Stephen M. Malone
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View article: Patterns of brain-wide associations reflect socioeconomics
Patterns of brain-wide associations reflect socioeconomics Open
Previous brain-wide association studies (BWAS) cross-sectionally linked a specific behavioral trait, most commonly IQ or psychopathology, to variation in brain function or structure. Here, we expanded the focus of BWAS from effect sizes to…
View article: Motion impact score for detecting spurious brain-behavior associations
Motion impact score for detecting spurious brain-behavior associations Open
In-scanner head motion introduces systematic bias to resting-state fMRI functional connectivity (FC) not completely removed by denoising algorithms. Researchers studying traits associated with motion (e.g. psychiatric disorders) need to kn…
View article: Cannabis use and suicidal thoughts and behavior: A multi-site, co-twin control study from adolescence through middle adulthood
Cannabis use and suicidal thoughts and behavior: A multi-site, co-twin control study from adolescence through middle adulthood Open
Background: Observational studies have repeatedly linked cannabis use to increased suicidality, yet cannabis use rarely exists in isolation from other risk factors. We therefore tested whether these associations reflect a causal effect, re…
View article: Teachers’ Perceptions and Experiences of Irish Secondary School Students with OCD
Teachers’ Perceptions and Experiences of Irish Secondary School Students with OCD Open
OCD is a prevalent mental disorder, particularly amongst adolescents, with prevalence rates between 1 and 3 percent globally. This study aimed to explore teachers’ perceptions and experiences of Irish secondary school students with OCD. In…
View article: Experiences and Perceptions of Adolescents with OCD Amongst a Sample of Secondary School Teachers in Ireland
Experiences and Perceptions of Adolescents with OCD Amongst a Sample of Secondary School Teachers in Ireland Open
OCD is a prevalent mental disorder, particularly amongst adolescents, with prevalence rates between 1 and 3 percent globally. This study aimed to explore experiences and perceptions of adolescents with obsessive-compulsive disorder (OCD) a…
View article: Clarifying the place of p300 in the empirical structure of psychopathology over development.
Clarifying the place of p300 in the empirical structure of psychopathology over development. Open
Psychophysiology can help elucidate the structure and developmental mechanisms of psychopathology, consistent with the Research Domain Criteria initiative. Cross-sectional research using categorical diagnoses indicates that P300 is an elec…
View article: Cognitive abilities are associated with rapid dynamics of electrophysiological connectome states
Cognitive abilities are associated with rapid dynamics of electrophysiological connectome states Open
Time-varying changes in whole-brain connectivity patterns, or connectome state dynamics, hold significant implications for cognition. However, connectome dynamics at fast (> 1Hz) timescales highly relevant to cognition are poorly understoo…
View article: Cognitive abilities are associated with rapid dynamics of electrophysiological connectome states
Cognitive abilities are associated with rapid dynamics of electrophysiological connectome states Open
Time-varying changes in whole-brain connectivity patterns, or connectome state dynamics, hold significant implications for cognition. However, connectome dynamics at fast (>1 Hz) timescales highly relevant to cognition are poorly unders…
View article: Rapid dynamics of electrophysiological connectome states are heritable
Rapid dynamics of electrophysiological connectome states are heritable Open
Time-varying changes in whole-brain connectivity patterns, or connectome state dynamics, are a prominent feature of brain activity with broad functional implications. While infraslow (<0.1 Hz) connectome dynamics have been extensively s…
View article: Curated Pacific Northwest AI-ready Seismic Dataset
Curated Pacific Northwest AI-ready Seismic Dataset Open
The curation of seismic data sets is the cornerstone of seismological research and the starting point of machine-learning applications in seismology. We present a 21-year-long AI-ready data set of diverse seismic event parameters, instrume…
View article: Supplementary Material for: Peri-Insular hemispherotomy: A systematic review and institutional experience
Supplementary Material for: Peri-Insular hemispherotomy: A systematic review and institutional experience Open
Purpose: Peri-insular hemispherotomy (PIH) is a hemispheric separation technique under the broader hemispherotomy group, a surgical treatment for patients with intractable epilepsy. Hemispherotomy techniques such as the PIH, vertical paras…
View article: Motion Impact Score for Detecting Spurious Brain-Behavior Associations
Motion Impact Score for Detecting Spurious Brain-Behavior Associations Open
Between-participant differences in head motion introduce systematic bias to resting state fMRI brain-wide association studies (BWAS) that is not completely removed by denoising algorithms. Researchers who study traits, or phenotypes associ…
View article: Longitudinal stability and change in time–frequency measures from an oddball task during adolescence and early adulthood
Longitudinal stability and change in time–frequency measures from an oddball task during adolescence and early adulthood Open
Time–frequency representations of electroencephalographic signals lend themselves to a granular analysis of cognitive and psychological processes. Characterizing developmental trajectories of time–frequency measures can thus inform us abou…
View article: Real-time seizure detection in paediatric intensive care patients: the RESET child brain protocol
Real-time seizure detection in paediatric intensive care patients: the RESET child brain protocol Open
Introduction Approximately 20%–40% of comatose children with risk factors in intensive care have electrographic-only seizures; these go unrecognised due to the absence of continuous electroencephalography (EEG) monitoring (cEEG). Utility o…
View article: Reproducible brain-wide association studies require thousands of individuals
Reproducible brain-wide association studies require thousands of individuals Open
Magnetic resonance imaging (MRI) has transformed our understanding of the human brain through well-replicated mapping of abilities to specific structures (for example, lesion studies) and functions 1–3 (for example, task functional MRI (fM…
View article: Cannabidiol and refractory epilepsy: parental and caregiver perspectives of participation in a compassionate access scheme
Cannabidiol and refractory epilepsy: parental and caregiver perspectives of participation in a compassionate access scheme Open
Background The Compassionate Access Scheme (CAS) being delivered through the Queensland Children’s Hospital is designed to allow access to an investigational purified Cannabidiol oral solution to paediatric patients with severe refractory …
View article: Testing the consequences of alcohol, cannabis, and nicotine use on hippocampal volume: a quasi-experimental cotwin control analysis of young adult twins
Testing the consequences of alcohol, cannabis, and nicotine use on hippocampal volume: a quasi-experimental cotwin control analysis of young adult twins Open
Background Alcohol, cannabis, and nicotine use are highly comorbid and alarmingly prevalent in young adults. The hippocampus may be particularly sensitive to substance exposure. This remains largely untested in humans and familial risk may…
View article: Longitudinal Stability and Change in Time-Frequency Measures from an Oddball Task During Adolescence and Early Adulthood
Longitudinal Stability and Change in Time-Frequency Measures from an Oddball Task During Adolescence and Early Adulthood Open
Time-frequency representations of electroencephalographic signals lend themselves to granular analysis of cognitive and psychological processes. Characterizing developmental trajectories of time-frequency measures can thus inform us about …
View article: Large‐scale collaboration in ENIGMA‐EEG: A perspective on the meta‐analytic approach to link neurological and psychiatric liability genes to electrophysiological brain activity
Large‐scale collaboration in ENIGMA‐EEG: A perspective on the meta‐analytic approach to link neurological and psychiatric liability genes to electrophysiological brain activity Open
Background and purpose The ENIGMA‐EEG working group was established to enable large‐scale international collaborations among cohorts that investigate the genetics of brain function measured with electroencephalography (EEG). In this perspe…
View article: Cannabidiol and refractory epilepsy: parental and caregiver perspectives of participation in a compassionate access scheme
Cannabidiol and refractory epilepsy: parental and caregiver perspectives of participation in a compassionate access scheme Open
Background The Compassionate Access Scheme (CAS) being delivered through the Queensland Children’s Hospital is designed to allow access to an investigational purified Cannabidiol oral solution to paediatric patients with severe refractory …
View article: Associations between adolescent cannabis use and young-adult functioning in three longitudinal twin studies
Associations between adolescent cannabis use and young-adult functioning in three longitudinal twin studies Open
Significance A widely voiced concern regarding cannabis legalization in the United States is that cannabis is harmful to minors, affecting the developing brain to increase emotional and cognitive problems while impairing functioning. Howev…
View article: Using multivariate endophenotypes to identify psychophysiological mechanisms associated with polygenic scores for substance use, schizophrenia, and education attainment
Using multivariate endophenotypes to identify psychophysiological mechanisms associated with polygenic scores for substance use, schizophrenia, and education attainment Open
Background To better characterize brain-based mechanisms of polygenic liability for psychopathology and psychological traits, we extended our previous report (Liu et al. Psychophysiological endophenotypes to characterize mechanisms of know…
View article: Orbitofrontal cortex thickness and substance use disorders in emerging adulthood: causal inferences from a co‐twin control/discordant twin study
Orbitofrontal cortex thickness and substance use disorders in emerging adulthood: causal inferences from a co‐twin control/discordant twin study Open
Background/aims Research linking orbitofrontal cortex (OFC) structure and substance use disorders (SUDs) is largely correlational and often implies a causal effect of addiction/substance exposure on the brain, but familial risk factors (e.…
View article: A grouped beta process model for multivariate resting‐state EEG microstate analysis on twins
A grouped beta process model for multivariate resting‐state EEG microstate analysis on twins Open
EEG microstate analysis investigates the collection of distinct temporal blocks that characterize the electrical activity of the brain. Brain activity within each microstate is stable, but activity switches rapidly between different micros…
View article: Associations Between Common Forms of Psychopathology and Fecundity: Evidence From a Prospective, Longitudinal Twin Study
Associations Between Common Forms of Psychopathology and Fecundity: Evidence From a Prospective, Longitudinal Twin Study Open
We examined associations between common psychiatric disorders and fecundity in a population-based cohort of 1,252 twins prospectively assessed from adolescence into adulthood. Major depressive disorder, anxiety disorders, and alcohol use d…
View article: A co‐twin–control analysis of adolescent and young adult drinking effects on learning and memory
A co‐twin–control analysis of adolescent and young adult drinking effects on learning and memory Open
Background and aims Existing evidence for a link between alcohol use and memory impairments in adolescents and young adults is largely correlational. We aimed to determine whether associations between drinking and episodic memory were cons…
View article: Cannabidiol and Refractory Epilepsy: Parental and Caregiver Perspectives of Participation in a Compassionate Access Scheme
Cannabidiol and Refractory Epilepsy: Parental and Caregiver Perspectives of Participation in a Compassionate Access Scheme Open
BackgroundThe Compassionate Access Scheme (CAS) being delivered through the Queensland Children’s Hospital is designed to allow access to an investigational purified Cannabidiol oral solution to paediatric patients with severe refractory e…