Stephen Maren
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View article: Hippocampal‐Prelimbic Coupling During Context‐Dependent Extinction Retrieval in Rats
Hippocampal‐Prelimbic Coupling During Context‐Dependent Extinction Retrieval in Rats Open
After fear conditioning, repeated presentation of the conditioned stimulus (CS) alone produces a context‐dependent extinction of learned fear. The hippocampus has a critical role in this process, but the mechanism by which contextual infor…
View article: Functional synaptic connectivity of engrafted spinal cord neurons with hindlimb motor circuitry in the injured spinal cord
Functional synaptic connectivity of engrafted spinal cord neurons with hindlimb motor circuitry in the injured spinal cord Open
Spinal cord injury (SCI) results in significant neurological deficits, and curative therapies are lacking. Neural progenitor cell (NPC) transplantation shows promise, as graft-derived neurons (GDNs) can integrate into host spinal cord and …
View article: Theta-paced stimulation of the thalamic nucleus reuniens entrains mPFC-HPC oscillations and facilitates the acquisition of extinction memories
Theta-paced stimulation of the thalamic nucleus reuniens entrains mPFC-HPC oscillations and facilitates the acquisition of extinction memories Open
This work suggests that the RE oscillatory activity is critical for the acquisition of extinction memories through the modulation of hippocampal-prefrontal network dynamics. In the future, RE theta-paced stimulation can be an important the…
View article: Locus Coeruleus-Amygdala Circuit Disrupts Prefrontal Control to Impair Fear Extinction
Locus Coeruleus-Amygdala Circuit Disrupts Prefrontal Control to Impair Fear Extinction Open
Background Stress undermines extinction learning and hinders exposure-based clinical therapies for a variety of neuropsychiatric disorders. In both animals and humans, dysfunction in the ventromedial prefrontal cortex (vmPFC) contributes t…
View article: Neural Representation of Associative Threat Learning in Pulvinar Divisions, Lateral Geniculate Nucleus, and Mediodorsal Thalamus in Humans
Neural Representation of Associative Threat Learning in Pulvinar Divisions, Lateral Geniculate Nucleus, and Mediodorsal Thalamus in Humans Open
Understanding the neural mechanisms underlying associative threat learning is essential for advancing behavioral models of threat and adaptation. We investigated distinct activation patterns across thalamic pulvinar divisions, lateral geni…
View article: The Beckman legacy and the future of interdisciplinary research
The Beckman legacy and the future of interdisciplinary research Open
The Beckman Institute for Advanced Science of Technology at the University of Illinois Urbana-Champaign was established in 1989 with the generous support of the Arnold and Mabel Beckman Foundation. It was built to break through disciplinar…
View article: Neural Representation of Associative Threat Learning in Pulvinar Divisions, Lateral Geniculate Nucleus, and Mediodorsal Thalamus in Humans
Neural Representation of Associative Threat Learning in Pulvinar Divisions, Lateral Geniculate Nucleus, and Mediodorsal Thalamus in Humans Open
Understanding the neural mechanisms underlying associative threat learning is essential for advancing behavioral models of threat and adaptation. We investigated distinct activation patterns across thalamic pulvinar divisions, lateral geni…
View article: Theta-paced stimulation of the thalamic nucleus reuniens entrains mPFC-HPC oscillations and facilitates the acquisition of extinction memories
Theta-paced stimulation of the thalamic nucleus reuniens entrains mPFC-HPC oscillations and facilitates the acquisition of extinction memories Open
Background The nucleus reuniens (RE) is a midline thalamic nucleus interconnecting the medial prefrontal cortex (mPFC) and the hippocampus (HPC), structures known to be involved in aversive memory processes. Recent work indicates that the …
View article: Associative coding of conditioned fear in the thalamic nucleus reuniens in rodents and humans
Associative coding of conditioned fear in the thalamic nucleus reuniens in rodents and humans Open
The nucleus reuniens (RE) is a midline thalamic structure interconnecting the medial prefrontal cortex (mPFC) and the hippocampus (HPC). Recent work in both rodents and humans implicates the RE in the adaptive regulation of emotional memor…
View article: Neural Representation of Associative Threat Learning in Pulvinar Divisions, Lateral Geniculate Nucleus, and Mediodorsal Thalamus in Humans
Neural Representation of Associative Threat Learning in Pulvinar Divisions, Lateral Geniculate Nucleus, and Mediodorsal Thalamus in Humans Open
Understanding the neural mechanisms underlying associative threat learning is essential for advancing behavioral models of threat and adaptation. We investigated distinct activation patterns across thalamic pulvinar divisions, lateral geni…
View article: Hippocampal ensembles regulate circuit-induced relapse of extinguished fear
Hippocampal ensembles regulate circuit-induced relapse of extinguished fear Open
Extinction learning is central to behavioral therapies for post-traumatic stress disorder (PTSD), but relapse poses a major challenge to this approach. Recent work has revealed a critical role for the thalamic nucleus reuniens (RE) in the …
View article: Hippocampal-prelimbic coupling during context-dependent extinction retrieval in rats
Hippocampal-prelimbic coupling during context-dependent extinction retrieval in rats Open
After fear conditioning, repeated presentation of the conditioned stimulus (CS) alone produces a context-dependent extinction of learned fear. The hippocampus has a critical role in this process, but the mechanism by which contextual infor…
View article: Functional synaptic connectivity of engrafted spinal cord neurons with locomotor circuitry in the injured spinal cord
Functional synaptic connectivity of engrafted spinal cord neurons with locomotor circuitry in the injured spinal cord Open
Spinal cord injury (SCI) results in significant neurological deficits, with no currently available curative therapies. Neural progenitor cell (NPC) transplantation has emerged as a promising approach for neural repair, as graft-derived neu…
View article: Associative coding of conditioned fear in the thalamic nucleus reuniens in rodents and humans
Associative coding of conditioned fear in the thalamic nucleus reuniens in rodents and humans Open
The nucleus reuniens (RE) is a midline thalamic structure interconnecting the medial prefrontal cortex (mPFC) and the hippocampus (HPC). Recent work in both rodents and humans implicates the RE in the adaptive regulation of emotional memor…
View article: Acute stress yields a sex-dependent facilitation of signaled active avoidance in rats
Acute stress yields a sex-dependent facilitation of signaled active avoidance in rats Open
Post-traumatic stress disorder (PTSD) is a debilitating disorder characterized by excessive fear, hypervigilance, and avoidance of thoughts, situations or reminders of the trauma. Among these symptoms, relatively little is known about the …
View article: Pharmacological stimulation of infralimbic cortex after fear conditioning facilitates subsequent fear extinction
Pharmacological stimulation of infralimbic cortex after fear conditioning facilitates subsequent fear extinction Open
The infralimbic (IL) division of the medial prefrontal cortex (mPFC) is a crucial site for extinction of conditioned fear memories in rodents. Recent work suggests that neuronal plasticity in the IL that occurs during (or soon after) fear …
View article: Ventral hippocampus mediates inter-trial responding in signaled active avoidance
Ventral hippocampus mediates inter-trial responding in signaled active avoidance Open
The hippocampus has a central role in regulating contextual processes in memory. We have shown that pharmacological inactivation of ventral hippocampus (VH) attenuates the context-dependence of signaled active avoidance (SAA) in rats. Here…
View article: Neural circuits for the adaptive regulation of fear and extinction memory
Neural circuits for the adaptive regulation of fear and extinction memory Open
The regulation of fear memories is critical for adaptive behaviors and dysregulation of these processes is implicated in trauma- and stress-related disorders. Treatments for these disorders include pharmacological interventions as well as …
View article: Parvalbumin-Positive Interneurons in the Medial Prefrontal Cortex Regulate Stress-Induced Fear Extinction Impairments in Male and Female Rats
Parvalbumin-Positive Interneurons in the Medial Prefrontal Cortex Regulate Stress-Induced Fear Extinction Impairments in Male and Female Rats Open
Stress has profound effects on fear extinction, a form of learning that is essential to behavioral therapies for trauma-related and stressor-related disorders. Recent work reveals that acute footshock stress reduces medial prefrontal corte…
View article: Thalamic nucleus reuniens coordinates prefrontal-hippocampal synchrony to suppress extinguished fear
Thalamic nucleus reuniens coordinates prefrontal-hippocampal synchrony to suppress extinguished fear Open
Traumatic events result in vivid and enduring fear memories. Suppressing the retrieval of these memories is central to behavioral therapies for pathological fear. The medial prefrontal cortex (mPFC) and hippocampus (HPC) have been implicat…
View article: Basal forebrain cholinergic signaling in the basolateral amygdala promotes strength and durability of fear memories
Basal forebrain cholinergic signaling in the basolateral amygdala promotes strength and durability of fear memories Open
The basolateral amygdala (BLA) complex receives dense cholinergic projections from the nucleus basalis of Meynert (NBM) and the horizontal limb of the diagonal band of Broca (HDB). The present experiments examined whether these projections…
View article: Nucleus reuniens inactivation does not impair consolidation or reconsolidation of fear extinction
Nucleus reuniens inactivation does not impair consolidation or reconsolidation of fear extinction Open
Recent data reveal that the thalamic nucleus reuniens (RE) has a critical role in the extinction of conditioned fear. Muscimol (MUS) infusions into the RE impair within-session extinction of conditioned freezing and result in poor long-ter…