Explanipedia

Toll-like Receptor 9 Induced Dendritic Cell Activation Promotes Anti-Myeloperoxidase Autoimmunity and Glomerulonephritis Open

Sharon Ford, Kim M. O’Sullivan, A. Richard Kitching, Stephen R. Holdsworth, Poh‐Yi Gan , et al. · 2023

ANCA-associated vasculitis (AAV) is intricately linked with infections. Toll-like receptors (TLR) provide a potential link between infection and anti-myeloperoxidase (MPO) autoimmunity. TLR9 ligation has been shown to promote anti-MPO auto…

Heterologous Immunity Between SARS-CoV-2 and Pathogenic Bacteria Open

Peter J. Eggenhuizen, Boaz H. Ng, Janet Chang, Rachel Cheong, Anusha Yellapragada , et al. · 2022

Heterologous immunity, when the memory T cell response elicited by one pathogen recognizes another pathogen, has been offered as a contributing factor for the high variability in coronavirus disease 2019 (COVID-19) severity outcomes. Here …

Ageing enhances cellular immunity to myeloperoxidase and experimental anti-myeloperoxidase glomerulonephritis Open

Maliha A. Alikhan, Juli Jaw, Lani Shochet, Kate Robson, Joshua D. Ooi , et al. · 2021

Objectives ANCA-associated vasculitis (AAV) is an autoimmune disease characterized by small blood vessel inflammation, commonly affecting the kidneys and respiratory tract. It is unclear why the incidence of this condition increases with a…

BCG Vaccine Derived Peptides Induce SARS-CoV-2 T Cell Cross-Reactivity Open

Peter J. Eggenhuizen, Boaz H. Ng, Janet Chang, Ashleigh L. Fell, Rachel Cheong , et al. · 2021

Epidemiological studies and clinical trials suggest Bacillus Calmette-Guérin (BCG) vaccine has protective effects against coronavirus disease 2019 (COVID-19). There are now over 30 clinical trials evaluating if BCG vaccination can prevent …

Emerging Cellular Therapies for Anti-myeloperoxidase Vasculitis and Other Autoimmune Diseases Open

Dragana Odobasic, Stephen R. Holdsworth · 2021

Anti-myeloperoxidase vasculitis (MPO-AAV) is a life-threatening autoimmune disease which causes severe inflammation of small blood vessels, mainly in the kidney. As for many other autoimmune diseases, current treatments, which consist of g…

Anti-CD20 mAb-Induced B Cell Apoptosis Generates T Cell Regulation of Experimental Myeloperoxidase ANCA-Associated Vasculitis Open

Poh‐Yi Gan, Jonathan Dick, Kim M. O’Sullivan, Virginie Oudin, Anne Cao Le , et al. · 2021

Significance Statement Myeloperoxidase ANCA-associated vasculitis (MPO-AAV) is an important cause of renal failure. Although rituximab has been shown to effectively attenuate MPO-AAV, its underlying mechanism of action beyond depletion of …

Neutrophil Extracellular Traps: A Potential Therapeutic Target in MPO-ANCA Associated Vasculitis? Open

Kim M. O’Sullivan, Stephen R. Holdsworth · 2021

Our understanding of immune recognition and response to infection and non-infectious forms of cell damage and death is rapidly increasing. The major focus is on host immunity and microbiological invasion. However, it is also clear that the…

Phagocyte extracellular traps in children with neutrophilic airway inflammation Open

Paul T. King, Lovisa Dousha, Nadeene Clarke, Jennifer Schaefer, Rosemary Carzino , et al. · 2021

Childhood lung infection is often associated with prominent neutrophilic airway inflammation and excess production of proteases such as neutrophil elastase (NE). The mechanisms responsible for this inflammation are not well understood. One…

The tissue culture of normal and diseased isolated glomeruli Open

Stephen R. Holdsworth · 2021

This thesis was scanned from the print manuscript for digital preservation and is copyright the author. Researchers can access this thesis by asking their local university, institution or public library to make a request on their behalf. M…

BCG vaccine derived peptides induce SARS-CoV-2 T cell cross-reactivity Open

Peter J. Eggenhuizen, Boaz H. Ng, Janet Chang, Ashleigh L. Fell, Wey Y. Wong , et al. · 2020

Epidemiological studies suggest that the Bacillus Calmette-Guérin (BCG) vaccine may have protective effects against coronavirus disease 2019 (COVID-19); and, there are now more than 15 ongoing clinical trials seeking to determine if BCG va…

Epitope specificity determines pathogenicity and detectability in ANCA-associated vasculitis Open

Aleeza J. Roth, Joshua D. Ooi, Jacob J. Hess, Mirjan M. van Timmeren, Elisabeth A. Berg , et al. · 2020

Anti-neutrophil cytoplasmic antibody–associated (ANCA-associated) small vessel necrotizing vasculitis is caused by immune-mediated inflammation of the vessel wall and is diagnosed in some cases by the presence of myeloperoxidase-specific a…

Animal Models of ANCA Associated Vasculitis Open

Lani Shochet, Stephen R. Holdsworth, A. Richard Kitching · 2020

Anti-neutrophil cytoplasmic antibody (ANCA) associated vasculitis (AAV) is a rare and severe autoimmune multisystemic disease. Its pathogenesis involves multiple arms of the immune system, as well as complex interactions between immune cel…

Acknowledgement to the Reviewers Open

Mauro Abbate, Ali F. Abdel-Wahab, Saudi Arabia, Masanori Abe, Georgi Abraham , et al. · 2020

Referee report. For: Crescentic glomerulonephritis: what’s different in South Asia? A single center observational cohort study [version 1; peer review: 2 approved] Open

Stephen R. Holdsworth · 2020

Tolerogenic Dendritic Cells Attenuate Experimental Autoimmune Antimyeloperoxidase Glomerulonephritis Open

Dragana Odobasic, Virginie Oudin, Kenji Ito, Poh‐Yi Gan, A. Richard Kitching , et al. · 2019

Significance Statement Current treatments for autoimmune anti-myeloperoxidase (anti-MPO) GN are only partially effective and have many adverse effects, including broad immunosuppression. Thus, safer, more targeted therapies are needed, ide…

A plasmid-encoded peptide from Staphylococcus aureus induces anti-myeloperoxidase nephritogenic autoimmunity Open

Joshua D. Ooi, Jhih‐Hang Jiang, Peter J. Eggenhuizen, Ling Ling Chua, Mirjan van Timmeren , et al. · 2019

Apoptotic Cell–Induced, Antigen-Specific Immunoregulation to Treat Experimental Antimyeloperoxidase GN Open

Poh‐Yi Gan, Andrea S. Godfrey, Joshua D. Ooi, Kim M. O’Sullivan, Virginie Oudin , et al. · 2019

Significance Statement Current therapies for myeloperoxidase-ANCA–associated vasculitis (MPO-AAV), an autoimmune disease causing rapidly progressive GN, are nonspecific with considerable toxicities. Previous research defined the nephritoge…

SAT-013 TOLEROGENIC CD40-DEFICIENT DENDRITIC CELLS ATTENUATE ANTI-MYELOPEROXIDASE VASCULITIS BY INDUCING REGULATORY B CELLS Open

Dragana Odobasic, Virginie Oudin, Koichi Ito, Diana Shu Yee Tan, A. Richard Kitching , et al. · 2019

Tolerogenic dendritic cells (DCs) are an inviting immunosuppressive tool for the treatment of inflammatory diseases, but their therapeutic efficacy has not been tested in autoimmune renal vasculitis. Here, we sought to determine whether to…

SAT-012 Peptidyl Arginase Deiminase 4 inhibition attenuates inflammation in murine experimental myeloperoxidase cytoplasmic antibody associated glomerulonephritis Open

Kim M. O’Sullivan, Poh‐Yi Gan, A. Richard Kitching, Stephen R. Holdsworth · 2019

Peptidyl arginine deiminases (PADs) are enzymes that generate citrullinated proteins, which are pro-inflammatory in both innate and adaptive immune responses. Citrullination of histone 3 (H3Cit) by PAD4 facilitates generation of neutrophil…

Biologicals targeting T helper cell subset differentiating cytokines are effective in the treatment of murine anti-myeloperoxidase glomerulonephritis Open

Poh‐Yi Gan, Amy J. Chan, Joshua D. Ooi, Jonathan Dick, Kei Nagai , et al. · 2019

A simple score can identify kidney transplant recipients at high risk of severe infection over the following 2 years Open

Claire Dendle, Kevan R. Polkinghorne, William R. Mulley, Poh‐Yi Gan, John Kanellis , et al. · 2019

Background The aim of this study was to determine whether a composite score of simple immune biomarkers and clinical characteristics could predict severe infections in kidney transplant recipients. Methods We conducted a prospective study …

Table of Contents Open

Deidra C. Crews, Aminu K. Bello, Gamal Saadi, A. Richard Kitching, Stephen R. Holdsworth , et al. · 2019

The renal draining lymph nodes in acute inflammatory kidney disease Open

A. Richard Kitching, Stephen R. Holdsworth · 2019

Intrarenal Toll-like receptor 4 and Toll-like receptor 2 expression correlates with injury in antineutrophil cytoplasmic antibody-associated vasculitis Open

Kim M. O’Sullivan, Sharon Ford, Anthony Longano, A. Richard Kitching, Stephen R. Holdsworth · 2018

In antineutrophil cytoplasmic antibody-associated vasculitis (AAV), Toll-like receptors (TLRs) may be engaged by infection-associated patterns and by endogenous danger signals, linking infection and innate inflammation with this autoimmune…

Delayed Diagnosis and Complications of Predominantly Antibody Deficiencies in a Cohort of Australian Adults Open

C Slade, Julian J. Bosco, Tran Bình Giang, Elizabeth Kruse, Rob G. Stirling , et al. · 2018

Our data are largely consistent with the experience of other centers internationally, with clear areas for improvement, including reducing diagnostic delay for patients with PADs. It is likely that these challenges will be in part overcome…

Natural killer cell function predicts severe infection in kidney transplant recipients Open

Claire Dendle, Poh‐Yi Gan, Kevan R. Polkinghorne, James Ngui, Rhonda L. Stuart , et al. · 2018

The aim of this study was to determine if natural killer cell number (CD3^- /CD16^± /CD56^± ) and cytotoxic killing function predicts severity and frequency of infection in kidney transplant recipients. A coho…

Seroresponses and safety of 13‐valent pneumococcal conjugate vaccination in kidney transplant recipients Open

Claire Dendle, Rhonda L. Stuart, Kevan R. Polkinghorne, Anne Balloch, John Kanellis , et al. · 2018

Background Conjugated pneumococcal vaccine is recommended for kidney transplant recipients, however, their immunogenicity and potential to trigger allograft rejection though generation of de novo anti‐human leukocyte antigen antibodies has…

The C3aR promotes macrophage infiltration and regulates ANCA production but does not affect glomerular injury in experimental anti-myeloperoxidase glomerulonephritis Open

Jonathan Dick, Poh‐Yi Gan, A. Richard Kitching, Stephen R. Holdsworth · 2018

The anti-neutrophil cytoplasmic antibody (ANCA) associated vasculitides are autoimmune diseases associated with significant morbidity and mortality. They often affect the kidney causing rapidly progressive glomerulonephritis. While signall…

Visualizing Macrophage Extracellular Traps Using Confocal Microscopy Open

Roleen Sharma, Kim M. O’Sullivan, Stephen R. Holdsworth, Philip G. Bardin, Paul T. King · 2017

A primary method used to define the presence of neutrophil extracellular traps (NETs) is confocal microscopy. We have modified established confocal microscopy methods to visualize macrophage extracellular traps (METs). These extracellular …

Deoxyribonuclease 1 reduces pathogenic effects of cigarette smoke exposure in the lung Open

Paul T. King, Roleen Sharma, Kim M. O’Sullivan, Judy M. Callaghan, Lovisa Dousha , et al. · 2017

Stephen R. Holdsworth YOU? Author Swipe