Stephen T.C. Wong
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View article: Supplementary Table 4 from Spatial Cross-talk Modeling of the Tumor Microenvironment Identifies CCR5-Mediated Glia-to-Glia Signaling as a Key Regulator of Brain Metastatic Progression
Supplementary Table 4 from Spatial Cross-talk Modeling of the Tumor Microenvironment Identifies CCR5-Mediated Glia-to-Glia Signaling as a Key Regulator of Brain Metastatic Progression Open
Ligand-receptor pairs mediating tumor-to-glia and glia-to-glia crosstalk
View article: Supplementary Figure 2 from Spatial Cross-talk Modeling of the Tumor Microenvironment Identifies CCR5-Mediated Glia-to-Glia Signaling as a Key Regulator of Brain Metastatic Progression
Supplementary Figure 2 from Spatial Cross-talk Modeling of the Tumor Microenvironment Identifies CCR5-Mediated Glia-to-Glia Signaling as a Key Regulator of Brain Metastatic Progression Open
Astrocyte activation on day 3, quantification of the size and number of GFAP+ cells at day 3 post-tumor injection, and oligodendrocytes phenotypic changes at day 28 post-tumor injection
View article: Supplementary Table 3 from Spatial Transcriptomics Depict Ligand–Receptor Cross-talk Heterogeneity at the Tumor-Stroma Interface in Long-Term Ovarian Cancer Survivors
Supplementary Table 3 from Spatial Transcriptomics Depict Ligand–Receptor Cross-talk Heterogeneity at the Tumor-Stroma Interface in Long-Term Ovarian Cancer Survivors Open
scRNAseq differentially expressed genes
View article: Supplementary Table 2 from Spatial Transcriptomics Depict Ligand–Receptor Cross-talk Heterogeneity at the Tumor-Stroma Interface in Long-Term Ovarian Cancer Survivors
Supplementary Table 2 from Spatial Transcriptomics Depict Ligand–Receptor Cross-talk Heterogeneity at the Tumor-Stroma Interface in Long-Term Ovarian Cancer Survivors Open
Spatial Transcriptomics differentially expressed genes
View article: Supplementary Table 4 from Spatial Transcriptomics Depict Ligand–Receptor Cross-talk Heterogeneity at the Tumor-Stroma Interface in Long-Term Ovarian Cancer Survivors
Supplementary Table 4 from Spatial Transcriptomics Depict Ligand–Receptor Cross-talk Heterogeneity at the Tumor-Stroma Interface in Long-Term Ovarian Cancer Survivors Open
MIA immune enrichment group comparison
View article: Supplementary Figures 1-11 from Spatial Transcriptomics Depict Ligand–Receptor Cross-talk Heterogeneity at the Tumor-Stroma Interface in Long-Term Ovarian Cancer Survivors
Supplementary Figures 1-11 from Spatial Transcriptomics Depict Ligand–Receptor Cross-talk Heterogeneity at the Tumor-Stroma Interface in Long-Term Ovarian Cancer Survivors Open
Supplementary Figures 1-11
View article: Supplementary Materials and Methods from Spatial Transcriptomics Depict Ligand–Receptor Cross-talk Heterogeneity at the Tumor-Stroma Interface in Long-Term Ovarian Cancer Survivors
Supplementary Materials and Methods from Spatial Transcriptomics Depict Ligand–Receptor Cross-talk Heterogeneity at the Tumor-Stroma Interface in Long-Term Ovarian Cancer Survivors Open
Supplementary Materials and Methods
View article: Assessing deep learning models for multi-class upper endoscopic disease segmentation: A comprehensive comparative study
Assessing deep learning models for multi-class upper endoscopic disease segmentation: A comprehensive comparative study Open
BACKGROUND Upper gastrointestinal (UGI) diseases present diagnostic challenges during endoscopy due to visual similarities, indistinct boundaries, and observer variability, which can lead to missed diagnoses and delayed treatment. Automate…
View article: From Time to Tissue: AI-Driven Net Water Uptake Mapping Enables Early Detection of Reversible Ischemia on Non-Contrast CT Scans
From Time to Tissue: AI-Driven Net Water Uptake Mapping Enables Early Detection of Reversible Ischemia on Non-Contrast CT Scans Open
Background: Non-contrast computed tomography (NCCT) is the most widely used initial imaging modality for acute ischemic stroke (AIS) triage, but its limited sensitivity to early ischemia changes constrains accurate lesion characterization.…
View article: Global innovative perspectives and trends on digital health and patient safety: highlights from the #DHPSP2024 networking event
Global innovative perspectives and trends on digital health and patient safety: highlights from the #DHPSP2024 networking event Open
Aim: This manuscript summarizes the key scientific and practical outcomes of the #DHPSP2024 digital networking event, focusing on emerging trends in digital health technologies, innovations in patient safety, and their implications for imp…
View article: Alzheimer’s disease disrupts intra-adipose neurovascular contact
Alzheimer’s disease disrupts intra-adipose neurovascular contact Open
View article: Identifying Retinal Features Using a Self-Configuring CNN for Clinical Intervention
Identifying Retinal Features Using a Self-Configuring CNN for Clinical Intervention Open
We demonstrate robust segmentation performance and generalizability across independently collected datasets. OCTAVE bridges the gap in publicly available datasets, supporting the development of AI tools for precise disease detection, monit…
View article: GD3 synthase drives resistance to p53-induced apoptosis in breast cancer by modulating mitochondrial function
GD3 synthase drives resistance to p53-induced apoptosis in breast cancer by modulating mitochondrial function Open
TP53 mutations are common in breast cancer (BC) and are associated with poor prognosis. GD3 synthase (GD3S/ ST8SIA1 ), a gene associated with breast cancer stem cells, is upregulated in tumors with p53 mutations. However, the functional re…
View article: Supplementary Table II from Tumor NOS2 and COX2 Spatial Juxtaposition with CD8<sup>+</sup> T Cells Promote Metastatic and Cancer Stem Cell Niches that Lead to Poor Outcome in ER<sup>−</sup> Breast Cancer
Supplementary Table II from Tumor NOS2 and COX2 Spatial Juxtaposition with CD8<sup>+</sup> T Cells Promote Metastatic and Cancer Stem Cell Niches that Lead to Poor Outcome in ER<sup>−</sup> Breast Cancer Open
Supplementary Table II summarizes �8+ T cells in designated regions of the tumors.
View article: Supplementary Figure 6 from Tumor NOS2 and COX2 Spatial Juxtaposition with CD8<sup>+</sup> T Cells Promote Metastatic and Cancer Stem Cell Niches that Lead to Poor Outcome in ER<sup>−</sup> Breast Cancer
Supplementary Figure 6 from Tumor NOS2 and COX2 Spatial Juxtaposition with CD8<sup>+</sup> T Cells Promote Metastatic and Cancer Stem Cell Niches that Lead to Poor Outcome in ER<sup>−</sup> Breast Cancer Open
Modulation of EpCAM and CD44v6+.
View article: Supplementary Figure 3 from Tumor NOS2 and COX2 Spatial Juxtaposition with CD8<sup>+</sup> T Cells Promote Metastatic and Cancer Stem Cell Niches that Lead to Poor Outcome in ER<sup>−</sup> Breast Cancer
Supplementary Figure 3 from Tumor NOS2 and COX2 Spatial Juxtaposition with CD8<sup>+</sup> T Cells Promote Metastatic and Cancer Stem Cell Niches that Lead to Poor Outcome in ER<sup>−</sup> Breast Cancer Open
Immune and tumor quantification
View article: Supplementary Figure 4 from Tumor NOS2 and COX2 Spatial Juxtaposition with CD8<sup>+</sup> T Cells Promote Metastatic and Cancer Stem Cell Niches that Lead to Poor Outcome in ER<sup>−</sup> Breast Cancer
Supplementary Figure 4 from Tumor NOS2 and COX2 Spatial Juxtaposition with CD8<sup>+</sup> T Cells Promote Metastatic and Cancer Stem Cell Niches that Lead to Poor Outcome in ER<sup>−</sup> Breast Cancer Open
Supplementary Fig. 4. Supplementary Fig. 4. Spatial UMAP analysis of CD8+/-NOS2+/-COX2+/- phenotypes in Deceased vs Alive patient tumors. Single cell neighborhood profile summary.
View article: Supplementary Figure 1 from Tumor NOS2 and COX2 Spatial Juxtaposition with CD8<sup>+</sup> T Cells Promote Metastatic and Cancer Stem Cell Niches that Lead to Poor Outcome in ER<sup>−</sup> Breast Cancer
Supplementary Figure 1 from Tumor NOS2 and COX2 Spatial Juxtaposition with CD8<sup>+</sup> T Cells Promote Metastatic and Cancer Stem Cell Niches that Lead to Poor Outcome in ER<sup>−</sup> Breast Cancer Open
Tumor NOS2 and COX2 expression induced by IFNg and TNFa
View article: Supplementary Figure 4 from Tumor NOS2 and COX2 Spatial Juxtaposition with CD8<sup>+</sup> T Cells Promote Metastatic and Cancer Stem Cell Niches that Lead to Poor Outcome in ER<sup>−</sup> Breast Cancer
Supplementary Figure 4 from Tumor NOS2 and COX2 Spatial Juxtaposition with CD8<sup>+</sup> T Cells Promote Metastatic and Cancer Stem Cell Niches that Lead to Poor Outcome in ER<sup>−</sup> Breast Cancer Open
Supplementary Fig. 4. Supplementary Fig. 4. Spatial UMAP analysis of CD8+/-NOS2+/-COX2+/- phenotypes in Deceased vs Alive patient tumors. Single cell neighborhood profile summary.
View article: Supplementary Figure 5 from Tumor NOS2 and COX2 Spatial Juxtaposition with CD8<sup>+</sup> T Cells Promote Metastatic and Cancer Stem Cell Niches that Lead to Poor Outcome in ER<sup>−</sup> Breast Cancer
Supplementary Figure 5 from Tumor NOS2 and COX2 Spatial Juxtaposition with CD8<sup>+</sup> T Cells Promote Metastatic and Cancer Stem Cell Niches that Lead to Poor Outcome in ER<sup>−</sup> Breast Cancer Open
Spatial dot plot of CD8+/-NOS2+/-COX2+/- phenotypes in tumor from deceased patient.
View article: Supplementary Table II from Tumor NOS2 and COX2 Spatial Juxtaposition with CD8<sup>+</sup> T Cells Promote Metastatic and Cancer Stem Cell Niches that Lead to Poor Outcome in ER<sup>−</sup> Breast Cancer
Supplementary Table II from Tumor NOS2 and COX2 Spatial Juxtaposition with CD8<sup>+</sup> T Cells Promote Metastatic and Cancer Stem Cell Niches that Lead to Poor Outcome in ER<sup>−</sup> Breast Cancer Open
Supplementary Table II summarizes �8+ T cells in designated regions of the tumors.
View article: Supplementary Table I from Tumor NOS2 and COX2 Spatial Juxtaposition with CD8<sup>+</sup> T Cells Promote Metastatic and Cancer Stem Cell Niches that Lead to Poor Outcome in ER<sup>−</sup> Breast Cancer
Supplementary Table I from Tumor NOS2 and COX2 Spatial Juxtaposition with CD8<sup>+</sup> T Cells Promote Metastatic and Cancer Stem Cell Niches that Lead to Poor Outcome in ER<sup>−</sup> Breast Cancer Open
Supplementary Table I summarizes pathological features of tumor immune microenvironment where NOS2+ inflamed regions are significantly higher in tumors from Deceased patients.
View article: Supplementary Figure 1 from Tumor NOS2 and COX2 Spatial Juxtaposition with CD8<sup>+</sup> T Cells Promote Metastatic and Cancer Stem Cell Niches that Lead to Poor Outcome in ER<sup>−</sup> Breast Cancer
Supplementary Figure 1 from Tumor NOS2 and COX2 Spatial Juxtaposition with CD8<sup>+</sup> T Cells Promote Metastatic and Cancer Stem Cell Niches that Lead to Poor Outcome in ER<sup>−</sup> Breast Cancer Open
Tumor NOS2 and COX2 expression induced by IFNg and TNFa
View article: Supplementary Figure 2 from Tumor NOS2 and COX2 Spatial Juxtaposition with CD8<sup>+</sup> T Cells Promote Metastatic and Cancer Stem Cell Niches that Lead to Poor Outcome in ER<sup>−</sup> Breast Cancer
Supplementary Figure 2 from Tumor NOS2 and COX2 Spatial Juxtaposition with CD8<sup>+</sup> T Cells Promote Metastatic and Cancer Stem Cell Niches that Lead to Poor Outcome in ER<sup>−</sup> Breast Cancer Open
Tumor analysis of NOS2 and COX2.
View article: Supplementary Table I from Tumor NOS2 and COX2 Spatial Juxtaposition with CD8<sup>+</sup> T Cells Promote Metastatic and Cancer Stem Cell Niches that Lead to Poor Outcome in ER<sup>−</sup> Breast Cancer
Supplementary Table I from Tumor NOS2 and COX2 Spatial Juxtaposition with CD8<sup>+</sup> T Cells Promote Metastatic and Cancer Stem Cell Niches that Lead to Poor Outcome in ER<sup>−</sup> Breast Cancer Open
Supplementary Table I summarizes pathological features of tumor immune microenvironment where NOS2+ inflamed regions are significantly higher in tumors from Deceased patients.
View article: Supplementary Figure 2 from Tumor NOS2 and COX2 Spatial Juxtaposition with CD8<sup>+</sup> T Cells Promote Metastatic and Cancer Stem Cell Niches that Lead to Poor Outcome in ER<sup>−</sup> Breast Cancer
Supplementary Figure 2 from Tumor NOS2 and COX2 Spatial Juxtaposition with CD8<sup>+</sup> T Cells Promote Metastatic and Cancer Stem Cell Niches that Lead to Poor Outcome in ER<sup>−</sup> Breast Cancer Open
Tumor analysis of NOS2 and COX2.
View article: Supplementary Figure 6 from Tumor NOS2 and COX2 Spatial Juxtaposition with CD8<sup>+</sup> T Cells Promote Metastatic and Cancer Stem Cell Niches that Lead to Poor Outcome in ER<sup>−</sup> Breast Cancer
Supplementary Figure 6 from Tumor NOS2 and COX2 Spatial Juxtaposition with CD8<sup>+</sup> T Cells Promote Metastatic and Cancer Stem Cell Niches that Lead to Poor Outcome in ER<sup>−</sup> Breast Cancer Open
Modulation of EpCAM and CD44v6+.
View article: Supplementary Figure 5 from Tumor NOS2 and COX2 Spatial Juxtaposition with CD8<sup>+</sup> T Cells Promote Metastatic and Cancer Stem Cell Niches that Lead to Poor Outcome in ER<sup>−</sup> Breast Cancer
Supplementary Figure 5 from Tumor NOS2 and COX2 Spatial Juxtaposition with CD8<sup>+</sup> T Cells Promote Metastatic and Cancer Stem Cell Niches that Lead to Poor Outcome in ER<sup>−</sup> Breast Cancer Open
Spatial dot plot of CD8+/-NOS2+/-COX2+/- phenotypes in tumor from deceased patient.
View article: Supplementary Figure 3 from Tumor NOS2 and COX2 Spatial Juxtaposition with CD8<sup>+</sup> T Cells Promote Metastatic and Cancer Stem Cell Niches that Lead to Poor Outcome in ER<sup>−</sup> Breast Cancer
Supplementary Figure 3 from Tumor NOS2 and COX2 Spatial Juxtaposition with CD8<sup>+</sup> T Cells Promote Metastatic and Cancer Stem Cell Niches that Lead to Poor Outcome in ER<sup>−</sup> Breast Cancer Open
Immune and tumor quantification
View article: Hydroxytyrosol, a Component of Olive Oil for Breast Cancer Prevention in Women at High Risk of Cancer
Hydroxytyrosol, a Component of Olive Oil for Breast Cancer Prevention in Women at High Risk of Cancer Open
Background: This study evaluates the effects of hydroxytyrosol (HT), a component of olive oil, on mammographic breast density reduction. We explored effects of HT on Wnt β ‐catenin and other pathways involved in cancer stem cell renewal, D…