Stephen Rose
YOU?
Author Swipe
View article: The Utility of Angular Velocity During Back Squat to Predict 1RM and Load–Velocity Profiling
The Utility of Angular Velocity During Back Squat to Predict 1RM and Load–Velocity Profiling Open
Linear velocity is commonly used to estimate 1-repetition maximum (1RM) from a load–velocity profile (LVP), as well as prescribe training intensity. However, no study has assessed angular velocity, which may be more representative of joint…
View article: Preclinical Evaluation of [ <sup>212</sup> Pb]Pb-ADVC001: A Prostate-Specific Membrane Antigen–Targeted α-Therapy for Prostate Cancer
Preclinical Evaluation of [ <sup>212</sup> Pb]Pb-ADVC001: A Prostate-Specific Membrane Antigen–Targeted α-Therapy for Prostate Cancer Open
Prostate-specific membrane antigen (PSMA)-directed radiopharmaceutical therapies continue to improve treatment outcomes in patients with metastatic castration-resistant prostate cancer. Here, we report the in vitro and in vivo characteriza…
View article: Longitudinal Monitoring of Glioblastoma Small Extracellular Vesicle Evolution Using a Nanodiagnostic to Detect Emergence of Glioma Stem Cells Driving Recurrent Disease
Longitudinal Monitoring of Glioblastoma Small Extracellular Vesicle Evolution Using a Nanodiagnostic to Detect Emergence of Glioma Stem Cells Driving Recurrent Disease Open
Assessing therapeutic response in glioblastoma (GBM) is a major factor limiting the clinical development of new and effective therapies. The intracranial location limits serial biopsies, and only provides an intermittent view of the tumor …
View article: Aqueous humour interleukin-6 and vision outcomes with anti-vascular endothelial growth factor therapy
Aqueous humour interleukin-6 and vision outcomes with anti-vascular endothelial growth factor therapy Open
Background This analysis evaluated aqueous humour (AH) interleukin (IL)-6 concentrations and the association between AH IL-6 and visual outcomes in patients with neovascular age-related macular degeneration (nAMD) or diabetic macular oedem…
View article: Cancer‐on‐Chip and Integrative Tumor Microenvironment Sensor Technologies for Progressing Precision Radiotherapy
Cancer‐on‐Chip and Integrative Tumor Microenvironment Sensor Technologies for Progressing Precision Radiotherapy Open
Precision radiotherapy, such as targeted radioligand therapy, accentuates the precise delivery of radiation to tumor cells while limiting radiation damage to surrounding normal cells. Although recent clinical trial data has shown targeted …
View article: First-in-Human<sup>212</sup>Pb-PSMA–Targeted α-Therapy SPECT/CT Imaging in a Patient with Metastatic Castration-Resistant Prostate Cancer
First-in-Human<sup>212</sup>Pb-PSMA–Targeted α-Therapy SPECT/CT Imaging in a Patient with Metastatic Castration-Resistant Prostate Cancer Open
There is significant interest in the development of 212Pb-PSMA–based targeted α-therapy for patients with metastatic castration-resistant prostate cancer. A previous phantom study has shown that 212Pb SPECT is feasible by imaging the 238.6…
View article: Comparison between [68Ga]Ga-PSMA-617 and [18F]FET PET as Imaging Biomarkers in Adult Recurrent Glioblastoma
Comparison between [68Ga]Ga-PSMA-617 and [18F]FET PET as Imaging Biomarkers in Adult Recurrent Glioblastoma Open
The aim of this prospective clinical study was to evaluate the potential of the prostate specific membrane antigen (PSMA) targeting ligand, [68Ga]-PSMA–Glu–NH–CO–NH–Lys-2-naphthyl-L-Ala-cyclohexane-DOTA ([68Ga]Ga-PSMA-617) as a positron em…
View article: Reduced cortical cholinergic innervation correlates with cognitive decline in mild cognitive impairment
Reduced cortical cholinergic innervation correlates with cognitive decline in mild cognitive impairment Open
Background Dysfunction of the cholinergic basal forebrain (BF) neurotransmitter system, including cholinergic axon denervation of the cortex, plays an important role in cognitive decline and dementia. The association of cortical cholinergi…
View article: Early brain morphometrics from neonatal MRI predict motor and cognitive outcomes at 2-years corrected age in very preterm infants
Early brain morphometrics from neonatal MRI predict motor and cognitive outcomes at 2-years corrected age in very preterm infants Open
Infants born very preterm face a range of neurodevelopmental challenges in cognitive, language, behavioural and/or motor domains. Early accurate identification of those at risk of adverse neurodevelopmental outcomes, through clinical asses…
View article: Predicting motor and cognitive outcomes from MRIs of brain structure in children with acquired brain injury: A pilot study
Predicting motor and cognitive outcomes from MRIs of brain structure in children with acquired brain injury: A pilot study Open
These preliminary associations reveal that motor and behavioral function can be estimated from MRI alone, highlighting the potential utility of the proposed pathology-robust MRI quantification tools to provide estimates of long-term clinic…
View article: Multi-Omics, an Integrated Approach to Identify Novel Blood Biomarkers of Alzheimer’s Disease
Multi-Omics, an Integrated Approach to Identify Novel Blood Biomarkers of Alzheimer’s Disease Open
The metabolomic and proteomic basis of mild cognitive impairment (MCI) and Alzheimer’s disease (AD) is poorly understood, and the relationships between systemic abnormalities in metabolism and AD/MCI pathogenesis is unclear. This study com…
View article: The relationship between chronic PTSD, cortical volumetry and white matter microstructure among Australian combat veterans
The relationship between chronic PTSD, cortical volumetry and white matter microstructure among Australian combat veterans Open
Background Posttraumatic stress disorder (PTSD) has been associated with volumetric and white matter microstructural changes among general and veteran populations. However, regions implicated have greatly varied and often conflict between …
View article: CUB Domain-Containing Protein 1 (CDCP1) is a rational target for the development of imaging tracers and antibody-drug conjugates for cancer detection and therapy
CUB Domain-Containing Protein 1 (CDCP1) is a rational target for the development of imaging tracers and antibody-drug conjugates for cancer detection and therapy Open
Rationale: An antibody-drug conjugate (ADC) is a targeted therapy consisting of a cytotoxic payload that is linked to an antibody which targets a protein enriched on malignant cells. Multiple ADCs are currently used clinically as anti-canc…
View article: Accumulation of amyloid‐β alters white matter integrity in cognitively unimpaired middle‐aged females
Accumulation of amyloid‐β alters white matter integrity in cognitively unimpaired middle‐aged females Open
Background The APOE‐ ε 4 allele is the strongest known genetic risk factor for Alzheimer’s disease (AD) and is associated with higher amyloid‐β (Aβ) deposition. White matter (WM) microstructural damages are known to occur early at the prec…
View article: Fully automated delineation of the optic radiation for surgical planning using clinically feasible sequences
Fully automated delineation of the optic radiation for surgical planning using clinically feasible sequences Open
Quadrantanopia caused by inadvertent severing of Meyer's Loop of the optic radiation is a well‐recognised complication of temporal lobectomy for conditions such as epilepsy. Dissection studies indicate that the anterior extent of Meyer's L…
View article: Preclinical Molecular PET-CT Imaging Targeting CDCP1 in Colorectal Cancer
Preclinical Molecular PET-CT Imaging Targeting CDCP1 in Colorectal Cancer Open
Colorectal cancer (CRC) is the third most common malignancy in the world, with 22% of patients presenting with metastatic disease and a further 50% destined to develop metastasis. Molecular imaging uses antigen-specific ligands conjugated …
View article: Automating Quantitative Measures of an Established Conventional MRI Scoring System for Preterm-Born Infants Scanned between 29 and 47 Weeks' Postmenstrual Age
Automating Quantitative Measures of an Established Conventional MRI Scoring System for Preterm-Born Infants Scanned between 29 and 47 Weeks' Postmenstrual Age Open
Measures of brain injury and impaired brain growth can be automatically extracted from neonatal MR imaging, which could assist with clinical reporting.
View article: Salivaomics as a Potential Tool for Predicting Alzheimer’s Disease During the Early Stages of Neurodegeneration
Salivaomics as a Potential Tool for Predicting Alzheimer’s Disease During the Early Stages of Neurodegeneration Open
Background: The metabolomic and proteomic basis of mild cognitive impairment (MCI) and Alzheimer’s disease (AD) is poorly understood and the relationships between systemic abnormalities in metabolism and AD/AMCI pathogenesis are unclear. O…
View article: Positron emission tomography and magnetic resonance imaging in experimental human malaria to identify organ-specific changes in morphology and glucose metabolism: A prospective cohort study
Positron emission tomography and magnetic resonance imaging in experimental human malaria to identify organ-specific changes in morphology and glucose metabolism: A prospective cohort study Open
Background Plasmodium vivax has been proposed to infect and replicate in the human spleen and bone marrow. Compared to Plasmodium falciparum , which is known to undergo microvascular tissue sequestration, little is known about the behavior…
View article: A Comparison of Techniques for PET Data-Driven Tracking of Head Motion
A Comparison of Techniques for PET Data-Driven Tracking of Head Motion Open
Background / AimsPatient motion during positron emission tomography (PET) imaging can corrupt the image by causing blurring and quantitation error due to misalignment with the attenuation correction image. Data-driven techniques for tracki…
View article: Fully Automated Delineation of the Optic Radiation for Surgical Planning using Clinically Accessible Sequences
Fully Automated Delineation of the Optic Radiation for Surgical Planning using Clinically Accessible Sequences Open
1 Abstract Quadrantanopia caused by inadvertent severing of Meyer’s Loop of the optic radiation is a well-recognised complication of temporal lobectomy for conditions such as epilepsy. Dissection studies indicate that the anterior extent o…