Stephen N. Gomperts
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View article: Towards optimizing the diagnosis of Lewy body dementia: Lessons from the NACC
Towards optimizing the diagnosis of Lewy body dementia: Lessons from the NACC Open
INTRODUCTION The diverse presentations and co‐pathologies of Lewy body dementia (LBD) present a diagnostic challenge. Utilizing the National Alzheimer's Coordinating Center (NACC) dataset, this study aimed to evaluate the concordance of pr…
View article: <i>APOE</i> ε4 linked effects on clinical features and neuropathology in dementia with Lewy bodies
<i>APOE</i> ε4 linked effects on clinical features and neuropathology in dementia with Lewy bodies Open
INTRODUCTION Apolipoprotein E ( APOE ) ε4 is a strong genetic risk factor for Alzheimer's disease (AD) neuropathologic changes, but its contribution to clinical features and pathology in dementia with Lewy bodies (DLB) is less clear. METHO…
View article: Imaging brain class I histone deacetylase changes in the Lewy body dementias and Parkinson’s disease
Imaging brain class I histone deacetylase changes in the Lewy body dementias and Parkinson’s disease Open
Background: Histone deacetylases (HDACs) are epigenetic molecules responsible for regulation of gene transcription. Altered expression of HDACs has been linked to neurodegenerative disease. Here, we used the class I HDAC PET radioligand [<…
View article: Exercise and Smoking: Yin and Yang Sharing Protective Power for Parkinson’s?
Exercise and Smoking: Yin and Yang Sharing Protective Power for Parkinson’s? Open
Compelling epidemiological evidence suggests that exercise and smoking are modifiable risk factors that are linked to a reduced risk of Parkinson’s disease, possibly because they both exert protective effects on neurodegeneration. Like Yin…
View article: Impaired hippocampal circuit function underlying memory encoding and consolidation precede robust Aβ deposition in a mouse model of alzheimer’s disease
Impaired hippocampal circuit function underlying memory encoding and consolidation precede robust Aβ deposition in a mouse model of alzheimer’s disease Open
View article: Plasma Phosphorylated <scp>Tau181</scp> as a Biomarker for Alzheimer's Disease Co‐Pathology in Lewy Body Disease
Plasma Phosphorylated <span>Tau181</span> as a Biomarker for Alzheimer's Disease Co‐Pathology in Lewy Body Disease Open
Background Plasma phosphorylated tau181 (pTau181) is proving to be a useful predictor of Alzheimer's disease (AD). AD co‐pathology is frequently observed across the Lewy body disease (LBD) spectrum. Objective To determine whether pTau181 i…
View article: Automated Imaging Differentiation for Parkinsonism
Automated Imaging Differentiation for Parkinsonism Open
Importance Magnetic resonance imaging (MRI) paired with appropriate disease-specific machine learning holds promise for the clinical differentiation of Parkinson disease (PD), multiple system atrophy (MSA) parkinsonian variant, and progres…
View article: Association of sleep network functional connectivity with hyperexcitability and cognition in Alzheimer’s disease
Association of sleep network functional connectivity with hyperexcitability and cognition in Alzheimer’s disease Open
Background Sleep disturbances are common in Alzheimer's disease (AD) and occur at early stages. Hyperexcitability also arises during sleep and can lead to epileptiform activity and seizures that impact memory consolidation. The underlying …
View article: Optogenetic targeting of cortical astrocytes selectively improves NREM sleep in an Alzheimer’s disease mouse model
Optogenetic targeting of cortical astrocytes selectively improves NREM sleep in an Alzheimer’s disease mouse model Open
Alzheimer's disease (AD) is a progressive neurodegenerative condition marked by memory impairments and distinct histopathological features such as amyloid-beta (Aβ) accumulations. Alzheimer's patients experience sleep disturbances at early…
View article: The association between cigarette smoking and dementia with Lewy bodies
The association between cigarette smoking and dementia with Lewy bodies Open
View article: Neuroprotection of low dose carbon monoxide in Parkinson’s disease models commensurate with the reduced risk of Parkinson’s among smokers
Neuroprotection of low dose carbon monoxide in Parkinson’s disease models commensurate with the reduced risk of Parkinson’s among smokers Open
Paradoxically, cigarette smoking is associated with a reduced risk of Parkinson's Disease (PD). This led us to hypothesize that carbon monoxide (CO) levels, which are constitutively but modestly elevated in smokers, might contribute to neu…
View article: Development of a New Positron Emission Tomography Imaging Radioligand Targeting RIPK1 in the Brain and Characterization in Alzheimer's Disease
Development of a New Positron Emission Tomography Imaging Radioligand Targeting RIPK1 in the Brain and Characterization in Alzheimer's Disease Open
Targeting receptor‐interacting protein kinase 1 (RIPK1) has emerged as a promising therapeutic stratagem for neurodegenerative disorders, particularly Alzheimer's disease (AD). A positron emission tomography (PET) probe enabling brain RIPK…
View article: Impaired hippocampal circuit function underlying memory encoding and consolidation precede robust Aβ deposition in a mouse model of Alzheimer’s disease
Impaired hippocampal circuit function underlying memory encoding and consolidation precede robust Aβ deposition in a mouse model of Alzheimer’s disease Open
Current therapeutic strategies for Alzheimer’s disease (AD) target amyloid-beta (Aβ) fibrils and high molecular weight protofibrils associated with plaques, but molecular cascades associated with AD may drive neural systems failure before …
View article: Differential Vulnerability of Hippocampal Subfields to Amyloid and Tau Deposition in the Lewy Body Diseases
Differential Vulnerability of Hippocampal Subfields to Amyloid and Tau Deposition in the Lewy Body Diseases Open
In LBD, volume loss in hippocampal output subregions-particularly the subiculum-is associated with functional cognition and AD-related deposits. Tau deposition appears to accelerate subiculum and CA1 atrophy, whereas Aβ does not. Subiculum…
View article: Sleep functional connectivity, hyperexcitability, and cognition in Alzheimer's disease
Sleep functional connectivity, hyperexcitability, and cognition in Alzheimer's disease Open
INTRODUCTION Sleep disturbances are common in Alzheimer's disease (AD) and may reflect pathologic changes in brain networks. To date, no studies have examined changes in sleep functional connectivity (FC) in AD or their relationship with n…
View article: Cellular resolution contributions to ictal population signals
Cellular resolution contributions to ictal population signals Open
Objective The increased amplitude of ictal activity is a common feature of epileptic seizures, but the determinants of this amplitude have not been identified. Clinically, ictal amplitudes are measured electrographically (using, e.g., elec…
View article: Lewy body dementia: Overcoming barriers and identifying solutions
Lewy body dementia: Overcoming barriers and identifying solutions Open
Despite its high prevalence among dementias, Lewy body dementia (LBD) remains poorly understood with a limited, albeit growing, evidence base. The public‐health burden that LBD imposes is worsened by overlapping pathologies, which contribu…
View article: Clearing the Smoke: What Protects Smokers from Parkinson's Disease?
Clearing the Smoke: What Protects Smokers from Parkinson's Disease? Open
The link between smoking and a lower risk of Parkinson's disease (PD) is one of the strongest environmental or lifestyle associations in neuroepidemiology. Growing evidence supports the hypothesis that the association is based on a neuropr…
View article: Health phenome of Parkinson’s patients reveals prominent mood-sleep cluster
Health phenome of Parkinson’s patients reveals prominent mood-sleep cluster Open
Background: Associations between phenotypic traits, environmental exposures, and Parkinson’s disease have largely been evaluated one-by-one, piecemeal, and pre-selections. A comprehensive picture of comorbidities, phenotypes, exposures, an…
View article: Sleep restoration by optogenetic targeting of GABAergic neurons reprograms microglia and ameliorates pathological phenotypes in an Alzheimer’s disease model
Sleep restoration by optogenetic targeting of GABAergic neurons reprograms microglia and ameliorates pathological phenotypes in an Alzheimer’s disease model Open
View article: Association of Plasma Phosphorylated Tau With the Response to Neflamapimod Treatment in Patients With Dementia With Lewy Bodies
Association of Plasma Phosphorylated Tau With the Response to Neflamapimod Treatment in Patients With Dementia With Lewy Bodies Open
NCT04001517 at ClinicalTrials.gov.
View article: Optogenetic targeting of astrocytes restores slow brain rhythm function and slows Alzheimer’s disease pathology
Optogenetic targeting of astrocytes restores slow brain rhythm function and slows Alzheimer’s disease pathology Open
Patients with Alzheimer’s disease (AD) exhibit non-rapid eye movement (NREM) sleep disturbances in addition to memory deficits. Disruption of NREM slow waves occurs early in the disease progression and is recapitulated in transgenic mouse …
View article: Neuroprotection of low dose carbon monoxide in Parkinson’s disease models commensurate with the reduced risk of Parkinson’s among smokers
Neuroprotection of low dose carbon monoxide in Parkinson’s disease models commensurate with the reduced risk of Parkinson’s among smokers Open
Paradoxically, cigarette smoking is associated with a reduced risk of Parkinson’s disease (PD). This led us to hypothesize that carbon monoxide (CO) levels, which are constitutively but modestly elevated in smokers, might contribute to neu…
View article: Optogenetic Targeting of Astrocytes Restores Slow Brain Rhythm Function and Slows Alzheimer’s Disease Pathology
Optogenetic Targeting of Astrocytes Restores Slow Brain Rhythm Function and Slows Alzheimer’s Disease Pathology Open
Patients with Alzheimer’s disease (AD) exhibit non-rapid eye movement (NREM) sleep disturbances in addition to memory deficits. Disruption of NREM slow waves occurs early in the disease progression and is recapitulated in transgenic mouse …
View article: EEG Entropy in REM Sleep as a Physiologic Biomarker in Early Clinical Stages of Alzheimer’s Disease
EEG Entropy in REM Sleep as a Physiologic Biomarker in Early Clinical Stages of Alzheimer’s Disease Open
Background: Alzheimer’s disease (AD) is associated with EEG changes across the sleep-wake cycle. As the brain is a non-linear system, non-linear EEG features across behavioral states may provide an informative physiologic biomarker of AD. …
View article: Additional file 1 of Sleep restoration by optogenetic targeting of GABAergic neurons reprograms microglia and ameliorates pathological phenotypes in an Alzheimer’s disease model
Additional file 1 of Sleep restoration by optogenetic targeting of GABAergic neurons reprograms microglia and ameliorates pathological phenotypes in an Alzheimer’s disease model Open
Supplementary Material 1: Table S1. Supplemental Statistical Analysis
View article: Disruption of hippocampal neuronal circuit function depends upon behavioral state in the APP/PS1 mouse model of Alzheimer’s disease
Disruption of hippocampal neuronal circuit function depends upon behavioral state in the APP/PS1 mouse model of Alzheimer’s disease Open
The Alzheimer’s disease-associated peptide amyloid-beta (Aβ) has been associated with neuronal hyperactivity under anesthesia, but clinical trials of anticonvulsants or neural system suppressors have, so far, failed to improve symptoms in …
View article: Preclinical and randomized clinical evaluation of the p38α kinase inhibitor neflamapimod for basal forebrain cholinergic degeneration
Preclinical and randomized clinical evaluation of the p38α kinase inhibitor neflamapimod for basal forebrain cholinergic degeneration Open
View article: Cellular contributions to ictal population signals
Cellular contributions to ictal population signals Open
Objective The amplitude of ictal activity is a defining feature of epileptic seizures, but the determinants of this amplitude have not been identified. Clinically, ictal amplitudes are measured electrographically (using e.g. EEG, ECoG, and…
View article: Towards a phenome-wide view of Parkinson’s disease
Towards a phenome-wide view of Parkinson’s disease Open
Background and Objectives Many studies have examined the relation between PD and environmental variables serially --- one candidate association at a time. In the real world however, both environmental exposures and patients are much more c…