Stephen T. Reece
YOU?
Author Swipe
View article: Intranasal delivery of mRNA expressing newly identified Acinetobacter baumannii antigens protects against bacterial lung disease
Intranasal delivery of mRNA expressing newly identified Acinetobacter baumannii antigens protects against bacterial lung disease Open
Vaccines are central to the strategy to control antimicrobial resistant (AMR) bacterial infections; one multidrug resistant pathogen of particular concern is Acinetobacter baumannii . In this study we identified two novel A. baumannii anti…
View article: A global collaboration for systematic analysis of broad-ranging antibodies against the SARS-CoV-2 spike protein
A global collaboration for systematic analysis of broad-ranging antibodies against the SARS-CoV-2 spike protein Open
View article: A global collaboration for systematic analysis of broad-ranging antibodies against the SARS-CoV-2 spike protein
A global collaboration for systematic analysis of broad-ranging antibodies against the SARS-CoV-2 spike protein Open
View article: Exploiting human immune repertoire transgenic mice for protective monoclonal antibodies against antimicrobial resistant Acinetobacter baumannii
Exploiting human immune repertoire transgenic mice for protective monoclonal antibodies against antimicrobial resistant Acinetobacter baumannii Open
The use of monoclonal antibodies for the control of drug resistant nosocomial bacteria may alleviate a reliance on broad spectrum antimicrobials for treatment of infection. We identify monoclonal antibodies that may prevent infection cause…
View article: Detection of <i>M. tuberculosis</i> DNA in peripheral blood mononuclear cells of tuberculosis contacts does not associate with blood RNA signatures for incipient tuberculosis
Detection of <i>M. tuberculosis</i> DNA in peripheral blood mononuclear cells of tuberculosis contacts does not associate with blood RNA signatures for incipient tuberculosis Open
Detection of M. tuberculosis DNA in TB contacts’ PBMCs does not associate with blood RNA signatures for incipient tuberculosis https://bit.ly/4dliODg
View article: Combining machine learning with high-content imaging to infer ciprofloxacin susceptibility in isolates of Salmonella Typhimurium
Combining machine learning with high-content imaging to infer ciprofloxacin susceptibility in isolates of Salmonella Typhimurium Open
View article: Toward a molecular microbial blood test for tuberculosis infection
Toward a molecular microbial blood test for tuberculosis infection Open
The World Health Organization's aim to end the global tuberculosis (TB) epidemic by 2050 cannot be achieved without taking measures to identify people with asymptomatic Mycobacterium tuberculosis (Mtb) infection and offer them an intervent…
View article: Combining machine learning with high-content imaging to infer ciprofloxacin susceptibility in clinical isolates of Salmonella Typhimurium
Combining machine learning with high-content imaging to infer ciprofloxacin susceptibility in clinical isolates of Salmonella Typhimurium Open
Antimicrobial resistance (AMR) is a growing public health crisis that requires innovative solutions. Presently we rely on exposing single organisms to an antimicrobial and growth to determine susceptibility; throughput and interpretation h…
View article: Detection of<i>M. tuberculosis</i>DNA in TB contacts’ PBMC does not associate with blood RNA signatures for incipient tuberculosis
Detection of<i>M. tuberculosis</i>DNA in TB contacts’ PBMC does not associate with blood RNA signatures for incipient tuberculosis Open
Background We have previously reported detection of genomic DNA of Mycobacterium tuberculosis (Mtb) in peripheral blood mononuclear cells (PBMC) of asymptomatic adults with recent household exposure to an index case of infectious pulmonary…
View article: Determinants of QuantiFERON Plus-diagnosed tuberculosis infection in adult Ugandan TB contacts: A cross-sectional study
Determinants of QuantiFERON Plus-diagnosed tuberculosis infection in adult Ugandan TB contacts: A cross-sectional study Open
Background The tuberculin skin test is commonly used to diagnose latent tuberculosis infection (LTBI) in resource-limited settings, but its specificity is limited by factors including cross-reactivity with BCG vaccine and environmental myc…
View article: Intranasal immunization with outer membrane vesicles (OMV) protects against airway colonization and systemic infection with Acinetobacter baumannii
Intranasal immunization with outer membrane vesicles (OMV) protects against airway colonization and systemic infection with Acinetobacter baumannii Open
View article: Detection of M. Tuberculosis DNA in TB Contacts’ PBMC Does Not Associate with Blood RNA Signatures for Incipient Tuberculosis
Detection of M. Tuberculosis DNA in TB Contacts’ PBMC Does Not Associate with Blood RNA Signatures for Incipient Tuberculosis Open
View article: Clinical and laboratory factors associated with neonatal sepsis mortality at a major Vietnamese children’s hospital
Clinical and laboratory factors associated with neonatal sepsis mortality at a major Vietnamese children’s hospital Open
Sepsis is a major cause of neonatal mortality and children born in low- and middle-income countries (LMICs) are at greater risk of severe neonatal infections than those in higher-income countries. Despite this disparity, there are limited …
View article: Detection of Mycobacterium tuberculosis complex DNA in CD34-positive peripheral blood mononuclear cells of asymptomatic tuberculosis contacts: an observational study
Detection of Mycobacterium tuberculosis complex DNA in CD34-positive peripheral blood mononuclear cells of asymptomatic tuberculosis contacts: an observational study Open
View article: Publisher Correction: A novel therapeutic antibody screening method using bacterial high-content imaging reveals functional antibody binding phenotypes of Escherichia coli ST131
Publisher Correction: A novel therapeutic antibody screening method using bacterial high-content imaging reveals functional antibody binding phenotypes of Escherichia coli ST131 Open
View article: Protecting intubated patients from the threat of antimicrobial resistant infections with monoclonal antibodies
Protecting intubated patients from the threat of antimicrobial resistant infections with monoclonal antibodies Open
View article: Detection of Mycobacterium tuberculosis DNA in CD34+ peripheral blood mononuclear cells of Ugandan adults with latent infection: a cross-sectional and nested prospective study
Detection of Mycobacterium tuberculosis DNA in CD34+ peripheral blood mononuclear cells of Ugandan adults with latent infection: a cross-sectional and nested prospective study Open
Background: Tuberculin skin test and interferon gamma release assay (IGRA) show limitations in diagnosing latent tuberculosis infection (LTBI) and poorly predict progression to active tuberculosis. This study will explore detection of Myco…
View article: A novel therapeutic antibody screening method using bacterial high-content imaging reveals functional antibody binding phenotypes of Escherichia coli ST131
A novel therapeutic antibody screening method using bacterial high-content imaging reveals functional antibody binding phenotypes of Escherichia coli ST131 Open
View article: A novel therapeutic antibody screening method using bacterial high-content imaging reveals functional antibody binding phenotypes of<i>Escherichia coli</i>ST131
A novel therapeutic antibody screening method using bacterial high-content imaging reveals functional antibody binding phenotypes of<i>Escherichia coli</i>ST131 Open
The increase of antimicrobial resistance (AMR), and lack of new classes of licensed antimicrobials, have made alternative treatment options for AMR pathogens increasingly attractive. Recent studies have demonstrated anti-bacterial efficacy…
View article: Detection of <i>M. tuberculosis</i> DNA in CD34-Positive Peripheral Blood Mononuclear Cells of Asymptomatic TB Contacts
Detection of <i>M. tuberculosis</i> DNA in CD34-Positive Peripheral Blood Mononuclear Cells of Asymptomatic TB Contacts Open
View article: Anatomic and Cellular Niches for <i>Mycobacterium tuberculosis</i> in Latent Tuberculosis Infection
Anatomic and Cellular Niches for <i>Mycobacterium tuberculosis</i> in Latent Tuberculosis Infection Open
Latent tuberculosis has been recognized for over a century, but discovery of new niches, where Mycobacterium tuberculosis resides, continues. We evaluated literature on M.tuberculosis locations during latency, highlighting that mesenchymal…
View article: Mycobacterium tuberculosis-Infected Hematopoietic Stem and Progenitor Cells Unable to Express Inducible Nitric Oxide Synthase Propagate Tuberculosis in Mice
Mycobacterium tuberculosis-Infected Hematopoietic Stem and Progenitor Cells Unable to Express Inducible Nitric Oxide Synthase Propagate Tuberculosis in Mice Open
Persistence of Mycobacterium tuberculosis within human bone marrow stem cells has been identified as a potential bacterial niche during latent tuberculosis. Using a murine model of tuberculosis, we show here that bone marrow stem and proge…
View article: Self-Amplifying RNA Vaccines Give Equivalent Protection against Influenza to mRNA Vaccines but at Much Lower Doses
Self-Amplifying RNA Vaccines Give Equivalent Protection against Influenza to mRNA Vaccines but at Much Lower Doses Open
New vaccine platforms are needed to address the time gap between pathogen emergence and vaccine licensure. RNA-based vaccines are an attractive candidate for this role: they are safe, are produced cell free, and can be rapidly generated in…
View article: NOS2-deficient mice with hypoxic necrotizing lung lesions predict outcomes of tuberculosis chemotherapy in humans
NOS2-deficient mice with hypoxic necrotizing lung lesions predict outcomes of tuberculosis chemotherapy in humans Open
During active TB in humans a spectrum of pulmonary granulomas with central necrosis and hypoxia exists. BALB/c mice, predominantly used in TB drug development, do not reproduce this complex pathology thereby inaccurately predicting clinica…
View article: Human and Mouse Hematopoietic Stem Cells Are a Depot for Dormant Mycobacterium tuberculosis
Human and Mouse Hematopoietic Stem Cells Are a Depot for Dormant Mycobacterium tuberculosis Open
An estimated third of the world’s population is latently infected with Mycobacterium tuberculosis (Mtb), with no clinical signs of tuberculosis (TB), but lifelong risk of reactivation to active disease. The niches of persisti…
View article: Neonatal Fc Receptor Regulation of Lung Immunoglobulin and CD103 <sup>+</sup> Dendritic Cells Confers Transient Susceptibility to Tuberculosis
Neonatal Fc Receptor Regulation of Lung Immunoglobulin and CD103 <sup>+</sup> Dendritic Cells Confers Transient Susceptibility to Tuberculosis Open
The neonatal Fc receptor (FcRn) extends the systemic half-life of IgG antibodies by chaperoning bound Fc away from lysosomal degradation inside stromal and hematopoietic cells. FcRn also transports IgG across mucosal barriers into the lume…