Stephen Vadia
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View article: The transcription factor DksA exerts opposing effects on cell division depending on the presence of ppGpp
The transcription factor DksA exerts opposing effects on cell division depending on the presence of ppGpp Open
Bacterial cell size is a multifactorial trait that is influenced by variables including nutritional availability and the timing of cell division. Prior work revealed a negative correlation between concentration of the alarmone (p)ppGpp (pp…
View article: The transcription factor DksA exerts opposing effects on cell division depending on the presence of ppGpp
The transcription factor DksA exerts opposing effects on cell division depending on the presence of ppGpp Open
Bacterial cell size is a multifactorial trait that is influenced by variables including nutritional availability and the timing of cell division. Prior work revealed a negative correlation between the alarmone (p)ppGpp (ppGpp) and cell len…
View article: The Absence of (p)ppGpp Renders Initiation of Escherichia coli Chromosomal DNA Synthesis Independent of Growth Rates
The Absence of (p)ppGpp Renders Initiation of Escherichia coli Chromosomal DNA Synthesis Independent of Growth Rates Open
Bacterial cells regulate their own chromosomal DNA synthesis and cell division depending on the growth conditions, producing more DNA when growing in nutritionally rich media than in poor media (i.e., human gut versus water reservoir). The…
View article: A Chemical Inhibitor of Cell Growth Reduces Cell Size in <i>Bacillus subtilis</i>
A Chemical Inhibitor of Cell Growth Reduces Cell Size in <i>Bacillus subtilis</i> Open
Bacteria exhibit complex responses to biologically active small molecules. These responses include reductions in transcriptional and translational efficiency, alterations in metabolic flux, and in some cases, dramatic changes in growth and…
View article: Mechanistic origin of cell-size control and homeostasis in bacteria
Mechanistic origin of cell-size control and homeostasis in bacteria Open
Evolutionarily divergent bacteria share a common phenomenological strategy for cell-size homeostasis under steady-state conditions. In the presence of inherent physiological stochasticity, cells following this “adder” principle gradually r…
View article: Relative Roles of Listeriolysin O, InlA, and InlB in Listeria monocytogenes Uptake by Host Cells
Relative Roles of Listeriolysin O, InlA, and InlB in Listeria monocytogenes Uptake by Host Cells Open
Listeria monocytogenes is a facultative intracellular pathogen that infects a wide variety of cells, causing the life-threatening disease listeriosis. L. monocytogenes virulence factors include two surface invasins, InlA and InlB, known to…
View article: Host cell perforation by listeriolysin O (LLO) activates a Ca<sup>2+</sup>-dependent cPKC/Rac1/Arp2/3 signaling pathway that promotes<i>Listeria monocytogenes</i>internalization independently of membrane resealing
Host cell perforation by listeriolysin O (LLO) activates a Ca<sup>2+</sup>-dependent cPKC/Rac1/Arp2/3 signaling pathway that promotes<i>Listeria monocytogenes</i>internalization independently of membrane resealing Open
Pathogen-induced host plasma membrane damage is a recently recognized mechanism used by pathogens to promote their entry into host cells. We identified key transducers activated upon host cell perforation by the pore-forming toxin LLO to p…
View article: Flux through lipid synthesis dictates bacterial cell size
Flux through lipid synthesis dictates bacterial cell size Open
Nutrients—and by extension biosynthetic capacity—positively impact cell size in organisms throughout the tree of life. In bacteria, cell size is reduced three-fold in response to nutrient starvation or accumulation of the alarmone ppGpp, a…