Steven L. Young
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View article: Society of Radiologists in Ultrasound response to ‘Proposed simplified protocol for initial assessment of endometriosis with transvaginal ultrasound’
Society of Radiologists in Ultrasound response to ‘Proposed simplified protocol for initial assessment of endometriosis with transvaginal ultrasound’ Open
Linked article: This Correspondence comments on Deslandes and Leonardi. Click here to view the article.
View article: Understanding how space travel affects the female reproductive system to the Moon and beyond
Understanding how space travel affects the female reproductive system to the Moon and beyond Open
As the space industry grows exponentially and aspirations for space travel expand, we are entering a new era where we will very likely become an interplanetary species. Although reproduction is an essential human function and necessary for…
View article: Defining the roles of local precipitation and anthropogenic water sources in driving the abundance of Aedes aegypti, an emerging disease vector in urban, arid landscapes
Defining the roles of local precipitation and anthropogenic water sources in driving the abundance of Aedes aegypti, an emerging disease vector in urban, arid landscapes Open
Understanding drivers of disease vectors’ population dynamics is a pressing challenge. For short-lived organisms like mosquitoes, landscape-scale models must account for their highly local and rapid life cycles. Aedes aegypti , a vector of…
View article: Fluoroestradiol PET-MRI imaging for detection of endometriosis lesions and symptom correlation
Fluoroestradiol PET-MRI imaging for detection of endometriosis lesions and symptom correlation Open
Endometriosis is a common cause of infertility, pelvic pain, and dysmenorrhea and there are prior case reports of lesion detection using an 18F-fluoroestradiol (FES) tracer with positron emission tomography (PET). We aimed to further inves…
View article: Uterine uptake of estrogen and progestogen-based radiotracers in rhesus macaques with endometriosis
Uterine uptake of estrogen and progestogen-based radiotracers in rhesus macaques with endometriosis Open
Purpose Few investigations have examined the uptake of radiotracers that target the prominent sex-steroid receptors in the uterus across the menstrual cycle and with disease state. We aimed to determine if uptake of the radiotracers that t…
View article: Meeting the demand for fertility services: the present and future of reproductive endocrinology and infertility in the United States
Meeting the demand for fertility services: the present and future of reproductive endocrinology and infertility in the United States Open
The field of reproductive endocrinology and infertility (REI) is at a crossroads; there is a mismatch between demand for reproductive endocrinology, infertility and assisted reproductive technology (ART) services, and availability of care.…
View article: Spaceflight alters insulin and estrogen signaling pathways
Spaceflight alters insulin and estrogen signaling pathways Open
Organismal adaptations to spaceflight have been characterized at the molecular level in model organisms, including Drosophila and C. elegans. Here we extend molecular work to energy metabolism and sex hormone signaling in mice and humans. …
View article: Effects of acute estradiol and progesterone on perimenstrual exacerbation of suicidal ideation and related symptoms: a crossover randomized controlled trial
Effects of acute estradiol and progesterone on perimenstrual exacerbation of suicidal ideation and related symptoms: a crossover randomized controlled trial Open
Female suicide attempts peak peri-menstrually—around the onset of menses—when the ovarian steroids estradiol (E2) and progesterone (P4) fall rapidly. Given preclinical evidence that withdrawal from either E2 or P4 can provoke behaviors con…
View article: Estrogen mediates inflammatory role of mast cells in endometriosis pathophysiology
Estrogen mediates inflammatory role of mast cells in endometriosis pathophysiology Open
Endometriosis is an estrogen dependent, chronic inflammatory disease characterized by the growth of endometrial lining outside of the uterus. Mast cells have emerged as key players in regulating not only allergic responses but also other m…
View article: Estrogen mediates inflammatory role of mast cells in endometriosis pathophysiology
Estrogen mediates inflammatory role of mast cells in endometriosis pathophysiology Open
Endometriosis is an estrogen dependent, chronic inflammatory disease characterized by the growth of endometrial lining outside of the uterus. Mast cells have emerged as key players in regulating not only allergic responses but also other m…
View article: The Estrogen Receptor α Cistrome in Human Endometrium and Epithelial Organoids
The Estrogen Receptor α Cistrome in Human Endometrium and Epithelial Organoids Open
Endometrial health is affected by molecular processes that underlie estrogen responses. We assessed estrogen regulation of endometrial function by integrating the estrogen receptor α (ESR1) cistromes and transcriptomes of endometrial biops…
View article: Progesterone Signaling in Endometrial Epithelial Organoids
Progesterone Signaling in Endometrial Epithelial Organoids Open
For pregnancy to be established, uterine cells respond to the ovarian hormones, estrogen, and progesterone, via their nuclear receptors, the estrogen receptor (ESR1) and progesterone receptor (PGR). ESR1 and PGR regulate genes by binding c…
View article: Pre-IVF treatment with a GnRH antagonist in women with endometriosis (PREGNANT): study protocol for a prospective, double-blind, placebo-controlled trial
Pre-IVF treatment with a GnRH antagonist in women with endometriosis (PREGNANT): study protocol for a prospective, double-blind, placebo-controlled trial Open
Introduction Infertility is a common complication of endometriosis. While in vitro fertilisation-embryo transfer (IVF) successfully treats endometriosis-associated infertility, there is some evidence that pregnancy rates may be diminished …
View article: Progesterone Signaling in Endometrial Epithelial Organoids
Progesterone Signaling in Endometrial Epithelial Organoids Open
For pregnancy to be established, uterine cells respond to the ovarian hormones, estrogen, and progesterone, via their nuclear receptors, the estrogen receptor (ESR1) and progesterone receptor (PGR). ESR1 and PGR regulate genes by binding c…
View article: The estrogen receptor α cistrome in human endometrium and epithelial organoids
The estrogen receptor α cistrome in human endometrium and epithelial organoids Open
Context Endometrial health is impacted by molecular processes that underlie estrogen responses. Objective To define estrogen regulation of endometrial function by integrating the estrogen receptor alpha (ESR1) cistrome and transcriptome of…
View article: Precipitation's complicated role in driving the abundance of an emerging disease vector in an urban, arid landscape
Precipitation's complicated role in driving the abundance of an emerging disease vector in an urban, arid landscape Open
Understanding drivers of disease vectors’ population dynamics is a pressing challenge for human health, however, for short-lived organisms like mosquitoes, landscape-scale models must account for the highly local and rapid scale of their l…
View article: SIRT1 plays an important role in implantation and decidualization during mouse early pregnancy
SIRT1 plays an important role in implantation and decidualization during mouse early pregnancy Open
Sirtuin 1 (SIRT1) is a member of the sirtuin family that functions to deacetylate both histones and non-histone proteins. Previous studies have identified significant SIRT1 upregulation in eutopic endometrium from infertile women with endo…