Hsien-Jue Chu
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View article: Dual-subtype feline immunodeficiency virus vaccine provides 12 months of protective immunity against heterologous challenge
Dual-subtype feline immunodeficiency virus vaccine provides 12 months of protective immunity against heterologous challenge Open
The duration of immunity of the dual-subtype feline immunodeficiency virus (FIV) vaccine, Fel-O-Vax FIV, for protection against subtype-B FIV was assessed in this study. Vaccinated cats along with controls were challenged with FIV FC1 , a …
View article: Induction of Adaptive T Regulatory Cells That Suppress the Allergic Response by Coimmunization of DNA and Protein Vaccines
Induction of Adaptive T Regulatory Cells That Suppress the Allergic Response by Coimmunization of DNA and Protein Vaccines Open
Allergen-induced immediate hypersensitivity (AIH) is a health issue of significant concern. This robust inflammatory reaction is initiated by the allergen-specific T cell responsiveness. Severe lesion reactions on skin are consequential pr…
View article: Experimental induction of chronic borreliosis in adult dogs exposed to Borrelia burgdorferi–infected ticks and treated with dexamethasone
Experimental induction of chronic borreliosis in adult dogs exposed to Borrelia burgdorferi–infected ticks and treated with dexamethasone Open
Objective —To develop a method to experimentally induce Borrelia burgdorferi infection in young adult dogs. Animals —22 healthy Beagles. Procedure —All dogs were verified to be free of borreliosis. Twenty 6-month-old dogs were exposed to B…
View article: Construction and characterization of a glycoprotein E gene-deleted bovine herpesvirus type 1 recombinant
Construction and characterization of a glycoprotein E gene-deleted bovine herpesvirus type 1 recombinant Open
Objective To construct and characterize a recombinant glycoprotein (g)E gene-deleted bovine herpesvirus (BHV) type 1 (BHV-1). Procedure The BHV-1 gE gene-coding region and the flanking upstream and downstream sequences were cloned. The afo…
View article: Field study of the safety, immunogenicity, and efficacy of an inactivated equine rotavirus vaccine
Field study of the safety, immunogenicity, and efficacy of an inactivated equine rotavirus vaccine Open
Objective— To determine safety, immunogenicity, and efficacy of an inactivated equine rotavirus vaccine. Design— Prospective randomized controlled trial. Animals— 316 pregnant Thoroughbred mares during the first year of the study and 311 d…
View article: Clinical evaluation of the efficacy of inoculating cattle with a vaccine containing Tritrichomonas foetus
Clinical evaluation of the efficacy of inoculating cattle with a vaccine containing Tritrichomonas foetus Open
Summary To test the efficacy of a polyvalent Tritrichomonas foetus vaccine, 130 nulliparous heifers were randomly assigned to either receive the test T foetus vaccine or to serve as nonvaccinated controls. The polyvalent test vaccine consi…
View article: Examination of Koch's postulates for Borrelia burgdorferi as the causative agent of limb/joint dysfunction in dogs with borreliosis
Examination of Koch's postulates for Borrelia burgdorferi as the causative agent of limb/joint dysfunction in dogs with borreliosis Open
Summary Borrelia burgdorferi has been implicated as the causative agent of borreliosis in dogs, which is characteristically a limb/joint disorder, but can be associated with multiple-organ dysfunction. Attempts to reproduce this disease by…
View article: Immunogenicity and efficacy study of a commercial Borrelia burgdorferi bacterin
Immunogenicity and efficacy study of a commercial Borrelia burgdorferi bacterin Open
Summary The immunogenicity and efficacy of a commercial Borrelia burgdorferi bacterin was evaluated for stimulation of the host immune response and protection against clinical disease associated with experimentally induced borreliosis in d…
View article: Comparison of the efficacy of three commercial feline leukemia virus vaccines in a natural challenge exposure
Comparison of the efficacy of three commercial feline leukemia virus vaccines in a natural challenge exposure Open
Summary Forty-seven kittens were exposed for 31 weeks to 12 FeLV-positive carrier cats. The carrier cats were infected with 2 laboratory strains of FeLV and at least 2 strains of street virus. Eleven nonvaccinated control kittens and 12 va…
View article: Antibody response of kittens after vaccination followed by exposure to feline leukemia virus-infected cats
Antibody response of kittens after vaccination followed by exposure to feline leukemia virus-infected cats Open
Summary Protein (western) blot analysis and virus-neutralization assay were used to evaluate the antibody response of specific-pathogen-free kittens to FeLV vaccination and followed by natural exposure. Several kittens had barely detectabl…