Stephen Saw
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View article: <i>Staphylococcus aureus</i> susceptibilities from wounds of patients who use illicit fentanyl
<i>Staphylococcus aureus</i> susceptibilities from wounds of patients who use illicit fentanyl Open
Objective: Develop a Staphylococcus aureus wound antibiogram among patients who use fentanyl (PWUF) presenting with acute S. aureus skin and soft tissue infections (SSTIs) in Philadelphia, Pennsylvania. Design: Retrospective, multisite coh…
View article: Antibiotic practice and stewardship in the management of neutropenic fever: a survey of US institutions
Antibiotic practice and stewardship in the management of neutropenic fever: a survey of US institutions Open
Objective: To describe neutropenic fever management practices among healthcare institutions. Design: Survey. Participants: Members of the Society for Healthcare Epidemiology of America Research Network (SRN) representing healthcare institu…
View article: 2562. Retrospective Analysis of Cefepime Intravenous Push versus Extended Infusion for the Treatment of Neutropenic Fever
2562. Retrospective Analysis of Cefepime Intravenous Push versus Extended Infusion for the Treatment of Neutropenic Fever Open
Background The outcomes associated with intravenous push (IVP) cefepime compared to extended infusion (EI) have not yet been studied. The objective of this study was to evaluate the effectiveness of IVP versus EI cefepime in patients with …
View article: 2749. Impact of rapid carbapenemase identification on management of patients with carbapenem-resistant Enterobacterales infections
2749. Impact of rapid carbapenemase identification on management of patients with carbapenem-resistant Enterobacterales infections Open
Background Carbapenem-resistant Enterobacterales (CRE) infections can lead to increased length of stay and mortality. Identification of the mechanism of resistance is vital to assist in antibiotic selection. In October 2021, our institutio…
View article: The Penn Medicine COVID-19 Therapeutics Committee—Reflections on a Model for Rapid Evidence Review and Dynamic Practice Recommendations During a Public Health Emergency
The Penn Medicine COVID-19 Therapeutics Committee—Reflections on a Model for Rapid Evidence Review and Dynamic Practice Recommendations During a Public Health Emergency Open
The Penn Medicine COVID-19 Therapeutics Committee—an interspecialty, clinician-pharmacist, and specialist–front line primary care collaboration—has served as a forum for rapid evidence review and the production of dynamic practice recommen…
View article: Antibiotic practice and stewardship in the management of neutropenic fever: A survey of US institutions
Antibiotic practice and stewardship in the management of neutropenic fever: A survey of US institutions Open
Background: Neutropenic fever management decisions are complex and result in prolonged duration of broad-spectrum antibiotics. Strategies for antibiotic stewardship in this context have been studied, including de-escalation of antibiotics …
View article: 751. Impact of Changing from a Three-step to Two-step Testing Algorithm for the Diagnosis of <i>Clostridioides difficile</i>
751. Impact of Changing from a Three-step to Two-step Testing Algorithm for the Diagnosis of <i>Clostridioides difficile</i> Open
Background The optimal method for laboratory diagnosis of Clostridioides difficile infection (CDI) remains undefined and national guidelines do not make a recommendation for a preferred diagnostic algorithm. Aiming to improve infection con…
View article: 82. Assessment of Clinical Outcomes and Antibiotic Prescribing Patterns Following Implementation of the GenMark ePlex® Blood Culture Identification Panel for Gram-positive Bloodstream Infections
82. Assessment of Clinical Outcomes and Antibiotic Prescribing Patterns Following Implementation of the GenMark ePlex® Blood Culture Identification Panel for Gram-positive Bloodstream Infections Open
Background Rapid diagnostic testing (RDT) of bloodstream pathogens provides key information sooner than conventional identification and susceptibility testing. The GenMark ePlex® blood culture identification gram-positive (BCID-GP) panel i…
View article: 168. Syndrome-Based Analysis of Oral Antimicrobial Stewardship Opportunities at Hospital Discharge
168. Syndrome-Based Analysis of Oral Antimicrobial Stewardship Opportunities at Hospital Discharge Open
Background Suboptimal oral antibiotic prescriptions (OAPs) are prevalent at discharge and contribute to treatment failure, resistance, toxicity, and excess costs. Syndrome-specific prescribing patterns have not been widely described at dis…
View article: 622. Evaluation of Vascular Access Device Selection in Patients Discharged on Outpatient Parenteral Antimicrobial Therapy
622. Evaluation of Vascular Access Device Selection in Patients Discharged on Outpatient Parenteral Antimicrobial Therapy Open
Background Selection of a vascular access device (VAD) is an important consideration for patients receiving outpatient parenteral antimicrobial therapy (OPAT). Midline catheters (MC) and peripherally inserted central catheters (PICC) are t…
View article: Real-world, Multicenter Experience With Meropenem-Vaborbactam for Gram-Negative Bacterial Infections Including Carbapenem-Resistant <i>Enterobacterales</i> and <i>Pseudomonas aeruginosa</i>
Real-world, Multicenter Experience With Meropenem-Vaborbactam for Gram-Negative Bacterial Infections Including Carbapenem-Resistant <i>Enterobacterales</i> and <i>Pseudomonas aeruginosa</i> Open
Background We aimed to describe the clinical characteristics and outcomes of patients treated with meropenem-vaborbactam (MEV) for a variety of gram-negative infections (GNIs), primarily including carbapenem-resistant Enterobacterales (CRE…
View article: 54. Effectiveness of a Venous Catheter Stewardship Intervention Targeting Parenteral Antimicrobial Therapy at Hospital Discharge
54. Effectiveness of a Venous Catheter Stewardship Intervention Targeting Parenteral Antimicrobial Therapy at Hospital Discharge Open
Background Peripherally inserted central catheters (PICCs) and midlines are often used in hospitalized patients who require outpatient parenteral antimicrobial therapy (OPAT) upon discharge. PICCs/midlines offer ease of insertion but still…
View article: 275. Comparison of Cefazolin versus Nafcillin for Methicillin-Susceptible <i>Staphylococcus aureus</i> Bacteremia with a Deep-Seated Source
275. Comparison of Cefazolin versus Nafcillin for Methicillin-Susceptible <i>Staphylococcus aureus</i> Bacteremia with a Deep-Seated Source Open
Background Historically, anti-staphylococcal penicillins have been the treatment of choice for methicillin-susceptible Staphylococcus aureus (MSSA) infections. However, cefazolin may have advantages over these agents including convenience …
View article: Assessing an intervention to improve the safety of automatic stop orders for inpatient antimicrobials
Assessing an intervention to improve the safety of automatic stop orders for inpatient antimicrobials Open
This study found that a targeted intervention was associated with a reduction in unintended antimicrobial treatment interruption related to ASOs.
View article: Real-world Multicenter Analysis of Clinical Outcomes and Safety of Meropenem-Vaborbactam in Patients Treated for Serious Gram-Negative Bacterial Infections
Real-world Multicenter Analysis of Clinical Outcomes and Safety of Meropenem-Vaborbactam in Patients Treated for Serious Gram-Negative Bacterial Infections Open
Fourty patients were treated with meropenem-vaborbactam (MEV) for serious Gram-negative bacterial (GNB) infections. Carbapenem-resistant Enterobacteriaceae (CRE) comprised 80.0% of all GNB infections. Clinical success occurred in 70.0% of …
View article: 124. Impact of Levofloxacin MIC on Outcomes with Levofloxacin Step-down Therapy in Enterobacteriaceae Bloodstream Infections
124. Impact of Levofloxacin MIC on Outcomes with Levofloxacin Step-down Therapy in Enterobacteriaceae Bloodstream Infections Open
Background The Clinical and Laboratory Standards Institute reduced the levofloxacin minimum inhibitory concentration (MIC) breakpoint from ≤2 to ≤0.5 mg/L for Enterobacteriaceae in 2019 guidelines. The reduction is based on Monte Carlo sim…
View article: 1012. Characterization of Antibiotic Superutilizers in the Inpatient Setting
1012. Characterization of Antibiotic Superutilizers in the Inpatient Setting Open
Background Inappropriate use of antibiotics is a major public health concern that contributes to increased antibiotic resistance, adverse effects, and healthcare costs. Little is known about the highest utilizers, or superutilizers, who ma…
View article: 1814. External Validation of Precision Antibiotic Therapy for Enterococcal Bloodstream Infections
1814. External Validation of Precision Antibiotic Therapy for Enterococcal Bloodstream Infections Open
BACKGROUND: ILÚM Heath Solutions, an infectious diseases software platform, developed precision antibiotic therapy (PAT) software to guide selection of therapy using data science, patient-specific factors, as well as historical patient, ph…