Stephen R. C. Howie
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View article: The development and implementation of an oxygen treatment solution for health facilities in low and middle-income countries
The development and implementation of an oxygen treatment solution for health facilities in low and middle-income countries Open
BACKGROUND: Oxygen reduces mortality from severe pneumonia and is a vital part of case management, but achieving reliable access to oxygen is challenging in low and middle-income country (LMIC) settings. We developed and field tested two o…
View article: Causes of severe pneumonia requiring hospital admission in children without HIV infection from Africa and Asia: the PERCH multi-country case-control study
Causes of severe pneumonia requiring hospital admission in children without HIV infection from Africa and Asia: the PERCH multi-country case-control study Open
View article: Zinc as an adjunct therapy in the management of severe pneumonia among Gambian children: randomized controlled trial
Zinc as an adjunct therapy in the management of severe pneumonia among Gambian children: randomized controlled trial Open
ISRCTN33548493.
View article: Referee report. For: Investigating Pneumonia Etiology Among Refugees and the Lebanese population (PEARL): A study protocol [version 1; referees: 2 approved with reservations]
Referee report. For: Investigating Pneumonia Etiology Among Refugees and the Lebanese population (PEARL): A study protocol [version 1; referees: 2 approved with reservations] Open
View article: Safety of Induced Sputum Collection in Children Hospitalized With Severe or Very Severe Pneumonia
Safety of Induced Sputum Collection in Children Hospitalized With Severe or Very Severe Pneumonia Open
The overall frequency of SAEs was very low, and the nature of most SAEs was manageable, demonstrating a low-risk safety profile for IS collection even among severely ill children in low-income-country settings. Healthcare providers should …
View article: Association of C-Reactive Protein With Bacterial and Respiratory Syncytial Virus–Associated Pneumonia Among Children Aged <5 Years in the PERCH Study
Association of C-Reactive Protein With Bacterial and Respiratory Syncytial Virus–Associated Pneumonia Among Children Aged <5 Years in the PERCH Study Open
Elevated CRP was positively associated with confirmed bacterial pneumonia and negatively associated with RSV pneumonia in PERCH. CRP may be useful for distinguishing bacterial from RSV-associated pneumonia, although its role in discriminat…
View article: Colonization Density of the Upper Respiratory Tract as a Predictor of Pneumonia—Haemophilus influenzae, Moraxella catarrhalis, Staphylococcus aureus, and Pneumocystis jirovecii
Colonization Density of the Upper Respiratory Tract as a Predictor of Pneumonia—Haemophilus influenzae, Moraxella catarrhalis, Staphylococcus aureus, and Pneumocystis jirovecii Open
There is evidence for an association between H. influenzae colonization density and H. influenzae-confirmed pneumonia in children; the association may be particularly informative in epidemiologic studies. Colonization densities of M. catar…
View article: Density of Upper Respiratory Colonization With Streptococcus pneumoniae and Its Role in the Diagnosis of Pneumococcal Pneumonia Among Children Aged <5 Years in the PERCH Study
Density of Upper Respiratory Colonization With Streptococcus pneumoniae and Its Role in the Diagnosis of Pneumococcal Pneumonia Among Children Aged <5 Years in the PERCH Study Open
Pneumococcal colonization density >6.9 log10 copies/mL was strongly associated with MCPP and could be used to improve estimates of pneumococcal pneumonia prevalence in childhood pneumonia studies. Our findings do not support its use for in…