Stephen H. Sinclair
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View article: Application of Deep Learning for Advanced Detection and Quantification of Drusen in Nonexudative AMD From Retinal Multispectral Imaging
Application of Deep Learning for Advanced Detection and Quantification of Drusen in Nonexudative AMD From Retinal Multispectral Imaging Open
Deep learning-assisted detection of drusen from multispectral retinal images will refine and improve clinical diagnosis of early nonexudative age-related macular degeneration.
View article: Laser Prophylaxis for Dry Age-Related Macular Degeneration: Current Evidence
Laser Prophylaxis for Dry Age-Related Macular Degeneration: Current Evidence Open
Purpose: To review the role of prophylactic panmacular laser treatment for age-related macular degeneration (AMD). Method: A narrative review of studies employing laser treatment for non-exudative (“dry”) AMD listed in the PubMed database.…
View article: Diabetic retinopathy: New concepts of screening, monitoring, and interventions
Diabetic retinopathy: New concepts of screening, monitoring, and interventions Open
The science of diabetes care has progressed to provide a better understanding of the oxidative and inflammatory lesions and pathophysiology of the neurovascular unit within the retina (and brain) that occur early in diabetes, even prediabe…
View article: Diabetes mellitus associated neurovascular lesions in the retina and brain: A review
Diabetes mellitus associated neurovascular lesions in the retina and brain: A review Open
Diabetes mellitus (DM) is now recognized as a system-wide, autoimmune, inflammatory, microvascular disorder, which, in the retina and brain results in severe multifocal injury now recognized as a leading cause, world-wide, of progressive v…
View article: Diabetes Mellitus Associated Progressive Neurovascular Retinal Injury: Recommendations for Imaging and Functional Testing and Potential Role for Early Intervention with Modern Retinal Laser Therapy
Diabetes Mellitus Associated Progressive Neurovascular Retinal Injury: Recommendations for Imaging and Functional Testing and Potential Role for Early Intervention with Modern Retinal Laser Therapy Open
Diabetes mellitus is now recognized as a systemic, autoimmune, microvascular disorder, which, in the retina results in severe, multifocal injury now recognized as a leading cause, world-wide, of progressive vision loss. To address this pro…
View article: <p>Slowed Progression of Age-Related Geographic Atrophy Following Subthreshold Laser</p>
Slowed Progression of Age-Related Geographic Atrophy Following Subthreshold Laser Open
In cohort of eyes with high-risk dry AMD, panmacular SDM slowed linear radial ARGA progression velocity 47% per year (p<0.0001) without adverse treatment effects. Validated, these findings would constitute an important advance in the preve…
View article: Diabetic Retinopathy–An Underdiagnosed and Undertreated Inflammatory, Neuro-Vascular Complication of Diabetes
Diabetic Retinopathy–An Underdiagnosed and Undertreated Inflammatory, Neuro-Vascular Complication of Diabetes Open
Diabetes mellitus is a world-wide epidemic and diabetic retinopathy, a devastating, vision-threatening condition, is one of the most common, diabetes-specific complications.Diabetic retinopathy is now recognized to be an inflammatory, neur…
View article: Diabetic Retinopathy–An Underdiagnosed and Undertreated Inflammatory, Neuro-Vascular Complication of Diabetes
Diabetic Retinopathy–An Underdiagnosed and Undertreated Inflammatory, Neuro-Vascular Complication of Diabetes Open
Diabetes mellitus is a world-wide epidemic and diabetic retinopathy, a devastating, vision-threatening condition, is one of the most common diabetes-specific complications. Diabetic retinopathy is now recognized to be an inflammatory, neur…
View article: Low incidence of choroidal neovascularization following subthreshold diode micropulse laser (SDM) in high-risk AMD
Low incidence of choroidal neovascularization following subthreshold diode micropulse laser (SDM) in high-risk AMD Open
In a review of a large group of eyes with exceptionally high-risk AMD, SDM was followed by a very low incidence of new CNV. If confirmed by further study, SDM would offer a new and highly effective treatment to reduce the risk of vision lo…
View article: Effect of Chronic Intraocular Erythropoietin on Measurements of Vision in Eyes with Geographic Atrophy Secondary to Age-Related Macular Degeneration
Effect of Chronic Intraocular Erythropoietin on Measurements of Vision in Eyes with Geographic Atrophy Secondary to Age-Related Macular Degeneration Open
View article: Correlations of Measurements of Vision with Patient Reported Functional Vision Outcomes
Correlations of Measurements of Vision with Patient Reported Functional Vision Outcomes Open
View article: Computer Measurement of Central Visual Acuity under Mesopic and Glare Conditions in Eyes with Nuclear Cataract
Computer Measurement of Central Visual Acuity under Mesopic and Glare Conditions in Eyes with Nuclear Cataract Open
whereas the pupil diameter of a healthy 20-year-old on average is 5.3 mm in dim illumination, the pupil of a 60-year-old typically has a diameter of 3.2 mm [20] resulting in one third of the retinal illumination in dim environments.Contras…
View article: Interactive Thresholding of Central Acuity under Contrast and Luminance Conditions Mimicking Real World Environments: 1. Evaluation against LogMAR Charts
Interactive Thresholding of Central Acuity under Contrast and Luminance Conditions Mimicking Real World Environments: 1. Evaluation against LogMAR Charts Open
Purpose:The Central Vision Analyzer (CVA) is an interactive, automated computer device that rapidly thresholds central acuity under conditions mimicking customary photopic and mesopic activities.In sequence, the CVA may test up to 6 enviro…