Stephen P.J. Fancy
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View article: Proinflammatory immune cells disrupt angiogenesis and promote germinal matrix hemorrhage in prenatal human brain
Proinflammatory immune cells disrupt angiogenesis and promote germinal matrix hemorrhage in prenatal human brain Open
View article: mTOR activation induces endolysosomal remodeling and nonclassical secretion of IL-32 via exosomes in inflammatory reactive astrocytes
mTOR activation induces endolysosomal remodeling and nonclassical secretion of IL-32 via exosomes in inflammatory reactive astrocytes Open
View article: Primary cilia control oligodendrocyte precursor cell proliferation in white matter injury via Hedgehog-independent CREB signaling
Primary cilia control oligodendrocyte precursor cell proliferation in white matter injury via Hedgehog-independent CREB signaling Open
View article: Astrocyte endfoot formation controls the termination of oligodendrocyte precursor cell perivascular migration during development
Astrocyte endfoot formation controls the termination of oligodendrocyte precursor cell perivascular migration during development Open
View article: CRISPRi screens in human iPSC-derived astrocytes elucidate regulators of distinct inflammatory reactive states
CRISPRi screens in human iPSC-derived astrocytes elucidate regulators of distinct inflammatory reactive states Open
View article: Proinflammatory Milieu Disrupts Homeostatic Microglia-Vascular Interactions to Promote Germinal Matrix Hemorrhage
Proinflammatory Milieu Disrupts Homeostatic Microglia-Vascular Interactions to Promote Germinal Matrix Hemorrhage Open
View article: mTOR activation induces endolysosomal remodeling and nonclassical secretion of IL-32 via exosomes in inflammatory reactive astrocytes
mTOR activation induces endolysosomal remodeling and nonclassical secretion of IL-32 via exosomes in inflammatory reactive astrocytes Open
Astrocytes respond and contribute to neuroinflammation by adopting inflammatory reactive states. Although recent efforts have characterized the gene expression signatures associated with these reactive states, the cell biology underlying i…
View article: CRISPRi screens in human astrocytes elucidate regulators of distinct inflammatory reactive states
CRISPRi screens in human astrocytes elucidate regulators of distinct inflammatory reactive states Open
In response to central nervous system injury or disease, astrocytes become reactive, adopting context-dependent states and functional outputs. Certain inflammatory insults induce reactive astrocytes that lose homeostatic functions and gain…
View article: Oligodendroglial ring finger protein Rnf43 is an essential injury-specific regulator of oligodendrocyte maturation
Oligodendroglial ring finger protein Rnf43 is an essential injury-specific regulator of oligodendrocyte maturation Open
View article: CNS fibroblasts form a fibrotic scar in response to immune cell infiltration
CNS fibroblasts form a fibrotic scar in response to immune cell infiltration Open
Fibrosis is a common pathological response to inflammation in many peripheral tissues and can prevent tissue regeneration and repair. Here, we identified persistent fibrotic scarring in the CNS following immune cell infiltration in the exp…
View article: Aberrant oligodendroglial–vascular interactions disrupt the blood–brain barrier, triggering CNS inflammation
Aberrant oligodendroglial–vascular interactions disrupt the blood–brain barrier, triggering CNS inflammation Open
Disruption of the blood-brain barrier (BBB) is critical to initiation and perpetuation of disease in multiple sclerosis (MS). We report an interaction between oligodendroglia and vasculature in MS that distinguishes human white matter inju…
View article: Transforming growth factor‐beta renders ageing microglia inhibitory to oligodendrocyte generation by CNS progenitors
Transforming growth factor‐beta renders ageing microglia inhibitory to oligodendrocyte generation by CNS progenitors Open
It is now well‐established that the macrophage and microglial response to CNS demyelination influences remyelination by removing myelin debris and secreting a variety of signaling molecules that influence the behaviour of oligodendrocyte p…
View article: Enhancing Oligodendrocyte Myelination Rescues Synaptic Loss and Improves Functional Recovery after Chronic Hypoxia
Enhancing Oligodendrocyte Myelination Rescues Synaptic Loss and Improves Functional Recovery after Chronic Hypoxia Open
View article: Lgl1 controls NG2 endocytic pathway to regulate oligodendrocyte differentiation and asymmetric cell division and gliomagenesis
Lgl1 controls NG2 endocytic pathway to regulate oligodendrocyte differentiation and asymmetric cell division and gliomagenesis Open
View article: Fibrinogen Activates BMP Signaling in Oligodendrocyte Progenitor Cells and Inhibits Remyelination after Vascular Damage
Fibrinogen Activates BMP Signaling in Oligodendrocyte Progenitor Cells and Inhibits Remyelination after Vascular Damage Open
View article: Clemastine rescues myelination defects and promotes functional recovery in hypoxic brain injury
Clemastine rescues myelination defects and promotes functional recovery in hypoxic brain injury Open
Hypoxia can injure brain white matter tracts, comprised of axons and myelinating oligodendrocytes, leading to cerebral palsy in neonates and delayed post-hypoxic leukoencephalopathy (DPHL) in adults. In these conditions, white matter injur…
View article: Supplementary Material for: Moderate-Grade Germinal Matrix Haemorrhage Activates Cell Division in the Neonatal Mouse Subventricular Zone
Supplementary Material for: Moderate-Grade Germinal Matrix Haemorrhage Activates Cell Division in the Neonatal Mouse Subventricular Zone Open
Precise temporal and spatial control of the neural stem/progenitor cells within the subventricular zone (SVZ) germinal matrix of the brain is important for normal development in the third trimester and the early postnatal period. The high …
View article: Accelerated remyelination during inflammatory demyelination prevents axonal loss and improves functional recovery
Accelerated remyelination during inflammatory demyelination prevents axonal loss and improves functional recovery Open
Demyelination in MS disrupts nerve signals and contributes to axon degeneration. While remyelination promises to restore lost function, it remains unclear whether remyelination will prevent axonal loss. Inflammatory demyelination is accomp…
View article: Author response: Accelerated remyelination during inflammatory demyelination prevents axonal loss and improves functional recovery
Author response: Accelerated remyelination during inflammatory demyelination prevents axonal loss and improves functional recovery Open
View article: Oligodendrocyte precursors migrate along vasculature in the developing nervous system
Oligodendrocyte precursors migrate along vasculature in the developing nervous system Open
Neuronal migrations follow vascular pathways In the developing brain, various types of cells migrate from their birthplaces to their workplaces. Oligodendrocyte precursors, which develop to form the insulating sheaths that make signal tran…
View article: Contents Vol. 38, 2017
Contents Vol. 38, 2017 Open
View article: Moderate-Grade Germinal Matrix Haemorrhage Activates Cell Division in the Neonatal Mouse Subventricular Zone
Moderate-Grade Germinal Matrix Haemorrhage Activates Cell Division in the Neonatal Mouse Subventricular Zone Open
Precise temporal and spatial control of the neural stem/progenitor cells within the subventricular zone (SVZ) germinal matrix of the brain is important for normal development in the third trimester and the early postnatal period. The high …
View article: Sox2 Sustains Recruitment of Oligodendrocyte Progenitor Cells following CNS Demyelination and Primes Them for Differentiation during Remyelination
Sox2 Sustains Recruitment of Oligodendrocyte Progenitor Cells following CNS Demyelination and Primes Them for Differentiation during Remyelination Open
Understanding the mechanisms of CNS remyelination is central to developing effective means by which this process can be therapeutically enhanced in chronic demyelinating diseases such as multiple sclerosis. In this study, we describe the r…
View article: Apcdd1 stimulates oligodendrocyte differentiation after white matter injury
Apcdd1 stimulates oligodendrocyte differentiation after white matter injury Open
Wnt signaling plays an essential role in developmental and regenerative myelination of the CNS, therefore it is critical to understand how the factors associated with the various regulatory layers of this complex pathway contribute to thes…
View article: Daam2-PIP5K Is a Regulatory Pathway for Wnt Signaling and Therapeutic Target for Remyelination in the CNS
Daam2-PIP5K Is a Regulatory Pathway for Wnt Signaling and Therapeutic Target for Remyelination in the CNS Open