Stephen R. Russell
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View article: Real-world short-term outcomes after switching to fixed-interval anti-VEGF therapy for neovascular AMD during the COVID-19 pandemic
Real-world short-term outcomes after switching to fixed-interval anti-VEGF therapy for neovascular AMD during the COVID-19 pandemic Open
View article: No Difference in Return-to-Sport Rate or Activity Level in People with Anterior Cruciate Ligament (ACL) Injury Managed with ACL Reconstruction or Rehabilitation Alone: A Systematic Review and Meta-Analysis
No Difference in Return-to-Sport Rate or Activity Level in People with Anterior Cruciate Ligament (ACL) Injury Managed with ACL Reconstruction or Rehabilitation Alone: A Systematic Review and Meta-Analysis Open
Background A common belief amongst patients and clinicians is that anterior cruciate ligament reconstruction is required to return to sport. It is not clear if this belief is supported by the best available research. Objective We aimed to …
View article: The Electronic Libraries programme: A progress report.
The Electronic Libraries programme: A progress report. Open
To give a progress report or a "snapshot" of the Electronic Libraries Programme is a challenging task. The programme, while still in its early stages, is progressing and expanding at a rapid rate. As libraries everywhere continue to grappl…
View article: Progressive inner retinal neurodegeneration in non-proliferative macular telangiectasia type 2
Progressive inner retinal neurodegeneration in non-proliferative macular telangiectasia type 2 Open
Purpose Patients with non-proliferative macular telangiectasia type 2 (MacTel) have ganglion cell layer (GCL) and nerve fibre layer (NFL) loss, but it is unclear whether the thinning is progressive. We quantified the change in retinal laye…
View article: Comparative long-term outcomes of vitrectomy combined with anterior chamber intraocular lens to intra-scleral haptic fixation of posterior chamber intraocular lens
Comparative long-term outcomes of vitrectomy combined with anterior chamber intraocular lens to intra-scleral haptic fixation of posterior chamber intraocular lens Open
Purpose To evaluate the long-term clinical outcomes in patients with combined pars plana vitrectomy (PPV) with anterior chamber intraocular lens (ACIOL) to intrascleral haptic fixation (ISHF) using the Agarwal technique with fibrin glue to…
View article: Predicting the Progression of Cancerous Tumors in Mice: A Machine and Deep Learning Intuition
Predicting the Progression of Cancerous Tumors in Mice: A Machine and Deep Learning Intuition Open
The study explores Artificial Intelligence (AI) powered modeling to predict the evolution of cancer tumor cells in mice under different forms of treatment. The AI models are analyzed against varying ambient and systemic parameters, e.g. dr…
View article: A Retrospective Longitudinal Study of 460 Patients with ABCA4-Associated Retinal Disease
A Retrospective Longitudinal Study of 460 Patients with ABCA4-Associated Retinal Disease Open
View article: CRISPRi-Mediated Treatment of Dominant Rhodopsin-Associated Retinitis Pigmentosa
CRISPRi-Mediated Treatment of Dominant Rhodopsin-Associated Retinitis Pigmentosa Open
Rhodopsin (RHO) mutations such as Pro23His are the leading cause of dominantly inherited retinitis pigmentosa in North America. As with other dominant retinal dystrophies, these mutations lead to production of a toxic protein produc…
View article: Long-term functional and structural outcomes in X-linked retinoschisis: implications for clinical trials
Long-term functional and structural outcomes in X-linked retinoschisis: implications for clinical trials Open
Introduction X-linked retinoschisis (XLRS) is an inherited retinal disease (IRD) caused by pathogenic mutations in the retinoschisin gene, RS1 . Affected individuals develop retinal layer separation, leading to loss of visual acuity (VA). …
View article: Data from Replication of Genetic Polymorphisms Reported to Be Associated with Taxane-Related Sensory Neuropathy in Patients with Early Breast Cancer Treated with Paclitaxel
Data from Replication of Genetic Polymorphisms Reported to Be Associated with Taxane-Related Sensory Neuropathy in Patients with Early Breast Cancer Treated with Paclitaxel Open
Purpose: Associations between taxane-related sensory neuropathy (TRSN) and single-nucleotide polymorphisms (SNP) have previously been reported, but few have been replicated in large, independent validation studies. This study evalua…
View article: Data from Replication of Genetic Polymorphisms Reported to Be Associated with Taxane-Related Sensory Neuropathy in Patients with Early Breast Cancer Treated with Paclitaxel
Data from Replication of Genetic Polymorphisms Reported to Be Associated with Taxane-Related Sensory Neuropathy in Patients with Early Breast Cancer Treated with Paclitaxel Open
Purpose: Associations between taxane-related sensory neuropathy (TRSN) and single-nucleotide polymorphisms (SNP) have previously been reported, but few have been replicated in large, independent validation studies. This study evalua…
View article: Supplementary Tables 1 - 5, Figures 1 - 2 from Replication of Genetic Polymorphisms Reported to Be Associated with Taxane-Related Sensory Neuropathy in Patients with Early Breast Cancer Treated with Paclitaxel
Supplementary Tables 1 - 5, Figures 1 - 2 from Replication of Genetic Polymorphisms Reported to Be Associated with Taxane-Related Sensory Neuropathy in Patients with Early Breast Cancer Treated with Paclitaxel Open
PDF file - 237KB, Supplementary Table 1: Published Studies of Putative Functional SNPs Supplementary Table 2a: Drug Regimens and Doses of Taxanes by Study Supplementary Table 2b: Comparison of Toxicity grades/rates by recruiting trial in P…
View article: Supplementary Tables 1 - 5, Figures 1 - 2 from Replication of Genetic Polymorphisms Reported to Be Associated with Taxane-Related Sensory Neuropathy in Patients with Early Breast Cancer Treated with Paclitaxel
Supplementary Tables 1 - 5, Figures 1 - 2 from Replication of Genetic Polymorphisms Reported to Be Associated with Taxane-Related Sensory Neuropathy in Patients with Early Breast Cancer Treated with Paclitaxel Open
PDF file - 237KB, Supplementary Table 1: Published Studies of Putative Functional SNPs Supplementary Table 2a: Drug Regimens and Doses of Taxanes by Study Supplementary Table 2b: Comparison of Toxicity grades/rates by recruiting trial in P…
View article: Supplementary Material for: Quality of life benefit and clinical predictors of complete skin clearance in psoriasis: a multicenter, prospective, real-world study
Supplementary Material for: Quality of life benefit and clinical predictors of complete skin clearance in psoriasis: a multicenter, prospective, real-world study Open
Background: Newer biologics, such as interleukin (IL)-17 inhibitors, make it possible to achieve complete skin clearance (CSC) in patients with moderate-to-severe psoriasis. However, the clinical meaningfulness and predictive factors of CS…
View article: Supplementary Material for: Quality of life benefit and clinical predictors of complete skin clearance in psoriasis: a multicenter, prospective, real-world study
Supplementary Material for: Quality of life benefit and clinical predictors of complete skin clearance in psoriasis: a multicenter, prospective, real-world study Open
Background: Newer biologics, such as interleukin (IL)-17 inhibitors, make it possible to achieve complete skin clearance (CSC) in patients with moderate-to-severe psoriasis. However, the clinical meaningfulness and predictive factors of CS…
View article: Supplementary Material for: Quality of life benefit and clinical predictors of complete skin clearance in psoriasis: a multicenter, prospective, real-world study
Supplementary Material for: Quality of life benefit and clinical predictors of complete skin clearance in psoriasis: a multicenter, prospective, real-world study Open
Background: Newer biologics, such as interleukin (IL)-17 inhibitors, make it possible to achieve complete skin clearance (CSC) in patients with moderate-to-severe psoriasis. However, the clinical meaningfulness and predictive factors of CS…
View article: Supplementary Material for: Quality of life benefit and clinical predictors of complete skin clearance in psoriasis: a multicenter, prospective, real-world study
Supplementary Material for: Quality of life benefit and clinical predictors of complete skin clearance in psoriasis: a multicenter, prospective, real-world study Open
Background: Newer biologics, such as interleukin (IL)-17 inhibitors, make it possible to achieve complete skin clearance (CSC) in patients with moderate-to-severe psoriasis. However, the clinical meaningfulness and predictive factors of CS…
View article: Intravitreal antisense oligonucleotide sepofarsen in Leber congenital amaurosis type 10: a phase 1b/2 trial
Intravitreal antisense oligonucleotide sepofarsen in Leber congenital amaurosis type 10: a phase 1b/2 trial Open
CEP290-associated Leber congenital amaurosis type 10 (LCA10) is a retinal disease resulting in childhood blindness. Sepofarsen is an RNA antisense oligonucleotide targeting the c.2991+1655A>G variant in the CEP290 gene to treat LCA10. In t…
View article: Restoration of Cone Sensitivity to Individuals with Congenital Photoreceptor Blindness within the Phase 1/2 Sepofarsen Trial
Restoration of Cone Sensitivity to Individuals with Congenital Photoreceptor Blindness within the Phase 1/2 Sepofarsen Trial Open
View article: RNA-based therapies in inherited retinal diseases
RNA-based therapies in inherited retinal diseases Open
Inherited retinal diseases (IRDs) are a genetically and phenotypically heterogeneous group of genetic eye disorders. There are more than 300 disease entities, and together this group of disorders affects millions of people globally and is …
View article: 89 Five-year update for the Phase III voretigene neparvovec study in biallelic RPE65 mutation–associated inherited retinal disease
89 Five-year update for the Phase III voretigene neparvovec study in biallelic RPE65 mutation–associated inherited retinal disease Open
Goal To determine whether ambulatory navigation, light sensitivity, and visual field (VF) improvements 1 year after voretigene neparvovec (VN) administration in patients with biallelic RPE65 mutation-associated inherited retinal dystrophy …
View article: Intrafamilial Variability of Ocular Manifestations of von Hippel-Lindau Disease
Intrafamilial Variability of Ocular Manifestations of von Hippel-Lindau Disease Open
View article: Long-Term Outcomes and Risk Factors for Severe Vision Loss in Autosomal Dominant Neovascular Inflammatory Vitreoretinopathy (ADNIV)
Long-Term Outcomes and Risk Factors for Severe Vision Loss in Autosomal Dominant Neovascular Inflammatory Vitreoretinopathy (ADNIV) Open
View article: Five-Year Post-Injection Results of the Phase 3 Trial of Voretigene Neparvovec-rzyl in Biallelic RPE65 Mutation-Associated Inherited Retinal Disease
Five-Year Post-Injection Results of the Phase 3 Trial of Voretigene Neparvovec-rzyl in Biallelic RPE65 Mutation-Associated Inherited Retinal Disease Open
View article: The effect of retinal scaffold modulus on performance during surgical handling
The effect of retinal scaffold modulus on performance during surgical handling Open
View article: LEBER CONGENITAL AMAUROSIS DUE TO CEP290 MUTATIONS—SEVERE VISION IMPAIRMENT WITH A HIGH UNMET MEDICAL NEED
LEBER CONGENITAL AMAUROSIS DUE TO CEP290 MUTATIONS—SEVERE VISION IMPAIRMENT WITH A HIGH UNMET MEDICAL NEED Open
Purpose: Leber congenital amaurosis due to CEP290 mutations (LCA10) is an inherited retinal disease that often results in severe visual impairment or blindness in early childhood. Currently, there are no approved treatments, highlighting t…
View article: Genetic Association between MMP9 and Choroidal Neovascularization in Age-Related Macular Degeneration
Genetic Association between MMP9 and Choroidal Neovascularization in Age-Related Macular Degeneration Open
View article: Comparison Between Graders in Detection of Diabetic Neovascularization With Swept Source Optical Coherence Tomography Angiography and Fluorescein Angiography
Comparison Between Graders in Detection of Diabetic Neovascularization With Swept Source Optical Coherence Tomography Angiography and Fluorescein Angiography Open