Stephen W. Page
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View article: Dr Ian ‘Sandy’ Graham Pearson (1927–2025)
Dr Ian ‘Sandy’ Graham Pearson (1927–2025) Open
View article: Therapeutic and Formulation Innovations in the Management of Canine Otitis Externa
Therapeutic and Formulation Innovations in the Management of Canine Otitis Externa Open
Canine Otitis Externa (COE) is a challenging otological disorder in dogs which causes significant irritation and discomfort. This comprehensive review provides an extensive analysis of COE with emphasis on the fundamentals of the condition…
View article: Antimicrobial prescribing guidelines for horses in Australia
Antimicrobial prescribing guidelines for horses in Australia Open
The growing problem of antimicrobial resistance also affects equine veterinarians with increasing frequency. Antimicrobial stewardship and responsible prescribing are essential for a future in which effective antimicrobials are available, …
View article: Screening and hit evaluation of a microbial metabolite library against the pathogenic Plasmodium falciparum and Toxoplasma gondii parasites
Screening and hit evaluation of a microbial metabolite library against the pathogenic Plasmodium falciparum and Toxoplasma gondii parasites Open
View article: Sex Differences in the Genetic Causes of Dilated Cardiomyopathy
Sex Differences in the Genetic Causes of Dilated Cardiomyopathy Open
View article: Antimicrobial stewardship in animal health: experience-based co-design framework to capture progress and accelerate improvement
Antimicrobial stewardship in animal health: experience-based co-design framework to capture progress and accelerate improvement Open
Antimicrobial stewardship (AMS) is essential for mitigating antimicrobial resistance (AMR) in animal health but implementing national initiatives is challenging due to diverse influencing factors and the need for context-specific approache…
View article: A review of natural products as a source of next-generation drugs against apicomplexan parasites
A review of natural products as a source of next-generation drugs against apicomplexan parasites Open
Despite the substantial global health and economic burden of apicomplexan parasites in humans and livestock, treatment options remain limited. Natural products have long played an important role in combating these diseases, offering divers…
View article: Targeting Acne: Development of Monensin-Loaded Nanostructured Lipid Carriers
Targeting Acne: Development of Monensin-Loaded Nanostructured Lipid Carriers Open
This research highlights the novel ability of MON against resistant acne-causing pathogens and the potential of MON-NLCs to deliver MON to the targeted epidermal skin layer effectively.
View article: Response to “Global trends in antimicrobial use in food-producing animals: 2020 to 2030”
Response to “Global trends in antimicrobial use in food-producing animals: 2020 to 2030” Open
View article: Antimicrobial stewardship: a definition with a One Health perspective
Antimicrobial stewardship: a definition with a One Health perspective Open
View article: Antimicrobial prescribing guidelines for sheep
Antimicrobial prescribing guidelines for sheep Open
These Guidelines and any recommendations presented in the Guidelines: Persons involved in the preparation of the Guidelines accept no responsibility or liability (in contract, tort including negligence or otherwise) for any consequence, da…
View article: Antimicrobial prescribing guidelines for dairy cattle
Antimicrobial prescribing guidelines for dairy cattle Open
These Guidelines and any recommendations presented in the Guidelines: Persons involved in the preparation of the Guidelines accept no responsibility or liability (in contract, tort including negligence or otherwise) for any consequence, da…
View article: Protein deficiency and related metabolic disturbances and its effects on drug metabolism in patients with burns
Protein deficiency and related metabolic disturbances and its effects on drug metabolism in patients with burns Open
View article: Oral administration of a 2-aminopyrimidine robenidine analogue (NCL195) significantly reduces <i>Staphylococcus aureus</i> infection and reduces <i>Escherichia coli</i> infection in combination with sub-inhibitory colistin concentrations in a bioluminescent mouse model
Oral administration of a 2-aminopyrimidine robenidine analogue (NCL195) significantly reduces <i>Staphylococcus aureus</i> infection and reduces <i>Escherichia coli</i> infection in combination with sub-inhibitory colistin concentrations in a bioluminescent mouse model Open
We have previously reported promising in vivo activity of the first-generation 2-aminopyramidine robenidine analogue NCL195 against Gram-positive bacteria (GPB) when administered via the systemic route. In this study, we examined the effic…
View article: Quality of amoxicillin/clavulanic acid oral formulations for intended veterinary use in the UK, Malaysia, Serbia and Thailand
Quality of amoxicillin/clavulanic acid oral formulations for intended veterinary use in the UK, Malaysia, Serbia and Thailand Open
Objectives Amoxicillin/clavulanate is the most commonly used oral antimicrobial drug in companion animals. The objective of the study was to detect types and frequency of deficits in the quality of veterinary oral formulations of amoxicill…
View article: The effect of doxapram on survival and APGAR score in newborn puppies delivered by elective caesarean: A randomized controlled trial
The effect of doxapram on survival and APGAR score in newborn puppies delivered by elective caesarean: A randomized controlled trial Open
Doxapram is marketed as a respiratory stimulant and is used by some veterinarians to help with neonatal apnoea, especially in puppies delivered by caesarean. There is a lack of consensus as to whether the drug is effective and data on its …
View article: Physicochemical properties of otic products for Canine Otitis Externa: comparative analysis of marketed products
Physicochemical properties of otic products for Canine Otitis Externa: comparative analysis of marketed products Open
Background Otitis externa is a commonly diagnosed dermatological disorder in canines. The pathogens primarily involved in canine otitis externa (COE) include Staphylococcus pseudintermedius, Pseudomonas aeruginosa, Proteus mirabilis, and M…
View article: Advanced Strategies of Drug Delivery via Oral, Topical, and Parenteral Administration Routes: Where Do Equine Medications Stand?
Advanced Strategies of Drug Delivery via Oral, Topical, and Parenteral Administration Routes: Where Do Equine Medications Stand? Open
While the global market for veterinary products has been expanding rapidly, there is still a lack of specialist knowledge of equine pharmaceutics. In many cases, the basic structure of the gastrointestinal tract (GIT) and integumentary sys…
View article: In Vitro Activity of Robenidine Analogues NCL259 and NCL265 against Gram-Negative Pathogens
In Vitro Activity of Robenidine Analogues NCL259 and NCL265 against Gram-Negative Pathogens Open
Multidrug-resistant (MDR) Gram-negative pathogens, especially Acinetobacter baumannii, Pseudomonas aeruginosa, Escherichia coli and Enterobacter spp., are recognized by the World Health Organization as the most critical priority pathogens …
View article: Antigiardial Activity of Novel Guanidine Compounds
Antigiardial Activity of Novel Guanidine Compounds Open
From four focused compound libraries based on the known anticoccidial agent robenidine, 44 compounds total were synthesised and screened for antigiardial activity. All active compounds were counter‐screened for antibiotic and cytotoxic act…
View article: Coexistent diabetes is associated with the presence of adverse phenotypic features in patients with hypertrophic cardiomyopathy
Coexistent diabetes is associated with the presence of adverse phenotypic features in patients with hypertrophic cardiomyopathy Open
Objective- Type 2 diabetes mellitus (DM) is associated with worsened clinical outcomes in hypertrophic cardiomyopathy (HCM) patients. We sought to investigate if hypertrophic cardiomyopathy patients with type 2 diabetes …
View article: Impact of a Novel Anticoccidial Analogue on Systemic Staphylococcus aureus Infection in a Bioluminescent Mouse Model
Impact of a Novel Anticoccidial Analogue on Systemic Staphylococcus aureus Infection in a Bioluminescent Mouse Model Open
In this study, we investigated the potential of an analogue of robenidine (NCL179) to expand its chemical diversity for the treatment of multidrug-resistant (MDR) bacterial infections. We show that NCL179 exhibits potent bactericidal activ…
View article: Governance Processes and Challenges for Reservation of Antimicrobials Exclusively for Human Use and Restriction of Antimicrobial Use in Animals
Governance Processes and Challenges for Reservation of Antimicrobials Exclusively for Human Use and Restriction of Antimicrobial Use in Animals Open
The majority of antimicrobials that are produced are administered to animals, particularly food animals. While the overall impact of antimicrobial use in animals on antimicrobial resistance in humans and the environment is unclear, it unde…
View article: Repurposing of the Fasciolicide Triclabendazole to Treat Infections Caused by Staphylococcus spp. and Vancomycin-Resistant Enterococci
Repurposing of the Fasciolicide Triclabendazole to Treat Infections Caused by Staphylococcus spp. and Vancomycin-Resistant Enterococci Open
One approach to combat the increasing incidence of multidrug-resistant (MDR) bacterial pathogens involves repurposing existing compounds with known safety and development pathways as new antibacterial classes with potentially novel mechani…
View article: Masthead
Masthead Open
The primary mission of AJOT is to publish research examining the effectiveness and efficiency of occupational therapy practice so that occupational therapy professionals can make informed, evidence-based decisions about best practice.In ad…
View article: Evaluation of Benzguinols as Next-Generation Antibiotics for the Treatment of Multidrug-Resistant Bacterial Infections
Evaluation of Benzguinols as Next-Generation Antibiotics for the Treatment of Multidrug-Resistant Bacterial Infections Open
Our recent focus on the “lost antibiotic” unguinol and related nidulin-family fungal natural products identified two semisynthetic derivatives, benzguinols A and B, with unexpected in vitro activity against Staphylococcus aureus isolates e…
View article: Antimicrobial prescribing guidelines for poultry
Antimicrobial prescribing guidelines for poultry Open
View article: Comparison of Two Transmission Electron Microscopy Methods to Visualize Drug-Induced Alterations of Gram-Negative Bacterial Morphology
Comparison of Two Transmission Electron Microscopy Methods to Visualize Drug-Induced Alterations of Gram-Negative Bacterial Morphology Open
In this study, we optimized and compared different transmission electron microscopy (TEM) methods to visualize changes to Gram-negative bacterial morphology induced by treatment with a robenidine analogue (NCL195) and colistin combination.…
View article: Development and Validation of a New Analytical Method for Estimation of Narasin Using Refractive Index Detector and its Greenness Evaluation
Development and Validation of a New Analytical Method for Estimation of Narasin Using Refractive Index Detector and its Greenness Evaluation Open
View article: Review for "Antimicrobial resistance in clinical bacterial isolates from horses in the UK"
Review for "Antimicrobial resistance in clinical bacterial isolates from horses in the UK" Open