Patrick Sharp
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View article: Assessment of Postoperative Analgesic Efficacy and Animal Well-Being Using a Novel Triaxial Accelerometer Device, the Rodent Fitbit-Like Telemetry Device
Assessment of Postoperative Analgesic Efficacy and Animal Well-Being Using a Novel Triaxial Accelerometer Device, the Rodent Fitbit-Like Telemetry Device Open
Accurate postoperative pain management is crucial for good animal welfare and science. We sought to evaluate mouse postoperative pain management efficacy by measuring activity using a novel triaxial acceleration device—the Rodent Fitbit-li…
View article: Tiletamine/Zolazepam and Ketamine with Dexmedetomidine (TKD) Cocktail Is as Effective as Tiletamine/Zolazepam and Ketamine with Xylazine (TKX) in Providing Pig General Anesthesia
Tiletamine/Zolazepam and Ketamine with Dexmedetomidine (TKD) Cocktail Is as Effective as Tiletamine/Zolazepam and Ketamine with Xylazine (TKX) in Providing Pig General Anesthesia Open
This study aimed to evaluate dexmedetomidine as an alternative to xylazine in pigs. We compared TKD (0.05 mL/kg) to TKX (0.05 mL/kg) in 20 male pigs undergoing unilateral cryptorchid castration (short-term, 45-min) or bilateral cryptorchid…
View article: Carprofen Attenuates Postoperative Mechanical and Thermal Hypersensitivity after Plantar Incision in Immunodeficient NSG Mice
Carprofen Attenuates Postoperative Mechanical and Thermal Hypersensitivity after Plantar Incision in Immunodeficient NSG Mice Open
Immunodeficient NSG mice are reported to be less responsive to buprenorphine analgesia. Here, we used NSG mice to compare the efficacy of the commonly used dose of carprofen (5 mg/kg) with 5 and 10 times that dose (25 and 50 mg/kg) for att…
View article: Assessment of a Combination of Tiletamine/Zolazepam, Ketamine, and Dexmedetomidine for Anesthesia of Swine (Sus domesticus)
Assessment of a Combination of Tiletamine/Zolazepam, Ketamine, and Dexmedetomidine for Anesthesia of Swine (Sus domesticus) Open
This study investigated the induction of anesthesia in swine by injection of tiletamine/zolazepam and ketamine in combination with either dexmedetomidine (TKD) or xylazine (TKX). We hypothesized that TKD would accelerate anesthesia onset a…
View article: Dexmedetomidine Effectively Sedates Asian Elephants (Elephas maximus)
Dexmedetomidine Effectively Sedates Asian Elephants (Elephas maximus) Open
This study investigated the sedative effects of dexmedetomidine in Asian elephants. We hypothesized that 2 µg/kg dexmedetomidine would provide sufficient standing sedation. A crossover design study was performed in three Asian elephants. E…
View article: Efficacy of 3 Buprenorphine Formulations for the Attenuation of Hypersensitivity after Plantar Incision in Immunodeficient NSG Mice
Efficacy of 3 Buprenorphine Formulations for the Attenuation of Hypersensitivity after Plantar Incision in Immunodeficient NSG Mice Open
Buprenorphine is perhaps the most prescribed analgesic for management of postoperative pain in mice. Although various buprenorphine formulations are effective in commonly used immunocompetent mouse strains, a knowledge gap exists regarding…
View article: The use of person-first language in scientific literature focused on drug-seeking behavior: a cross-sectional analysis
The use of person-first language in scientific literature focused on drug-seeking behavior: a cross-sectional analysis Open
Context Person first language (PFL) – a way of referring to individuals with medical conditions or disability that emphasizes the person over their condition or disability – is important in reducing the stigma surrounding individuals who e…
View article: Insulin delivery devices 100 years on
Insulin delivery devices 100 years on Open
The extraction of insulin from the pancreas and its subsequent use in the treatment of diabetes presented a new set of problems. Of these, insulin delivery is perhaps so obvious that it does not get the attention it deserves. Syringes dedi…
View article: Tiletamine/zolazepam and dexmedetomidine with tramadol provide effective general anesthesia in rats
Tiletamine/zolazepam and dexmedetomidine with tramadol provide effective general anesthesia in rats Open
Background Tiletamine/zolazepam is a dissociative anesthetic combination commonly used in small animals but information is limited in rats. The alpha‐2 agonist, dexmedetomidine, has gained popularity in laboratory animal anesthesia. Tramad…
View article: Screening for pancreatic ductal adenocarcinoma in the population with diabetes
Screening for pancreatic ductal adenocarcinoma in the population with diabetes Open
Pancreatic ductal adenocarcinoma (PDAC) is an uncommon condition with an incidence of about 8–12 cases per 100,000 of the population per year. Presentation is often late, treatment outcomes poor and the mortality rate is high. There is no …
View article: Mouse Anesthesia: The Art and Science
Mouse Anesthesia: The Art and Science Open
There is an art and science to performing mouse anesthesia, which is a significant component to animal research. Frequently, anesthesia is one vital step of many over the course of a research project spanning weeks, months, or beyond. It i…
View article: Type 1 versus type 2 diabetes: is it time for a change?
Type 1 versus type 2 diabetes: is it time for a change? Open
Is there a case for redefining our classification of diabetes to inform clinical practice for the benefit of patients? Dr Patrick Sharp here explores this key question, and provides practical advice – at the same time evaluating salient pa…
View article: The use of glucose measurements to improve screening for diabetes in clinical practice
The use of glucose measurements to improve screening for diabetes in clinical practice Open
Introduction: it is estimated that 4 million people will be living with diabetes in England by 2025. It is imperative that we can accurately identify people at risk of diabetes and target interventions to prevent its development.Aim: to de…