figure S4 from Upregulated Glucose Metabolism Correlates Inversely with CD8<sup>+</sup> T-cell Infiltration and Survival in Squamous Cell Carcinoma
Figure S4 from Upregulated Glucose Metabolism Correlates Inversely with CD8<sup>+</sup> T-cell Infiltration and Survival in Squamous Cell Carcinoma Open
Figure S4. Pathway and survival analysis of genes negatively associated with the leukocyte module (M1) eigengene. (A) Each module whose eigengene inversely correlated with ME1 were represented as a node connected to some of the top-ranked …
View article: Figure S5 from Upregulated Glucose Metabolism Correlates Inversely with CD8<sup>+</sup> T-cell Infiltration and Survival in Squamous Cell Carcinoma
Figure S5 from Upregulated Glucose Metabolism Correlates Inversely with CD8<sup>+</sup> T-cell Infiltration and Survival in Squamous Cell Carcinoma Open
Figure S5. Magnitude and breadth of T-cell response to HPV-16 E7/E6 DNA vaccine. The E7/E6 DNA vaccine (VB1025) was obtained from Agnete Fredriksen and Ole Brekke (Vaccibody, Oslo, Norway). It encodes a HPV-16 E7/E6 fusion protein, which f…
View article: Table S2 from Upregulated Glucose Metabolism Correlates Inversely with CD8<sup>+</sup> T-cell Infiltration and Survival in Squamous Cell Carcinoma
Table S2 from Upregulated Glucose Metabolism Correlates Inversely with CD8<sup>+</sup> T-cell Infiltration and Survival in Squamous Cell Carcinoma Open
Table S2. Excel spreadsheet of enriched GO terms (Bonferoni adj.P< 0.05) and top 20 negatively enriched MSigDB hallmark gene sets.
View article: Figure S1 from Upregulated Glucose Metabolism Correlates Inversely with CD8<sup>+</sup> T-cell Infiltration and Survival in Squamous Cell Carcinoma
Figure S1 from Upregulated Glucose Metabolism Correlates Inversely with CD8<sup>+</sup> T-cell Infiltration and Survival in Squamous Cell Carcinoma Open
Figure S1. Overview of workflow.
View article: Figure S3 from Upregulated Glucose Metabolism Correlates Inversely with CD8<sup>+</sup> T-cell Infiltration and Survival in Squamous Cell Carcinoma
Figure S3 from Upregulated Glucose Metabolism Correlates Inversely with CD8<sup>+</sup> T-cell Infiltration and Survival in Squamous Cell Carcinoma Open
Figure S3. Increased expression of the CD8+ T-cell signature has a prognostic value for overall survival. (A and B) Kaplan-Meier estimates of overall survival among patients grouped according to expression of genes with the strongest membe…
View article: Data from Upregulated Glucose Metabolism Correlates Inversely with CD8<sup>+</sup> T-cell Infiltration and Survival in Squamous Cell Carcinoma
Data from Upregulated Glucose Metabolism Correlates Inversely with CD8<sup>+</sup> T-cell Infiltration and Survival in Squamous Cell Carcinoma Open
Antibodies that block T-cell–regulatory checkpoints have recently emerged as a transformative approach to cancer treatment. However, the clinical efficacy of checkpoint blockade depends upon inherent tumor immunogenicity, with variation in…
View article: Table S1 from Upregulated Glucose Metabolism Correlates Inversely with CD8<sup>+</sup> T-cell Infiltration and Survival in Squamous Cell Carcinoma
Table S1 from Upregulated Glucose Metabolism Correlates Inversely with CD8<sup>+</sup> T-cell Infiltration and Survival in Squamous Cell Carcinoma Open
Table S1. Complete list of identified modules in the HNSC network and their top GO Biological Process category.
View article: Data from Targeting Carcinoembryonic Antigen with DNA Vaccination: On-Target Adverse Events Link with Immunologic and Clinical Outcomes
Data from Targeting Carcinoembryonic Antigen with DNA Vaccination: On-Target Adverse Events Link with Immunologic and Clinical Outcomes Open
Purpose: We have clinically evaluated a DNA fusion vaccine to target the HLA-A*0201–binding peptide CAP-1 from carcinoembryonic antigen (CEA605–613) linked to an immunostimulatory domain (DOM) from fragment C of tetanus t…
View article: Table S2 from PD-1 Blockade and CD27 Stimulation Activate Distinct Transcriptional Programs That Synergize for CD8<sup>+</sup> T-Cell–Driven Antitumor Immunity
Table S2 from PD-1 Blockade and CD27 Stimulation Activate Distinct Transcriptional Programs That Synergize for CD8<sup>+</sup> T-Cell–Driven Antitumor Immunity Open
List of genes in clusters 3 and 4 with the greatest fold-changes between monotherapy and combination therapy groups
View article: Data from Targeting Carcinoembryonic Antigen with DNA Vaccination: On-Target Adverse Events Link with Immunologic and Clinical Outcomes
Data from Targeting Carcinoembryonic Antigen with DNA Vaccination: On-Target Adverse Events Link with Immunologic and Clinical Outcomes Open
Purpose: We have clinically evaluated a DNA fusion vaccine to target the HLA-A*0201–binding peptide CAP-1 from carcinoembryonic antigen (CEA605–613) linked to an immunostimulatory domain (DOM) from fragment C of tetanus t…
View article: Figure S3 from Upregulated Glucose Metabolism Correlates Inversely with CD8<sup>+</sup> T-cell Infiltration and Survival in Squamous Cell Carcinoma
Figure S3 from Upregulated Glucose Metabolism Correlates Inversely with CD8<sup>+</sup> T-cell Infiltration and Survival in Squamous Cell Carcinoma Open
Figure S3. Increased expression of the CD8+ T-cell signature has a prognostic value for overall survival. (A and B) Kaplan-Meier estimates of overall survival among patients grouped according to expression of genes with the strongest membe…
View article: Table S3 from Upregulated Glucose Metabolism Correlates Inversely with CD8<sup>+</sup> T-cell Infiltration and Survival in Squamous Cell Carcinoma
Table S3 from Upregulated Glucose Metabolism Correlates Inversely with CD8<sup>+</sup> T-cell Infiltration and Survival in Squamous Cell Carcinoma Open
Table S3. Complete list of identified modules in the SCC consensus network and their top GO Biological Process category.
View article: Data from PD-1 Blockade and CD27 Stimulation Activate Distinct Transcriptional Programs That Synergize for CD8<sup>+</sup> T-Cell–Driven Antitumor Immunity
Data from PD-1 Blockade and CD27 Stimulation Activate Distinct Transcriptional Programs That Synergize for CD8<sup>+</sup> T-Cell–Driven Antitumor Immunity Open
Purpose: PD-1 checkpoint blockade has revolutionized the field of cancer immunotherapy, yet the frequency of responding patients is limited by inadequate T-cell priming secondary to a paucity of activatory dendritic cells (DC). DC s…
View article: Table S1 from PD-1 Blockade and CD27 Stimulation Activate Distinct Transcriptional Programs That Synergize for CD8<sup>+</sup> T-Cell–Driven Antitumor Immunity
Table S1 from PD-1 Blockade and CD27 Stimulation Activate Distinct Transcriptional Programs That Synergize for CD8<sup>+</sup> T-Cell–Driven Antitumor Immunity Open
List of genes represented in the heatmap
View article: Table S2 from PD-1 Blockade and CD27 Stimulation Activate Distinct Transcriptional Programs That Synergize for CD8<sup>+</sup> T-Cell–Driven Antitumor Immunity
Table S2 from PD-1 Blockade and CD27 Stimulation Activate Distinct Transcriptional Programs That Synergize for CD8<sup>+</sup> T-Cell–Driven Antitumor Immunity Open
List of genes in clusters 3 and 4 with the greatest fold-changes between monotherapy and combination therapy groups
View article: Supplementary Figures 1-6, Supplementary Tables 1-2 from Targeting Carcinoembryonic Antigen with DNA Vaccination: On-Target Adverse Events Link with Immunologic and Clinical Outcomes
Supplementary Figures 1-6, Supplementary Tables 1-2 from Targeting Carcinoembryonic Antigen with DNA Vaccination: On-Target Adverse Events Link with Immunologic and Clinical Outcomes Open
Supplementary Figure S1: Detection of CAP-1-specific T-cells Supplementary Figure S2: Effect of CAP-1-specific responses on OS Supplementary Figure S3: Effect of tumor load on vaccine-induced responses Supplementary Figure S4: Discovery of…
View article: Figure S1 from Upregulated Glucose Metabolism Correlates Inversely with CD8<sup>+</sup> T-cell Infiltration and Survival in Squamous Cell Carcinoma
Figure S1 from Upregulated Glucose Metabolism Correlates Inversely with CD8<sup>+</sup> T-cell Infiltration and Survival in Squamous Cell Carcinoma Open
Figure S1. Overview of workflow.
View article: Figure S2 from Upregulated Glucose Metabolism Correlates Inversely with CD8<sup>+</sup> T-cell Infiltration and Survival in Squamous Cell Carcinoma
Figure S2 from Upregulated Glucose Metabolism Correlates Inversely with CD8<sup>+</sup> T-cell Infiltration and Survival in Squamous Cell Carcinoma Open
Figure S2. Analysis of gene coexpression and eigengene relationships with overall survival. (A) Box-and-whisker plots of the Pearson correlation between a module gene's expression profile and the deviance residual, a measure of observed mi…
View article: Supplementary Figures 1-6, Supplementary Tables 1-2 from Targeting Carcinoembryonic Antigen with DNA Vaccination: On-Target Adverse Events Link with Immunologic and Clinical Outcomes
Supplementary Figures 1-6, Supplementary Tables 1-2 from Targeting Carcinoembryonic Antigen with DNA Vaccination: On-Target Adverse Events Link with Immunologic and Clinical Outcomes Open
Supplementary Figure S1: Detection of CAP-1-specific T-cells Supplementary Figure S2: Effect of CAP-1-specific responses on OS Supplementary Figure S3: Effect of tumor load on vaccine-induced responses Supplementary Figure S4: Discovery of…
View article: Table S3 from Upregulated Glucose Metabolism Correlates Inversely with CD8<sup>+</sup> T-cell Infiltration and Survival in Squamous Cell Carcinoma
Table S3 from Upregulated Glucose Metabolism Correlates Inversely with CD8<sup>+</sup> T-cell Infiltration and Survival in Squamous Cell Carcinoma Open
Table S3. Complete list of identified modules in the SCC consensus network and their top GO Biological Process category.
View article: Figure S4 from Upregulated Glucose Metabolism Correlates Inversely with CD8<sup>+</sup> T-cell Infiltration and Survival in Squamous Cell Carcinoma
Figure S4 from Upregulated Glucose Metabolism Correlates Inversely with CD8<sup>+</sup> T-cell Infiltration and Survival in Squamous Cell Carcinoma Open
Figure S4. Pathway and survival analysis of genes negatively associated with the leukocyte module (M1) eigengene. (A) Each module whose eigengene inversely correlated with ME1 were represented as a node connected to some of the top-ranked …
View article: Table S1 from PD-1 Blockade and CD27 Stimulation Activate Distinct Transcriptional Programs That Synergize for CD8<sup>+</sup> T-Cell–Driven Antitumor Immunity
Table S1 from PD-1 Blockade and CD27 Stimulation Activate Distinct Transcriptional Programs That Synergize for CD8<sup>+</sup> T-Cell–Driven Antitumor Immunity Open
List of genes represented in the heatmap
View article: Table S1 from Upregulated Glucose Metabolism Correlates Inversely with CD8<sup>+</sup> T-cell Infiltration and Survival in Squamous Cell Carcinoma
Table S1 from Upregulated Glucose Metabolism Correlates Inversely with CD8<sup>+</sup> T-cell Infiltration and Survival in Squamous Cell Carcinoma Open
Table S1. Complete list of identified modules in the HNSC network and their top GO Biological Process category.
View article: Figures S1-S5 from PD-1 Blockade and CD27 Stimulation Activate Distinct Transcriptional Programs That Synergize for CD8<sup>+</sup> T-Cell–Driven Antitumor Immunity
Figures S1-S5 from PD-1 Blockade and CD27 Stimulation Activate Distinct Transcriptional Programs That Synergize for CD8<sup>+</sup> T-Cell–Driven Antitumor Immunity Open
Figure S1: Agonist anti-CD27 is superior to other anti-TNFRSF mAbs for CD8+ T-cell expansion in vivo; Figure S2: Agonist anti-CD27 and PD-1/L1 blockade combine to promote expansion of OT-I T cells in response to high and low affinity pepti…