Explanipedia

Venous Thromboembolic Events in Cancer Immunotherapy: A Narrative Review Open

Cosmo Fowler, Stephen M. Pastores · 2025

Venous thromboembolism (VTE) represents a significant complication of cancer immunotherapy, with emerging evidence suggesting distinct pathophysiological mechanisms compared to traditional chemotherapy-associated thrombosis. This narrative…

1104 Obstructive Sleep Apnea Is Associated with a Higher Incidence of Venous Thromboembolism After Total Hip Arthroplasty Open

Cosmo Fowler, Abdulhakim Tlimat, Donald L. Bliwise, Nancy A. Collop, Stephen M. Pastores , et al. · 2025

Introduction Obstructive sleep apnea (OSA) is a prevalent condition that is strongly associated with cardiovascular comorbidities and has been shown to predict poor outcomes in the post-surgical population. Assessing the independent effect…

Adverse Effects Related to Corticosteroid Use in Sepsis, Acute Respiratory Distress Syndrome, and Community-Acquired Pneumonia: A Systematic Review and Meta-Analysis Open

Dipayan Chaudhuri, Lori Israelian, Zbigniew Putowski, Jay Prakash, Tyler Pitre , et al. · 2024

OBJECTIVES: We postulate that corticosteroid-related side effects in critically ill patients are similar across sepsis, acute respiratory distress syndrome (ARDS), and community-acquired pneumonia (CAP). By pooling data across all trials t…

EMPOWER: A Multi-Site Pilot Trial to Reduce Distress in Surrogate Decision-Makers in the ICU Open

Wendy G. Lichtenthal, Lindsay Lief, Madeline Rogers, David Russell, Martin Viola , et al. · 2024

Tranexamic Acid in Upper Gastrointestinal Bleeding is Associated With Venous and Arterial Thromboembolic Events Open

Cosmo Fowler, Jason Nasser, Brittany Fera, Lauren Chism, Stephen M. Pastores · 2024

OBJECTIVES: To determine the risk difference of arterial and venous thromboembolic events between patients with upper gastrointestinal bleeding (UGIB) who received and did not receive tranexamic acid. DESIGN: Retrospective cohort study. SE…

Corticosteroids in Sepsis and Septic Shock: A Systematic Review, Pairwise, and Dose-Response Meta-Analysis Open

Tyler Pitre, Katherine Drover, Dipayan Chaudhuri, Dena Zeraaktkar, Kusum Menon , et al. · 2024

OBJECTIVES: To perform a systematic review and meta-analysis to assess the efficacy and safety of corticosteroids in patients with sepsis. DATA SOURCES: We searched PubMed, Embase, and the Cochrane Library, up to January 10, 2023. STUDY SE…

CARDIAC IMMUNE-RELATED ADVERSE EVENTS IN LUNG CANCER PATIENTS RECEIVING IMMUNE CHECKPOINT INHIBITORS Open

Sany Kumar, Cosmo Fowler, Ajit Thota, Stephen M. Pastores · 2023

POSTSURGICAL VASCULAR OUTCOMES AND THEIR ASSOCIATION WITH OBSTRUCTIVE SLEEP APNEA: RESULTS FROM A NATIONAL COHORT Open

Cosmo Fowler, Lauren Chism, Stephen M. Pastores, Dennis Auckley · 2023

TRACHEOSTOMY IN CANCER PATIENTS ADMITTED TO THE ICU: EXPERIENCE FROM A COMPREHENSIVE CANCER CENTER Open

Sany Kumar, Ajit Thota, COSMO FOWLER, KELLY HUANG, KATE D. TAYBAN , et al. · 2023

VASCULAR TOXICITIES OF IMMUNE CHECKPOINT INHIBITOR THERAPIES IN LUNG CANCER: A NATIONWIDE SURVEY Open

Cosmo Fowler, Lauren Chism, Sany Kumar, Ajit Thota, Stephen M. Pastores · 2023

Feasibility Assessment of a Biomarker-Guided Kidney-Sparing Sepsis Bundle: The Limiting Acute Kidney Injury Progression In Sepsis Trial Open

Hernando Gómez, Alexander Zarbock, Stephen M. Pastores, György Frendl, Sven Bercker , et al. · 2023

OBJECTIVES: To determine the feasibility, safety, and efficacy of a biomarker-guided implementation of a kidney-sparing sepsis bundle (KSSB) of care in comparison with standard of care (SOC) on clinical outcomes in patients with sepsis. DE…

Gender, Race, and Ethnicity in Critical Care Fellowship Programs in the United States From 2016 to 2021 Open

Stephen M. Pastores, Natalie Kostelecky, Hao Zhang · 2023

IMPORTANCE: A diverse and inclusive critical care workforce is vital to the provision of culturally appropriate and effective care to critically ill patients of all backgrounds. OBJECTIVES: The purpose of this study is to determine the tre…

Flow-Sizing Critical Care Resources* Open

Joseph L. Nates, John M. Oropello, Neeraj Badjatia, Gregory J. Beilman, Craig M. Coopersmith , et al. · 2023

OBJECTIVES: To describe the factors affecting critical care capacity and how critical care organizations (CCOs) within academic centers in the U.S. flow-size critical care resources under normal operations, strain, and surge conditions. DA…

Disseminated intravascular coagulation after cryoablation for metastatic pancreatic cancer: a case report Open

Alina Dulu, Yekaterina Tayban, Joanne Delaleu, F. Cornélis, Stephen M. Pastores · 2023

DIC is an unusual but life-threatening complication of advanced pancreatic cancer.

Corticosteroids in Community-Acquired Bacterial Pneumonia: a Systematic Review, Pairwise and Dose-Response Meta-Analysis Open

Tyler Pitre, Daniyal Abdali, Dipayan Chaudhuri, Stephen M. Pastores, Andrea M. Nei , et al. · 2023

Graduates of a Multidisciplinary Critical Care Training Program from 2000 to 2020: Looking at Their First Job Open

Stephen M. Pastores, Natalie Kostelecky, Neil A. Halpern · 2022

The majority of CCM fellowship graduates from our program practiced CCM at community teaching hospitals, rounded in multiple ICUs, and were compensated primarily by the hospital.

Steroids in the acutely ill: Evolving recommendations and practice Open

Stephen M. Pastores · 2022

Critical illness-related corticosteroid insufficiency (CIRCI) is a state of systemic inflammation involving dysregulation of the hypothalamic-pituitary-adrenal axis, altered cortisol metabolism, and tissue resistance to corticosteroids. Ma…

Analysis of Intent and Reason for Oncologic Therapy Administration in Cancer Patients Admitted to the Intensive Care Unit Open

David Shaz, Stephen M. Pastores, Lokesh Dayal, Justin Berkowitz, Natalie Kostelecky , et al. · 2021

Purpose To investigate the intent of, and reason for, administration of oncologic therapies in the intensive care unit (ICU). Methods Single center, retrospective, cohort study of patients with cancer who received oncologic therapies at a …

Discharge prescribing of enteral opioids in opioid naïve patients following non-surgical intensive care: A retrospective cohort study Open

Luis Tollinche, Kenneth Seier, Gloria Yang, Kay See Tan, Yekaterina Tayban , et al. · 2021

ESOPHAGEAL FISTULA AND SYNCOPE: A CASE OF CARDIAC TAMPONADE AFTER AN ESOPHAGOGASTRODUODENOSCOPY Open

Leslie Kao, Bahaadin Al-Jarani, Stephen M. Pastores, ZUHAIR SALAH · 2021

SEVERE REFRACTORY IMMUNE THROMBOCYTOPENIA IN AN ONCOLOGY PATIENT WITH COVID-19: RARE BUT FATAL! Open

Alina Dulu, Stephen M. Pastores, Katherine Silvey, Kate Tayban · 2021

A VERY PROLONGED AND ULTIMATELY FATAL COURSE OF COVID-19 IN A PATIENT WITH LYMPHOMA Open

Alina Dulu, Kate Tayban, Anna Ford, Stephen M. Pastores · 2021

A MATTER OF PERCEPTION: IMPACT OF COVID-19 PANDEMIC ON TRAINEE PROCEDURAL COMPETENCY IN THE ICU Open

Saamia Hossain, Stephen M. Pastores · 2021

Clinical Characteristics, Management, and Outcomes of Cancer Patients With Coronavirus Disease 2019 Admitted to the ICU Open

Michael K. M. Dang, Isha Bhatt, Alina Dulu, Hao Zhang, Natalie Kostelecky , et al. · 2021

OBJECTIVES: Adult patients with cancer have a greater likelihood of developing severe illness and death from coronavirus disease 2019 compared with patients without cancer. We sought to characterize the clinical characteristics and outcome…

Bursting at the Seams: Barotrauma in Coronavirus Disease 2019 Acute Respiratory Distress Syndrome Patients* Open

Saamia Hossain, Stephen M. Pastores · 2021

1 Critical Care Center, Department of Anesthesiology and Critical Care Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 2 Weill Cornell Medical College, New York, NY *See also p. 491. The authors have disclosed that they do n…

Critically ill patients with severe immune checkpoint inhibitor related neurotoxicity: A multi-center case series Open

Prabalini Rajendram, Heather Torbic, Abhijit Duggal, Jeanneé Campbell, Michael Hovden , et al. · 2021

Angiotensin-II to the Rescue: Assessing Angiotensin-II in Cancer Patients with Refractory Septic Shock Open

Kevin Lazo, Ji Can Yang, Stephen M. Pastores · 2021

Corticosteroids in COVID-19 and non-COVID-19 ARDS: a systematic review and meta-analysis Open

Dipayan Chaudhuri, Kiyoka Sasaki, Aram Karkar, Sameer Sharif, Kimberly Lewis , et al. · 2021

Oncologic immunomodulatory agents in patients with cancer and COVID-19 Open

Justin Jee, Aaron J. Stonestrom, Sean M. Devlin, Teresa Nguyentran, Beatriz Wills , et al. · 2021

Toxic ‘Toxo’ in the heart: Cardiac toxoplasmosis following a hematopoietic stem cell transplant- a case report Open

Padmastuti Akella, Isha Bhatt, Mustapha Serhan, Dilip D. Giri, Stephen M. Pastores · 2021

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