Steven A. Pergam
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View article: A Network for Advancing Prevention and Treatment of Infections Among Immunocompromised Individuals
A Network for Advancing Prevention and Treatment of Infections Among Immunocompromised Individuals Open
Importance Immunocompromised individuals are a large and growing population who are at increased risk for infectious diseases. There has and continues to be a lack of focus on clinical trials to establish the safety and efficacy of therapi…
View article: P-118. Patient Reported Outcomes (PRO) Analysis of the Phase 2 Multi-Center, Prospective, Randomized, Double-Blind Study Assessing Nitazoxanide for the Treatment of Norovirus in Hematopoietic Stem Cell and Solid Organ Transplant Recipients
P-118. Patient Reported Outcomes (PRO) Analysis of the Phase 2 Multi-Center, Prospective, Randomized, Double-Blind Study Assessing Nitazoxanide for the Treatment of Norovirus in Hematopoietic Stem Cell and Solid Organ Transplant Recipients Open
Background Norovirus (NoV) results in relapsing, remitting diarrhea in immunocompromised hosts (ICH). No prospective studies of existing therapies including nitazoxanide (NTZ) have included evaluation of patient reported outcomes (PRO) or …
View article: P-1750. Assessment of Antimicrobial Stewardship Guided CYP2C19 Pharmacogenomic Voriconazole Dosing: Practicalities and Impact on Clinical Management
P-1750. Assessment of Antimicrobial Stewardship Guided CYP2C19 Pharmacogenomic Voriconazole Dosing: Practicalities and Impact on Clinical Management Open
Background Pharmacogenomic testing of CYP2C19 is a potential tool to optimize dosing of voriconazole (VCZ), a drug with a narrow therapeutic index and interpatient variability. An onsite CYP2C19 assay was developed to improve the accessibi…
View article: P-25. Evaluating the Immunogenicity and Safety of Either Two High-Dose or Two Standard-Dose Influenza Vaccines Over Two Consecutive Seasons in Adult Hematopoietic Cell Transplant Recipients
P-25. Evaluating the Immunogenicity and Safety of Either Two High-Dose or Two Standard-Dose Influenza Vaccines Over Two Consecutive Seasons in Adult Hematopoietic Cell Transplant Recipients Open
Background Adult hematopoietic cell transplant (HCT) recipients are at high risk of influenza complications but have suboptimal immune responses to influenza vaccines. Our previous phase II trial in adult HCT recipients demonstrated that t…
View article: P-2001. Limited Yield of Weekly SARS-CoV-2 Surveillance Testing Among Asymptomatic Hematopoietic Cell Transplant and Chimeric Antigen Receptor T-Cell Therapy Recipients
P-2001. Limited Yield of Weekly SARS-CoV-2 Surveillance Testing Among Asymptomatic Hematopoietic Cell Transplant and Chimeric Antigen Receptor T-Cell Therapy Recipients Open
Background Surveillance testing for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) among asymptomatic patients is used in some healthcare settings to prevent outbreaks. We examined the utility of weekly SARS-CoV-2 testing amo…
View article: Limited yield of SARS-CoV-2 screening in asymptomatic hematopoietic cell transplant and chimeric antigen receptor T-cell therapy patients
Limited yield of SARS-CoV-2 screening in asymptomatic hematopoietic cell transplant and chimeric antigen receptor T-cell therapy patients Open
Early in the COVID-19 pandemic, screening was initiated in several settings to mitigate asymptomatic transmission of SARS-CoV-2. However, this practice was later discouraged by the Society for Healthcare Epidemiology of America. This singl…
View article: Society for Healthcare Epidemiology of America position statement on pandemic preparedness for policymakers: mitigating supply shortages.
Society for Healthcare Epidemiology of America position statement on pandemic preparedness for policymakers: mitigating supply shortages. Open
The COVID-19 has had major direct (e.g., deaths) and indirect (e.g., social inequities) effects in the United States. While the public health response to the epidemic featured some important successes (e.g., universal masking ,and rapid de…
View article: SHEA position statement on pandemic preparedness for policymakers: the role of healthcare epidemiologists in communicating during infectious diseases outbreaks.
SHEA position statement on pandemic preparedness for policymakers: the role of healthcare epidemiologists in communicating during infectious diseases outbreaks. Open
Background Effective communication is a fundamental aspect of any emergency response, including outbreaks of infectious diseases, epidemics, and pandemics, during which rapidly evolving conditions, and changing or conflicting recommendatio…
View article: SHEA position statement on pandemic preparedness for policymakers: pandemic data collection, maintenance, and release.
SHEA position statement on pandemic preparedness for policymakers: pandemic data collection, maintenance, and release. Open
The Society for Healthcare Epidemiology in America (SHEA) strongly supports modernization of data collection processes and the creation of publicly available data repositories that include a wide variety of data elements and mechanisms for…
View article: Epidemiology and Outcomes of Recurrent <i>C Difficile</i> Infection Among Hematopoietic Cell Transplant Recipients: A Single-center, Retrospective 10-year Study
Epidemiology and Outcomes of Recurrent <i>C Difficile</i> Infection Among Hematopoietic Cell Transplant Recipients: A Single-center, Retrospective 10-year Study Open
Background There are limited data on the contemporary epidemiology of recurrent Clostridioides difficile infection (CDI) among hematopoietic cell transplant (HCT) recipients. We aimed to determine the incidence, risk factors, and outcomes …
View article: SHEA position statement on pandemic preparedness for policymakers: emerging infectious threats.
SHEA position statement on pandemic preparedness for policymakers: emerging infectious threats. Open
Background Emerging infectious diseases (EID) are defined as pathogens that have recently been identified in a population or had previously reduced in scope but are rapidly increasing in incidence or geographic range. Pandemics occur when …
View article: Ceftriaxone-resistant viridans streptococci bacteraemia among patients treated at a large comprehensive cancer care centre: a retrospective eighteen-year study
Ceftriaxone-resistant viridans streptococci bacteraemia among patients treated at a large comprehensive cancer care centre: a retrospective eighteen-year study Open
Objectives Viridans streptococci (VS) are opportunistic oral commensals and a common cause of bacteraemia in neutropenic patients. In this retrospective single centre cohort study, we investigated the prevalence of ceftriaxone resistance i…
View article: SHEA position statement on pandemic preparedness for policymakers: introduction and overview
SHEA position statement on pandemic preparedness for policymakers: introduction and overview Open
Throughout history, pandemics and their aftereffects have spurred society to make substantial improvements in healthcare. After the Black Death in 14 th century Europe, changes were made to elevate standards of care and nutrition that resu…
View article: SHEA position statement on pandemic preparedness for policymakers: building a strong and resilient healthcare workforce
SHEA position statement on pandemic preparedness for policymakers: building a strong and resilient healthcare workforce Open
Throughout the COVID-19 pandemic, many areas in the United States experienced healthcare personnel (HCP) shortages tied to a variety of factors. Infection prevention programs, in particular, faced increasing workload demands with little op…
View article: SHEA position statement on pandemic preparedness for policymakers: building a strong and resilient healthcare workforce.
SHEA position statement on pandemic preparedness for policymakers: building a strong and resilient healthcare workforce. Open
Throughout the COVID-19 pandemic, many areas in the United States experienced healthcare personnel (HCP) shortages tied to a variety of factors. Infection prevention programs, in particular, faced increasing workload demands with little op…
View article: SHEA position statement on pandemic preparedness for policymakers: introduction and overview.
SHEA position statement on pandemic preparedness for policymakers: introduction and overview. Open
Throughout history, pandemics and their aftereffects have spurred society to make substantial improvements in healthcare. After the Black Death in 14th century Europe, changes were made to elevate standards of care and nutrition that resul…
View article: How Immunocompromised Hosts Were Left Behind in the Quest to Control the COVID-19 Pandemic
How Immunocompromised Hosts Were Left Behind in the Quest to Control the COVID-19 Pandemic Open
The immunocompromised population was disproportionately affected by the severe acute respiratory syndrome coronavirus 2 pandemic. However, these individuals were largely excluded from clinical trials of vaccines, monoclonal antibodies, and…
View article: Clinical outcomes and frequency of persistent infection among immunosuppressed patients treated with bebtelovimab for COVID‐19 infection at an ambulatory cancer center
Clinical outcomes and frequency of persistent infection among immunosuppressed patients treated with bebtelovimab for COVID‐19 infection at an ambulatory cancer center Open
Background There are limited data on clinical outcomes associated with the use of bebtelovimab for the treatment of coronavirus disease 2019 (COVID‐19) among cancer patients. We aimed to define the clinical characteristics and outcomes amo…
View article: 663. Epidemiology and outcomes of recurrent <i>C. difficile</i> infection among hematopoietic cell transplant recipients
663. Epidemiology and outcomes of recurrent <i>C. difficile</i> infection among hematopoietic cell transplant recipients Open
Background Recent updates in Clostridioides difficile infection (CDI) treatment guidelines among hematopoietic cell transplant (HCT) recipients recommend fidaxomicin as first line therapy as it reduces the risk of recurrent CDI. We aimed t…
View article: 920. A Phase 2 Multi-Center, Prospective, Randomized, Double-Blind Study to Assess the Clinical and Antiviral Efficacy and Safety of Nitazoxanide for the Treatment of Norovirus in Hematopoietic Stem Cell and Solid Organ Transplant Recipients
920. A Phase 2 Multi-Center, Prospective, Randomized, Double-Blind Study to Assess the Clinical and Antiviral Efficacy and Safety of Nitazoxanide for the Treatment of Norovirus in Hematopoietic Stem Cell and Solid Organ Transplant Recipients Open
Background Norovirus (NoV) results in potentially severe, relapsing, remitting diarrhea in immunocompromised hosts (ICH). A number of interventions, including nitazoxanide (NTZ), have been tried with unclear success in managing cases of No…
View article: Lessons From the COVID-19 Pandemic: Updating Our Approach to Masking in Health Care Facilities
Lessons From the COVID-19 Pandemic: Updating Our Approach to Masking in Health Care Facilities Open
The COVID-19 pandemic has upended societal norms and changed the way the health risks associated with respiratory viral infections are viewed. In this commentary, the authors advocate for mindfulness of continuing areas of uncertainty alon…
View article: Comparison of Two High-Dose Versus Two Standard-Dose Influenza Vaccines in Adult Allogeneic Hematopoietic Cell Transplant Recipients
Comparison of Two High-Dose Versus Two Standard-Dose Influenza Vaccines in Adult Allogeneic Hematopoietic Cell Transplant Recipients Open
Background Adult hematopoietic cell transplant (HCT) recipients are at high risk for influenza-related morbidity and mortality and have suboptimal influenza vaccine immune responses compared to healthy adults, particularly within 2 years o…
View article: Association of Self-Reported COVID-19 Vaccination Status with COVID-19 Infection among Adult Long-Term Hematopoietic Cell Transplantation Survivors
Association of Self-Reported COVID-19 Vaccination Status with COVID-19 Infection among Adult Long-Term Hematopoietic Cell Transplantation Survivors Open
View article: Analysis of Antibiotic Exposure and Development of Acute Graft-vs-Host Disease Following Allogeneic Hematopoietic Cell Transplantation
Analysis of Antibiotic Exposure and Development of Acute Graft-vs-Host Disease Following Allogeneic Hematopoietic Cell Transplantation Open
Importance Certain antibiotic exposures have been associated with increased rates of acute graft-vs-host disease (aGVHD) after allogeneic hematopoietic cell transplantation (allo-HCT). Since antibiotic exposure can both affect and be affec…
View article: Successful Treatment of Persistent Symptomatic Coronavirus Disease 19 Infection With Extended-Duration Nirmatrelvir-Ritonavir Among Outpatients With Hematologic Cancer
Successful Treatment of Persistent Symptomatic Coronavirus Disease 19 Infection With Extended-Duration Nirmatrelvir-Ritonavir Among Outpatients With Hematologic Cancer Open
Persistent symptomatic coronavirus disease 2019 (COVID-19) is a distinct clinical entity among patients with hematologic cancer and/or profound immunosuppression. The optimal medical management is unknown. We describe 2 patients who had sy…
View article: Antiviral Prescribing Among Patients at an Ambulatory Cancer Center With Laboratory-Confirmed Influenza
Antiviral Prescribing Among Patients at an Ambulatory Cancer Center With Laboratory-Confirmed Influenza Open
Among 133 cancer outpatients diagnosed with influenza between 2016 and 2018, 110 (83%) were prescribed oseltamivir. Among 109 with a known symptom onset date, 53% presented for care and 31% were prescribed oseltamivir within 48 hours. Pati…
View article: Invasive fungal infections after CLAG-M/CLAG chemotherapy for acute myeloid leukemia and high-grade myeloid neoplasms
Invasive fungal infections after CLAG-M/CLAG chemotherapy for acute myeloid leukemia and high-grade myeloid neoplasms Open
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View article: Frequently Asked Questions about Mpox (Formerly Monkeypox Disease) for Hematopoietic Cell Transplantation and Chimeric Antigen Receptor T Cell Recipients from the American Society for Transplantation and Cellular Therapy
Frequently Asked Questions about Mpox (Formerly Monkeypox Disease) for Hematopoietic Cell Transplantation and Chimeric Antigen Receptor T Cell Recipients from the American Society for Transplantation and Cellular Therapy Open
View article: Frequently Asked Questions on Coronavirus Disease 2019 Vaccination for Hematopoietic Cell Transplantation and Chimeric Antigen Receptor T-Cell Recipients From the American Society for Transplantation and Cellular Therapy and the American Society of Hematology
Frequently Asked Questions on Coronavirus Disease 2019 Vaccination for Hematopoietic Cell Transplantation and Chimeric Antigen Receptor T-Cell Recipients From the American Society for Transplantation and Cellular Therapy and the American Society of Hematology Open
Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), disproportionately affects immunocompromised and elderly patients. Not only are hematopoietic cell transplantation (HCT) and chime…
View article: Self-Reported Experiences of Adult Hematopoietic Cell Transplantation Survivors with COVID-19 Vaccination and Infection
Self-Reported Experiences of Adult Hematopoietic Cell Transplantation Survivors with COVID-19 Vaccination and Infection Open
BACKGROUND Hematopoietic cell transplantation (HCT) survivors are at an increased risk of COVID-19 infection and complications. There are scant data for HCT recipients regarding compliance and experiences with COVID-19 vaccination or uptak…