Stephen V. Gordon
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View article: Accurate and robust classification of <i>Mycobacterium bovis</i>-infected cattle using peripheral blood RNA-seq data
Accurate and robust classification of <i>Mycobacterium bovis</i>-infected cattle using peripheral blood RNA-seq data Open
The zoonotic bacterium, Mycobacterium bovis , causes bovine tuberculosis (bTB) and is closely related to Mycobacterium tuberculosis , the primary cause of human tuberculosis (hTB). Bovine TB remains recalcitrant to eradication in endemic c…
View article: SNiPgenie: a tool for microbial SNP site detection from whole-genome sequencing data
SNiPgenie: a tool for microbial SNP site detection from whole-genome sequencing data Open
Whole-genome sequencing (WGS) of microbial pathogens provides a high-resolution approach to antibiotic resistance profiling, lineage classification and outbreak surveillance. Identification of SNPs across the genome by alignment against a …
View article: Genetic control of the transcriptional response to active tuberculosis disease and treatment
Genetic control of the transcriptional response to active tuberculosis disease and treatment Open
The functional impact of genomic regulatory variation during active TB disease and anti-TB treatment (ATT) remains poorly understood. Here, using 240 paired whole-blood RNA-seq samples from n = 48 active TB patients who underwent ATT, we c…
View article: Transcriptional comparison between the PhoPR system of Mycobacterium tuberculosis and Mycobacterium bovis on an M. bovis AF2122/97 genetic background
Transcriptional comparison between the PhoPR system of Mycobacterium tuberculosis and Mycobacterium bovis on an M. bovis AF2122/97 genetic background Open
Tuberculosis (TB) is an infectious disease that affects humans and animals. The pathogens that cause TB belong to the Mycobacterium tuberculosis Complex (MTBC), with Mycobacterium tuberculosis and Mycobacterium bovis as the main representa…
View article: Investigation of WQ-3810, a Fluoroquinolone with a High Potential Against Fluoroquinolone-Resistant Mycobacterium avium
Investigation of WQ-3810, a Fluoroquinolone with a High Potential Against Fluoroquinolone-Resistant Mycobacterium avium Open
Background/Objectives: Mycobacterium avium, a member of Mycobacterium avium complex (MAC), is an emerging opportunistic pathogen causing MAC-pulmonary disease (PD). Fluoroquinolones (FQs), along with ethambutol (EMB) and rifampicin, are re…
View article: SNiPgenie: A tool for microbial SNP site detection from whole genome sequencing data
SNiPgenie: A tool for microbial SNP site detection from whole genome sequencing data Open
Whole-genome sequencing (WGS) of microbial pathogens provides a high-resolution approach to antibiotic resistance profiling, lineage classification, and outbreak surveillance. Identification of single nucleotide polymorphisms (SNPs) across…
View article: Development of a multiplex loop-mediated isothermal amplification (LAMP) method for differential detection of <i>Mycobacterium bovis</i> and <i>Mycobacterium tuberculosis</i> by dipstick DNA chromatography
Development of a multiplex loop-mediated isothermal amplification (LAMP) method for differential detection of <i>Mycobacterium bovis</i> and <i>Mycobacterium tuberculosis</i> by dipstick DNA chromatography Open
Although human tuberculosis (TB) caused by Mycobacterium bovis is clinically, pathologically, and radiologically indistinguishable from Mycobacterium tuberculosis -caused TB, M. bovis is innately resistant to pyrazinamide, a key first-line…
View article: Genetic control of the transcriptional response to active tuberculosis disease and treatment
Genetic control of the transcriptional response to active tuberculosis disease and treatment Open
Summary Understanding the functional impact of genomic sequence variants is critical for evaluating the role of genetic variation in the host response during tuberculosis (TB) disease and anti-TB treatment (ATT). Hitherto, there have been …
View article: Integrative genomics sheds light on the immunogenetics of tuberculosis in cattle
Integrative genomics sheds light on the immunogenetics of tuberculosis in cattle Open
Mycobacterium bovis causes bovine tuberculosis (bTB), an infectious disease of cattle that represents a zoonotic threat to humans. Research has shown that the peripheral blood (PB) transcriptome is perturbed during bTB disease but the geno…
View article: SNiPgenie: A tool for microbial SNP site detection from whole genome sequencing data
SNiPgenie: A tool for microbial SNP site detection from whole genome sequencing data Open
Whole-genome sequencing (WGS) of microbial pathogens provides a high-resolution approach to antibiotic resistance profiling, lineage classification, and outbreak surveillance. Identification of single nucleotide polymorphisms (SNPs) across…
View article: Complete genome and transcriptome of <i>Mycobacterium bovis</i> 3488, a clinical isolate with a novel deletion at the RD1 locus
Complete genome and transcriptome of <i>Mycobacterium bovis</i> 3488, a clinical isolate with a novel deletion at the RD1 locus Open
In members of the Mycobacterium tuberculosis complex, the RD1 locus encodes a type VII secretion system involved in virulence. Herein, we describe the genome and transcriptomic analysis of Mycobacterium bovis 3488, a clinical isolate from …
View article: Isolation and genetic analysis of mycobacteria from suspect tuberculous lesions in slaughtered cattle from Wolaita, Ethiopia
Isolation and genetic analysis of mycobacteria from suspect tuberculous lesions in slaughtered cattle from Wolaita, Ethiopia Open
Bovine tuberculosis (bTB), caused by Mycobacterium bovis and other members of the Mycobacterium tuberculosis complex (MTBC), is a significant concern for livestock and public health in Ethiopia. This study aimed to isolate and genetically …
View article: Isolation and genetic analysis of mycobacteria from suspect tuberculous lesions in slaughtered cattle from Wolaita, Ethiopia
Isolation and genetic analysis of mycobacteria from suspect tuberculous lesions in slaughtered cattle from Wolaita, Ethiopia Open
Bovine tuberculosis (bTB), caused by Mycobacterium bovis and other members of the Mycobacterium tuberculosis complex (MTBC), is a significant concern for livestock and public health in Ethiopia. This study aimed to isolate and genetically …
View article: Isolation and genetic analysis of mycobacteria from suspect tuberculous lesions in slaughtered cattle from Wolaita, Ethiopia
Isolation and genetic analysis of mycobacteria from suspect tuberculous lesions in slaughtered cattle from Wolaita, Ethiopia Open
Bovine tuberculosis (bTB), caused by Mycobacterium bovis and other members of the Mycobacterium tuberculosis complex (MTBC), is a significant concern for livestock and public health in Ethiopia. This study aimed to isolate and genetically …
View article: Insights into the production and evolution of lantibiotics from a computational analysis of peptides associated with the lanthipeptide cyclase domain
Insights into the production and evolution of lantibiotics from a computational analysis of peptides associated with the lanthipeptide cyclase domain Open
Lanthipeptides are a large group of ribosomally encoded peptides cyclized by thioether and methylene bridges, which include the lantibiotics, lanthipeptides with antimicrobial activity. There are over 100 experimentally characterized lanth…
View article: Corrigendum: Lack of methoxy-mycolates characterizes the geographically restricted lineage 7 of Mycobacterium tuberculosis complex
Corrigendum: Lack of methoxy-mycolates characterizes the geographically restricted lineage 7 of Mycobacterium tuberculosis complex Open
Microbiology Society journals contain high-quality research papers and topical review articles. We are a not-for-profit publisher and we support and invest in the microbiology community, to the benefit of everyone. This supports our princi…
View article: Integrative genomics sheds light on the immunobiology of tuberculosis in cattle
Integrative genomics sheds light on the immunobiology of tuberculosis in cattle Open
Mycobacterium bovis causes bovine tuberculosis (bTB), an infectious disease of cattle that poses a zoonotic threat to humans. Research has shown that bTB susceptibility is a heritable trait, and that the peripheral blood (PB) transcriptome…
View article: Whole-Genome sequencing in routine Mycobacterium bovis epidemiology – scoping the potential
Whole-Genome sequencing in routine Mycobacterium bovis epidemiology – scoping the potential Open
Mycobacterium bovis the main agent of bovine tuberculosis (bTB), presents as a series of spatially-localised micro-epidemics across landscapes. Classical molecular typing methods applied to these micro-epidemics, based on genotyping a few …
View article: Can a regional approach be applied to achieve eradication of bovine tuberculosis in Ireland?
Can a regional approach be applied to achieve eradication of bovine tuberculosis in Ireland? Open
Given the lack of progress in recent years, new approaches must be considered in relation to the eradication of bovine tuberculosis (TB, caused by Mycobacterium bovis) in Ireland.This study examines the potential effectiveness of a regiona…
View article: Integrative and comparative genomic analyses of mammalian macrophage responses to intracellular mycobacterial pathogens
Integrative and comparative genomic analyses of mammalian macrophage responses to intracellular mycobacterial pathogens Open
Mycobacterium tuberculosis , the causative agent of human tuberculosis (hTB), is currently classed as the thirteenth leading cause of death worldwide. Mycobacterium bovis , a close evolutionary relative of M. tuberculosis , causes bovine t…
View article: Differences in Faecal Microbiome Taxonomy, Diversity and Functional Potential in a Bovine Cohort Experimentally Challenged with Mycobacterium avium subsp. paratuberculosis (MAP)
Differences in Faecal Microbiome Taxonomy, Diversity and Functional Potential in a Bovine Cohort Experimentally Challenged with Mycobacterium avium subsp. paratuberculosis (MAP) Open
Mycobacterium avium subspecies paratuberculosis (MAP) is the causative agent of Johne’s disease in ruminants, a chronic enteritis which results in emaciation and eventual loss of the animal. Recent advances in metagenomics have allowed a m…
View article: Lack of methoxy-mycolates characterizes the geographically restricted lineage 7 of Mycobacterium tuberculosis complex
Lack of methoxy-mycolates characterizes the geographically restricted lineage 7 of Mycobacterium tuberculosis complex Open
Lineage 7 (L7) emerged in the phylogeny of the Mycobacterium tuberculosis complex (MTBC) subsequent to the branching of ‘ancient’ lineage 1 and prior to the Eurasian dispersal of ‘modern’ lineages 2, 3 and 4. In contrast to the major MTBC …
View article: Characterization of DNA Gyrase Activity and Elucidation of the Impact of Amino Acid Substitution in GyrA on Fluoroquinolone Resistance in Mycobacterium avium
Characterization of DNA Gyrase Activity and Elucidation of the Impact of Amino Acid Substitution in GyrA on Fluoroquinolone Resistance in Mycobacterium avium Open
The emergence of fluoroquinolone (FQ) resistance has further compounded the control of emerging Mycobacterium avium -associated nontuberculous mycobacteria infections worldwide. For M. avium , the association of FQ resistance and mutations…
View article: Long term dietary vitamin D3 supplementation impacts both microbicidal and inflammatory responses to ex-vivo Mycobacterium bovis BCG challenge in dairy calves
Long term dietary vitamin D3 supplementation impacts both microbicidal and inflammatory responses to ex-vivo Mycobacterium bovis BCG challenge in dairy calves Open
Vitamin D deficiency (VDD) is associated with enhanced susceptibility to multiple respiratory diseases in humans, including tuberculosis. However, the consequences of VDD for disease susceptibility in calves are unknown. Previously we deve…