Stephen Tomlin
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View article: ‘They Take the Mum Off You When You Come In’: An Ethnographic Study of Parent Experiences of Medicines Safety Systems in English Hospitals
‘They Take the Mum Off You When You Come In’: An Ethnographic Study of Parent Experiences of Medicines Safety Systems in English Hospitals Open
Introduction Medication safety in healthcare settings is a persistent problem, and children may be at greater risk of harm than adults. Most existing research examining medication safety for hospitalised children is from the perspective of…
View article: Real-World Evidence of 3D Printing of Personalised Paediatric Medicines and Evaluating Its Potential in Children with Cancer: A Scoping Review
Real-World Evidence of 3D Printing of Personalised Paediatric Medicines and Evaluating Its Potential in Children with Cancer: A Scoping Review Open
Personalised medicine, facilitated by advancements like 3D printing, may offer promise in oncology. This scoping review aims to explore the applicability of 3D printing for personalised pharmaceutical dosage forms in paediatric cancer care…
View article: SP5 Children’s and families’ views of 3d-printed/personalised medicines in clinical practice
SP5 Children’s and families’ views of 3d-printed/personalised medicines in clinical practice Open
Background Children and young people are three times more likely than adults to experience harm from medicines.1 75–85% of patients suffer from unwanted side effects from therapy not based on individual requirements2 resulting in 1 in 15 h…
View article: SP3 An exploratory study to characterise dosing instructions on dispensed paediatric medicines labels
SP3 An exploratory study to characterise dosing instructions on dispensed paediatric medicines labels Open
Aim The dispensing label is the primary means by which healthcare professionals communicate dosing instructions on how and when to administer a medicine to patients. Yet, the misreading or misinterpreting of dosing instructions is frequent…
View article: SP6 Exploring the factors affecting patient access to authorised paediatric medicines in clinical practice
SP6 Exploring the factors affecting patient access to authorised paediatric medicines in clinical practice Open
Aim Recent decades have seen the development of regulatory frameworks aimed at increasing the availability of medicines authorised for children. In Europe, the Paediatric Use Marketing Authorisation (PUMA) was introduced to incentivise the…
View article: Understanding the informal aspects of medication processes to maintain patient safety in hospitals: a sociotechnical ethnographic study in paediatric units
Understanding the informal aspects of medication processes to maintain patient safety in hospitals: a sociotechnical ethnographic study in paediatric units Open
Adverse drug events (ADEs) are common in hospitals, affecting one in six child in-patients. Medication processes are complex systems. This study aimed to explore the work-as-done of medication safety in three English paediatric units using…
View article: P31 Oral propranolol liquid: a snapshot survey of concentrations in use
P31 Oral propranolol liquid: a snapshot survey of concentrations in use Open
Aim For several drugs available as licensed liquids, multiple concentrations exist. Four different propranolol concentrations are available: 1 mg/mL, 2 mg/mL, 8 mg/mL and 10 mg/mL. 1 Existence of multiple concentrations increases the chanc…
View article: P07 Hormonal contraceptives: safe for use in adolescent girls?
P07 Hormonal contraceptives: safe for use in adolescent girls? Open
Aim There is an increased use of Hormonal Contraceptives (HCs) in female adolescents, during a period of growth, development and hormonal changes. 1 2 Due to the limited long-term safety data available for adolescents, most of the guidelin…
View article: The impact of the COVID-19 pandemic on antimicrobial prescribing at a specialist paediatric hospital: an observational study
The impact of the COVID-19 pandemic on antimicrobial prescribing at a specialist paediatric hospital: an observational study Open
Background The COVID-19 pandemic has severely impacted healthcare delivery and there are growing concerns that the pandemic will accelerate antimicrobial resistance. Objectives To evaluate the impact of the COVID-19 pandemic on antibiotic …
View article: Establishing dose bands for commonly prescribed oral medications for children in the UK: Results of a Delphi study
Establishing dose bands for commonly prescribed oral medications for children in the UK: Results of a Delphi study Open
Objective To establish weight‐based dose bands for commonly used oral medicines, given in liquid forms, for children in the UK that could be used for prescribing and administering accurate and safe drug doses. Methods A list of commonly pr…
View article: Cost-Consequences Analysis of Increased Utilization of Triple-Chamber-Bag Parenteral Nutrition in Preterm Neonates in Seven European Countries
Cost-Consequences Analysis of Increased Utilization of Triple-Chamber-Bag Parenteral Nutrition in Preterm Neonates in Seven European Countries Open
The safety of parenteral nutrition (PN) remains a concern in preterm neonates, impacting clinical outcomes and health-care-resource use and costs. This cost-consequence analysis assessed national-level impacts of a 10-percentage point incr…
View article: P46 Dose-banding limits for commonly prescribed medications for children in the UK
P46 Dose-banding limits for commonly prescribed medications for children in the UK Open
Aim Currently, majority of prescribed medication doses are calculated according to a child’s body weight without considering the available drug products for administration or the therapeutic range of the drug. This can lead to lack of cons…
View article: P47 Extent of paediatric exposure to pharmaceutical excipients: an exploratory study
P47 Extent of paediatric exposure to pharmaceutical excipients: an exploratory study Open
Aim The assumption that excipients are inactive therefore non-harmful to patients is a declining opinion due to raised safety concerns of excipient activity, particularly in children. 1 There is limited data on the safety of excipients in …
View article: Pharmacokinetic and pharmacodynamic evidence of adrenaline administered via auto‐injector for anaphylactic reactions: A review of literature
Pharmacokinetic and pharmacodynamic evidence of adrenaline administered via auto‐injector for anaphylactic reactions: A review of literature Open
Anaphylaxis is a severe allergic reaction that can lead to death if not treated quickly. Adrenaline (epinephrine) is the first‐line treatment for anaphylaxis and its prompt administration is vital to reduce mortality. Following a number of…
View article: GAPPS (Grading and Assessment of Pharmacokinetic-Pharmacodynamic Studies) a critical appraisal system for antimicrobial PKPD studies – development and application in pediatric antibiotic studies
GAPPS (Grading and Assessment of Pharmacokinetic-Pharmacodynamic Studies) a critical appraisal system for antimicrobial PKPD studies – development and application in pediatric antibiotic studies Open
Introduction: There are limited data on optimal dosing of antibiotics in different age groups for neonates and children. Clinicians usually consult pediatric formularies or online databases for dose selection, but these have variable recom…
View article: Impact of the e-prescribing system on the incidence and nature of drug-related problems in children in a Saudi hospital
Impact of the e-prescribing system on the incidence and nature of drug-related problems in children in a Saudi hospital Open
Objectives To determine the impact of a computerised physician order entry (CPOE) system on the drug-related problems’ (DRPs) incidence and characteristics in hospitalised children in a Saudi hospital, and to compare DRPs incidence pre-/po…
View article: Evaluation of the practice of dose-rounding in paediatrics
Evaluation of the practice of dose-rounding in paediatrics Open
Objectives To investigate the rounding of prescribed drug doses for paediatric administration. Methods A cross-sectional medication chart review was conducted at a UK paediatric hospital. Proposed administration dose volumes were calculate…
View article: Pediatric pharmacokinetics of the antibiotics in the access and watch groups of the 2019 WHO model list of essential medicines for children: a systematic review
Pediatric pharmacokinetics of the antibiotics in the access and watch groups of the 2019 WHO model list of essential medicines for children: a systematic review Open
Introduction: Pharmacokinetic-pharmacodynamic (PK-PD) studies of antibiotics in pediatrics are limited. Pediatric dosing regimens for many antimicrobial drugs have been historically derived from adult pharmacokinetic data. Most pediatric f…
View article: Pediatric pharmacokinetics of the antibiotics in the access and watch groups of the 2019 WHO model list of essential medicines for children: a systematic review
Pediatric pharmacokinetics of the antibiotics in the access and watch groups of the 2019 WHO model list of essential medicines for children: a systematic review Open
Introduction: Pharmacokinetic-pharmacodynamic (PK-PD) studies of antibiotics in pediatrics are limited. Pediatric dosing regimens for many antimicrobial drugs have been historically derived from adult pharmacokinetic data. Most pediatric f…
View article: MOESM2 of Mapping the prevalence and nature of drug related problems among hospitalised children in the United Kingdom: a systematic review
MOESM2 of Mapping the prevalence and nature of drug related problems among hospitalised children in the United Kingdom: a systematic review Open
Additional file 2. Study Summary.