Steven S. Shen
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View article: Immunotherapy promotes tumor adapted TNF-producing neutrophils that impair T cell clonal expansion and resident memory formation in pancreatic ductal adenocarcinoma 2236
Immunotherapy promotes tumor adapted TNF-producing neutrophils that impair T cell clonal expansion and resident memory formation in pancreatic ductal adenocarcinoma 2236 Open
Description Pancreatic ductal adenocarcinoma (PDA) establishes a proinflammatory and fibrotic microenvironment that shields malignant cells from immune attack. Agonistic aCD40 + immune checkpoint blockade + chemotherapy has transient antit…
View article: IL-15 complex with agonistic anti-CD40 + anti-PDL1 overcomes T cell exhaustion and drives a T-bet+ effector program for pancreatic ductal adenocarcinoma eradication 3573
IL-15 complex with agonistic anti-CD40 + anti-PDL1 overcomes T cell exhaustion and drives a T-bet+ effector program for pancreatic ductal adenocarcinoma eradication 3573 Open
Description New approaches are needed to improve immunotherapy outcomes in the lethal malignancy, pancreatic ductal adenocarcinoma (PDA). As such, we performed scRNA-seq combined with scV(D)J-seq of tumor-infiltrating and peripheral CD8 T …
View article: A Ten-Year Retrospective Review of Medical Records of Patients Admitted with Meningitis or Encephalitis at Five Hospitals in the United States Highlights the Potential for Under-Ascertainment of Invasive Meningococcal Disease
A Ten-Year Retrospective Review of Medical Records of Patients Admitted with Meningitis or Encephalitis at Five Hospitals in the United States Highlights the Potential for Under-Ascertainment of Invasive Meningococcal Disease Open
Laboratory confirmation of invasive meningococcal disease (IMD) relies on detection of Neisseria meningitidis in a biological specimen. Clinical management guidelines for patients presenting with signs and/or symptoms of meningitis and enc…
View article: Supplementary Figure 3 from IL-15 Complex Enhances Agonistic Anti-CD40 + Anti-PDL1 by Correcting the T-bet to Tox Ratio in CD8<sup>+</sup> T cells Infiltrating Pancreatic Ductal Adenocarcinoma
Supplementary Figure 3 from IL-15 Complex Enhances Agonistic Anti-CD40 + Anti-PDL1 by Correcting the T-bet to Tox Ratio in CD8<sup>+</sup> T cells Infiltrating Pancreatic Ductal Adenocarcinoma Open
CD8 T cell differentiation in PDA.
View article: Supplementary Figure 5 from IL-15 Complex Enhances Agonistic Anti-CD40 + Anti-PDL1 by Correcting the T-bet to Tox Ratio in CD8<sup>+</sup> T cells Infiltrating Pancreatic Ductal Adenocarcinoma
Supplementary Figure 5 from IL-15 Complex Enhances Agonistic Anti-CD40 + Anti-PDL1 by Correcting the T-bet to Tox Ratio in CD8<sup>+</sup> T cells Infiltrating Pancreatic Ductal Adenocarcinoma Open
Antigen specificity and functionality of predominant TCRs from tumors from immunotherapy treated mice.
View article: Supplementary Figure 9 from IL-15 Complex Enhances Agonistic Anti-CD40 + Anti-PDL1 by Correcting the T-bet to Tox Ratio in CD8<sup>+</sup> T cells Infiltrating Pancreatic Ductal Adenocarcinoma
Supplementary Figure 9 from IL-15 Complex Enhances Agonistic Anti-CD40 + Anti-PDL1 by Correcting the T-bet to Tox Ratio in CD8<sup>+</sup> T cells Infiltrating Pancreatic Ductal Adenocarcinoma Open
IL15C synergizes with immunotherapy to target poorly immunogenic KPC2 tumors
View article: Data from IL-15 Complex Enhances Agonistic Anti-CD40 + Anti-PDL1 by Correcting the T-bet to Tox Ratio in CD8<sup>+</sup> T cells Infiltrating Pancreatic Ductal Adenocarcinoma
Data from IL-15 Complex Enhances Agonistic Anti-CD40 + Anti-PDL1 by Correcting the T-bet to Tox Ratio in CD8<sup>+</sup> T cells Infiltrating Pancreatic Ductal Adenocarcinoma Open
Agonistic anti-CD40 with anti–PD-1 can elicit objective responses in a small number of patients with pancreatic ductal adenocarcinoma (PDA). Better understanding of their individual effects on the pancreatic tumor microenvironment will hel…
View article: Supplementary Tables from IL-15 Complex Enhances Agonistic Anti-CD40 + Anti-PDL1 by Correcting the T-bet to Tox Ratio in CD8<sup>+</sup> T cells Infiltrating Pancreatic Ductal Adenocarcinoma
Supplementary Tables from IL-15 Complex Enhances Agonistic Anti-CD40 + Anti-PDL1 by Correcting the T-bet to Tox Ratio in CD8<sup>+</sup> T cells Infiltrating Pancreatic Ductal Adenocarcinoma Open
Supplementary Tables 1-5
View article: Supplementary Figure 1 from IL-15 Complex Enhances Agonistic Anti-CD40 + Anti-PDL1 by Correcting the T-bet to Tox Ratio in CD8<sup>+</sup> T cells Infiltrating Pancreatic Ductal Adenocarcinoma
Supplementary Figure 1 from IL-15 Complex Enhances Agonistic Anti-CD40 + Anti-PDL1 by Correcting the T-bet to Tox Ratio in CD8<sup>+</sup> T cells Infiltrating Pancreatic Ductal Adenocarcinoma Open
Single cell transcriptional atlas following anti-PDL1 or agonistic anti-CD40
View article: Supplementary Figure 2 from IL-15 Complex Enhances Agonistic Anti-CD40 + Anti-PDL1 by Correcting the T-bet to Tox Ratio in CD8<sup>+</sup> T cells Infiltrating Pancreatic Ductal Adenocarcinoma
Supplementary Figure 2 from IL-15 Complex Enhances Agonistic Anti-CD40 + Anti-PDL1 by Correcting the T-bet to Tox Ratio in CD8<sup>+</sup> T cells Infiltrating Pancreatic Ductal Adenocarcinoma Open
Agonistic anti-CD40 + anti-PDL1 promotes tumor-specific CD8 T cell differentiation in spleen
View article: Supplementary Figure 7 from IL-15 Complex Enhances Agonistic Anti-CD40 + Anti-PDL1 by Correcting the T-bet to Tox Ratio in CD8<sup>+</sup> T cells Infiltrating Pancreatic Ductal Adenocarcinoma
Supplementary Figure 7 from IL-15 Complex Enhances Agonistic Anti-CD40 + Anti-PDL1 by Correcting the T-bet to Tox Ratio in CD8<sup>+</sup> T cells Infiltrating Pancreatic Ductal Adenocarcinoma Open
A fraction of TSTEM and TEFF are in the vasculature in dLN and tumor
View article: Supplementary Figure 6 from IL-15 Complex Enhances Agonistic Anti-CD40 + Anti-PDL1 by Correcting the T-bet to Tox Ratio in CD8<sup>+</sup> T cells Infiltrating Pancreatic Ductal Adenocarcinoma
Supplementary Figure 6 from IL-15 Complex Enhances Agonistic Anti-CD40 + Anti-PDL1 by Correcting the T-bet to Tox Ratio in CD8<sup>+</sup> T cells Infiltrating Pancreatic Ductal Adenocarcinoma Open
CD4 T cells and tumor antigen are required for anti-CD40 driven TSTEM accumulation in PDA
View article: Supplementary FIgure 8 from IL-15 Complex Enhances Agonistic Anti-CD40 + Anti-PDL1 by Correcting the T-bet to Tox Ratio in CD8<sup>+</sup> T cells Infiltrating Pancreatic Ductal Adenocarcinoma
Supplementary FIgure 8 from IL-15 Complex Enhances Agonistic Anti-CD40 + Anti-PDL1 by Correcting the T-bet to Tox Ratio in CD8<sup>+</sup> T cells Infiltrating Pancreatic Ductal Adenocarcinoma Open
IL-15C promotes the activity of dual therapy by promoting T-bet in tumor-infiltrating T cells
View article: Supplementary Figure 4 from IL-15 Complex Enhances Agonistic Anti-CD40 + Anti-PDL1 by Correcting the T-bet to Tox Ratio in CD8<sup>+</sup> T cells Infiltrating Pancreatic Ductal Adenocarcinoma
Supplementary Figure 4 from IL-15 Complex Enhances Agonistic Anti-CD40 + Anti-PDL1 by Correcting the T-bet to Tox Ratio in CD8<sup>+</sup> T cells Infiltrating Pancreatic Ductal Adenocarcinoma Open
Comparison of human and murine tumor-infiltrating CD8 T cells.
View article: IL-15 Complex Enhances Agonistic Anti-CD40 + Anti-PDL1 by Correcting the T-bet to Tox Ratio in CD8+ T cells Infiltrating Pancreatic Ductal Adenocarcinoma
IL-15 Complex Enhances Agonistic Anti-CD40 + Anti-PDL1 by Correcting the T-bet to Tox Ratio in CD8+ T cells Infiltrating Pancreatic Ductal Adenocarcinoma Open
Agonistic anti-CD40 with anti–PD-1 can elicit objective responses in a small number of patients with pancreatic ductal adenocarcinoma (PDA). Better understanding of their individual effects on the pancreatic tumor microenvironment will hel…
View article: Interobserver reproducibility of a hybrid three‐tier grading system of papillary nonmuscle invasive urothelial carcinoma: an international Uropathology study
Interobserver reproducibility of a hybrid three‐tier grading system of papillary nonmuscle invasive urothelial carcinoma: an international Uropathology study Open
Aims A hybrid‐three tier system with low grade (LG), high grade‐ G2 (HG‐G2), high grade‐ G3 (HG‐G3) has been proposed in recognition of, and to help address, the clinical heterogeneity within high grade WHO 2004/2022. We assessed interobse…
View article: Custom R Flexdashboard for molecular genetic pathology quality tracking
Custom R Flexdashboard for molecular genetic pathology quality tracking Open
View article: The Role of Dynamic Contrast Enhanced Magnetic Resonance Imaging in Evaluating Prostate Adenocarcinoma: A Partially‐Blinded Retrospective Study of a Prostatectomy Patient Cohort With Whole Gland Histopathology Correlation and Application of PI‐RADS or TNM Staging
The Role of Dynamic Contrast Enhanced Magnetic Resonance Imaging in Evaluating Prostate Adenocarcinoma: A Partially‐Blinded Retrospective Study of a Prostatectomy Patient Cohort With Whole Gland Histopathology Correlation and Application of PI‐RADS or TNM Staging Open
Background Dynamic contrast‐enhanced (DCE) magnetic resonance imaging (MRI) in the current Prostate Imaging‐Reporting and Data System version 2.1 (PI‐RADS v2.1) is considered optional, with primary scoring based on T2‐weighted imaging (T2W…
View article: Global Epidemiology of Meningococcal Disease-Causing Serogroups Before and After the COVID-19 Pandemic: A Narrative Review
Global Epidemiology of Meningococcal Disease-Causing Serogroups Before and After the COVID-19 Pandemic: A Narrative Review Open
Invasive meningococcal disease (IMD) is associated with high morbidity and mortality and predominantly caused by five Neisseria meningitidis serogroups (A/B/C/W/Y). Polysaccharide conjugate vaccines induce T-cell-dependent immune responses…
View article: Mucosal Healing Among Black and White Patients With Inflammatory Bowel Disease
Mucosal Healing Among Black and White Patients With Inflammatory Bowel Disease Open
INTRODUCTION: Crohn's disease and ulcerative colitis are characterized by chronic inflammation of the gastrointestinal tract. Mucosal healing (MH) is a therapeutic goal in patients with inflammatory bowel disease (IBD). Current data sugges…
View article: Cecal Metastasis of Clear Cell Renal Cell Carcinoma After Previous Nephrectomy
Cecal Metastasis of Clear Cell Renal Cell Carcinoma After Previous Nephrectomy Open
Metastasis of renal cell carcinoma (RCC) to the gastrointestinal (GI) tract is exceedingly rare. We present a case of a man in his 40s with a history of RCC that had metastasized to his abdominal wall and brain who then presented with abdo…
View article: NUPR1 packaged in extracellular vesicles promotes murine triple-negative breast cancer in a type 1 interferon-independent manner
NUPR1 packaged in extracellular vesicles promotes murine triple-negative breast cancer in a type 1 interferon-independent manner Open
Aim: This study aims to elucidate the involvement of triple-negative breast cancer (TNBC)-derived extracellular vesicles in metastasis. The loss of components in the type 1 interferon (IFN1) signaling pathway has been linked to the promoti…
View article: Recent Advances in Genitourinary Tumors: Updates From the 5th Edition of the World Health Organization Blue Book Series
Recent Advances in Genitourinary Tumors: Updates From the 5th Edition of the World Health Organization Blue Book Series Open
Context.— Urinary and Male Genital Tumours is the 8th volume of the World Health Organization Classification of Tumours series, 5th edition. Released in hard copy in September 2022, it presents an update to the classification of male genit…
View article: CD115+ monocytes protect microbially experienced mice against E. coli-induced sepsis
CD115+ monocytes protect microbially experienced mice against E. coli-induced sepsis Open
View article: International Opinions on Grading of Urothelial Carcinoma: A Survey Among European Association of Urology and International Society of Urological Pathology Members
International Opinions on Grading of Urothelial Carcinoma: A Survey Among European Association of Urology and International Society of Urological Pathology Members Open
Grading of non-muscle-invasive bladder cancer (NMIBC) is a matter of ongoing debate and lacks international consensus. We surveyed urologists and pathologists of European Association of Urology and International Society of Urological Patho…
View article: Supplementary Table S4 from Gene Expression Changes in an Animal Melanoma Model Correlate with Aggressiveness of Human Melanoma Metastases
Supplementary Table S4 from Gene Expression Changes in an Animal Melanoma Model Correlate with Aggressiveness of Human Melanoma Metastases Open
Supplementary Table S4 from Gene Expression Changes in an Animal Melanoma Model Correlate with Aggressiveness of Human Melanoma Metastases
View article: Supplementary Table S4 from Gene Expression Changes in an Animal Melanoma Model Correlate with Aggressiveness of Human Melanoma Metastases
Supplementary Table S4 from Gene Expression Changes in an Animal Melanoma Model Correlate with Aggressiveness of Human Melanoma Metastases Open
Supplementary Table S4 from Gene Expression Changes in an Animal Melanoma Model Correlate with Aggressiveness of Human Melanoma Metastases
View article: Supplementary Table S1 from Gene Expression Changes in an Animal Melanoma Model Correlate with Aggressiveness of Human Melanoma Metastases
Supplementary Table S1 from Gene Expression Changes in an Animal Melanoma Model Correlate with Aggressiveness of Human Melanoma Metastases Open
Supplementary Table S1 from Gene Expression Changes in an Animal Melanoma Model Correlate with Aggressiveness of Human Melanoma Metastases
View article: Supplementary Table S3 from Gene Expression Changes in an Animal Melanoma Model Correlate with Aggressiveness of Human Melanoma Metastases
Supplementary Table S3 from Gene Expression Changes in an Animal Melanoma Model Correlate with Aggressiveness of Human Melanoma Metastases Open
Supplementary Table S3 from Gene Expression Changes in an Animal Melanoma Model Correlate with Aggressiveness of Human Melanoma Metastases
View article: Supplementary Table S6 from Gene Expression Changes in an Animal Melanoma Model Correlate with Aggressiveness of Human Melanoma Metastases
Supplementary Table S6 from Gene Expression Changes in an Animal Melanoma Model Correlate with Aggressiveness of Human Melanoma Metastases Open
Supplementary Table S6 from Gene Expression Changes in an Animal Melanoma Model Correlate with Aggressiveness of Human Melanoma Metastases