Stephen Meisburger
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View article: Examining <i>E.coli</i> aspartate transcarbamoylase with high-pressure crystallography
Examining <i>E.coli</i> aspartate transcarbamoylase with high-pressure crystallography Open
Many key biochemical pathways are regulated allosterically. High-resolution structure determination using macromolecular X-ray crystallography (MX) is a powerful method to elucidate allosteric mechanisms. However, a key limitation of MX is…
View article: Determining the Mechanism of DJ-1 Using Mix-and-Inject Synchrotron Serial Crystallography
Determining the Mechanism of DJ-1 Using Mix-and-Inject Synchrotron Serial Crystallography Open
Determining the molecular basis of enzyme catalytic activity is a central challenge in biochemistry. Time-resolved serial X-ray crystallography using X-ray free electron (XFELs) and synchrotron sources allows enzyme reactions to be observe…