Stephen Meek
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View article: The cow udder is a potential mixing vessel for influenza A viruses
The cow udder is a potential mixing vessel for influenza A viruses Open
The incursion of high pathogenicity avian influenza A virus (IAV) into US dairy cows is unprecedented in the era of molecular diagnosis and pathogen sequencing. This raises questions over the likelihood of further outbreaks and whether dai…
View article: Redundancy of p75NTR neurotrophin receptor function in development, growth and fertility in the rat
Redundancy of p75NTR neurotrophin receptor function in development, growth and fertility in the rat Open
The p75NTR neurotrophin receptor has positive and negative roles regulating cell survival in the nervous system. Unambiguous interpretation of p75NTR function in vivo has been complicated, however, by residual expression of alternate forms…
View article: MeCP2 binds to methylated DNA independently of phase separation and heterochromatin organisation
MeCP2 binds to methylated DNA independently of phase separation and heterochromatin organisation Open
Correlative evidence has suggested that the methyl-CpG-binding protein MeCP2 contributes to the formation of heterochromatin condensates via liquid-liquid phase separation. This interpretation has been reinforced by the observation that he…
View article: <i>p75NTR</i>neurotrophin receptor function is redundant for development, growth and fertility in the rat
<i>p75NTR</i>neurotrophin receptor function is redundant for development, growth and fertility in the rat Open
The p75NTR neurotrophin receptor has positive and negative roles regulating cell survival in the nervous system. Unambiguous interpretation of p75NTR function in vivo has been complicated, however, by residual expression of alternate forms…
View article: MeCP2 binds to methylated DNA independently of phase separation and heterochromatin organisation
MeCP2 binds to methylated DNA independently of phase separation and heterochromatin organisation Open
Correlative evidence has suggested that DNA methylation promotes the formation of transcriptionally silent heterochromatin. Accordingly, the methyl-CpG binding domain protein MeCP2 is often portrayed as a constituent of heterochromatin. Th…
View article: Stem cell-derived porcine macrophages as a new platform for studying host-pathogen interactions
Stem cell-derived porcine macrophages as a new platform for studying host-pathogen interactions Open
View article: Stem cell-derived macrophages as a new platform for studying host-pathogen interactions in livestock
Stem cell-derived macrophages as a new platform for studying host-pathogen interactions in livestock Open
Infectious diseases of farmed and wild animals pose a recurrent threat to food security and human health. The macrophage, a key component of the innate immune system, is the first line of defence against many infectious agents and plays a …
View article: Modulation of APLNR Signaling Is Required during the Development and Maintenance of the Hematopoietic System
Modulation of APLNR Signaling Is Required during the Development and Maintenance of the Hematopoietic System Open
View article: Hypoxanthine phosphoribosyltransferase (HPRT)‐deficiency is associated with impaired fertility in the female rat
Hypoxanthine phosphoribosyltransferase (HPRT)‐deficiency is associated with impaired fertility in the female rat Open
The purine hypoxanthine plays important role in regulating oocyte maturation and early embryonic development. The enzyme hypoxanthine phosphoribosyltransferase (HPRT) recycles hypoxanthine to generate substrates for nucleotide synthesis an…
View article: Modulation of Aplnr signaling is required during the development and maintenance of the hematopoietic system
Modulation of Aplnr signaling is required during the development and maintenance of the hematopoietic system Open
Apelin receptor (Aplnr/Agtrl1/Apj) marks a transient cell population during the differentiation of hematopoietic progenitor cells (HPCs) from pluripotent stem cells but the function of this signalling pathway during hematopoietic developme…
View article: A Stem Cell Reporter for Investigating Pluripotency and Self-Renewal in the Rat
A Stem Cell Reporter for Investigating Pluripotency and Self-Renewal in the Rat Open
Rat embryonic stem cells (rESCs) are capable of contributing to all differentiated tissues, including the germ line in chimeric animals, and represent a unique, authentic alternative to mouse embryonic stem cells for studying stem cell plu…
View article: Correction: Pleiotropic Impacts of Macrophage and Microglial Deficiency on Development in Rats with Targeted Mutation of the <i>Csf1r</i> Locus
Correction: Pleiotropic Impacts of Macrophage and Microglial Deficiency on Development in Rats with Targeted Mutation of the <i>Csf1r</i> Locus Open
In the analysis of gene expression in the brain, the sample labels for the pituitary gland and olfactory bulb were reversed. As a consequence, the clusters in Fig. 10B were mislabeled. A corrected version of Fig. 10 is shown below, along w…
View article: A novel approach to differentiate rat embryonic stem cells in vitro reveals a role for RNF12 in activation of X chromosome inactivation
A novel approach to differentiate rat embryonic stem cells in vitro reveals a role for RNF12 in activation of X chromosome inactivation Open
View article: Single cell transcriptional profiling of rat embryonic stem cells defined by Rex1-EGFP reporter expression
Single cell transcriptional profiling of rat embryonic stem cells defined by Rex1-EGFP reporter expression Open
Rat embryonic stem cells exhibit basal levels of spontaneous differentiation in 2i+LIF (2iL) culture. Expression of a stem cell specific Rex1-EGFP knock-in reporter transgene in rat ESCs was used to isolate functionally distinct subsets of…
View article: Pleiotropic Impacts of Macrophage and Microglial Deficiency on Development in Rats with Targeted Mutation of the <i>Csf1r</i> Locus
Pleiotropic Impacts of Macrophage and Microglial Deficiency on Development in Rats with Targeted Mutation of the <i>Csf1r</i> Locus Open
We have produced Csf1r-deficient rats by homologous recombination in embryonic stem cells. Consistent with the role of Csf1r in macrophage differentiation, there was a loss of peripheral blood monocytes, microglia in the brain, epidermal L…
View article: LIF-dependent survival of embryonic stem cells is regulated by a novel palmitoylated Gab1 signalling protein
LIF-dependent survival of embryonic stem cells is regulated by a novel palmitoylated Gab1 signalling protein Open
The cytokine leukaemia inhibitory factor (LIF) promotes self-renewal of mouse embryonic stem cells (ESCs) through activation of the transcription factor Stat3. However, the contribution of other ancillary pathways stimulated by LIF in ESCs…
View article: From engineering to editing the rat genome
From engineering to editing the rat genome Open
View article: Reduced levels of dopamine and altered metabolism in brains of HPRT knock-out rats: a new rodent model of Lesch-Nyhan Disease
Reduced levels of dopamine and altered metabolism in brains of HPRT knock-out rats: a new rodent model of Lesch-Nyhan Disease Open
Lesch-Nyhan disease (LND) is a severe neurological disorder caused by loss-of-function mutations in the gene encoding hypoxanthine phosphoribosyltransferase (HPRT), an enzyme required for efficient recycling of purine nucleotides. Although…